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Rosuvastatin reduces rat intestinal ischemia-reperfusion injury associated with the preservation of endothelial nitric oxide synthase protein

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World Journal of Gastroenterology 2006年第13期12卷 2024-2030页

作者： Yuji Naito Kazuhiro Katada Tomohisa Takagi Hisato Tsuboi Masaaki Kuroda Osamu Handa satoshi kokura Norimasa Yoshida Hiroshi Ichikawa Toshikazu Yoshikawa Department of Medical Proteomics Kyoto Prefectural University of Medicine Kyoto 602-8566Japan Inflammation and Immunology Graduate School of Medical Science Kyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Biomedical Safety Science Kyoto Prefectural University of Medicine Kyoto 602-8566Japan Molecular Gastroenterology and Hepatology Graduate School of Medical Science Kyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Food Sciences and Nutritional Health The Faculty of Human Environment Kyoto Prefectural UniversityKyoto 606-8522Japan

瞄准：为了在 ischemia-reperfusion (红外) 上调查 rosuvastatin 的保护的效果，并且在内皮的氮的氧化物 synthase (eNOS ) 的表示上决定这个代理人的效果，在老鼠导致了小肠的损害和发炎蛋白质。方法：肠的损坏被为 30 min 夹钳优异 m... 详细信息

瞄准：为了在 ischemia-reperfusion (红外) 上调查 rosuvastatin 的保护的效果，并且在内皮的氮的氧化物 synthase (eNOS ) 的表示上决定这个代理人的效果，在老鼠导致了小肠的损害和发炎蛋白质。方法：肠的损坏被为 30 min 夹钳优异 mes 伤寒动脉和腹的箱子在男 Sprague-Dawley 老鼠导致，为 60 min 由灌注列在后面。在生理盐水溶解的 Rosuvastatin intraperitoneally 被管理在局部缺血前的 60 min。肠的粘膜损害和发炎的严厉被几个生物化学的标记，以及由组织检查所见评估。eNOS 的蛋白质层次被西方的污点决定。结果：当粘膜的索引损坏，管腔内血红素和蛋白质的层次显著地在假冒操作组与那些相比在红外组被增加。然而，这些增加被处理显著地以一种剂量依赖者方式与 rosuvastatin 禁止。rosuvastatin 的保护的效果被组织检查所见也证实。到红外的小肠的暴露导致了 thiobarbituric 的重要增加描绘的粘膜发炎酸反应的物质，联系织物的 myeloperoxidase 活动，和老鼠的粘膜内容导致 cytokine 的嗜中性的 chemoattractant-1 (CINC-1 ) 和肿瘤坏死 factor-alpha (TNF-alpha ) 。在红外以后的煽动性的参数的这些增加被预告的处理显著地在 10 mg/kg 的剂量与 rosuvastatin 禁止。而且， CINC-1 和 TNF-alpha 的 mRNA 表示在红外以后被增加，并且这增加被 rosuvastatin 也禁止。eNOS 的粘膜蛋白质层次在红外期间减少了，但是在与 rosuvastatin 对待的老鼠被保存。结论：Rosuvastatin 禁止老鼠红外导致的肠的损害和发炎，和它的保护与 eNOS 的保藏被联系蛋白质。

关键词：肠疾病缺血再灌注损伤内皮氧化酶蛋白基因

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转换式TIG—MIG焊的电弧现象和效果

电焊机 1985年第6期 43-46页

作者： satoshi kokura 王晓宝

最近研究的一种电弧焊方法,其焊接电流在TIG和MIG焊的两电极间交替转换,以防止电弧在两电极之间的相互影响。在这种焊接方法中,所观测到的电弧现象表明,MIG焊丝的尖端很容易熔化。由于TIG电弧的辐照的帮助,熔滴周期性地从焊丝过渡到熔... 详细信息

最近研究的一种电弧焊方法,其焊接电流在TIG和MIG焊的两电极间交替转换,以防止电弧在两电极之间的相互影响。在这种焊接方法中,所观测到的电弧现象表明,MIG焊丝的尖端很容易熔化。由于TIG电弧的辐照的帮助,熔滴周期性地从焊丝过渡到熔池中而无飞溅。TIG和MIG焊的焊接电流可以单独地改变,而在两电极间电弧无相互

关键词： MIG 焊接电流 TIG 电弧焊弧焊熔焊

Microarray Profiling of Gene Expression Patterns in Giomerular Celis of Astaxanthin-Treated Diabetic Mice: An Approach on Nutrigenomics

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Microarray Profiling of Gene Expression Patterns in Giomerul...

Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development

The International Meeting of the Society for Free Radical Research(SFRR)-Asia & the Third International Symposium on Natural Antioxidants-Molecular Mechanisms and Health Effects(ISNA)

作者： Yuji Naito Satomi Akagiri Masaaki Kuroda Tomohisa Takagi Osamu Handa satoshi kokura Hiroshi Ichikawa Norimasa Yoshida Toshikazu Yoshikawa Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto

Diabetic nephropathy is characterized by the proliferation of glomerular mesangium cells and the accumulation of extra-cellular matrix. In the previous study, we demonstrated that astaxanmin reduced glomerular oxidative stress as well as inhibited the increase of urinary albumin in diabetic db/db mice. High-density DNA microarrays that examine expression of many genes simultaneously not only can provide new information about gene function, but also generate insights into transcriptional processes, and identify new mechanism of pathogenesis. The aim of the present study is to determine the gene expression patterns in glomerular cells of astaxanthin-treated mice by using a microarray technique.

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World Journal of Hepatology 2015年第27期7卷 2757-2764页

作者： satoshi Shakado Shotaro Sakisaka Kazuaki Chayama Takeshi Okanoue Joji Toyoda Namiki Izumi Akihiro Matsumoto Tetsuo Takehara Akio Ido Yoichi Hiasa Kentaro Yoshioka Hideyuki Nomura Yoshiyuki Ueno Masataka Seike Hiromitsu Kumada Department of Gastro-enterology and Medicine Faculty of Medicine Fukuoka University Department of Gastroenterology and Metabolism Applied Life Sciences Graduate School of Biome-dical and Health SciencesHiroshima University Center of Gastroenterology and Hepatology Saiseikai Suita Hospital Department of Gastroenterology and Hepatology Sapporo Kousei Hospital Department of Gastroenterology and Hepatology Musashino Red-Cross Hospital Department of Medicine Shinshu University School of Medicine Department of Gastroenterology and Hepa-tology Osaka University Graduate School of Medicine Department of Gastroenterology and Hepatology Kagoshima University Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine Department of Liver Biliary Tract and Pancreas Diseases Fujita Health University the Center for Liver Disease Shin-Kokura Hospital Department of Gastroenterology Yamagata University Department of Gastroenterology Faculty of Medicine Oita University Department of Hepatology Toranomon Hospital

AIM: To investigate risk factors for development of hepatocellular carcinoma(HCC) in patients with hepatitis C virus-related liver cirrhosis(LC-C).METHODS: To evaluate the relationship between clinical factors including virological response and the development of HCC in patients with LC-C treated with interferon(IFN) and ribavirin, we conducted a multicenter, retrospective study in 14 hospitals in Japan. All patients had compensated LC-C with clinical or histological data available. HCC was diagnosed by the presence of typical hypervascular characteristics on computed tomography and/or magnetic resonance imaging.RESULTS: HCC was diagnosis in 50(21.6%) of 231 LC-C patients during a median observation period of 3.8 years after IFN and ribavirin therapy. Patients who developed HCC were older(P = 0.018) and had higher serum levels of pretreatment alpha-fetoprotein(AFP)(P = 0.038). Multivariate analysis revealed the following independent risk factors for HCC development: history of treatment for HCC [P < 0.001, odds ratio(OR) = 15.27, 95%CI: 4.98-59.51], AFP levels of ≥ 10 ng/m L(P = 0.009, OR = 3.89, 95%CI: 1.38-11.94), and des-γ-carboxy prothrombin(DCP) levels of ≥ 40 m AU/mL at 24 wk after the completion of IFN and ribavirin therapy(P < 0.001, OR = 24.43, 95%CI: 4.11-238.67).CONCLUSION: We suggested that the elevation of AFP and DCP levels at 24 wk after the completion of IFN and ribavirin therapy were strongly associated with the incidence of HCC irrespective of virological response among Japanese LC-C patients.

关键词： Des-γ-carboxy prothrombin Hepatocellular carcinoma

Importance of virological response in the early stage of telaprevir-based triple therapy for hepatitis C

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World Journal of Hepatology 2015年第26期7卷 2688-2695页

作者： satoshi Hiramine Norihiro Furusyo Eiichi Ogawa Makoto Nakamuta Eiji Kajiwara Hideyuki Nomura Kazufumi Dohmen Kazuhiro Takahashi Takeaki Satoh Koichi Azuma Akira Kawano Toshimasa Koyanagi Kazuhiro Kotoh Shinji Shimoda Jun Hayashi Depart- ment of General Internal Medicine Kyushu University Hospital Department of Gastroenterology Kyushu Medical CenterNational Hospital Organization Department of Hepatology Steel Memorial Yahata Hospital the Center for Liver Disease Shin-Kokura Hospital Department of Internal Medicine Chihaya Hospital Department of Medicine Hamanomachi Hospital Center for Liver Disease National Hospital Organization Kokura Medical Center Department of Medicine Kyushu Central Hospital Department of Medicine Kitakyushu Municipal Medical Center Department of Medicine Fukuoka City Hospital Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Kyushu General Internal Medicine Center Hara- Doi Hospital

AIM: To investigate the efficacy of virological response(VR) to telaprevir(TVR)-based triple therapy in predicting treatment outcome of hepatitis C.METHODS: This prospective, multicenter study consisted of 253 Japanese patients infected with hepatitis C virus(HCV) genotype 1b. All received 12 wk of TVR in combination with 24 wk of pegylatedinterferon-α(IFN-α) and ribavirin. Serum HCV RNA was tested at weeks 1, 2, 3, 4, 6, 8, 12, 16, 20, and 24. VR was defined as undetectable serum HCV RNA. Sustained virological response(SVR) was VR at 24 wk after the end of treatment and was regarded as a successful outcome.RESULTS: Of 253 patients, 207(81.8%) achieved SVR. The positive predictive value of VR for SVR was 100% at week 2, after which it gradually decreased, and was over 85% to week 12. The negative predictive value(NPV) gradually increased, reaching 100% at week 12. The upslope of the NPV showed a large increase from week 4(40.6%) to week 6(82.4%). There was a moderate concordance between the SVR and VR at week 6(kappa coefficient = 0.44), although other VRs had poor concordance to SVR. Multiple logistic regression analysis extracted VR at week 6(P < 0.0001, OR = 63.8) as an independent factor contributing to SVR. In addition, the interleukin-28 B single nucleotide polymorphism and response to previous pegylated-IFN-α and ribavirin therapy were identified as independent factors for SVR.CONCLUSION: VR at week 6, but not at week 4, is an efficient predictor of both SVR and non-SVR to TVRbased triple therapy.

关键词： Chronic hepatitis C Direct-acting antiviral agent