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Plant Communications 2020年第1期1卷 201-212页

作者： sara Colanero Andrea Tagliani Pierdomenico Perata Silvia Gonzali PlantLab Institute of Life SciencesScuola Superiore Sant’AnnaPisaItaly

Tomato(Solanum lycopersicum)fruits are typically red at ripening,with high levels of carotenoids and a low content in *** work has been done to enrich the spectrum of their healthbeneficial phytochemicals,and interspecific crosses with wild species have successfully led to purple anthocyanin-colored *** Aft(Anthocyanin fruit)tomato accession inherited from Solanum chilense the ability to accumulate anthocyanins in fruit peel through the introgression of loci controlling anthocyanin pigmentation,including four R2R3 MYB transcription factor-encoding ***,we carried out a comparative functional analysis of these transcription factors in wild-type and Aft plants,and tested their ability to take part in the transcriptional complexes that regulate the biosynthetic pathway and their effi-ciency in inducing anthocyanin *** differences emerged for SlAN2like,both in the expression level and protein functionality,with splicing mutations determining a complete loss of function of the wild-type *** transcription factor thus appears to play a key role in the anthocyanin fruit *** data provide new clues to the long-awaited genetic basis of the Aft phenotype and contribute to understand why domesticated tomato fruits display a homogeneous red coloration without the typical purple streaks observed in wild tomato species.

关键词： Solanum lycopersicum tomato Aft anthocyanin R2R3 MYB transcription factors MBW complex

Beyond the gluten-free diet:Innovations in celiac disease therapeutics

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World Journal of Gastroenterology 2024年第38期30卷 4194-4210页

作者： sara Massironi Marianna Franchina Alessandra Elvevi Donatella Barisani Division of Gastroenterology Fondazione IRCCS San Gerardo dei TintoriUniversity of Milano-BicoccaMonza 20900Italy Department of Gastroenterology IRCCS San Gerardo dei TintoriMonza 20900LombardyItaly School of Medicine and Surgery University of Milano-BicoccaMonza 20900Italy

Celiac disease(CD)is an autoimmune disorder exacerbated by the ingestion of gluten in genetically susceptible individuals,leading to intestinal inflammation and *** chronic disease affects approximately 1%of the world’s po-pulation and is a growing health challenge due to its increasing *** development of CD is a complex interaction between genetic predispositions and environmental factors,especially gluten,culminating in a dysregulated immune *** only effective treatment at present is a strict,lifelong gluten-free ***,adherence to this diet is challenging and often incomplete,so research into alternative therapies has *** advances in under-standing the molecular and immunological aspects of CD have spearheaded the development of novel pharmacologic strategies that should provide more effec-tive and manageable treatment *** review examines the latest inno-vations in CD *** focus is on drugs in advanced clinical phases and targeting specific signaling pathways critical to the disease *** dis-cuss both quantitative strategies such as enzymatic degradation of gluten,and qualitative approaches including immunomodulation and induction of gluten *** treatments currently under investigation include transglu-taminase inhibitors,which prevent the modification of gluten peptides,and nano-particle-based therapies to recalibrate the immune *** new therapies not only promise to improve patient outcomes but are also expected to improve quality of life by reducing the burden of dietary *** integration of these new therapies could revolutionize the treatment of CD and shift the para-digm from strict dietary restrictions to a more flexible and patient-friendly thera-peutic *** review provides a comprehensive overview of the future prospects of CD treatment and emphasizes the importance of continued research and multidisciplinary collab-oration to inte

关键词： Celiac disease Gluten tolerance Enzymatic degradation Therapeutic advances Transglutaminase inhibitors Tight junction modulators

Retail E-Commerce Market Analysis Based on Consumer,Government and Industry Levels:A Case of Kazakhstan

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Retail E-Commerce Market Analysis Based on Consumer,Governme...

作者： sara Nurzhanova 上海交通大学

学位级别：硕士

While electronic commerce is not a new phenomenon in many countries and has developed quite aggressively reaching its maturity in the markets such as the USA or China,it is still emerging and rising in some developing countries such as ***,retail e-commerce in Kazakhstan is growing rapidly attracting the attention of possible *** such,there is a need for a comprehensive study about the business-to-consumers（B2C）retail ecommerce in the region as there is a lack of comprehensive academic research in this *** study investigates Kazakhstani retail e-commerce focused on three key *** three aspects are factors influencing consumer e-commerce adoption,the role of government in e-commerce development as well as overall retail e-commerce industry *** on a review of the literature,an online questionnaire about consumer adoption factors was distributed among consumers and non-consumers of online *** a result,205 respondents participated in the *** analysis of survey findings shows that Perceived Usefulness（PU）and delivery Time and Fee（DTF）are the two factors among the six（Perceived Usefulness（PU）,Perceived Ease of Use（PEOU）,Perceived Risk（PR）,Economic Benefit（EB）,Customer Service（CS）,and delivery Time and Fee（DTF））mattering in consumer e-commerce ***,Perceived Usefulness（PU）has a positive relationship with consumer e-commerce adoption in terms of monthly shopping frequency,delivery Time and Fee（DTF）is negatively related to the dependent *** detect the government role in retail e-commerce development,a semistructured interview was *** interview participants were middle and senior positioned professionals in e-commerce giant firms and *** the five selected success factors,the Kazakhstani government is found to play a significant role in fostering e-commerce through the three determinants: e-commerce infrastructure,awareness and literacy,and business ***

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Experimental Electromagnetic Characterization of High Temperature Superconductors Coils Located in Proximity to Electromagnetically Active Materials

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Fluid Dynamics & Materials Processing 2022年第5期18卷 1529-1537页

作者： Yazid Statra sara Fawaz Hocine Menana Bruno Douine Universitéde Lorraine GREENNancyF-54000France

The electromagnetic properties of high temperature superconductors(HTS)are characterized with the explicit intent to improve their integration in electric power systems.A tape and a coil made of Bismuth Strontium Calcium Copper Oxide(BSCCO)are considered in the presence of electromagnetically active materials in order to mimic properly the electromagnetic environment typical of electrical *** characterization consists of the determining the critical current and the AC losses at different values of the frequency and the transport *** effects induced by the proximity of the active materials are studied and some related experimental issues are analyzedc.

关键词： AC losses HTS coils experimental characterization proximity of electromagnetically active materials

Ontogenetic shifts in perceptions of safety along structural complexity gradients in a territorial damselfish

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Current Zoology 2019年第2期65卷 183-188页

作者： Yinny CHAN sara LO Alyssa QUAN Daniel T. BLUMSTEIN Department of Ecology and Evolutionary Biology University of California Los Angeles CA USA

Age and body size can influence predation risk and hence habitat use. Many species undergo ontogenetic shifts in habitat use as individuals grow larger and have different age-specific predation pressures. On coral reefs, a number of fish species are more tolerant of threats in structurally complex habitats that contain more refuges than in less structurally complex habitats. However, we do not know how risk perception varies with age, and whether age interacts with habitat complexity. Adults and juveniles, because of their size, may face different risks in structurally simple versus complex habitats. We used flight initiation distanee as a metric to analyze perceptions of risk in a species of damselfish Stegastes nigricans. All else being equal, fish fleeing at greater distances are inferred to perceive higher risk. We targeted juvenile and adult damselfish to assess whether there are ontogenetic shifts in perceptions of safety in relation to structural complexity, inferred based on percent coral cover and rugosity. We found that adult damselfish tolerated closer approach in more complex habitats as measured by percent coral cover, but not rugosity, whereas juvenile fish always allowed closer approach than adult fish regardless of complexity. This ontogenetic shift in habitat use may result from juvenile fish taking bigger risks to maximize growth, whereas older animals, who are closer to their maximum body size, can afford to take fewer risks and protect their assets.

关键词： Stegastes nigricans habitat complexity risk assessment ontogenetic shifts antipredator behavior flight initiation distanee

Reserve estimation of the high phosphorous stockpile at the Choghart iron mine of Iran using geostatistical modeling

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Mining Science and Technology 2010年第6期20卷 855-860页

作者： KASMAEE sara GHOLAMNEJAD Javad YARAHMADI Alireza MOJTAHEDZADEH Hosein Department of Mining and Metallurgical Engineering Yazd University

An attempt to estimate the reserves in the High Phosphorous stockpile （HP） at the Choghart Iron mine of Iran was carded out using geostatistical modeling. Grade and tonnage estimates of ore stockpiles can help convert them into a valuable ore reserve. This is valuable in consideration of increasing metal demand, and the depletion of in situ ore reserves, around the world. Estimation of reserves in stockpiles is difficult partly because of geological and grade discontinuities created during the dumping of the ore piles. Data input for the HP stockpile at Choghart was performed based upon pre-existing information gathered during extraction from the various mining benches. After establishing the input data files the reserve estimates were found using geostatistical methods aided by the international mining software SURPAC. The stockpile was divided in to three domains and the reserves in each domain were estimated separately. A grade block model was used to compute the reserve. Fe% and P% were estimated using the Ordinary Kriging method. The results showed that the total tonnage of the HP stockpile is 4.5 million tons with an average zrade of 55% Fe and 1.03% P.

关键词： stockpile reserve estimation geostatistics Ordinary Kriging

An Innovative MCDM Approach to Offshore Wind Potential Analysis ——Examples in Southeast Asia

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An Innovative MCDM Approach to Offshore Wind Potential Analy...

作者： sara Cudemo 上海交通大学

学位级别：硕士

Among the different forms of renewable energy,wind offshore is definitely one of the most *** to the International Energy Agency,wind offshore alone would be able to satisfy the whole world's electricity ***,whereas academic and business resources can be found in Europe,China and North America,almost no information is available for other Asian *** fill this void,secondary and primary research was conducted on three selected countries,namely India,Vietnam and the Philippines,to assess their market *** insinuate that,from the perspective of an international investor,Vietnam can be considered the most attractive *** and the Philippines fall quite behind,but strong development can be expected in the coming ***,it appears that the point of view of the stakeholder involved in the analysis can influence the final outcome of the *** study proposes a new theoretical framework for the analysis of developing markets,as well as offering an up to date database on the offshore wind industry in India,Vietnam and the Philippines.

关键词： renewable energy offshore wind Analytic Hierarchy Process Vietnam India the Philippines international investors

Variant Wasserstein Generative Adversarial Network Applied on Low Dose CT Image Denoising

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Computers, Materials & Continua 2023年第5期75卷 4535-4552页

作者： Anoud A.Mahmoud Hanaa A.Sayed sara S.Mohamed Department of Mathematics and Computer Science Faculty of ScienceNew Valley UniversityNew Valley72511Egypt Department of Computer Science College of Computer Science and Engineering Taibah UniversityMedina42221KSA Department of Mathematics Faculty of ScienceAssiut UniversityAssiut71516Egypt

Computed Tomography(CT)images have been extensively employed in disease diagnosis and treatment,causing a huge concern over the dose of radiation to which patients are *** the radiation dose to get a better image may lead to the development of genetic disorders and cancer in the patients;on the other hand,decreasing it by using a Low-Dose CT(LDCT)image may cause more noise and increased artifacts,which can compromise the ***,image reconstruction from LDCT image data is necessary to improve radiologists’judgment and *** study proposed three novel models for denoising LDCT images based on Wasserstein Generative Adversarial Network(WGAN).They were incorporated with different loss functions,including Visual Geometry Group(VGG),Structural Similarity Loss(SSIM),and Structurally Sensitive Loss(SSL),to reduce noise and preserve important information on LDCT images and investigate the effect of different types of loss ***,experiments have been conducted on the Graphical Processing Unit(GPU)and Central Processing Unit(CPU)to compare the performance of the proposed *** results demonstrated that images from the proposed WGAN-SSIM,WGAN-VGG-SSIM,and WGAN-VGG-SSL were denoised better than those from state-of-the-art models(WGAN,WGAN-VGG,and SMGAN)and converged to a stable equilibrium compared with WGAN and *** proposed models are effective in reducing noise,suppressing artifacts,and maintaining informative structure and texture details,especially WGAN-VGG-SSL which achieved a high peak-signalto-noise ratio(PNSR)on both GPU(26.1336)and CPU(25.8270).The average accuracy of WGAN-VGG-SSL outperformed that of the state-ofthe-art methods by 1 *** prove that theWGAN-VGG-SSL is more stable than the other models on both GPU and CPU.

关键词： Machine learning deep learning image denoising low dose CT loss function

Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 3-16页

作者： sara Mattana Silvia Caponi Francesco Tamagnini Daniele Fioretto Francesca Palombo Department of Physics and Geology University of Perugia Perugia I-06123Italy Istituto Officina dei Materiali del CNR(CNR-IOM)-Unita di Perugia Department of Physics and Geology University of Perugia Perugia I-06123Italy Hatherly Laboratories Medical School University of ExeterExeter EX44PSUK School of Physics and Astronomy University of Exeter Exeter EX44QLUK

A myloidopathy is one of the most prominent hallmarks of Alkheimer's disease(AD),the leading cause of dementia worldwide,and is characterized by the accumulation of amyloid plaques in the brain *** plaques consist of abnornal deposits mainly composed of an aggregation-prone protein fragment,B-amyloid 140/1-42,into the extracellular *** micro-spectroscopy is an all-optical contactless technique that is based on the interaction between visible light and longitudinal acoustic waves or phonons,giving access to the viscoelasticity of a sample on a subcellular ***,we describe the first application of micromechanical mapping based on Brillouin scattering spectroscopy to probe the stifness of individual amyloid plaques in the hippocampal part of the brain of a B-amyloid overexpressi ng transgenic *** analysis based on Brillouin and Raman microspectroscopy showed that amyloid plaques have a complex structure with a rigid core of B-pleated shoet conformation(B-aryloid)protein sur-rounded by a softer ring-shaped region richer in lipids and other protein *** preliminary results give a new insight into the plaque biophysics and biomechanics,and a valuable contrast mechanism for the study and diagnosis of amnyloidopathy.

关键词： Alzheimer's imaging vibrational spectrosecopy protein misfolding light scattering