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Solvent-Free Synthesis of Carboxylic Acids and Amide Analogs of CAPE(Caffeic Acid Phenethyl Ester)under Infrared Irradiation Conditions

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Green and Sustainable Chemistry 2015年第2期5卷 81-91页

作者： Pablo A.Martínez-Soriano Jose R.Macías-Perez Ana Maria Velazquez Brigida del Carmen Camacho-Enriquez Gustavo Pretelin-Castillo Monica B.Ruiz-Sanchez Victor H.Abrego-Reyes saul villa-trevino Enrique Angeles Laboratorio de Quimica Medicinal y Teorica Departamento de Ciencias QuimicasFES CuautitlanUniversidad Nacional Autonoma de MexicoCuautitlan IzcalliMexico Departamento de Biologia celular Centro de Investigacion y Estudios AvanzadosInstituto Politecnico NacionalMexicoD.F.Mexico Qsar Analytics S.A.de C.V.Ciudad Satelite Naucalpan de JuarezMexico

A convenient and easy method is described for the formation of carboxamides from carboxylic acids and primary amines in solventless conditions using infrared (IR) light. Thus, under IR light, cinnamic acid derivatives... 详细信息

关键词： Amides Carboxylic Acids Amines Infrared Light Solventless CAPE CAPA Cinnamic Acid Analogs

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Aqueous extracts from Tenebrio molitor larval and pupal stages inhibit early hepatocarcinogenesis in vivo

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第12期22卷 1045-1052页

作者： Armando ZEPEDA-BASTIDA Juan OCAMPO-LOPEZ Brisa Rodope ALARCON-SANCHEZU Osiris German IDELFONSO-GARCIA Sandra ROSAS-MADRIGAL Diana Ivette APARJCIO-BAUTISTA Julio Isael PEREZ-CARREON saul villa-trevino Jaime ARELLANES-ROBLEDO Institute of Agricultural Sciences Autonomous University of Hidalgo State-ICAP-UAEHHidalgo 43600Mexico Laboratory of Liver Diseases National Institute of Genomic Medicine-INMEGENCDMX 14610Mexico Department of Cell Biology Center for Research and Advanced Studies of the National Polytechnic Institute-CINVESTAV-IPNCDMX 07360Mexico Laboratory of Cardiovascular Diseases National Institute of Genomic Medicine-INMEGENCDMX 14610Mexico Proteomics Unit National Institute of Genomic Medicine-INMEGENCDMX 14610Mexico Directorate of Catedras National Council of Science and Technology-CONACYTCDMX 03940Mexico

Hepatocellular carcinoma(HCC),which is the most frequent primary liver malignancy,is ranked as the sixth most common cancer and the third leading cause of cancer-related deaths worldwide,with its incidence expected to continue *** of the reasons is that most patients are diagnosed at an advanced stage when therapeutic options are *** development of HCC is attributed to a chronic exposition to either one or a combination of low amounts of different hepatotoxins,such as in hepatitis virus infection,alcohol consumption,aflatoxin from contaminated foods,metabolic factors,and exposure to chemical carcinogens from tobacco smoke(Fomer et al.,2018).

关键词： smoke attributed alcohol

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road to stemness in hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第37期23卷 6750-6776页

作者： Teresita NJ Flores-Téllez Saúl villa-trevino Carolina Pina-Vázquez Departam ento de Biología Celular Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAV-IPN) Av.IPN No.2508 Col

Carcinogenic process has been proposed to relay on the capacity to induce local tissue damage and proliferative repair. Liver has a great regeneration capacity and currently, most studies point towards the dominant role of hepatocytes in regeneration at all levels of liver damage. The most frequent liver cancer is hepatocellular carcinoma(HCC). Historical findings originally led to the idea that the cell of origin of HCC might be a progenitor cell. However, current linage tracing studies put the progenitor hypothesis of HCC origin into question. In agreement with their dominant role in liver regeneration, mature hepatocytes are emerging as the cell of origin of HCC, although, the specific hepatocyte subpopulation of origin is yet to be determined. The relationship between the cancer cell of origin(CCO) and cancer-propagating cells, known as hepatic cancer stem cell(HCSC) is unknown. It has been challenging to identify the definitive phenotypic marker of HCSC, probably due to the existence of different cancer stem cells(CSC) subpopulations with different functions within HCC. There is a dynamic interconversion among different CSCs, and between CSC and non-CSCs. Because of that, CSC-state is currently defined as a description of a highly adaptable and dynamic intrinsic property of tumor cells, instead of a static subpopulation of a tumor. Altered conditions could trigger the gain of stemness, some of them include: EMT-MET, epigenetics, microenvironment and selective stimulus such as chemotherapy. This CSC heterogeneity and dynamism makes them out reach from therapeutic protocols directed to a single target. A further avenue of research in this line will be to uncover mechanisms that trigger this interconversion of cell populations within tumors and target it.

关键词： Cancer stem cell Liver progenitor cell Liver stem progenitor cell Stemness Plasticity Cancer cell of origin Cancer stem cells subpopulations

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