Aqueous extracts from Tenebrio molitor larval and pupal stages inhibit early hepatocarcinogenesis in vivo

作     者：Armando ZEPEDA-BASTIDA Juan OCAMPO-LOPEZ Brisa Rodope ALARCON-SANCHEZU Osiris German IDELFONSO-GARCIA Sandra ROSAS-MADRIGAL Diana Ivette APARJCIO-BAUTISTA Julio Isael PEREZ-CARREON Saul VILLA-TREVINO Jaime ARELLANES-ROBLEDO Armando ZEPEDA-BASTIDA;Juan OCAMPO-LóPEZ;Brisa Rodope ALARCóN-SáNCHEZ;Osiris Germán IDELFONSO-GARCíA;Sandra ROSAS-MADRIGAL;Diana Ivette APARICIO-BAUTISTA;Julio Isael PéREZ-CARREóN;Saúl VILLA-TREVI?O;Jaime ARELLANES-ROBLEDO

作者机构：Institute of Agricultural SciencesAutonomous University of Hidalgo State-ICAP-UAEHHidalgo 43600Mexico Laboratory of Liver DiseasesNational Institute of Genomic Medicine-INMEGENCDMX 14610Mexico Department of Cell BiologyCenter for Research and Advanced Studies of the National Polytechnic Institute-CINVESTAV-IPNCDMX 07360Mexico Laboratory of Cardiovascular DiseasesNational Institute of Genomic Medicine-INMEGENCDMX 14610Mexico Proteomics UnitNational Institute of Genomic Medicine-INMEGENCDMX 14610Mexico Directorate of CatedrasNational Council of Science and Technology-CONACYTCDMX 03940Mexico 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2021年第22卷第12期

页      面：1045-1052页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：funded by the National Council of Science and Technology(CONACYT No.CF2019-53358) the National Institute of Genomic Medicine(INMEGEN No.06/2017/I) the Unit of Production and Experimentation of Laboratory Animals of Center for Research and Advanced Studies of the National Polytechnic Institute(UPEAL-CINVESTAV-IPN No.0114-14) the Autonomous University of Hidalgo State(UAEH No.SEP-PFCE 2018) CONACYT-Mexico for awarding the masters(No.484737) doctoral fellowships(No.752715) CONACYT-Mexico for awarding the doctoral fellowship(No.431419) the Cátedras-CONACYT program 

主　　题：smoke attributed alcohol 

摘      要：Hepatocellular carcinoma(HCC),which is the most frequent primary liver malignancy,is ranked as the sixth most common cancer and the third leading cause of cancer-related deaths worldwide,with its incidence expected to continue *** of the reasons is that most patients are diagnosed at an advanced stage when therapeutic options are *** development of HCC is attributed to a chronic exposition to either one or a combination of low amounts of different hepatotoxins,such as in hepatitis virus infection,alcohol consumption,aflatoxin from contaminated foods,metabolic factors,and exposure to chemical carcinogens from tobacco smoke(Fomer et al.,2018).