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αB-crystallin mini-peptides support corneal healing in vitro and in vivo in rabbit model

International Journal of Ophthalmology(English edition) 2024年第10期17卷 1772-1779页

作者： Namrata Maity Aditya Konar sarbani hazra Department of Veterinary Surgery&Radiology West Bengal University of Animal and Fishery SciencesKolkata 700037India CSIR-IICB Kolkata 700032India

AIM:To evaluate if topical use ofαB-crystallin minipeptides supports corneal healing following flap ***:Cultured corneal cells were treated with fluorescent taggedαB-crystallin mini-peptides to assess its *** corneal cells pre-treated with or without the mini-peptides were exposed to H2O2 and cell viability was examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** of neurites of cultured trigeminal neurones was examined following treatment either withαB-crystallin mini-peptides or *** trigeminal neurones were pre-treated either withαB-crystallin mini-peptides or crystallin protein and exposed to H2O2 and presence of beading in the dendrites and axons was *** flap surgery was conducted on rabbit cornea and treated topically either withαB-crystallin peptide(0.5 mg/mL thrice daily for 14d)or phosphate-buffered saline(PBS).Corneal healing was evaluated under slit-lamp biomicroscope,mRNA expression of inflammatory cytokines were assessed and the corneas were evaluated by ***:Internalization ofαB-crystallin mini-peptides was ascertained by the detection of fluorescence within the corneal *** MTT assay revealed that treatment withαB-crystallin mini-peptide reduced cell death induced by H2O2 *** mini-peptides did not influence the elongation of trigeminal neurites,but significantly(P<0.05)reduced beading in the *** rabbit eye,the treated corneas showed reduced hyper-reflective zones(P<0.05)and suppression in the expression of inflammatory *** examination also revealed reduction of inflammatory response in treated ***:TheαB-crystallin mini-peptides restrict the damage to corneal cells and neurons and aids in corneal healing.

关键词： corneal healing αB-crystallin cytoprotection neuroprotection

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Comparison of design of intraocular lens versus the material for PCO prevention

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International Journal of Ophthalmology(English edition) 2012年第1期5卷 59-63页

作者： sarbani hazra Himangshu Palui Geeta K Vemuganti Department of Veterinary Surgery & Radiology West Bengal University of Animal and Fishery Sciences Kolkata India Prof & Dean Medical Sciences University of Hyderabad India Hyderabad India

AIM: To evaluate the influence of different intraocular lens(IOL) designs made of PMMA on posterior capsular opacification(PCO) and compare with foldable designs.· METHODS: Phacoemulsification and IOL implantation was done in one eye of 24 New Zealand White rabbits, with IOL of two different designs (Square edged or round edge) and two different materials(PMMA or HEMA). After three months, the animals were sacrificed and enucleated. Evaluation of PCO included posterior view, migration of anterior capsular epithelial cells to the posterior capsule following epithelial-mesenchymal transition were assessed by staining the histological sections of posterior capsule by hematoxylin-eosin(HE) and Periodic acid- Schiff (PAS). The IOLs were extracted and stained with HE to evaluate the presence of adherent cells on the lens surface. · RESULTS: PCO was highest with round edged rigid lens. There was no significant difference in the PCO between the square edged PMMA and square edged foldable lens.· CONCLUSION: It is the design of the IOL not the material that offers protection on PCO formation.

关键词： design material of intraocular lens posterior capsular opacification

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Spontaneous Resolution of Cataract and Medical Management of Corneal Opacity in an Indian Parrot—<i>Psittacula krameri manillensis</i>

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Open Journal of Veterinary Medicine 2013年第2期3卷 184-186页

作者： sarbani hazra Department of Veterinary Surgery & Radiology West Bengal University of Animal & Fishery Sciences Kolkata India

A 35-year-old Indian parrot (Psittacula krameri manillensis) was presented to the Department of Veterinary Surgery & Radiology, West Bengal University of Animal and Fishery Sciences with a history of blepharospasm and corneal lesion OS. Test with fluorescein dye was negative. The dense corneal opacity (macula) was identified as involving the posterior corneal layer. The further ophthalmic examination was done and hypermature phacolytic cataract was diagnosed. No other abnormality was detected. Medical management with topical nepafenac prednisolone and triple antibiotic was instituted. The corneal lesion subsided completely within one week followed by spontaneous resorption of the cataract. The treatment protocol was successfully eliminated the discomfort and intraocular lesions in the senile parrot.

关键词： Medical Management Senile Cataract Parrot

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用于白内障超声乳化训练的活体白内障动物模型(英文)

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国际眼科杂志 2008年第6期8卷 1091-1094页

作者： sarbani hazra Dipak K De Arup K Bose Biswarup Roy 印度加尔各答市西孟加拉动物与水产科学大学兽医外科学与放射学系印度西孟加拉邦眼显微外科和激光中心印度西孟加拉邦加尔各答市 R.G.Kar医学院及医院眼科

目的：制备用于白内障超声乳化训练的活体白内障动物模型。方法：狗在全身麻醉下用26号带有斜面的针刺破左眼的晶状体前囊，制备白内障模型，形成白内障后，行超声乳化手术。结果：眼部检查显示晶状体后部皮质混浊开始于穿刺术后5～7d... 详细信息

目的：制备用于白内障超声乳化训练的活体白内障动物模型。方法：狗在全身麻醉下用26号带有斜面的针刺破左眼的晶状体前囊，制备白内障模型，形成白内障后，行超声乳化手术。结果：眼部检查显示晶状体后部皮质混浊开始于穿刺术后5～7d，并于术后75d白内障全部形成，在所有的白内障形成的眼上行超声乳化手术，并植入人工晶状体，所有的狗均恢复了视力。结论：考虑到无经验的眼科医生在行白内障超声乳化手术的初始阶段引起的巨大损失，我们认为这个活的动物模型明显优于目前用于训练超声乳化手术的尸体眼。

关键词：白内障训练模型超声乳化狗

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局部麻醉对兔眼心反射和眼角膜愈合的影响(英文)

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国际眼科杂志 2009年第12期9卷 2255-2259页

作者： Jay Singh Subhasis Roy Prasenjit Mukherjee Debajyoti Konar Aditya Konar sarbani hazra 西孟加拉动物与水产科学大学印度加尔各答 ESIC医院及职业病防治中心印度加尔各答印度化学生物学研究所印度加尔各答

目的:在兔模型中利用局部麻醉来研究两种麻醉剂的眼心反射发生率及其预防,同时我们还研究了局部麻醉对角膜愈合的影响。方法:健康的成年新西兰白兔(雌雄皆有)48只,分成两组(A组和B组),分别用氯胺酮(A组,24例)、异丙酚(B组,24例)麻醉。... 详细信息

目的:在兔模型中利用局部麻醉来研究两种麻醉剂的眼心反射发生率及其预防,同时我们还研究了局部麻醉对角膜愈合的影响。方法:健康的成年新西兰白兔(雌雄皆有)48只,分成两组(A组和B组),分别用氯胺酮(A组,24例)、异丙酚(B组,24例)麻醉。在此双盲研究中,通过用或不用局部麻醉(40g/L利多卡因,5g/L盐酸丙美卡因,5g/L布比卡因)对眼睛的不同干预,记录各组眼心反射发生率。应用每种局部麻醉后,通过对眼睛的临床检查,组织病理学,胶原染色以及投射电子显微等方法对术后1d长达7d角膜毒性和愈合进行评估。结果:在氯胺酮的麻醉下未出现眼心反射,而在异丙酚的麻醉下,心率显著下降(P<0.01)。因此,局部麻醉可以成功地防止眼心反射的发生并且不影响角膜愈合。结论:局部麻醉没有任何局部副作用,可以被推荐用来预防眼心反射。

关键词：眼心反射局部麻醉角膜愈合氯胺酮异丙酚

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