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Carbon Nanotubes in Biology and Medicine:In vitro and in vivo Detection,Imaging and Drug Delivery

Nano Research 2009年第2期2卷 85-120页

作者： Zhuang Liu scott tabakman Kevin Welsher Hongjie Dai Department of Chemistry Stanford UniversityCA 94305USA

Carbon nanotubes exhibit many unique intrinsic physical and chemical properties and have been intensively explored for biological and biomedical applications in the past few *** this comprehensive review,we summarize the main results from our and other groups in this field and clarify that surface functionalization is critical to the behavior of carbon nanotubes in biological *** detection of biological species with carbon nanotubes can be realized after surface passivation to inhibit the non-specific binding of biomolecules on the hydrophobic nanotube *** nanosensors based on nanotubes provide a label-free approach to biological ***-enhanced Raman spectroscopy of carbon nanotubes opens up a method of protein microarray with detection sensitivity down to 1 fmol/*** vitro and in vivo toxicity studies reveal that highly water soluble and serum stable nanotubes are biocompatible,nontoxic,and potentially useful for biomedical *** vivo biodistributions vary with the functionalization and possibly also size of nanotubes,with a tendency to accumulate in the reticuloendothelial system(RES),including the liver and spleen,after intravenous *** well functionalized,nanotubes may be excreted mainly through the biliary pathway in *** nanotube-based drug delivery has shown promise in various In vitro and in vivo experiments including delivery of small interfering RNA(siRNA),paclitaxel and ***,single-walled carbon nanotubes with various interesting intrinsic optical properties have been used as novel photoluminescence,Raman,and photoacoustic contrast agents for imaging of cells and *** multidisciplinary explorations in this field may bring new opportunities in the realm of biomedicine.

关键词： Carbon nanotubes biomedical applications surface functionalization biosensor drug delivery biomedical imaging

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Multiplexed Five-Color Molecular Imaging of Cancer Cells and Tumor Tissues with Carbon Nanotube Raman Tags in the Near-Infrared

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Nano Research 2010年第3期3卷 222-233页

作者： Zhuang Liu scott tabakman Sarah Sherlock Xiaolin Li Zhuo Chen Kaili Jiang Shoushan Fan Hongjie Dai Functional Nano&Soft Materials Laboratory(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Department of Chemistry Stanford UniversityStanfordCA 94305USA Department of Physics and Tsinghua-Foxconn Nanotechnology Research Center Tsinghua UniversityBeijing 100084China

Single-walled carbon nanotubes(SWNTs)with five different C13/C12 isotope compositions and well-separated Raman peaks have been synthesized and conjugated to five targeting ligands in order to impart molecular *** Raman imaging of live cells has been carried out by highly specific staining of cells with a five-color mixture of *** vivo multiplexed Raman imaging of tumor samples uncovers a surprising up-regulation of epidermal growth factor receptor(EGFR)on LS174T colon cancer cells from cell culture to in vivo tumor *** is the first time five-color multiplexed molecular imaging has been performed in the near-infrared(NIR)region under a single laser *** zero interfering background of imaging is achieved due to the sharp Raman peaks unique to nanotubes over the low,smooth autofluorescence background of biological species.

关键词： Carbon nanotubes Raman scattering biomedicine multiplexed imaging

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High Performance In Vivo Near-IR (>1 μm) Imaging and Photothermal Cancer Therapy with Carbon Nanotubes

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Nano Research 2010年第11期3卷 779-793页

作者： Joshua T.Robinson Kevin Welsher scott M.tabakman Sarah P.Sherlock Hailiang Wang Richard Luong Hongjie Dai Department of Chemistry Stanford UniversityStanfordCA 94305USA Department of Comparative Medicine Stanford University School of MedicineStanfordCA 94305USA

Short single-walled carbon nanotubes(SWNTs)functionalized by PEGylated phospholipids are biologically non-toxic and long-circulating nanomaterials with intrinsic near infrared photoluminescence(NIR PL),characteristic Raman spectra,and strong optical absorbance in the near infrared(NIR).This work demonstrates the first dual application of intravenously injected SWNTs as photoluminescent agents for in vivo tumor imaging in the 1.0-1.4μm emission region and as NIR absorbers and heaters at 808 nm for photothermal tumor elimination at the lowest injected dose(70μg of SWNT/mouse,equivalent to 3.6 mg/kg)and laser irradiation power(0.6 W/cm2)reported to *** vivo resonance Raman imaging revealed the SWNT distribution within tumors at a high spatial *** tumor elimination was achieved for large numbers of photothermally treated mice without any toxic side effects after more than six months ***,side-by-side experiments were carried out to compare the performance of SWNTs and gold nanorods(AuNRs)at an injected dose of 700μg of AuNR/mouse(equivalent to 35 mg/kg)in NIR photothermal ablation of tumors in *** effective tumor elimination with SWNTs was achieved at 10 times lower injected doses and lower irradiation powers than for *** results suggest there are significant benefits of utilizing the intrinsic properties of biocompatible SWNTs for combined cancer imaging and therapy.

关键词： Photothermal cancer SWNT imaging treatment

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Multiplexed cytokine detection on plasmonic gold substrates with enhanced near-infrared fluorescence

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Nano Research 2013年第2期6卷 113-120页

作者： Bo Zhang Jordan Price Guosong Hong scott M. tabakman Hailiang Wang Justin A. Jarrell Ju Feng Paul J. Utz Hongjie Dai Department of Chemistry Stanford University Stanford California USA Department of Medicine Division of Immunology and Rheumatology Stanford University School of Medicine Stanford California USA Institute for Immunity Transplantation and Infection Stanford University School of Medicine Stanford California USA

Protein microarrays based on fluorescence detection have been widely utilized for high-throughput functional proteomic analysis. However, a drawback of such assays has been low sensitivity and narrow dynamic range, limiting their capabilities, especially for detecting low abundance biological molecules such as cytokines in human samples. Here, we present fluorescence-enhancing microarrays on plasmonic gold films for multiplexed cytokine detection with up to three orders of magnitude higher sensitivity than on conventional nitrocellulose and glass substrates. Cytokine detection on the gold plasmonic substrate is about one to two orders of magnitude more sensitive than enzyme-linked immunosorbent assay (ELISA) and can be multiplexed. A panel of six cytokines (Vascular endothelial growth factor (VEGF), Interleukin 1β (IL-1β), Interleukin 4 (IL-4), Interleukin 6 (IL-6), Interferon γ (IFN-γ), and Tumor necrosis factor (TNF)) were detected in the culture media of cancer cells. This work establishes a new method of high throughput multiplexed cytokine detection with higher sensitivity and dynamic range than ELISA.

关键词：荧光检测细胞因子玻璃基板复用近红外表面等离子体激元酶联免疫吸附试验血管内皮生长因子

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