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Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic

Asian Pacific Journal of Tropical Medicine 2011年第11期4卷 866-869页

作者： Shashi kant Singh saurabh k sinha Sk Prasad R kumar Bhawani S Bithu S Sadish kumar P Singh Varanasi College of Pharmacy Uttar PradeshVaranasiIndia Department of Pharmaceutics Institute of TechnologyBanaras Hindu UniversityVaranasiUttar PradeshIndia Institute of Technology and Sciences Paramedical College(Pharmacy)MuradnagarUttar PradeshIndia Uday Pratap College VaranasiUttar PradeshIndia

Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera *** was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin *** synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/*** and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral ***:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 ***:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines.

关键词： Mangifera indica Mangiferin Antipyretic

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Comparative study of leakage power in CNTFET over MOSFET device

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Journal of Semiconductors 2014年第11期35卷 40-45页

作者： Sanjeet kumar sinha saurabh Chaudhury Department of Electrical Engineering NIT SilcharAssam-788010India

A comparison of the CNTFET device with the MOSFET device in the nanometer regime is reported. The characteristics of both devices are observed as varying the oxide thickness. Thereafter, we have analyzed the effect of the chiral vector and the temperature on the threshold voltage of the CNTFET device. After simulation on the HSPICE tool, we observed that the high threshold voltage can be achieved at a low chiral vector pair. It is also observed that the effect of temperature on the threshold voltage of the CNTFET is negligibly small. After that, we have analyzed the channel length variation and their impact on the threshold voltage of the CNTFET as well as MOSFET devices. We found an anomalous effect from our simulation result that the threshold voltage increases with decreasing the channel length in CNTFET devices; this is contrary to the well known short channel effect. It is observed that at below the 10 nm channel length, the threshold voltage is increased rapidly in the case of the CNTFET device, whereas in the case of the MOSFET device, the threshold voltage decreases drastically.

关键词： MOSFET CNTFET temperature oxide thickness threshold voltage channel length

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A hybrid wavelet and time plane based method for QT interval measurement in ECG signals

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Journal of Biomedical Science and Engineering 2009年第4期2卷 280-286页

作者： Swanirbhar Majumder saurabh Pal Sidhartha Dhar Abhijit sinha Abhijit Roy Dept of ECE NERIST (Deemed University) Arunachal Pradesh India Haldia Institute of Technology Haldia West Bengal India.

Here we present a method of QT interval meas-urement for Physionet's online QT Challenge ECG database using the combination of wavelet and time plane feature extraction mechanisms. For this we mainly combined two previous works one done using the Daubechies 6 wavelet and one time plane based with modifications in their algorithms and inclusion of two more wavelets (Daubechies 8 and Symlet 6). But found that out of these three wavelets Daube-chies 6 and 8 gives the best output and when averaged with the interval of time plane feature extraction method it gives least percentage of error with respect to the median reference QT interval as specified by Physionet. Our modified time plane feature extraction scheme along with the wavelet method together produces best re-sults for automated QT wave measurement as its regular verification is important for analyzing cardiac health. For the V2 chest lead particularly whose QT wave is of tremendous significance we have tested on 530 recordings of Physionet. This is because delay in cardiac repolarization causes ventricular tachyarrhythmias as well as Torsade de pointes (TdP). A feature of TdP is pronounced prolongation of the QT interval in the supraventricular beat preceding the ar-rhythmia. TdP can degenerate into ventricular fibrillation, leading to sudden death.

关键词： ECG QT Physionet TdP

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ChatGPT将如何改变学术界

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科技纵览 2023年第6期 57-58页

作者： saurabh sinha Liz Burd Jaco du Preez 南非约翰内斯堡大学澳大利亚昆士兰格里菲斯大学南非豪登省百夫长的萨博格林泰克防务公司

2022年11月,OpenAl公司发布了ChatGPT,这是迄今为止人工智能在现实世界中最重要的应用之一。该工具允许其用户快速生成结构独特的复杂文本内容。因此,这些内容有可能避开传统反抄袭工具的检测,这给大学如何评图片:阿拉米图片社估学生的... 详细信息

2022年11月,OpenAl公司发布了ChatGPT,这是迄今为止人工智能在现实世界中最重要的应用之一。该工具允许其用户快速生成结构独特的复杂文本内容。因此,这些内容有可能避开传统反抄袭工具的检测,这给大学如何评图片:阿拉米图片社估学生的学习和技能发展带来了问题。许多用于评估学生的评价类型都要求他们通过调查内容并以书面论文或报告的形式整理其学习成果,以证明他们已经理解了新的学习资料。

关键词：人工智能 GPT Chat 反抄袭快速生成学生的评价学生的学习

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A hybrid wavelet and time plane based method for QT interval measurement in ECG signals

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Journal of Biomedical Science and Engineering（生物医学工程） 2009年第4期

作者： Swanirbhar Majumder saurabh Pal Sidhartha Dhar Abhijit sinha Abhijit Roy

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