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Why are COVID-19 travel bubbles a tightrope walk?An investigation based on the Trans-Tasmanian case

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Communications in Transportation Research 2023年第1期3卷 37-43页

作者： Xiaoqian Sun sebastian wandelt Anming Zhang National Key Laboratory of CNS/ATM School of Electronic and Information EngineeringBeihang UniversityBeijing100191China Sauder School of Business University of British ColumbiaVancouverBCCanada

The COVID-19 pandemic has hit the transportation sector hard;particularly air transportation,as a major mode of long-distance transportation,has been affected *** the dawn of COVID-19,politicians and policy makers have discussed the idea of introducing travel bubbles between countries(or counties),to allow for a continued exchange of people and *** eponymous Trans-Tasmanian travel bubble is a major example,involving quarantine-free travel between Australia and New *** both countries have tried to form a travel bubble various times,recurring setbacks and difficulties were *** October 2021,this ambitious project presumably has come to an end,with both countries announcing the essential capitulation of their COVIDZero strategies and a planned opening towards broader international *** this study,we perform a close investigation of the history behind the Trans-Tasmanian travel bubble as an on-off relationship,identifying a set of drivers for the serious problems involving a sustainable setup and *** develop a framework which represents important factors for successful travel bubbles and believe that the satisfaction of all factors at once is extremely *** results and insights are not specific to the Trans-Tasmanian case only,although it is taken as a running example,but can be generalized to various scales and *** hope that our study contributes to the literature by improving our understanding of the highly buzzed travel bubble concept,while providing empirical evidence for the troubles that inherently make such bubbles a tightrope walk.

关键词： COVID-19 Travel bubble Australia New Zealand

Exploiting global information in complex network repair processes

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Chinese Journal of Aeronautics 2017年第3期30卷 1086-1100页

作者： Tianyu WANG Jun ZHANG sebastian wandelt School of Electronic and Information Engineering Beihang University 100083 Beijing ChinaBeoing Key Laboratory Jor Network-based Cooperative ATM 100083 Beijing China

Robustness of complex networks has been studied for decades,with a particular focus on network *** on network repair,on the other hand,has been conducted only very lately,given the even higher complexity and absence of an effective evaluation metric.A recently proposed network repair strategy is self-healing,which aims to repair networks for larger components at a low cost only with local *** this paper,we discuss the effectiveness and efficiency of self-healing,which limits network repair to be a multi-objective optimization problem and makes it difficult to measure its *** leads us to a new network repair evaluation *** the time complexity of the computation is very high,we devise a greedy ranking *** on both real-world and random networks show the effectiveness of our new metric and repair *** study contributes to optimal network repair algorithms and provides a gold standard for future studies on network repair.

关键词： Complex network Global information Greedy ranking Optimality Self-healing

Robustness analysis metrics for worldwide airport network：A comprehensive study

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Chinese Journal of Aeronautics 2017年第2期30卷 500-512页

作者： Sun Xiaoqian Volker Gollnick sebastian wandelt School of Electronic and Information Engineering Beihang University 100083 Beijing China Beijing Key Laboratory for Network-based Cooperative A TM Beijing 100083 China Beijing Laboratory for General Aviation Technology Beijing 100083 China Institute of Air Transportation Systems German Aerospace Center Blohmstrasse 18 21079 Hamburg Germany

Robustness of transportation networks is one of the major challenges of the 21 st *** paper investigates the resilience of global air transportation from a complex network point of view,with focus on attacking strategies in the airport network,i.e.,to remove airports from the system and see what could affect the air traffic system from a passenger＇s ***,we identify commonalities and differences between several robustness measures and attacking strategies,proposing a novel notion of functional robustness：unaffected passengers with *** apply twelve attacking strategies to the worldwide airport network with three weights,and evaluate three robustness *** find that degree and Bonacich based attacks harm passenger weighted network *** evaluation is geared toward a unified view on air transportation network attack and serves as a foundation on how to develop effective mitigation strategies.

关键词： Air transportation systems resilience Airport network Attacking strategy Robustness measure

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高效四维航迹数据清洗技术

Transactions of Nanjing University of Aeronautics and Astronautics 2020年第2期37卷 288-299页

作者：谭鑫孙小倩张春晓 wandelt sebastian 北京航空航天大学国家空管新航行系统技术重点实验室北京100191 北京航空航天大学电子信息工程学院北京100191

随着航空业的快速发展和新兴的众包,如Flightradar24和FlightAware等的涌现,大量空中交通数据,特别是四维(4D)航迹数据已公开于众。为了保证结果的准确性和可靠性,包括识别和减少错误在内的数据清洗,是分析4D航迹数据的第一步。为此对4... 详细信息

随着航空业的快速发展和新兴的众包,如Flightradar24和FlightAware等的涌现,大量空中交通数据,特别是四维(4D)航迹数据已公开于众。为了保证结果的准确性和可靠性,包括识别和减少错误在内的数据清洗,是分析4D航迹数据的第一步。为此对4D航迹数据进行如下清洗:应用反向传播神经网络算法将误差修复;用牛顿插值法对每次航行样本进行等间隔采样来获得均匀分布的4D航迹数据;进而提出一种在保持轨迹固有形状前提下的数据压缩方法,以及基于密度的有噪聚类(Density based spatial clustering of applications with noise,DB SCAN)对样本点中的离群点进行识别。采用欧洲空域一天的4D航迹数据集进行验证,结果表明所提方法比现有方法更高效、快速。本文的数据预处理研究结果为下一阶段的4D航迹分析奠定了基础。

关键词：四维航迹数据清洗异常值检测修复

Defense and anti-defense mechanisms of bacteria and bacteriophages

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 181-196页

作者： Xiaoqing WANG sebastian LEPTIHN School of Medicine Lishui UniversityLishui 323000China University of Edinburgh Medical School Biomedical SciencesCollege of Medicine&Veterinary MedicineThe University of EdinburghEdinburgh EH89JZUK HMU Health and Medical University Am Anger 64/73-99084 ErfurtGermany

In the post-antibiotic era,the overuse of antimicrobials has led to a massive increase in antimicrobial resistance,leaving medical doctors few or no treatment options to fight infections caused by *** use of bacteriophages is a promising alternative to treat infections,supplementing or possibly even replacing *** phages for therapy is possible,since these bacterial viruses can kill bacteria specifically,causing no harm to the normal ***,bacteria have developed a multitude of sophisticated and complex ways to resist infection by phages,including abortive infection and the clustered regularly interspersed short palindromic repeats(CRISPR)/CRISPR-associated(Cas)*** also can evolve and acquire new anti-defense strategies to continue *** in-depth exploration of both defense and anti-defense mechanisms would contribute to optimizing phage therapy,while we would also gain novel insights into the microbial *** this paper,we summarize recent research on bacterial phage resistance and phage anti-defense mechanisms,as well as collaborative win-win systems involving both virus and host.

关键词： Bacteriophage Phage resistance Abortive infection Phage therapy

Ink-structing the future of vascular tissue engineering:a review of the physiological bioink design

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Bio-Design and Manufacturing 2024年第2期7卷 181-205页

作者： Judith Synofzik sebastian Heene Rebecca Jonczyk Cornelia Blume Institute for Technical Chemistry Leibniz University Hannover30167 HannoverGermany

Three-dimensional(3D)printing and bioprinting have come into view for a plannable and standardizable generation of implantable tissue-engineered constructs that can substitute native tissues and *** tissue-engineered structures are intended to integrate with the patient’s *** tissue engineering(TE)is relevant in TE because it supports the sustained oxygenization and nutrition of all tissue-engineered *** have a specific role,representingthenecessarymedium for printability and vascular cell *** review aims to understand the requirements for the design of vascular ***,an in-depth analysis of vascular cell interaction with their native environment must be gained.A physiological bioink suitable for a tissue-engineered vascular graft(TEVG)must not only ensure good printability but also induce cells to behave like in a native vascular vessel,including self-regenerative and growth *** review describes the general structure of vascular walls with wall-speciﬁc cell and extracellular matrix(ECM)components and biomechanical properties and ***,the physiological role of vascular ECM components for their interaction with vascular cells and the mode of interaction is *** currently available or imaginable bioinks are described from physiological matrix proteins to nonphysiologically occurring but natural chemical compounds useful for vascular *** physiological performance of these bioinks is evaluated with regard to biomechanical properties postprinting,with a view to current animal studies of 3D printed vascular ***,the main challenges for further bioink development,suitable bioink components to create a self-assembly bioink concept,and future bioprinting strategies are *** concepts are discussed in terms of their suitability to be part of a TEVG with a high potential for later clinical use.

关键词： Vascular wall histology Vascular cells Microenvironment Extracellular matrix Cell–matrix interaction Bioink Printability

Olfactory immune response to SARS-CoV-2

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Cellular & Molecular Immunology 2024年第2期21卷 134-143页

作者： sebastian A.Wellford E.Ashley Moseman Department of Integrative Immunobiology Duke University School of MedicineDurhamNCUSA

Numerous pathogens can infect the olfactory tract,yet the pandemic caused by SARS-CoV-2 has strongly emphasized the importance of the olfactory mucosa as an immune *** in the nasal passages,the olfactory mucosa is directly exposed to the environment to sense airborne odorants;however,this also means it can serve as a direct route of entry from the outside world into the *** a result,olfactotropic infections can have serious consequences,including dysfunction of the olfactory system,CNS invasion,dissemination to the lower respiratory tract,and transmission between *** research has shown that a distinctive immune response is needed to protect this neuronal and mucosal tissue.A better understanding of innate,adaptive,and structural immune barriers in the olfactory mucosa is needed to develop effective therapeutics and vaccines against olfactotropic microbes such as ***,we summarize the ramifications of SARS-CoV-2 infection of the olfactory mucosa,review the subsequent immune response,and discuss important areas of future research for olfactory immunity to infectious disease.

关键词： Mucosal immunology Neuroimmunology Infectious Disease Sars-CoV-2

Seasonal variations in dissolved organic matter concentration and composition in an outdoor system for bank filtration simulation

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Journal of Environmental Sciences 2024年第1期135卷 252-261页

作者： Muhammad Zeeshan Omamah Ali Shamas Tabraiz Aki sebastian Ruhl German Environment Agency Section II 3.3Schichauweg 5812307BerlinGermany Technische Universitat Berlin Water TreatmentKF4Str.des 17.Juni 13510623BerlinGermany Natural and Applied Sciences Section School of Psychology and Life SciencesCanterbury Christ Church UniversityCanterburyCT11QUUK

Dissolved organic matter(DOM)in surface waters can vary markedly in character depending on seasonal variations such as rainfall intensity,UV radiations and *** in DOM as well as temperature and rainfall intensity over the year can affect the biochemical processes occurring in bank filtration(BF).Identification and characterization of DOM in the surface water could help to optimize the water treatment and provide stable and safe drinking *** study investigated year-long variations of DOM concentrations and compositions in a surface water of a circulated outdoor pond(research facility)connected to a BF *** was dominated by humic substances and a changing pattern of DOM in surface water was observed throughout the year.A significant increase of DOM(~38%)in surface water was noted in August compared to *** fluorescent DOM showed that DOM in summer was enriched with the degradable fraction whilst non-degradable fraction was dominated in winter.A constant(1.7±0.1 mg/L)effluent DOM was recirculated in the system throughout the *** removal through BF varied between 4%to 39%and was achieved within a few meters after infiltration and significantly correlated with influent DOM concentration(R^(2)=0.82,p0.05)change in the removal of DOM was observed in two subsurface layers(upper and lower).This study highlights the presence of a constant non-degradable DOM in the bank filtrate,which was not affected by temperature,redox conditions and UV radiations.

关键词： Bank filtration Dissolved organic matter Dissolved oxygen Fluorescence spectroscopy Excitation-emission matrix

Severe aspiration pneumonia in the elderly

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Journal of Intensive Medicine 2024年第3期4卷 307-317页

作者： sebastian Ocrospoma Marcos I.Restrepo Division of Pulmonary Diseases&Critical Care Medicine University of Texas Health San AntonioSan AntonioTXUSA Section of Pulmonary&Critical Care Medicine South Texas Veterans Health Care SystemSan AntonioTXUSA

The global population is aging at an unprecedented rate,resulting in a growing and vulnerable elderly population in need of efficient comprehensive healthcare services that include long-term care and skilled nursing *** this context,severe aspiration pneumonia,a condition that carries substantial morbidity,mortality,and financial burden,especially among elderly patients requiring admission to the intensive care unit,has attracted greater *** pneumonia is defined as a pulmonary infection related to aspiration or dysphagia in *** episodes of coughing on food or liquid intake,a history of relevant underlying conditions,abnormalities on videofluoroscopy or water swallowing,and gravity-dependent shadow distribution on chest imaging are among the clues that suggest *** with aspiration pneumonia tend to be elderly,frail,and suffering from more comorbidities than those without this ***,we comprehensively address the epidemiology,clinical characteristics,diagnosis,treatment,prevention,and prognosis of severe aspiration community-acquired pneumonia in the elderly to optimize care of this high-risk demographic,enhance outcomes,and minimize the healthcare costs associated with this *** preventive measures and effective management strategies is vital in ensuring the well-being of our aging population.

关键词： Aspiration pneumonia Aged Critical illness Swallowing disorders Frailty Antibacterial agents