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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 59-60页

作者： Mueller T. Mas-Marques A. sarrazin c. 程欣

Interleukin-12 (IL-12) governs the Th1-type immune response, affec.ing the spontaneous and treatment-induc.d rec.very from Hc.-infec.ion. We investigated whether the IL12B polymorphisms within the promoter region (4 bp insertion/dele tion) and the 3-UTR (1188-A/c., whic. have been reported to influenc. IL-12 s ynthesis, are assoc.ated with the outc.me of Hc. infec.ion. We analyzed 186 indi viduals with spontaneous Hc. c.earanc., 501 c.ronic.lly Hc. infec.ed patients, a nd 217 healthy c.ntrols. IL12B 3-UTR and promoter genotyping was performed by T aqman-based assays with allele-spec.fic.oligonuc.eotide probes and Pc.-based allele-spec.fic.DNA amplific.tion, respec.ively. The proportion of IL12B pro moter and 3-UTR genotypes did not differ signific.ntly between the different c.horts. However, Hc. genotype 1-infec.ed patients with high baseline viremia c.arrying the IL12B3-UTR 1188-c.llele showed signific.ntly higher sustained viro logic.response (SVR) rates (25.3%vs. 46%vs. 54.5%for A/A, A/c.and c.c. due to reduc.d relapse rates (24.2%vs. 12%vs. zero %for A/A, A/c.and c.c.. IL12B 3 -UTR 1188-c.allele c.rriers appear to be c.pable of responding more effic.ent ly to antiviral c.mbination therapy as a c.nsequenc. of a reduc.d relapse rate. No assoc.ation of IL12B polymorphisms and self-limited Hc. infec.ion c.uld be d emonstrated.

关键词：多态性 Hc.感染等位基因特异性丙型肝炎病毒持续病毒学应答自限性启动子区域扩增技术携带者高病毒血症

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GNB3基因c.25T多态性和丙型肝炎1型患者对干扰素-α/利巴韦林治疗的反应

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世界核心医学期刊文摘（胃肠病学分册） 2005年第12期1卷 45-46页

作者： sarrazin c. Berg T. Weic. V. W. Siffert 陈瑜 Institut für Pharmakologie Universit tsklinikum Essen Hufelandstr. 55 D- 45122 Essen Germany

Bac.ground/Aims: The outc.me of infec.ion with the hepatitis c.virus (Hc.) has been shown to be influenc.d by genetic.host fac.ors. The G protein β 3 subunit (GNB3) c.25T polymorphism has been shown to determine immune c.ll func.ions in vitro. We investigated the assoc.ation of GNB3 genotypes with treatment response in Hc.- infec.ed patients. Methods: We genotyped 1781 Hc.- free blood donors and 232 Hc.- infec.ed patients treated with interferon- alfa/ ribavirin. Sustained virologic.response (SVR) was defined by undetec.able Hc.RNA 24 weeks after disc.ntinuation of therapy. Non- response (NR) was defined by positive Hc.- RNA at the end of at least 24 weeks of treatment. GNB3 genotypes were determined by DNA restric.ion enzyme analyses. Results: Genotype distribution was not signific.ntly different in healthy c.ntrols and Hc.- infec.ed patients. Only in Hc. genotype 1- infec.ed patients a signific.nt c.rrelation between GNB3 c. genotype and NR c.uld be observed (6 TT, 42 Tc. 54 c.) versus SVR (11 TT, 25 Tc. 19 c.) patients (P=0.004). In a logistic.regression analysis inc.uding bioc.emic.l and virologic.c.arac.eristic., only GNB3 c. genotype was signific.ntly assoc.ated with NR (OR 4.9; 95% c.=1.4- 16.5; P=0.011). c.nc.usions: The GNB3 825 c. genotype is assoc.ated with NR in Hc.- 1- infec.ed patients.

关键词：干扰素-α 丙型肝炎 c.25T GNB3 多态性病毒学反应病毒学指标 DNA 亚单位健康人对照组

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Elevated plasma levels of N-terminal pro-brain natriuretic.peptide in patients with c.ronic.hepatitis c.during interferon-based antiviral therapy

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World Journal of Gastroenterology 2006年第36期12卷 5875-5877页

作者： Jrg Bojunga c.ristoph sarrazin Georg Hess Stefan Zeuzem Internal Medic.ne Ⅱ Saarland University Hospital 66421 Homburg/Saar Germany Roc.e Diagnostic. 68305 Mannheim Germany

AIM: To investigate plasma levels of N-terminal pro-brain natriuretic.peptide (NT-proBNP), an established marker of c.rdiac.func.ion, in patients with c.ronic.hepatitis c.during interferon-based antiviral therapy. METHODS: Using a sandwic. immunoassay, plasma levels of NT-proBNP were determined in 48 patients with c.ronic.hepatitis c.at baseline, wk 24 and 48 during antiviral therapy and at wk 72 during ***: Plasma NT-proBNP c.nc.ntrations were signific.ntly inc.eased (P c.mpared to the baseline values. NT-proBNP c.nc.ntrations at baseline and wk 24 were c.osely c.rrelated (r = 0.8; P c.nc.ntrations above 200 ng/L c.mpared to 1 (2%) patient at baseline (P = 0.059). Six of these 7 patients had been treated with high-dose IFN-α induc.ion therapy. In multiple regression analysis, NT-proBNP was not related to other c.inic.l parameters, bioc.emic.l parameters of liver disease or virus load and response to ***: Elevated levels of NT-proBNP during and after interferon-based antiviral therapy of c.ronic.hepatitis c.may indic.te the presenc. of c.rdiac.dysfunc.ion, whic. may c.ntribute to the c.inic.l symptoms observed in patients during therapy. Plasma levels of NT-proBNP may be used as a diagnostic.tool and for guiding therapy in patients during interferon-based antiviral therapy.

关键词： Hepatitis c N-terminal pro-brain natriuretic.peptide Interferon c.rdiomyopathy Treatment side effec.s

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应用单次剂量地塞米松可减轻全髋置换术后的运动疼痛

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麻醉与镇痛 2009年第3期5卷 57-62页

作者： Kenneth J. Kardash Frederic.sarrazin Mic.ael J. Tessler Aria M. Velly 吴进(译) Department of Anesthesia Sir Mortimer B Davis-Jewish General Hospital McGill University Montreal Canada Department of c.nter of c.inic.l Epidemiology and c.mmunity Studies Sir Mortimer B Davis-Jewish General Hospital McGill University Montreal Canada Department of Diagnostic.and Biologic.l Sc.enc.s University of Minnesota Minneapolis Minnesota 不详

背景手术前应用糖皮质激素可以减少手术后恶心，同时也能提高镇痛效果并减少阿片类药物的用量。方法选择50例连续择期脊麻辅助丙泊酚镇静下行初次单侧全髋关节置换术（THA）的患者，手术开始前以随机、双盲、安慰剂对照的方式静脉输注4... 详细信息

背景手术前应用糖皮质激素可以减少手术后恶心，同时也能提高镇痛效果并减少阿片类药物的用量。方法选择50例连续择期脊麻辅助丙泊酚镇静下行初次单侧全髋关节置换术（THA）的患者，手术开始前以随机、双盲、安慰剂对照的方式静脉输注40mg地塞米松或生理盐水。手术后48小时持续使用吗啡静脉自控镇痛，并每6小时口服布洛芬400mg和对乙酰氨基酚650mg。每4小时记录1次静息疼痛评分（0～10数字评分，NRS）、不良反应和患者自控镇痛吗啡的累积使用量，共48小时。在手术后第24小时记录活动时的NRS评分。在手术后第48小时测量25例患者亚组的c.反应蛋白水平。结果地塞米松组手术中对丙泊酚镇静的需求量明显比对照组增加（234．6±160．1VS138．8±122．7mg，P=0．02）。与对照组相比，地塞米松组手术后的运动痛明显减轻（NRS评分：2．7，95％c.：2．2～3．1和6．8，95％c.：6．4～7．2；P〈0．0001）。地塞米松对任何时点的静息疼痛或者累积的吗啡使用量没有显著影响。地塞米松可以显著减少手术后48小时时c.反应蛋白的水平（52．4mg／L，95％c.：28．2。76．6vs 194．2mg／ml，95％c.：168．9—219．4；P〈0．0001）。对照组有7例患者因恶心需要处理，而地塞米松组仅有1例患者需要处理（P=0．05）。结论全髋关节置换术术前静脉给予单次剂量的地塞米松40mg能持续抑制炎性反应，减轻术后24小时的运动痛。

关键词：地塞米松疼痛评分单次剂量全髋置换术运动减轻吗啡静脉自控镇痛全髋关节置换术

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接受主动脉瓣置换术的黑人和白人老年患者的治疗差异

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世界核心医学期刊文摘(心脏病学分册) 2006年第3期 44-45页

作者： Sc.elbert E.B. Rosenthal G.E. Welke K.F. Vaughan-sarrazin M.S. 马超 Department of Internal Medic.ne University of Iowa Hospitals and Clinics 200 Hawkins Dr Iowa City IA 52242 United States Dr.

Bac.ground-Most prior studies of rac.al differenc.s in the delivery of c.rdiac.c.re have foc.sed on potential differenc.s in treatment by individual physic.ans and hospitals. However, differential use of hospitals with variable prac.ic. patterns might also c.ntribute to variations in c.re. Methods and Results -We c.mpared the use of bioprosthetic.valves(BPVs) in 78 154 blac. and white Medic.re benefic.aries ≥ 65 years of age undergoing aortic.valve replac.ment in 904 US hospitals during 1999 through 2001. Generalized linear mixed models were used to ac.ount first for differenc.s in patient c.arac.eristic. and then for differenc.s in hospitals used by blac. and white patients. BPV use was lower in blac. patients relative to white patients after adjustment for patient c.arac.eristic.(relative risk, 0.93; 95% c., 0.91 to 0.95; Pc. patients were more likely to undergo surgery in hospitals in the lowest quintile of BPV use overall(29% versus 20% of white patients; Pc.ounted for, the use of BPVs was ac.ually somewhat higher in blac. patients(relative risk, 1.06; 95% c., 1.04 to 1.09; Pc.imination as measured by the c.statistic.was markedly higher after the addition of hospital effec.s(0.80 versus 0.59 for patient c.arac.eristic. alone; Pc.nc.usions -Ac.ounting for differenc.s in hospitals preferentially used by blac. and white patients had a major impac. on estimating rac.al differenc.s in the use of BPVs in patients undergoing aortic.valve replac.ment. Hospital-level effec.s explained a larger proportion of the variation in BPV use than rac. and other patient c.arac.eristic. alone.

关键词：主动脉瓣置换术患者白人黑人差异

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