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Gastrointestinal stromal tumors:a multidisciplinary challenge

World Journal of Gastroenterology 2018年第18期24卷 1925-1941页

作者： Juan Manuel Sanchez-Hidalgo Manuel Duran-Martinez Rafael Molero-Payan sebastian rufian-pena Alvaro Arjona-Sanchez Angela Casado-Adam Antonio Cosano-Alvarez Javier Briceno-Delgado Department of General and Digestive Surgery Reina Sofia University HospitalAvda.Menéndez Pidal s/nCordoba 14004Spain Department of Intern Medicine Reina Sofia University HospitalAvda.Menéndez Pidal s/nCordoba 14004Spain Lipids and Atherosclerosis Research Unit IMIBIC/Hospital Universitario Reina Sofía/Universidad de CórdobaCordoba 14004Spain

Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumors located in the alimentary tract. Its usual manifestation is gastrointestinal bleeding. However, small asymptomatic lesions are frequently detected as incidental finding. Characteristically, most GISTs(> 95%) are positive for the KIT protein(CD117) by IHC staining and approximately 80%-90% of GISTs carry a mutation in the c-KIT or PDGFRA genes. Mutational analysis should be performed when planning adjuvant and neoadjuvant therapy, due to its possible resistance to conventional treatment. The arise of tyrosine kinase inhibitor has supposed a revolution in GISTs treatment being useful as adjuvant, neoadjuvant or recurrence disease treatment. That is why a multidisciplinary approach to this disease is required. The correct characterization of the tumor at diagnosis(the diagnosis of recurrences and the evaluation of the response to treatment with tyrosine kinase inhibitors) is fundamental for facing these tumors and requires specialized Endoscopist, Radiologists and Nuclear Medicine Physician. Surgery is the only potentially curative treatment for suspected resectable GIST. In the case of high risk GISTs, surgery plus adjuvantImatinib-Mesylate for 3 years is the standard treatment. Neoadjuvant imatinib-mesylate should be considered to shrink the tumor in case of locally advanced primary or recurrence disease, unresectable or potentially resectable metastasic tumors, and potentially resectable disease in complex anatomic locations to decrease the related morbidity. In the case of Metastatic GIST under Neoadjuvant treatment, when there are complete response, stable disease or limited disease progression, complete cytoreductive surgery could be a therapeutic option if feasible.

关键词： Gastrointestinal stromal tumors Surgery Oncology Radiology Endoscopy Nuclear medicine Pathology Disease management Tyrosine kinase inhibitors Gastroenterology

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Complications of extrahepatic echinococcosis:Fistulization of an adrenal hydatid cyst into the intestine

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World Journal of Gastroenterology 2008年第9期14卷 1467-1469页

作者： Juan Francisco Ruiz-Rabelo Manuel Gomez-Alvarez Joaquin Sanchez-Rodriguez sebastian rufian Pea Department of General Surgery Reina Sofia University Hospital Avda Menendez Pidal S/N Cordoba 14004 Spain

Echinococcal cysts are usually found in liver and lungs, but any other organ can potentially be involved. Extrahepatic disease due to hydatid cyst may develop in the abdominal and pelvic cavity, aside from in other less common locations, which may make both diagnosis and treatment more complex. We present a rare case of extrahepatic echinococcosis in a 70-year old patient with a 4-d history of dull abdominal pain, anemia within the transfusion range and fever. She underwent surgery for left renal hydatid cysts 30 years ago. After non operative treatment, imaging studies showed a calcified hydatid cyst in a retrogastric location communicating with a proximal jejunal loop. En-block resection of the mass together with the adrenal gland was performed including closure of the enteric fistula. Anatomic pathology confirmed the diagnosis of a calcified hydatid cyst of left adrenal origin. Surgery is the treatment of choice and most authors recommend removal of cyst and adrenal gland.

关键词： Echinococcosis Adrenal cyst Surgery

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Strategies to reduce hepatitis C virus recurrence after liver transplantation

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World Journal of Hepatology 2013年第5期5卷 237-250页

作者： Ruben Ciria María Pleguezuelo Shirin Elizabeth Khorsandi Diego Davila Abid Suddle Hector Vilca-Melendez sebastian rufian Manuel de la Mata Javier Briceo Pedro López Cillero Nigel Heaton Institute of Liver Studies King’s College HospitalLondon SE5 9RSUnited Kingdom Unit of Hepatology and Liver Transplantation University Hospital Reina Sofías/n 1400 CórdobaSpain Unit of Hepatobiliary Surgery and Liver Transplantation University Hospital Reina Sofías/n 1400 CórdobaSpain

Hepatitis C virus (HCV) is a major health problem that leads to chronic hepatitis, cirrhosis and hepatocellular carcinoma, being the most frequent indication for liver transplantation in several countries. Unfortunately, HCV re-infects the liver graft almost invariably following reperfusion, with an accelerated history of recurrence, leading to 10%-30% of patients progressing to cirrhosis within 5 years of transplantation. In this sense, some groups have even advocated for not retransplanting this patients, as lower patient and graftoutcomes have been reported. However, the management of HCV recurrence is being optimized and several strategies to reduce post-transplant recurrence could improve outcomes, decrease the rate of re-transplantation and optimize the use of available grafts. Three moments may be the focus of potential actions in order to decrease the impact of viral recurrence: the pretransplant moment, the transplant environment and the post-transplant management. In the pre-transplant setting, it is not well established if reducing the pre transplant viral load affects the risk for HCV progression after transplant. Obviously, antiviral treatment can render the patient HCV RNA negative post transplant but the long-term benefit has not yet been fully established to justify the cost and clinical risk. In the transplant moment, factors as donor age, cold ischemia time, graft steatosis and ischemia/reperfusion injury may lead to a higher and more aggressive viral recurrence. After the transplant, discussion about immunosuppression and the moment to start the treatment (prophylactic, pre-emptive or once-confirmed) together with new antiviral drugs are of interest. This review aims to help clinicians have a global overview of posttransplant HCV recurrence and strategies to reduce its impact on our patients.

关键词： Hepatitis C virus Recurrence Liver Trans- plantation Outcomes

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Control of disability glare by means of electrochromic filtering glasses:A pilot study

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Journal of Innovative Optical Health Sciences 2017年第1期10卷 11-20页

作者： Rosa Maria Coco-Martín Ruben Cuadrado-Asensio Ceesar Vega-Colado Ricardo Vergaz Jose M.Sanchez-pena Ana Viñuales Sergi Peris Pau Artús M.Begona Coco-Martín IOBA Universidad de ValladolidValladolidSpain GDAF-UC3M Grupo de Displays y Aplicaciones Fotonicas Department de Tecnologia Electronica Universidad Carlos III de MadridSpain IK4-CIDETEC Parque Tecnologico de San Sebastian GuipuzcoaSpain Indo Optical Group Departamento I+D SantCugat del Valles BarcelonaSpain GIDFYS European University Miguel de Cervantes(UEMC)Department of HealthSciencesSpain

Purpose:To evaluate the potential clinical usability of a new prototype of ophthalmic blue light filters developed by using electrochromic technology in pseudophakic patients complaining of ***:A prototype of electrochromic device was developed,with a specific frame that enclosed an electronic driver that allowed personalizing its function for each patient.A pro-spective,observational case series study was performed to test *** patients who had un-dergone cataract surgery with clear intraocular lenses and complaining of glare were included in the *** outcome measures were the results obtained in the satisfaction questionnaire that was delivered to ***,visual acuity,contrast sensitivity,and reading ability data were evaluated with and without the prototype under diferent lighting conditions and different modes of the prototype after a complete month of *** transmittance was also ***:Visual acuity,contrast sensitivity and reading function did not change significantly with prototype *** main activity for which the prototype was used was *** one patient found that the dimming level was *** patients reported variable discomfort when passing tunnels,not sufficiently clear indoors,or put on and remove *** lenses slightly decreased their transmittance at the end of the ***:Glasses based on elect rochromic technology may be acceptable for outdoor/indoor use and for distance-near *** studies with larger samples must be conducted to confirm the clinical usability of these glasses.

关键词： Optical filters electro-optical devices technical visual aids electronic control.

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National Forest Inventories capture the multifunctionality of managed forests in Germany

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Forest Ecosystems 2021年第1期8卷 50-68页

作者： Nadja K.Simons María R.Felipe-Lucia Peter Schall Christian Ammer Jürgen Bauhus Nico Blüthgen Steffen Boch François Buscot Markus Fischer Kezia Goldmann Martin M.Gossner Falk Hänsel Kirsten Jung Peter Manning Thomas Nauss Yvonne Oelmann Rodica pena Andrea Polle Swen C.Renner Michael Schloter Ingo Schöning Ernst-Detlef Schulze Emily F.Solly Elisabeth Sorkau Barbara Stempfhuber Tesfaye Wubet Jörg Müller sebastian Seibold Wolfgang W.Weisser Terrestrial Ecology Research Group Technische Universität MünchenHans-Carl-von-Carlowitz-Platz 285354 FreisingGermany Present address:Ecological Networks Technische Universität DarmstadtSchnittspahnstraße 364287 DarmstadtGermany Helmholtz Centre for Environmental Research-UFZ Department of Ecosystem ServicesDeutscher Platz 5e04103 LeipzigGermany Present address:German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-Leipzig Deutscher Platz 5e04103 LeipzigGermany Silviculture and Forest Ecology of the Temperate Zones University of GöttingenBüsgenweg 137077 GöttingenGermany Centre for Biodiversity and Sustainable Land-use University of GöttingenBüsgenweg 137073 GöttingenGermany Chair of Silviculture Faculty of Environment and Natural ResourcesUniversity of FreiburgTennenbacherstr.479106 FreiburgGermany Ecological Networks Technische Universität DarmstadtSchnittspahnstraße 364287 DarmstadtGermany Institute of Plant Sciences University of BernAltenbergrain 213013 BernSwitzerland Biodiversity and Conservation Biology WSL Swiss Federal Research InstituteZürcherstrasse 1118903 BirmensdorfSwitzerland Helmholtz Centre for Environmental Research-UFZ Department of Soil EcologyTheodor-Lieser-Straße 406120 Halle(Saale)Germany German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-Leipzig Deutscher Platz 5e04103 LeipzigGermany Forest Entomology WSL Swiss Federal Research InstituteZürcherstrasse 1118903 BirmensdorfSwitzerland Department of Environmental Systems Science Institute of Terrestrial EcosystemsETH ZürichUniversitätstr 168092 ZürichSwitzerland Environmental Informatics University of MarburgDeutschhausstraße 1235032 MarburgGermany Evolutionary Ecology and Conservation Genomics Ulm UniversityAlbert-Einstein-Allee 1189069 UlmGermany Senckenberg Biodiversity and Climate Research Centre Senckenberganlage 2560325 Frankfurt am MainGermany Geoecology University of TübingenRümelinstraße 19-2372070 TübingenGermany Present address:Department of Sustaina

Background:Forests perform various important ecosystem functions that contribute to ecosystem *** many parts of the world,forest management has shifted from a focus on timber production to multi-purpose forestry,combining timber production with the supply of other forest ecosystem ***,it is unclear which forest types provide which ecosystem services and to what extent forests primarily managed for timber already supply multiple ecosystem *** on a comprehensive dataset collected across 150 forest plots in three regions differing in management intensity and species composition,we develop models to predict the potential supply of 13 ecosystem *** use those models to assess the level of multifunctionality of managed forests at the national level using national forest inventory ***:Looking at the potential supply of ecosystem services,we found trade-offs(*** both bark beetle control or dung decomposition and both productivity or soil carbon stocks)as well as synergies(*** temperature regulation,carbon storage and culturally interesting plants)across the 53 most dominant forest types in *** single forest type provided all ecosystem services *** ecosystem services showed comparable levels across forest types(*** or richness of saprotrophs),while others varied strongly,depending on forest structural attributes(*** availability or cover of edible plants)or tree species composition(*** nitrification activity).Variability in potential supply of ecosystem services was only to a lesser extent driven by environmental ***,the geographic variation in ecosystem function supply across Germany was closely linked with the distribution of main tree ***:Our results show that forest multifunctionality is limited to subsets of ecosystem *** importance of tree species composition highlights that a lack of multifunctionality at the stand lev

关键词： Ecosystem processes and services Forest management Structural diversity Tree species composition Trade-offs and synergies Forest productivity

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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