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AB038. Pathological neovascularization in retinopathy of prematurity is regulated by heme-derived iron trafficking

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Annals of Eye Science 2019年第1期 213-213页

作者： Tapan Agnihotri Nicholas Kim Gael Cagnone Jin Sung Kim Emilie Heckel Sheetal Pundir Perrine Gaub Florian Wunnemann Walter Szarek Hyman Schipper Jean-sebastien Joyal Department of Pharmacology and Therapeutics McGill UniversityMontréalQCCanada Department of Pediatrics Pharmacology and OphthalmologyCHU Sainte-Justine Research CenterUniversitéde MontrealMontréalQCCanada Department of Chemistry Queen’s UniversityKingstonONCanada

Background:Retinopathy of prematurity(ROP)is an eye disease of the immature newborn characterized by pathological neovascularization(NV).ROP classically arises due to changes in oxygen availability in the ***,other factors,such as red blood cell(RBC)transfusion,independently contribute to disease *** molecules,rich in RBC,are the primary source of endogenous *** is metabolized by heme oxygenase(HO)into biliverdin,carbon monoxide,and ferrous *** iron levels stabilize hypoxia-inducible factor 1α(HIF1α),the main transcription factor of vascular endothelial growth factor(VEGF)that drives *** we investigate the role of heme metabolism in pathological ***:ROP was studied using the well-characterized oxygen-induced retinopathy(OIR)mouse ***-type(WT)pups are exposed to high oxygen concentrations(FiO275%)for 5 days,from the post-natal day(P)7 to 12,and subsequently returned to room air until retinal collection at P12,P14,&*** are then analyzed via single-cell RNAseq,RT-qPCR,western blot,Prussian blue staining,and immunostaining techniques to elucidate the effect of OIR on iron metabolism and *** OIR,we quantified vaso-obliteration(VO)and pathologic neovascular(NV)areas at P17 to assess the effects of1 Hmox1 competitive inhibition,and2Hmox1 allosteric ***:Iron trafficking genes across different retinal cell-types were upregulated in OIR,including CP,FTH1,IREB2,TF,and ***,Prussian blue staining suggests iron accumulation in retinal vessels exposed to ***1 mRNA(n=7,P<0.01 at P17)and protein expression(n=3,P<0.05)were increased 3.8-fold from P12 to *** and single-cell RNAseq confirmed that Hmox1 predominantly resides in retinal microglial *** and allosterically Hmox1 inhibition decreased NV by 15%(n=15,P=0.02)and 60%(n=5,P<0.01)***:Iron metabolism has seldom been explored in the context of *** microglial heme metabolis

关键词： Retinopathy of prematurity(ROP) iron metabolism microglia

***-cell transcriptomics identifies cell-specific signatures of pathological angiogenesis

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Annals of Eye Science 2019年第1期 215-215页

作者： Gael Cagnone Sheetal Pundir Nick Kim Emilie Heckel Jin Sung Kim Perrine Gaub Florian Wunnemann Piet van Vliet Severine Leclerc Gregor Andelfinger Sylvain Chemtob Jean-sebastien Joyal CHU Ste-Justine Research Center Universitéde MontréalMontréalQCCanada Faculty of Medicine Department of Pharmacology and PhysiologyUniversitéde MontréalMontréalQCCanada Faculty of Medicine Department of PediatricsUniversity of MontrealUniversitéde MontréalMontréalQCCanada Department of Pharmacology and Therapeutics McGill UniversityMontréalQCCanada

Background:To treat vascular proliferative diseases,anti-VEGF therapies have shown systemic adverse effects attributable to the lack of selectivity between pathological and physiological ***,identifying the molecular mechanisms that are only specific to pathological cell types is crucial to develop better precision ***:Here,we used different cell type enrichment approaches combined with single-cell RNA sequencing to define the transcriptomic changes within each retinal cell types in a mouse model of ischemic *** retinal model develops pathological neovascularization(NV)in response to local hypoxia following oxygen-induced vessel obliteration(P7 to P12).The NV phenotype is characterized by the progressive appearance of vascular tufts resulting from misguided,abnormal proliferation of endothelial cells that we monitored at 3 consecutive time points-P12,P14 and P17(peak of NV).Results:By following the dynamic response to hypoxia,our experimental design reveals how pathological angiogenesis is specifically associated with significant metabolic adaptations in different subtypes of endothelial cells(i.e.,Tips vs Stalk cells).We also identify a pathological subtype of glial cells over-expressing VEGFA and pro-inflammatory IL-1 receptor *** subtype of activated glial cells was targeted using selective IL1R antagonist treatment which reduced glial activation,inflammation,NV and promotes physiological angiogenesis,therefore improving tissue ***:Our results illustrate how analyzing cell type heterogeneity in tissues developing pathological angiogenesis allows establishing better targeting therapies to restore vascular integrity.

关键词： Single-cell RNAseq angiogenesis pathological vascularization metabolism inflammation

压缩背斜的运动速率对尼日尔深水三角洲斜坡稳定性的影响

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海洋地质 2009年第1期25卷 51-51页

作者： sebastien Garziglia Nabil Sultan Antonio Cattaneo Michel VOISSET 杨丽娟（译）闫章存（校对）海洋开发研究院法国不详

Sultan等（2007）最近研究了深水尼日尔拆离褶皱带，揭示出现代海底存在三处滑坡。这些滑坡位于平均倾角约2°的陆坡处，全部是在-个背斜构造的脊线上。Sultan等（2007）利用柱形空腔膨胀理论模拟了压缩构造运动，评估了沉积层上部的张... 详细信息

Sultan等（2007）最近研究了深水尼日尔拆离褶皱带，揭示出现代海底存在三处滑坡。这些滑坡位于平均倾角约2°的陆坡处，全部是在-个背斜构造的脊线上。Sultan等（2007）利用柱形空腔膨胀理论模拟了压缩构造运动，评估了沉积层上部的张力。采用三维陆坡稳定性模型SAMU-3D所作的斜坡稳定性评估结果表明背斜的压缩变形可能是上述地区陆坡滑塌的触发机制（Sultan等，2007）。这些结论中还有一个悬而未决的问题，也就是压缩背斜的运动速率在滑坡易发到破坏的过程中有何影响。

关键词：背斜构造压缩变形运动速率尼日尔斜坡稳定性深水三角洲稳定性评估

Dense matter with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 28-44页

作者： Anna L.Watts WenFei Yu Juri Poutanen Shu Zhang Sudip Bhattacharyya Slavko Bogdanov Long Ji Alessandro Patruno Thomas E.Riley Pavel Bakala Altan Baykal Federico Bernardini Ignazio Bombaci Edward Brown Yuri Cavecchi Deepto Chakrabarty Jér?me Chenevez Nathalie Degenaar Melania Del Santo Tiziana Di Salvo Victor Doroshenko Maurizio Falanga Robert D.Ferdman Marco Feroci Angelo F.Gambino MingYu Ge Svenja K.Greif sebastien Guillot Can Gungor Dieter H.Hartmann Kai Hebeler Alexander Heger Jeroen Homan Rosario Iaria Jean in 't Zand Oleg Kargaltsev Aleksi KurkelaTheoretical Physics Department CERN XiaoYu Lai Ang Li XiangDong Li ZhaoSheng Li Manuel Linares FangJun Lu Simin Mahmoodifar Mariano Méndez M.Coleman Miller Sharon Morsink Joonas N?ttil? Andrea Possenti Chanda Prescod-Weinstein JinLu Qu Alessandro Riggio Tuomo Salmi Andrea Sanna Andrea Santangelo Hendrik Schatz Achim Schwenk LiMing Song Eva?rámková Benjamin Stappers Holger Stiele Tod Strohmayer Ingo Tews Laura Tolos Gabriel T?r?k David Tsang Martin Urbanec Andrea Vacchi RenXin Xu YuPeng Xu Silvia Zane GuoBao Zhang ShuangNan Zhang WenDa Zhang ShiJie Zheng Xia Zhou Anton Pannekoek Institute for Astronomy University of Amsterdam Shanghai Astronomical Observatory Tuorla Observatory Department of Physics and Astronomy University of Turku Nordita KTH Royal Institute of Technology and Stockholm University Institute of High Energy Physics Chinese Academy Sciences Tata Institute of Fundamental Research Columbia Astrophysics Laboratory Columbia University Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen Leiden Observatory Leiden University Research Center for Computational Physics and Data Processing Silesian University in Opava Physics Department Middle East Technical University INAF Osservatorio Astronomico di Roma New York University Abu Dhabi Dipartimento di Fisica Enrico Fermi University of Pisa INFN Italian National Institute for Nuclear Physics Department of Physics and Astronomy Michigan State University Department of Astrophysical Sciences Princeton University Mathematical Sciences and STAG Research Centre University of Southampton MIT Kavli Institute for Astrophysics and Space Research DTU Space Technical University of Denmark INAF/IASF Palermo via Ugo La Malfa 153 Universita degli Studi di Palermo Dipartimento di Fisica e Chimica International Space Science Institute (ISSI) Faculty of Science University of East Anglia INAF Istituto di Astrofisica e Planetologie Spaziali Institut für Kernphysik Technische Universit?t Darmstadt ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Instituto de Astrof'?sica Pontificia Universidad Católica de Chile Department of Physics & Astronomy Kinard Lab of Physics Clemson University School of Physics and Astronomy Monash University SRON Netherlands Institute for Space Research Department of Physics The George Washington University Faculty of Science and Technology University of Stavanger School of Physics and Mechanical & Electrical Engineering Hubei University of Education Department of Astronomy Xiamen University (Haiyun Campus) School of Astronomy and Space

In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry(eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020 s.

关键词： neutron X-rays dense matter equation of state

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为缓和医疗正名改变观念比改变名字更重要

英国医学杂志中文版 2020年第4期23卷 183-184页

作者： Kirsty Boyd sebastien Moine Scott A Murray Deborah Bowman Nicole Brun 赵或墨(译) 宁晓红(校) Primary Palliative Care Group Usher Institute of Population Health Sciences and InformaticsUniversity of EdinburghUK St George's University of LondonUK Sydney School of Education and Social Work University of SydneyAustralia 北京协和医院老年医学科

世界卫生组织(WHO)首次提出“缓和医疗(palliative care)”这个概念已经30年了,我们依然没有真正认同这个理念。开展缓和医疗以来,终末期患者的照护情况得到了显著的改善,关于“死亡”的探讨也渐渐不再是禁忌话题。很多国家政府和国际... 详细信息

世界卫生组织(WHO)首次提出“缓和医疗(palliative care)”这个概念已经30年了,我们依然没有真正认同这个理念。开展缓和医疗以来,终末期患者的照护情况得到了显著的改善,关于“死亡”的探讨也渐渐不再是禁忌话题。很多国家政府和国际组织开始提倡推广缓和医疗。柳叶刀健康委员会(Lancet Commission)更激进地提出,对于全球数百万终末期患者,对缓和医疗的自主选择是基本人权。

关键词：终末期患者柳叶刀缓和医疗改变观念自主选择 Lancet 基本人权

Global prevalence of occult hepatitis C virus: A systematic review and meta-analysis

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World Journal of Methodology 2022年第3期12卷 179-190页

作者： Donatien Serge Mbaga sebastien Kenmoe Jacky Njiki Bikoï Guy Roussel Takuissu Marie Amougou-Atsama Etienne Atenguena Okobalemba Jean Thierry Ebogo-Belobo Arnol Bowo-Ngandji Martin Gael Oyono Jeannette Nina Magoudjou-Pekam Ginette Irma Kame-Ngasse Alex Durand Nka Alfloditte Flore Feudjio Cromwel Zemnou-Tepap Elie Adamou Velhima Juliette Laure Ndzie Ondigui Rachel Audrey Nayang-Mundo Sabine Aimee Touangnou-Chamda Yrene Kamtchueng Takeu Jean Bosco Taya-Fokou Chris Andre Mbongue Mikangue Raoul Kenfack-Momo Cyprien Kengne-Ndé Carole Stephanie Sake Seraphine Nkie Esemu Richard Njouom Lucy Ndip Sara Honorine Riwom Essama Department of Microbiology The University of Yaounde IYaounde 00237Cameroon Department of Microbiology and Parasitology University of BueaBuea 00237Cameroon Department of Virology Centre Pasteur of CameroonYaounde 00237Cameroon Centre of Research in Food Food Security and NutritionInstitute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Centre de Recherche sur les Maladies Emergentes et Re-Emergentes Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Faculty of Medicine and Biomedical Science The University of Yaounde IYaounde 00237Cameroon Medical Research Centre Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Laboratory of Parasitology and Ecology The University of Yaounde IYaounde 00237Cameroon Department of Biochemistry The University of Yaounde IYaounde 00237Cameroon Virology Laboratory Chantal Biya International Reference Center for Research on HIV/AIDS Prevention and ManagementYaounde 00237Cameroon

BACKGROUND Occult hepatitis C infection(OCI)is characterized by the presence of hepatitis C virus(HCV)RNA in the liver,peripheral blood mononuclear cells(PBMC)and/or ultracentrifuged serum in the absence of detectable HCV-RNA in *** has been described in several categories of populations including hemodialysis patients,patients with a sustained virological response,immunocompromised individuals,patients with abnormal hepatic function,and apparently healthy *** To highlight the global prevalence of *** We performed a systematic and comprehensive literature search in the following 4 electronic databases PubMed,EMBASE,Global Index Medicus,and Web of Science up to 6th May 2021 to retrieve relevant studies published in the *** studies were unrestricted population categories with known RNA status in serum,PBMC,liver tissue and/or ultracentrifuged *** were extracted independently by each author and the Hoy et al tool was used to assess the quality of the included *** used the random-effect meta-analysis model to estimate the proportions of OCI and their 95%confidence intervals(95%CI).The Cochran's Q-test and the I2 test statistics were used to assess heterogeneity between *** plot and Egger test were used to examine publication bias.R software version 4.1.0 was used for all *** The electronic search resulted in 3950 *** obtained 102 prevalence data from 85 included *** pooled prevalence of seronegative OCI was estimated to be 9.61%(95%CI:6.84-12.73)with substantial heterogeneity[I^(2)=94.7%(95%CI:93.8%-95.4%),P<0.0001].Seropositive OCI prevalence was estimated to be 13.39%(95%CI:7.85-19.99)with substantial heterogeneity[I^(2)=93.0%(90.8%-94.7%)].Higher seronegative OCI prevalence was found in Southern Europe and Northern Africa,and in patients with abnormal liver function,hematological disorders,and kidney *** seropositive OCI prevalence was found in Southern Europe,Northern

关键词： Occult hepatitis C virus infection Prevalence Worldwide Peripheral blood mononuclear cells Hepatitis C virus

《日本钢铁协会》Vol．55（2015），No．10，P2237—2246高马氏体双相钢的微观组织与力学性能的关系

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水钢科技 2015年第4期 51-62页

作者： Irina PUSHKAREVA sebastien ALLAIN Colin SCOTT Abdelkrim REDJA MIA Antoine MOULIN 高长益刘立德张东升叶雅妮赵光凤加拿大矿产与能源技术中心法国科学院法国阿塞洛研究所首钢水钢技术中心贵州六盘水553028

我们研究了淬火状态和淬火＋回火状态的高马氏体（马氏体组分〉60％）双相钢的微观组织、力学性能和断裂机理之间的关系。力学性能由拉伸检验和孔洞扩展试验测量。在淬火状态下．孔洞扩展率随铁素体组分的增加而降低，与均匀延伸率成非... 详细信息

我们研究了淬火状态和淬火＋回火状态的高马氏体（马氏体组分〉60％）双相钢的微观组织、力学性能和断裂机理之间的关系。力学性能由拉伸检验和孔洞扩展试验测量。在淬火状态下．孔洞扩展率随铁素体组分的增加而降低，与均匀延伸率成非线性的反比关系。对于所有的马氏体组分，回火明显地改善孔洞扩展率；在230-460℃回火温度范围内。孔洞扩展率随回火温度的上升而单调地增加，而屈服强度则呈现出复杂的关系。回火研究表明，在马氏体组分不变的情况下。孔洞扩展率与塑性断裂应变呈线性关系。但是，当马氏体组分变化时，线性关系参数大大地改变。在简单的拉伸莉试中，主要的断裂机理是：在淬火状态下，铁素体与马氏体或马氏体与马氏体界面的分离：在回火状态下，马氏体与碳化物界面的分离。我们用Beremin标准定性地描述断裂机理。

关键词：双相钢力学性能微观组织断裂模型化

2019年全球、地区和国家5岁以下儿童呼吸道合胞病毒引发急性下呼吸道感染疾病负担研究的系统分析

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中国病毒病杂志 2023年第2期13卷 81-95页

作者： You Li Xin Wang Dianna M.Blau Mauricio T.Caballero Daniel R.Feikin Christopher J.Gill Shabir A.Madhi Saad B.Omer Eric A.F Simoes Harry Campbell Ana Bermejo Pariente Darmaa Bardach Quique Bassat Jean-sebastien Casalegno Giorgi Chakhunashvili Nigel Crawford Daria Danilenko Lien Anh Ha Do Marcela Echavarria Angela Gentile Aubree Gordon Terho Heikkinen QSue Huang Sophie Jullien Anand Krishnan Eduardo Luis Lopez Josko Markic Ainara Mira-Iglesias Hannah CMoore Jocelyn Moyes Lawrence Mwananyanda DJames Nokes Faseeha Noordeen Evangeline Obodai Nandhini Palani Candice Romero Vahid Salimi Ashish Satav Euri Seo Zakhar Shchomak Rosalyn Singleton Kirill Stolyarov Sonia K Stoszek Anne von Gottberg Danielle Wurzel Lay-Myint Yoshida Chee Fu Yung Heather J Zar Harish Nair 张甜甜从兵兵邓舒予不详南京医科大学公共卫生学院江苏南京211166

背景呼吸道合胞病毒(respiratory syncytial virus,RSV)是引起婴幼儿急性下呼吸道感染最常见的病原体。此前估计,2015年全球60月龄以下儿童共发生3 310万次RSV相关急性下呼吸道感染,导致118 200人死亡。此后,几项社区监测研究获得了对RS... 详细信息

背景呼吸道合胞病毒(respiratory syncytial virus,RSV)是引起婴幼儿急性下呼吸道感染最常见的病原体。此前估计,2015年全球60月龄以下儿童共发生3 310万次RSV相关急性下呼吸道感染,导致118 200人死亡。此后,几项社区监测研究获得了对RSV相关社区死亡的更精确估计。本文旨在更新2019年全球、地区和国家层面60月龄以下儿童RSV相关急性下呼吸道感染的发病率和死亡率,重点关注总体死亡率和在研RSV免疫制剂针对的更窄的婴儿年龄组。方法检索获得MEDLINE、Embase、Global Health、CINAHL、Web of Science、LILACS、OpenGrey、中国知网、万方和维普数据库2017—2020年发表文献中的新数据,并纳入RSV GEN合作者提供的未发表数据,以扩展全球RSV疾病负担数据集。纳入的研究符合以下条件:报告了社区中或需要住院治疗的60月龄以下儿童RSV原发性急性下呼吸道感染的数据;报告了至少连续12个月的数据,但院内病死率或RSV季节性定义明确的地区除外;报告了RSV相关急性下呼吸道感染的发病率、住院率、院内病死率或急性下呼吸道感染住院的RSV阳性比例。如果病例定义不明或应用不一致、RSV感染未经实验室确认或仅基于血清学检测、报告的急性下呼吸道感染病例少于50例,则排除该研究。本研究应用广义线性混合效应模型(generalized linear mixed-effects model,GLMM)估计了2019年全球和地区(按国家发展状况和世界银行收入分类)RSV相关急性下呼吸道感染的发病率、住院率和院内病死率;通过基于危险因素的模型估计了国家层面RSV相关急性下呼吸道感染的发病率;通过GLMM开发了新模型,纳入最新的RSV社区死亡率数据,用于估计RSV的总体死亡率。本综述已在PROSPERO注册(CRD42021252400)。结果除了先前综述中纳入的317项研究外,还纳入了113项符合条件的新研究以及51项未发表的研究,共计481项研究。据估计,2019年全球60月龄以下儿童中,共发生3 300万(置信区间为2 540万~4 460万)次RSV相关急性下呼吸道感染,导致360万(290万~460万)例住院、26 300(15 100~49 100)例院内死亡以及101 400(84 500~125 200)例可归因于RSV的总死亡数。在0~6个月的婴儿中,共发生660万(460万~970万)次RSV相关急性下呼吸道感染,导致140万(100万~200万)例住院、13 300(6 800~28 100)例院内死亡以及45 700(38 400~55 900)例可归因于RSV的总死亡数。60月龄以下和28 d~6月龄儿童的死亡中分别有2.0%(置信区间为1.6%~2.4%)和3.6%(3.0%~4.4%)归因于RSV。在各年龄组中,95%以上的RSV相关急性下呼吸道感染事件和97%以上的可归因于RSV的死亡事件都发生在中低收入国家。结论 RSV显著增加了全球60月龄以下儿童的发病和死亡负担,尤其是在出生后前6个月和中低收入国家。本研究强调了全球RSV疾病的总体死亡率负担,60月龄以下儿童中,每50例死亡就有1例可归因于RSV;28 d至6个月大的婴儿中,每28例死亡就有1例可归因于RSV。每1例RSV相关急性下呼吸道感染院内死亡,对应社区中约3例可归因于RSV的死亡。对6月龄内婴儿提供保护的RSV被动免疫计划有望对减轻RSV疾病负担,但实施计划时,仍需要更多数据来了解RSV疾病负担高峰可能向大龄转移的影响。

关键词：呼吸道合胞病毒下呼吸道感染儿童疾病负担住院发病率死亡率病死率模型估计系统分析