Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic

作     者：Shashi Kant Singh Saurabh K Sinha SK Prasad R Kumar Bhawani S Bithu S Sadish Kumar P Singh 

作者机构：Varanasi College of PharmacyUttar PradeshVaranasiIndia Department of PharmaceuticsInstitute of TechnologyBanaras Hindu UniversityVaranasiUttar PradeshIndia Institute of Technology and SciencesParamedical College(Pharmacy)MuradnagarUttar PradeshIndia Uday Pratap CollegeVaranasiUttar PradeshIndia 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2011年第4卷第11期

页      面：866-869页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the University Grants Commission(UGC) New Delhi India for the financial support to Mr.Shashi Kant Singh 

主　　题：Mangifera indica Mangiferin Antipyretic 

摘      要：Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera *** was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin *** synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/*** and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral ***:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 ***:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines.