检索结果-南通市图书馆

Defense and anti-defense mechanisms of bacteria and bacteriophages

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 181-196页

作者： Xiaoqing WANG sebastian LEPTIHN School of Medicine Lishui UniversityLishui 323000China University of Edinburgh Medical School Biomedical SciencesCollege of Medicine&Veterinary MedicineThe University of EdinburghEdinburgh EH89JZUK HMU Health and Medical University Am Anger 64/73-99084 ErfurtGermany

In the post-antibiotic era,the overuse of antimicrobials has led to a massive increase in antimicrobial resistance,leaving medical doctors few or no treatment options to fight infections caused by *** use of bacteriophages is a promising alternative to treat infections,supplementing or possibly even replacing *** phages for therapy is possible,since these bacterial viruses can kill bacteria specifically,causing no harm to the normal ***,bacteria have developed a multitude of sophisticated and complex ways to resist infection by phages,including abortive infection and the clustered regularly interspersed short palindromic repeats(CRISPR)/CRISPR-associated(Cas)*** also can evolve and acquire new anti-defense strategies to continue *** in-depth exploration of both defense and anti-defense mechanisms would contribute to optimizing phage therapy,while we would also gain novel insights into the microbial *** this paper,we summarize recent research on bacterial phage resistance and phage anti-defense mechanisms,as well as collaborative win-win systems involving both virus and host.

关键词： Bacteriophage Phage resistance Abortive infection Phage therapy

No effect of invasive tree species on aboveground biomass increments of oaks and pines in temperate forests

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forest Ecosystems 2024年第4期11卷 401-413页

作者： sebastian Bury Marcin K.Dyderski Institute of Dendrology Polish Academy of SciencesParkowa 562-035 KornikPoland

Prunus serotina and Robinia pseudoacacia are the most widespread invasive trees in Central *** addition,according to climate models,decreased growth of many economically and ecologically important native trees will likely be observed in the *** aimed to assess the impact of these two neophytes,which differ in the biomass range and nitrogen-fixing abilities observed in Central European conditions,on the relative aboveground biomass increments of native oaks Qucrcus robur and *** and Scots pine Pinus *** aimed to increase our understanding of the relationship between facilitation and competition between woody alien species and overstory native *** established 72 circular plots(0.05 ha)in two different forest habitat types and stands varying in age in western *** chose plots with different abundances of the studied neophytes to determine how effects scaled along the quantitative invasion ***,we collected growth cores of the studied native species,and we calculated aboveground biomass increments at the tree and stand ***,we used generalized linear mixed-effects models to assess the impact of invasive species abundances on relative aboveground biomass increments of native tree *** did not find a biologically or statistically significant impact of invasive *** or *** on the relative aboveground,biomass increments of native oaks and pines along the quantitative gradient of invader biomass or on the proportion of total stand biomass accounted for by *** neophytes did not act as native tree growth stimulators but also did not compete with them for resources,which would escalate the negative impact of climate change on pines and *** neophytes should not significantly modify the carbon sequestration capacity of the native *** work combines elements of the per capita effect of invasion with research on mixed forest management.

关键词： Invasion ecology Exotic trees Relative aboveground biomass increment Competition Facilitation Carbon sequestration

Ink-structing the future of vascular tissue engineering:a review of the physiological bioink design

在线全文

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2024年第2期7卷 181-205页

作者： Judith Synofzik sebastian Heene Rebecca Jonczyk Cornelia Blume Institute for Technical Chemistry Leibniz University Hannover30167 HannoverGermany

Three-dimensional(3D)printing and bioprinting have come into view for a plannable and standardizable generation of implantable tissue-engineered constructs that can substitute native tissues and *** tissue-engineered structures are intended to integrate with the patient’s *** tissue engineering(TE)is relevant in TE because it supports the sustained oxygenization and nutrition of all tissue-engineered *** have a specific role,representingthenecessarymedium for printability and vascular cell *** review aims to understand the requirements for the design of vascular ***,an in-depth analysis of vascular cell interaction with their native environment must be gained.A physiological bioink suitable for a tissue-engineered vascular graft(TEVG)must not only ensure good printability but also induce cells to behave like in a native vascular vessel,including self-regenerative and growth *** review describes the general structure of vascular walls with wall-speciﬁc cell and extracellular matrix(ECM)components and biomechanical properties and ***,the physiological role of vascular ECM components for their interaction with vascular cells and the mode of interaction is *** currently available or imaginable bioinks are described from physiological matrix proteins to nonphysiologically occurring but natural chemical compounds useful for vascular *** physiological performance of these bioinks is evaluated with regard to biomechanical properties postprinting,with a view to current animal studies of 3D printed vascular ***,the main challenges for further bioink development,suitable bioink components to create a self-assembly bioink concept,and future bioprinting strategies are *** concepts are discussed in terms of their suitability to be part of a TEVG with a high potential for later clinical use.

关键词： Vascular wall histology Vascular cells Microenvironment Extracellular matrix Cell–matrix interaction Bioink Printability

Olfactory immune response to SARS-CoV-2

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2024年第2期21卷 134-143页

作者： sebastian A.Wellford E.Ashley Moseman Department of Integrative Immunobiology Duke University School of MedicineDurhamNCUSA

Numerous pathogens can infect the olfactory tract,yet the pandemic caused by SARS-CoV-2 has strongly emphasized the importance of the olfactory mucosa as an immune *** in the nasal passages,the olfactory mucosa is directly exposed to the environment to sense airborne odorants;however,this also means it can serve as a direct route of entry from the outside world into the *** a result,olfactotropic infections can have serious consequences,including dysfunction of the olfactory system,CNS invasion,dissemination to the lower respiratory tract,and transmission between *** research has shown that a distinctive immune response is needed to protect this neuronal and mucosal tissue.A better understanding of innate,adaptive,and structural immune barriers in the olfactory mucosa is needed to develop effective therapeutics and vaccines against olfactotropic microbes such as ***,we summarize the ramifications of SARS-CoV-2 infection of the olfactory mucosa,review the subsequent immune response,and discuss important areas of future research for olfactory immunity to infectious disease.

关键词： Mucosal immunology Neuroimmunology Infectious Disease Sars-CoV-2

Beyond network centrality: individual-level behavioral traits for predicting information superspreaders in social media

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第7期11卷 148-157页

作者： Fang Zhou Linyuan Lü Jianguo Liu Manuel sebastian Mariani Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of China School of Cyber Science and Technology University of Science and Technology of China Department of Digital Economics Shanghai University of Finance and Economics URPP Social Networks Universit?t Zürich

Understanding the heterogeneous role of individuals in large-scale information spreading is essential to manage online behavior as well as its potential offline consequences. To this end, most existing studies from diverse research domains focus on the disproportionate role played by highly connected ‘hub’ ***, we demonstrate here that information superspreaders in online social media are best understood and predicted by simultaneously considering two individual-level behavioral traits: influence and susceptibility. Specifically, we derive a nonlinear network-based algorithm to quantify individuals' influence and susceptibility from multiple spreading event data. By applying the algorithm to large-scale data from Twitter and Weibo, we demonstrate that individuals' estimated influence and susceptibility scores enable predictions of future superspreaders above and beyond network centrality, and reveal new insights into the network positions of the superspreaders.

关键词： complex networks social networks social media information spreading superspreaders

Seasonal variations in dissolved organic matter concentration and composition in an outdoor system for bank filtration simulation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第1期135卷 252-261页

作者： Muhammad Zeeshan Omamah Ali Shamas Tabraiz Aki sebastian Ruhl German Environment Agency Section II 3.3Schichauweg 5812307BerlinGermany Technische Universitat Berlin Water TreatmentKF4Str.des 17.Juni 13510623BerlinGermany Natural and Applied Sciences Section School of Psychology and Life SciencesCanterbury Christ Church UniversityCanterburyCT11QUUK

Dissolved organic matter(DOM)in surface waters can vary markedly in character depending on seasonal variations such as rainfall intensity,UV radiations and *** in DOM as well as temperature and rainfall intensity over the year can affect the biochemical processes occurring in bank filtration(BF).Identification and characterization of DOM in the surface water could help to optimize the water treatment and provide stable and safe drinking *** study investigated year-long variations of DOM concentrations and compositions in a surface water of a circulated outdoor pond(research facility)connected to a BF *** was dominated by humic substances and a changing pattern of DOM in surface water was observed throughout the year.A significant increase of DOM(~38%)in surface water was noted in August compared to *** fluorescent DOM showed that DOM in summer was enriched with the degradable fraction whilst non-degradable fraction was dominated in winter.A constant(1.7±0.1 mg/L)effluent DOM was recirculated in the system throughout the *** removal through BF varied between 4%to 39%and was achieved within a few meters after infiltration and significantly correlated with influent DOM concentration(R^(2)=0.82,p0.05)change in the removal of DOM was observed in two subsurface layers(upper and lower).This study highlights the presence of a constant non-degradable DOM in the bank filtrate,which was not affected by temperature,redox conditions and UV radiations.

关键词： Bank filtration Dissolved organic matter Dissolved oxygen Fluorescence spectroscopy Excitation-emission matrix

Wear dependent virtual flow rate sensor for progressing cavity pumps with deformable stator

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 1346-1353页

作者： Jens Müller sebastian Leonow Johannes Schulz Christian Hansen Martin Monnigmann Ruhr-Universitat Bochum Universit atsstraûe 150Bochum44801Germany SEEPEX GmbH Scharnh olzstraûe 344Bottrop46240Germany

This contribution presents a novel wear dependent virtual flow rate sensor for single stage single lobe progressing cavity pumps. We study the wear-induced material loss of the pump components and the impact of this material loss on the volumetric efficiency. The results are combined with an established backflow model to implement a backflow calculation procedure that is adaptive to wear. We use a laboratory test setup with a highly abrasive fluid and operate a pump from new to worn condition to validate our approach. The obtained measurement data show that the presented virtual sensor is capable of calculating the flow rate of a pump being subject to wear during its regular operation.

关键词： Backflow Progressing cavity pump Virtual sensor Wear

Integration of bio-inspired limb-like structure damping into motor suspension of high-speed trains to enhance bogie hunting stability

在线全文

学校读者我要写书评

暂无评论

Railway Engineering Science 2024年第3期32卷 324-343页

作者： Heng Zhang Liang Ling sebastian Stichel Wanming Zhai State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu 610031China Department of Engineering Mechanics KTH Royal Institute of TechnologyStockholmSweden

Hunting stability is an important performance criterion in railway *** study proposes an incorporation of a bio-inspired limb-like structure(LLS)-based nonlinear damping into the motor suspension system for traction units to improve the nonlinear critical speed and hunting stability of high-speed trains(HSTs).Initially,a vibration transmission analysis is conducted on a HST vehicle and a metro vehicle that suffered from hunting motion to explore the effect of different motor suspension systems from on-track ***,a simplified lateral dynamics model of an HST bogie is established to investigate the influence of the motor suspension on the bogie hunting *** bifurcation analysis is applied to optimize the motor suspension parameters for high critical ***,the nonlinear damping of the bio-inspired LLS,which has a positive correlation with the relative displacement,can further improve the modal damping of hunting motion and nonlinear critical speed compared with the linear motor suspension ***,a comprehensive numerical model of a high-speed train,considering all nonlinearities,is established to investigate the influence of different types of motor *** simulation results are well consistent with the theoretical *** benefits of employing nonlinear damping of the bio-inspired LLS into the motor suspension of HSTs to enhance bogie hunting stability are thoroughly validated.

关键词： High-speed train Hunting stability Bio-inspired limb-like structure Motor suspension Nonlinear damping

Role of circular economy,energy transition,environmental policy stringency,and supply chain pressure on CO_(2)emissions in emerging economies

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2024年第3期15卷 209-220页

作者： Sunil Tiwari Kamel Si Mohammed Grzegorz Mentel sebastian Majewski Irum Shahzadi Department of Tourism Studies School of Business StudiesCentral University of KeralaIndia Faculty of Economics and Management Department of EconomicsUniversity of Ain TemouchentAlgeria Department of Quantitative Methods Faculty of ManagementRzeszow University of Technology35-959 RzeszowPoland Institute of Economics and Finance University of Szczecinul.A.Mickiewicza 6471-101 SzczecinPoland Department of Business Administration IQRA University Karachi-75300Pakistan Department of Production EngineeringSão Paulo State University(UNESP)BauruBrazil

This paper investigates the effect of the circular economy on CO_(2)emissions growth by considering the role of energy transition,climate policy stringency,industrialization,and supply chain pressure from 1997 to 2020 using panel quantile Autoregressive Distributed Lags(QARDL)and the panel *** employ cointegration association in the long run among the variables,and the results of the two models confirm *** reveal that circular economy and climate policy stringency significantly negatively impact carbon *** the other hand,the energy transition,industrialization,and supply chain pressures are crucial to determining CO_(2)emissions in the short and long *** finding further explores that municipal waste generation recycling is considerable at the mean and upper 90th quantiles than the lower ***,the empirical results of the current study provide acumens for policymakers of advanced economies and emerging markets to maintain the balance among circular economy,energy transition,environmental policy stringency,and supply chain pressure for reducing CO_(2)emissions without halting economic growth and sustainable ***,practical implications are reported through the lens of carbon neutrality and structural changes.

关键词： Circular economy Energy transition Supply chain Carbon emissions Panel QARDL