白介素12B的多态性对HCV感染后自然康复和治疗诱导康复的影响

作     者：Mueller T. Mas-Marques A. Sarrazin C. 程欣 

出 版 物：《世界核心医学期刊文摘（胃肠病学分册）》 (Core Journals in Gastroenterology)

年 卷 期：2005年第1卷第2期

页      面：59-60页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：多态性 HCV感染 等位基因特异性 丙型肝炎病毒 持续病毒学应答 自限性 启动子区域 扩增技术 携带者 高病毒血症 

摘      要：Interleukin-12 (IL-12) governs the Th1-type immune response, affecting the spontaneous and treatment-induced recovery from HCV-infection. We investigated whether the IL12B polymorphisms within the promoter region (4 bp insertion/dele tion) and the 3-UTR (1188-A/C), which have been reported to influence IL-12 s ynthesis, are associated with the outcome of HCV infection. We analyzed 186 indi viduals with spontaneous HCV clearance, 501 chronically HCV infected patients, a nd 217 healthy controls. IL12B 3-UTR and promoter genotyping was performed by T aqman-based assays with allele-specific oligonucleotide probes and PCR-based allele-specific DNA amplification, respectively. The proportion of IL12B pro moter and 3-UTR genotypes did not differ significantly between the different cohorts. However, HCV genotype 1-infected patients with high baseline viremia c arrying the IL12B3-UTR 1188-Callele showed significantly higher sustained viro logic response (SVR) rates (25.3%vs. 46%vs. 54.5%for A/A, A/C and C/C) due to reduced relapse rates (24.2%vs. 12%vs. zero %for A/A, A/C and C/C). IL12B 3 -UTR 1188-C-allele carriers appear to be capable of responding more efficient ly to antiviral combination therapy as a consequence of a reduced relapse rate. No association of IL12B polymorphisms and self-limited HCV infection could be d emonstrated.