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Ultrasonically Assisted Regioselective Nitration of Aromatic Compounds in Presence of Certain Group V and VI Metal Salts

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Green and Sustainable Chemistry 2012年第3期2卷 97-111页

作者： Sariah Sana Kamatala Chinna Rajanna Kancharla Rajendar Reddy Muddam Bhooshan Marri Venkateswarlu Mukka satish kumar Kusampally Uppalaiah Department of Chemistry Osmania University Hyderabad India

Ultrasonically assisted nitration reactions (USANR) with anilides, moderately activated and non-activated aromatic compounds underwent smoothly and afforded good yields of products with high regio selectivity. Observed longer reaction times (6 - 8 hrs.) in metal catalyzed reactions reduced to (1 - 2 hrs.) under sonication. When ortho position is blocked para derivatives are obtained, and ortho nitro products are obtained when para position is blocked. In case of USANR of aromatic carbonyl and related compounds the effect of sonication is much more effective. The reactions could be completed only in few minutes.

关键词： Ultrasonically Assisted Regioselective Nitration Group V and VI Metal Salts Reduction in Reaction Times

Mesenchymal Stem Cells (MSCs) as a Novel Therapeutic Option for nCOVID-19—A Review

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Open Journal of Regenerative Medicine 2020年第2期9卷 20-35页

作者： Madhan Jeyaraman Rajeswari Somasundaram Talagavadi Channaiah Anudeep satish Shringeri Ajay kumar V. Vinodh Rashmi Jain Manish Khanna Indian Stem Cell Study Group (ISCSSG) Lucknow India Department of Orthopedics School of Medical Sciences and Research Sharda University Greater Noida India Postdoctoral Research Associate (BIRAC-BIG) Department of Microbiology PSG BioNEST PSG TECH Coimbatore India Department of Plastic Surgery Topiwala National Medical College and BYL Nair Ch. Hospital Mumbai India Department of Orthopedics JJM Medical College Davangere India AARI Research Institute Chennai India School of Medical Sciences and Research Sharda University Greater Noida India Indian Stem Cell Study Group (ISCSSG) Lucknow India Department of Orthopaedics Hind Institute of Medical Sciences Safedabad India

The novel Coronavirus Disease (nCOVID-19) is a highly contagious viral infection which emerged as “Pneumonia of Unknown Etiology” at Hubei province of Wuhan city in China. The health authorities provided a considerable empirical evidence after this outbreak and it was notified that the causative virus, named Novel Coronavirus (subsequently SARS-CoV-2) is the culprit for progressively exerting grim effects not only on individual patients but also on the International public health, with high mutational tendencies. WHO declared nCOVID-19 as a Pandemic on 11th March 2020. The spike glycoprotein of SARS-CoV-2 plays a pivotal role in the entry of virus into the cell and it further interacts with ACE-II receptors which are widely distributed on the human cell surface especially on alveolar type II cells (AT-2) and endothelium. The mortality in nCOVID-19 patients is usually preceded by acute respiratory distress syndrome (ARDS) because of the cytokine storm. Advanced molecular biology and regenerative sciences renders a breakthrough in the treatment of severely ill nCOVID-19 patients with Mesenchymal Stem Cells (MSCs). Autologous or allogenic MSCs attenuate cytokine storm, improvise lung compliance, regulate inflammatory response, maintain functional alveoli microenvironment, promote endogenous regeneration and repair with no or minimal side effects. MSCs are naturally resistant to this novel Coronavirus. Even though it is corroborated with evidences from current clinical trials and pilot study, we emphasize the need for conducting more clinical trials with ethical consideration to prove the efficacy and safety of MSCs in combating nCOVID-19 infection and its complications.

关键词： Coronavirus nCOVID-19 Mesenchymal Stem Cells WHO Pandemic Level of Evidence - Level I

农村母牛在受精和未受精发情期内血红蛋白与某些血清生化成分的含量

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国外畜牧学（草食家畜） 1992年第1期 50-51页

作者： satish kumar 周化媛

曾有人报道发情期间的血红蛋白和血清中某些生化成分,会影响母牛的受精状况及其繁殖行为。据推测各种生化成分的缺乏或过剩是与家畜受精状况有联系的。进行本研究是为了查明农村难归类的母牛,在受精和未受精的发情期内某些生化成分的含... 详细信息

曾有人报道发情期间的血红蛋白和血清中某些生化成分,会影响母牛的受精状况及其繁殖行为。据推测各种生化成分的缺乏或过剩是与家畜受精状况有联系的。进行本研究是为了查明农村难归类的母牛,在受精和未受精的发情期内某些生化成分的含量。材料和方法将26头鉴定为发情的母羊供作试验,在发情中期—后期(发情12—20小时),用优质精液(50％活精子)人工授精。人工授精45天后,经直肠检查诊断妊娠,已妊娠母牛,归入受精发情期组,其余归入未受精发情期组。

关键词：牛母牛受精发情期血红蛋白

Safety and Efficacy of Ultra-Thin, Biodegradable Polymer Coated Sirolimus-Eluting Supralimus-Core Stents in Real-World Patients: Outcomes at 24-Month Follow-Up

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World Journal of Cardiovascular Diseases 2018年第11期8卷 523-532页

作者： Kala Jeethender kumar Jain Subash Dasarapu Sai satish Oruganti Jyotsna Maddury Srinivas Bhyravavajhala Rama kumari Nuthalapati Vanaparthi Satya Bharathi Lakshmi Rajender Betham Anil kumar Enikapalli Nizam’s Institute of Medical Sciences Hyderabad Telangana India

Aim: The purpose of this registry was to establish long-term safety and efficacy through implantation of Supralimus-Core sirolimus-eluting stents (SES) in real-world patients with coronary artery disease (CAD). Methods:The present registry was a retrospective, singe-arm, single-centre, investigator-initiated registry. A total of 372 consecutive patients were implanted with Supralimus-Core SES between January 2015 and November 2016. The primary endpoints were major adverse cardiac events (MACE), a composite of cardiac death, myocardial infarction (MI), target lesion revascularization (TLR) and target vessel revascularization (TVR) at 24 months. The secondary endpoints were all-cause death and all separate components of the primary endpoint. Additional endpoints included events of stent thrombosis classified as definite, probable, and possible stent thrombosis. Follow-ups were conducted at 30-days, 6-months, 12-months and 24-months after the index procedure. Results: The mean age of the registry population was 56.3 ± 11.1 years. Males constituted 276 (74.2%) patients. Hypertensives, diabetics, alcoholics, tobacco chewers and smokers comprised 198 (53.2%), 160 (43.0%), 93 (25.0%), 91 (24.5%) and 88 (23.7%) of the registry population, respectively. The mean length and diameter of stents implanted was 19.3 ± 8.8 mm and 2.9 ± 0.3 mm, respectively. At the 24-month follow-up, MACE was reported in 14 (3.8%) patients. Cardiac death, MI, TLR and TVR was reported in 7 (1.9%), 4 (1.1%), 3 (0.8%) and 4 (1.1%) patients, respectively. Overall stent thrombosis occurred in 4 (1.1%) patients. Conclusions: The low MACE rate of 3.8% at the 24-month follow-up indicates favorable long-term results after implantation of the ultra-thin strut Supralimus-Core SES in all-comer, real-world patients.

关键词： Biodegradable Polymer Cobalt-Chromium Coronary Artery Disease Drug Eluting Stents Percutaneous Coronary Intervention Sirolimus-Eluting Stent

Fine-mapping and validation of the genomic region underpinning pear red skin colour

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Horticulture Research 2019年第1期6卷 1607-1613页

作者： satish kumar Chris Kirk Cecilia Hong Deng Claudia Wiedow Mengfan Qin Richard Espley Jun Wu Lester Brewer The New Zealand Institute for Plant and Food Research Limited Hawkes Bay Research CentreHavelock NorthNew Zealand The New Zealand Institute for Plant and Food Research Limited Palmerston North Research CentrePalmerston NorthNew Zealand The New Zealand Institute for Plant and Food Research Limited Mount Albert Research CentreAucklandNew Zealand Centre of Pear Engineering Technology Research Nanjing Agricultural University210095 NanjingChina The New Zealand Institute for Plant and Food Research Limited Motueka Research CentreMotuekaNew Zealand

Red skin colour is an important target trait in various pear breeding *** this study,the genetic control of red skin colour was investigated in an interspecific population derived using the descendants of the red sport European pear cultivar‘Max Red Bartlett’(MRB)and the red-blushed Chinese pear cultivar‘Huobali’.Approximately 550 seedlings from nine families were phenotyped for red skin over-colour coverage(Ocolcov)and the intensity of red over-colour(Ocolint)on a 0–9 scale,and genotyped using ***-wide association analyses were conducted using 7500 high-quality single nucleotide polymorphisms(SNPs).Genomic regions on linkage groups(LG)4 and 5 were found to be associated,and the best SNP(S578_25116)on LG4 accounted for~15%of phenotypic variation in Ocolcov and *** association of S578_25116 with Ocolcov and Ocolint was successfully validated in a sample of~200 European and Asian pear *** association with red skin at locus S578_25116 was not present in Asian pear accessions,suggesting its close proximity to the MRB’s Cardinal *** putative candidate genes,including MYB transcription factors(PCP027962 and PCP027967),were identified in the quantitative trait locus region on LG4 and await functional validation.

关键词： cultivar breeding colour

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二十一世纪的木材防腐技术

国外林业 1987年第3期 36-39页

作者： Kamini Kohli satish kumar 俞东波

引言木材是一种极易变质的有机材料,如无适当保护,它常常在短期内损坏,而需过早更换,这样使用木材是不经济的。为防止这种损失,过去几十年里研究了几种重要的木材防腐剂。这期间一些极其有效的防腐剂得到发展。1933年Dehradun林业研究... 详细信息

引言木材是一种极易变质的有机材料,如无适当保护,它常常在短期内损坏,而需过早更换,这样使用木材是不经济的。为防止这种损失,过去几十年里研究了几种重要的木材防腐剂。这期间一些极其有效的防腐剂得到发展。1933年Dehradun林业研究所研制的铜—铬—砷混合物,目前在美国使用了40,000吨,而印度已用了70,000吨(Anon,

关键词：硫代醋酸催化剂 WPG 白蚁抗腐木材防腐木材保存软材木材

In-Vivo Anti-Hyperlipidemic Activity and Preliminary Phytochemical Screening of Canephora robusta

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American Journal of Molecular Biology 2020年第1期10卷 44-50页

作者： Kishan Pavani Jankuti Anusha Govindula Rajkumar Jampala Mohammad Arif Pasha Aligeti Sravan kumar Sunayana Soorammagari Chinnela satish Mahankali Naga Ganesh Department of Pharmaceutics Vaageswari College of Pharmacy Karimnagar India Department of Pharmacology Vaageswari College of Pharmacy Karimnagar India Department of Pharmaceutical Chemistry Vaageswari College of Pharmacy Karimnagar India Department of Clinical Pharmacy Vaageswari College of Pharmacy Karimnagar India Department of Pharmaceutics Geethanjali College of Pharmacy Hyderabad India

The main aim of this study is to determine the anti-hyerlipidemic and anti-obesity activity of Canephora robusta in hyperlipidemia induced rats. Prepared coffee bean extract (GCE) was procured from the market which is unroasted and contains more quantity of caffeine and chlorogenic acid when compared to roasted coffee. Male albino Wister rats are fed with high fat diet (HFD) for weeks to induce hyperlipidemia in rats, which are divided into 4 groups with 4 animals in each group. Test GCBE was given in doses of 200 mg/kg and 400 mg/kg to III and IV groups which are fed with HFD for 30 days. Then blood samples were collected through retro-orbital sinus by capillaries and serum is separated for analysis. The result obtained from lipid profile which includes total cholesterol, triglycerides, very low density lipoproteins, and low density lipoproteins shows the decreased level when compared to the hyperlipidemic control. This shows the significant reduction of total body weight (p < 0.05) when given with dose of 200 mg/kg and 400 mg/kg. The present study suggests that GCBE has anti-obesity and anti-hyperlipidemic activity, where 400 mg/kg is more effective to reduce the total body weight and lipid levels when compared to 200 mg/kg. Further studies on this extract may lead to identify the possible mechanism of action and isolation of active principle from the same.

关键词： Anti-Hyerlipidemic Anti-Obesity Lipoproteins Hyperlipidemia

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控制结晶器液流改善板坯质量

钢铁译文集 2008年第1期 36-41页

作者： D. satish kumar 韦菁（译）段玉玲（校对）

钢的洁净度是扁材产品生产的基本要求。通过控制结晶器中液流的特性以及弯月面表面的波动便可达到这一要求。本文描述了JSW钢铁公司为控制钢水流动、水口堵塞和喷气率而进行的优化浇铸参数计算中所采用的数学方法。结果表明，结晶器液... 详细信息

钢的洁净度是扁材产品生产的基本要求。通过控制结晶器中液流的特性以及弯月面表面的波动便可达到这一要求。本文描述了JSW钢铁公司为控制钢水流动、水口堵塞和喷气率而进行的优化浇铸参数计算中所采用的数学方法。结果表明，结晶器液面波动现象得到了极大改善，而且即使在较高的铸速下，也能生产出优质的板坯。

关键词：结晶器液面波动水口堵塞浸入式水口

Studies on the Internal Ballistics of Composite Solid Rocket Propellants Incorporating Nano-Structured Catalysts

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Advances in Aerospace Science and Technology 2017年第4期2卷 48-72页

作者： Mukesh R. Sivasubramaniyam R. Elangovan R. R. Abhinaya Sree R. Harish R. Rajashree D. satish kumar Kanhar Department of Aeronautical Engineering A.C.S College of Engineering Bangalore India Department of Mechanical Engineering A.C.S College of Engineering Bangalore India

This paper deals with the analysis of burn rate using various catalysts of Iron Oxide and determining which gives the higher burn rate with low pressure variation. The Ammonium Perchlorate (AP) was obtained and ground into fine powder with the particle size ranging from 63 to 125 μm. The propellant strands were prepared with proportions by mixing AP with the binder (Hydroxyl Terminated Polybutadiene), the catalyst (Iron Oxide), curing agent (Isophorone diisocyanate) and the plasticizer (Dioctyladipate). The prepared propellant mixture was cured at around 63 deg C to get various propellant strands. The first strand was prepared with the absence of a catalyst to set an initial base of comparison with other Iron Oxide catalysts, namely, Flower Shaped, Micro and Nano, based on the size of the particles. The combustion process was carried out in a strand burner, which was in turn connected to a data acquisition system. The obtained output was analysed in the form of graphs. The burn rate was achieved by calculating the slope of the graph i.e . by calculating the difference between the highest and the lowest peak of the graph and dividing the total time by the answer. The experiment was repeated with the different catalyst types, as mentioned above, at different pressures. It was observed that the Nano shaped Iron Oxide exhibits better burning characteristics when compared to the rest with the pressure index of 0.792. In this paper, the various experiments carried out along with their procedures are explained in detail. The results obtained and the techniques used are also elaborately described in this paper.

关键词： Ammonium Perchlorate Dioctyladipate Hydroxyl Terminated