High Performance In Vivo Near-IR (>1 μm) Imaging and Photothermal Cancer Therapy with Carbon Nanotubes
在 vivo 在附近的高效 -- 红外(> 1 m ) 有碳 nanotubes 的成像和 photothermal 癌症治疗作者机构：Department of ChemistryStanford UniversityStanfordCA 94305USA Department of Comparative MedicineStanford University School of MedicineStanfordCA 94305USA
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2010年第3卷第11期
页 面：779-793页
核心收录：
学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学]
基 金：This work was supported by Ensysce Biosciences CCNE-TR at Stanford University and NIH-NCI RO1 CA135109-02
主 题：Photothermal cancer SWNT imaging treatment
摘 要：Short single-walled carbon nanotubes(SWNTs)functionalized by PEGylated phospholipids are biologically non-toxic and long-circulating nanomaterials with intrinsic near infrared photoluminescence(NIR PL),characteristic Raman spectra,and strong optical absorbance in the near infrared(NIR).This work demonstrates the first dual application of intravenously injected SWNTs as photoluminescent agents for in vivo tumor imaging in the 1.0-1.4μm emission region and as NIR absorbers and heaters at 808 nm for photothermal tumor elimination at the lowest injected dose(70μg of SWNT/mouse,equivalent to 3.6 mg/kg)and laser irradiation power(0.6 W/cm2)reported to *** vivo resonance Raman imaging revealed the SWNT distribution within tumors at a high spatial *** tumor elimination was achieved for large numbers of photothermally treated mice without any toxic side effects after more than six months ***,side-by-side experiments were carried out to compare the performance of SWNTs and gold nanorods(AuNRs)at an injected dose of 700μg of AuNR/mouse(equivalent to 35 mg/kg)in NIR photothermal ablation of tumors in *** effective tumor elimination with SWNTs was achieved at 10 times lower injected doses and lower irradiation powers than for *** results suggest there are significant benefits of utilizing the intrinsic properties of biocompatible SWNTs for combined cancer imaging and therapy.
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