检索结果-南通市图书馆

Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第12期8卷 5686-5726页

作者： Priyanka dey Talukdar Urmi Chatterji Cancer Research Laboratory Department of ZoologyUniversity of Calcutta35 Ballygunge Circular RoadKolkata 700019 West BengalIndia

Specific cell states in metazoans are established by the symphony of gene expression programs that necessitate intricate synergic interactions between transcription factors and the *** of these regulatory molecules is associated with cell state transitions,which in turn is accountable for diverse maladies,including developmental disorders,metabolic disorders,and most significantly,cancer.A decade back most transcription factors,the key enablers of disease development,were historically viewed as‘undruggable’;however,in the intervening years,a wealth of literature validated that they can be targeted indirectly through transcriptional co-activators,their confederates in various physiological and molecular *** co-activators,along with transcription factors,have the ability to initiate and modulate transcription of diverse genes necessary for normal physiological functions,whereby,deregulation of such interactions may foster tissue-specific disease ***,it is essential to analyze how these co-activators modulate specific multilateral processes in coordination with other *** proposed review attempts to elaborate an in-depth account of the transcription co-activators,their involvement in transcription regulation,and context-specific contributions to pathophysiological *** review also addresses an issue that has not been dealt with in a comprehensive manner and hopes to direct attention towards future research that will encompass patient-friendly therapeutic strategies,where drugs targeting co-activators will have enhanced benefits and reduced side *** insights into currently available therapeutic interventions and the associated constraints will eventually reveal multitudes of advanced therapeutic targets aiming for disease amelioration and good patient prognosis.

关键词： therapeutic eventually potential

Approach for C_(1)to C_(2)products commencing from carbon dioxide:A brief review

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum 2024年第3期10卷 373-398页

作者： G.R.dey Radiation and Photochemistry Division Bhabha Atomic Research CentreTrombayMumbai 400085India Homi Bhabha National Institute AnushaktinagarMumbai 400094India

The carbon dioxide(CO_(2))conversion to useable compounds remains a great contest to scientists,engineers,and environmentalists with regard to the reverse of the oxidative degradation of *** conversion is essential for the development of complementary fuels and raw materials for various industries,which in turn will help in avoiding the drastic increase in tropospheric temperature due to greenhouse effect leading to global *** solar energy is the earth's essential power source along with the other various forms of energy for example fossil fuels,hydropower,wind,and biomaterials,*** final goal is to establish the artificial photosynthesis,which can be replicated thru various chemical reduction techniques of CO_(2)by employing appropriate photo-,thermal-and electro-catalysts in order to produce different one carbon atom(C_(1))and higher carbon atoms containing ***,the utilization of clean and sustainable CO_(2)towards high-value products is of great interest today due to the recognized environmental worries and subsequent lessening of the fossil fuels utilization load to meet the energy demand of *** way,solar energy can directly and/or indirectly be altered and stored in chemical energy form for industrial as well as societal *** this article our endeavor is to summarize the advances in CO_(2)chemical reduction research area till date especially in free radical-based methods such as electrochemical,photochemical and plasma chemical for the development of carbon species up to two carbon(C_(2))atoms containing products perceived in the chemical reduction of CO_(2).The author hopes that this piece of work will be helpful to researchers and readers who are focused on the field of CO_(2).

关键词： Photocatalysis Electrocatalysis Plasmolysis Thermolysis Carbon dioxide Chemical reduction

Perovskite solar cells: recent progress and strategies developed for minimizing interfacial recombination

在线全文

学校读者我要写书评

暂无评论

Frontiers of Materials Science 2022年第2期16卷 41-54页

作者： Rengasamy DHANABAL Suhash Ranjan dey Combinatorial Materials Laboratory Department of Materials Science and Metallurgical EngineeringIndian Institute of Technology HyderabadKandiSangareddy 502284TelanganaIndia

Organometallic perovskite is a new generation photovoltaic material with exemplary properties such as high absorption co-efficient,optimal bandgap,high defect tolerance factor and long carrier diffusion ***,suitable electrodes and charge transport materials are required to fulfill photovoltaic processes where interfaces between hole transport material/perovskite and perovskite/electron transport material are affected by phenomena of charge carrier separation,transportation,collection by the interfaces and band *** on recent available literature and several strategies for minimizing the recombination of charge carriers at the interfaces,this review addresses the properties of hole transport materials,relevant working mechanisms,and the interface engineering of perovskite solar cell(PSC)device architecture,which also provides significant insights to design and development of PSC devices with high efficiency.

关键词： light absorption p–i–n and n–i–p structure interface recombination build-in potential perovskite solar cell

cis-trans Engineering： Advances and Perspectives on Customized Transcriptional Regulation in Plants

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2018年第7期11卷 886-898页

作者： Ankita Shrestha Ahamed Khan Nrisingha dey Division of Microbial and Plant Biotechnology Institute of Life Sciences Department of Biotechnology Government of India Chandrasekharpur Bhubaneswar Odisha India These authors contributed equally to this article.

Coordinated transcriptional control employing synthetic promoters and transcription factors （TFs） can be used to achieve customized regulation of gene expression in planta. Synthetic promoter technology has yielded a series of promoters with modified cis-regulatory elements that provide useful tools for efficient modulation of gene expression. In addition, the use of zinc fingers （ZFs）, transcription activator-like effectors （TALEs）, and catalytically inactive clustered regularly interspaced short palindromic repeats （CRISPR）-associated protein 9 （dCas9） has made it feasible to engineer TFs that can produce targeted gene expression regulation; these approaches are particularly effective when artificial TFs are coupled with transcriptional activators or repressors. This review focuses on strategies used to engineer both promoters and TFs in the context of targeted transcriptional regulation. We also discuss the creation of synthetic inducible platforms, which can be used to impart stress tolerance to plants. We propose that combinatorial ＂cis-trans engineering＂ using a CRISPR-dCas9-based bipartite module could be used to regulate the expression of multiple target genes. This approach provides an attractive tool for introduction of specific qualitative traits into plants, thus enhancing their overall environmental adaptability.

关键词： cis engineering trans engineering synthetic TFs dCas9 bipartite module

Sulfide oxidation in fluidized bed bioreactor using nylon support material

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2012年第3期24卷 512-519页

作者： Varsha Midha M K Jha Apurba dey Department of Chemical Engineering National Institute of TechnologyJalandhar 144011India Department of Biotechnology National Institute of Technology DurgapurIndia

A continuous fluidized bed bioreactor （FBBR） with nylon support particles was used to treat synthetic sulfide wastewater at different hydraulic retention time of 25, 50 and 75 min and upflow velocity of 14, 17 and 20 m/hr. The effects of upflow velocity, hydraulic retention time and reactor operation time on sulfide oxidation rate were studied using statistical model. Mixed culture obtained from the activated sludge, taken from tannery effluent treatment plant, was used as a source for microorganisms. The diameter and density of the nylon particles were 2-3 mm and 1140 kg/m3, respectively. Experiments were carried out in the reactor at a temperature of （30 ± 2）°C, at a fixed bed height of 16 cm after the formation of biofilm on the surface of support particles. Biofilm thickness reached （42 ± 3） μm after 15 days from reactor start-up. The sulfide oxidation, sulfate and sulfur formation is examined at all hydraulic retention times and upflow velocities. The results indicated that almost 90%-92% sulfide oxidation was achieved at all hydraulic retention times. Statistical model could explain 94% of the variability and analysis of variance showed that upflow velocity and hydraulic retention time slightly affected the sulfide oxidation rate. The highest sulfide oxidation of 92% with 70% sulfur was obtained at hydraulic retention time of 75 min and upflow velocity of 14 m/hr.

关键词： biofilm fluidized bed bioreactor mixed culture sulfide oxidation

Prospects of utilization of waste dumped low-grade limestone for iron making: A case study

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2020年第3期30卷 367-372页

作者： Shobhana dey Laxmikanta Sahu Binish Chaurasia Bibhuranjan Nayak Mineral Processing Division CSIR-National Metallurgical LaboratoryJamshedpur 831007India Central Characterization Department CSIR-Institute of Minerals and Materials TechnologyBhubaneswar 751013India

Low grade dumped limestone sample having high silica of 8.1%, 36.8% CaO, and 3% Al2O3 has been studied with the aim to reduce the silica level to below 3% for its utilization in iron making. Beneficiation study of the sample was initiated with desliming of the feed sample of -100 μm to remove the siliceous ultrafine particles and to improve the feed quality. Flotation study was carried out by column flotation technique varying the collector dosage, superficial air flow velocity and froth depth to assess their effect on silica reduction and CaO recovery. It was observed that increased collector dosage and superficial air velocity increases the recovery of CaO, and increase in the froth depth reduces the mass flow and silica content in the concentrate. The best result was found at 1.25 cm/sec superficial air velocity, 25 cm froth depth, 1.25 kgpt collector dosage and concentrate assayed 47.3% CaO, 2.8% silica with 72% CaO recovery.

关键词： Dumped limestone sample Column flotation Waste utilization Textual occurrence Mineral phases

Characterization of Almostη-Ricci–Yamabe Soliton and Gradient Almostη-Ricci–Yamabe Soliton on Almost Kenmotsu Manifolds

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2023年第4期39卷 728-748页

作者： Somnath MONDAL Santu dey Arindam BHATTACHARYYA Department of Mathematics Jadavpur UniversityKolkata-700032India Department of Mathematics Bidhan Chandra College Asansol-4West Bengal-713304India

The prime object in this article is to study an almostη-Ricci-Yamabe soliton and gradient almostη-Ricci-Yamabe soliton within the framework of almost Kenmotsu *** is shown that normal almost Kenmotsu manifold admitting an almostη-Ricci-Yamabe soliton or gradientη-Ricci-Yamabe soliton is locally isometric to hyperbolic space H^(2n+1)(-1).Next,we prove that if a(κ,μ)almost Kenmotsu manifold admits an almostη-Ricci-Yamabe soliton,then the manifold isη-***,we find the condition for non-normal almost Kenmotsu manifolds acknowledging gradient almostη-Ricci-Yamabe ***,an almostη-Ricci-Yamabe soliton on(κ,μ)’-almost Kenmotsu manifold has been ***,we construct an example of a gradient almostη-Ricci-Yamabe soliton on a 3-dimensional Kenmotsu manifold.

关键词： Ricci soliton (k μ)-almost Kenmotsu manifold (r μ)-almost Kenmotsu manifold n-Ricci-Yamabe soliton

Experimental and numerical evaluation of multidirectional compressive and flexure behavior of three-dimensional printed concrete

在线全文

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2023年第11期17卷 1643-1661页

作者： Lalit KUMAR Dhrutiman dey Biranchi PANDA Nelson MUTHU Department of Mechanical Engineering Indian Institute of Technology GuwahatiAssam 781039India

Three-dimensional concrete printing(3DCP)can proliferate the industrialization of the construction sector,which is notoriously conservative and indolent toward ***,the mechanical behavior of 3DCP should be characterized and modeled considering the interfaces when its performance is thoroughly compared to that of the existing concrete construction *** study presents an experimental and numerical investigation of uniaxial compression and three-point bending(TPB)tests on extruded 3DCP beams in different loading *** orientation of translational and depositional interfaces with respect to the direction of loading influenced the *** the elastic and post-damage behavior of the 3DCP specimens were compared with those of the conventionally cast specimen under quasi-static loading *** the higher compressive strength of the casted specimen,the flexural strength of the 3DCP specimens was *** study employed the finite element and cohesive zone models of the appropriate calibrated traction-separation law to model fracture in the notched TPB ***,the real-time acoustic emission test revealed the nature of failure phenomenon of three-dimensional-printed specimens under flexion,and accordingly,the cohesive law was *** predicted load-displacement responses are in good agreement with the experimental ***,the effects of cohesive thickness and notch shape on the performance under bending were explored through parametric studies.

关键词： three-dimensional printing anisotropy flexure compression cohesive zone model finite element model

Influence of bank vegetation and gravel bed on velocity and Reynolds stress distributions

在线全文

学校读者我要写书评

暂无评论

International Journal of Sediment Research 2009年第2期24卷 236-246页

作者： Hossein AFZALIMEHR Subhasish dey Department of Water Engineering Isfahan University of Technology Department of Civil Engineering Indian Institute of Technology

This paper presents the results of a laboratory flume experimental study on the interaction of bank vegetation and gravel bed on the flow velocity(primarily on the location of the maximum velocity,Umax) and the Reynolds stress distributions. The results reveal that the dip of the maximum velocity below the water surface is up to 35% of flow depth and the difference between Umax and the velocity at the water surface is considerable in the presence of vegetation on the walls. The zone of the log-law varies from y/h=2 up to 15 percent of flow depth and it does not depend on distance from the wall. Deviation of the velocity profile in the outer layer over a gravel bed with vegetation cover on the walls is much larger than the case of flow over a gravel bed without vegetation cover on the walls. The presence of vegetation on the walls changes uniform flow to non-uniform flow. This fact can be explained by considering the nonlinear Reynolds stress distribution and location of maximum velocity in each profile at different distances across the flume. The Reynolds stress distributions at the distance 0.02 m from the wall have negative values and away from the wall,they change the sign taking positive values with specific convex form with apex in higher location. Average of von Karman constant κ for this study is equal to 0.16. Based on κ=0.16,the methods of Clauser and the Reynolds stress are compatible for determination of shear velocity.

关键词： Bank vegetation Uniform flow Reynolds stress Gravel bed Von Karman constant