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Presentation, patterns and predictive value of baseline liver tests on outcomes in COVID-19 patients without chronic liver disease

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World Journal of Gastroenterology 2021年第42期27卷 7350-7361页

作者： David Bernstein Nitzan Roth Angela kim Marica Epstein David Hirschwerk Charlotte L kvasnovsky sanjaya k.satapathy Department of Medicine/Hepatology Northwell HealthZucker School of Medicine at Hofstra/NorthwellManhassetNY 11030United States Division of Infectious Diseases Department of Medicine Northwell HealthZucker School of Medicine at Hofstra/NorthwellManhassetNY 11030United States Cohen Children's Medical Center Zucker School of Medicine at Hofstra/NorthwellNew Hyde ParkNY 11042United States

BACkGROUND Coronavirus disease 2019(COVID-19)infection is known to cause abnormal hepatic *** long term consequences of such elevations are *** To assessed the prevalence and prognostic value of initial liver enzymes in a large cohort of COVID-19 *** We reviewed electronic medical records of 10614 COVID-19 patients without known chronic liver disease who were admitted to our health system from March 1,2020,to April 30,*** analyzed baseline demographics and liver *** primary outcome was in-hospital mortality,and the secondary outcome was a composite of in-hospital mortality or need for mechanical *** Subjects with abnormal liver tests had increased risks of mortality and composite outcome when compared to patients with normal measurements on unadjusted analysis and after adjustment for demographic *** In our diverse patient population,liver enzyme abnormalities are associated with increased mortality and the need for mechanical ventilation in subjects without chronic liver *** patients are at the greatest risk for poor outcomes.

关键词： COVID-19 Liver enzymes Outcomes Predictors

NAFLD Epidemiology, Emerging Pharmacotherapy, Liver Transplantation Implications and the Trends in the United States

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Journal of Clinical and Translational Hepatology 2020年第2期8卷 215-221页

作者： Chiranjeevi Gadiparthi Moshe Spatz Simi Greenberg Umair Iqbal Sowjanya kanna sanjaya k.satapathy Arkady Broder Aijaz Ahmed Division of Gastroenterology Hepatology and Clinical NutritionSaint Peter’s University HospitalNew BrunswickNJUSA Rutgers Robert Wood Johnson Medical School PiscatawayNJUSA Nova Southeastern University College of Osteopathic Medicine DavieFLUSA Geisinger Commonwealth School of Medicine DanvillePAUSA Division of Gastroenterology Allegheny Health NetworkTarentumPAUSA Northwell Health Division of Hepatology&Sandra Atlas Bass Center for Liver DiseasesManhassetNYUSA Stanford University School of Medicine Division of Gastroenterology and HepatologyStanfordCAUSA

Nonalcoholic fatty liver disease (NAFLD) is a hepatic mani-festation of metabolic syndrome. The spread of obesity worldwide in pandemic proportions has led to a rapid rise of NAFLD in developed and developing countries alike. There are no approved pharmacological agents to treat steatohepatitis or advanced fibrosis but obeticholic acid recently has shown some promise in phase III trial. Currently, NAFLD is the number one etiology for simultaneous liver and kidney trans-plantation in the USA, second most common indication for liver transplantation (LT) and projected to become number one very soon. LT for NAFLD poses unique challenges, as these patients are generally older, obese and more likely to have a number of metabolic risk factors. Bariatric surgery is an option and can be considered if a structured weight loss program does not achieve the sustained weight loss goal. Comprehensive cardiovascular risk assessment and aggres-sive management of comorbid conditions are crucial in the LT evaluation process to improve post-transplant survival. Re-current nonalcoholic steatohepatitis after LT is not uncom-mon, and thus warrants primary and secondary prevention strategies through a multidisciplinary approach. Prevalence of NAFLD in a donor population is a unique and growing concern that limits the access to quality liver grafts.

关键词： NAFLD NAFL NASH Liver transplantation

Non-alcoholic fatty liver and chronic kidney disease:Retrospect,introspect,and prospect

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World Journal of Gastroenterology 2021年第17期27卷 1864-1882页

作者： Rajiv Heda Masahiko Yazawa Michelle Shi Madhu Bhaskaran Fuad Zain Aloor Paul J Thuluvath sanjaya k.satapathy Department of Internal Medicine Tulane University School of MedicineNew OrleansLA 70112United States Department of Nephrology and Hypertension St.Marianna University School of MedicineKawasaki 216-8511Japan Department of Internal Medicine Donald and Barbara Zucker School of MedicineNorthwell HealthManhassetNY 11030United States Department of Nephrology Northwell Health/Zucker School of Medicine at HosftraManhassetNY 11030United States Department of Internal Medicine Baylor College of MedicineHoustonTX 77030United States Institute of Digestive Health&Liver Diseases Mercy Medical CenterBaltimoreMD 21202United States

With the growing prevalence of obesity and diabetes in the United States and across the world,a rise in the overall incidence and prevalence of non-alcoholic fatty liver disease(NAFLD)is *** risk factors for NAFLD are also associated with the development of chronic kidney disease(CkD).We review the epidemiology,risk factors,genetics,implications of gut dysbiosis,and specific pathogenic mechanisms linking NAFLD to *** such as ectopic lipid accumulation,cellular signaling abnormalities,and the interplay between fructose consumption and uric acid accumulation have led to the emergence of potential therapeutic implications for this patient *** evaluation in the setting of both NAFLD and CkD is also *** strategies for surveillance and management include the monitoring of comorbidities,the use of non-invasive fibrosis scoring systems,and the measurement of laboratory ***,we discuss the management of patients with NAFLD and CkD,from preventative measures to experimental interventions.

关键词： Nonalcoholic fatty liver disease Chronic kidney disease Nonalcoholic steatohepatitis Organ transplant genetic Microbiome Pathophysiology

Use of direct-acting antiviral agents in hepatitis C virusinfected liver transplant candidates

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World Journal of Gastroenterology 2018年第3期24卷 315-322页

作者： Chiranjeevi Gadiparthi George Cholankeril Brandon J Perumpail Eric R Yoo sanjaya k.satapathy Satheesh Nair Aijaz Ahmed Division of Gastroenterology and Hepatology University of Tennessee Health Sciences CenterMemphisTN 38104United States Division of Gastroenterology and Hepatology Stanford University School of MedicineStanfordCA 94304United States Drexel University College of Medicine PhiladelphiaPA 19129United States Department of Medicine Santa Clara Valley Medical CenterSan JoseCA 95128United States

Since the advent of direct acting antiviral(DAA) agents, chronic hepatitis C virus(HCV) treatment has evolved at a rapid pace. In contrast to prior regimen involving ribavirin and pegylated interferon, these newer agents are highly effective, well-tolerated, have shorter course of therapy and safer essentially in all HCV patients including those with advanced liver disease and following liver transplantation. Clinicians caring for HCV-infected patients on the liver transplant(LT) waitlist are often faced with a dilemma whether to treat HCV infection before or after liver transplantation. Sustained virological response(SVR) rates following HCV treatment may improve hepatic function sufficiently enough to negate the need for LT in certain patients. On the other hand, the decrease in MELD without improvement in quality of life in certain patients may lead to delay or dropout from potentially curative LT surgery list. In this context, our review focuses on the approach to and optimal timing of DAA-based treatment of HCV infection in LT candidates in the peri-transplant period.

关键词： Hepatitis C virus Direct-acting antiviral therapy Liver transplantation Purgatory Model for End-stage liver disease Sustained virological response

Splenic arteriovenous fistula leading to non-cirrhotic portal hypertension:a case report

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Gastroenterology Report 2023年第1期11卷 545-547页

作者： Ahmad Abou Yassine Hassan Al Moussawi Malek kreidieh Loai Dahabra Mustafa Al-Roubaie sanjaya satapathy Department of Internal Medicine Staten Island University HospitalNorthwell HealthStaten IslandNYUSA Division of Gastroenterology Department of Internal MedicineStaten Island University HospitalNorthwell HealthStaten IslandNYUSA Department of Radiology North Shore University HospitalNorthwell HealthManhassetNYUSA Department of Gastroenterology North Shore University HospitalNorthwell HealthManhassetNYUSA

Introduction Non-cirrhotic portal hypertension(NCPH)is a rare disease characterized by portal hypertension in the absence of cirrhosis or other causes of liver disease and splanchnic venous *** case is a rare presenta... 详细信息

关键词： hypertension fistula arteriovenous

Direct scaling of residual displacements for bilinear and pinching oscillators

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 129-149页

作者： Mohammad Saifullah Vinay k.Gupta Department of Civil Engineering Indian Institute of Technology KanpurKanpur 208016India

The estimation of residual displacements in a structure due to an anticipated earthquake event has increasingly become an important component of performance-based earthquake engineering because controlling these displacements plays an important role in ensuring cost-feasible or cost-effective repairs in a damaged structure after the *** attempt is made in this study to obtain statistical estimates of constant-ductility residual displacement spectra for bilinear and pinching oscillators with 5%initial damping,directly in terms of easily available seismological,site,and model *** of the available models for the bilinear and pinching oscillators are useful when design spectra for a seismic hazard at a site are not *** statistical estimates of a residual displacement spectrum are proposed in terms of earthquake magnitude,epicentral distance,site geology parameter,and three model parameters for a given set of ductility demand and a hysteretic energy capacity coefficient in the case of bilinear and pinching models,as well as for a given set of pinching parameters for displacement and strength at the breakpoint in the case of pinching model *** proposed scaling model is applicable to horizontal ground motions in the western *** earthquake magnitudes less than 7 or epicentral distances greater than 20 km.

关键词： residual displacement spectrum bilinear hysteresis model pinching hysteresis model nonlinear analysis scaling model

Analysis of the Oscillatory Flows of Multiple Shock Waves in a Constant Area Duct

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Journal of Thermal Science 2024年第3期33卷 794-806页

作者： k JAMES Jintu kIM Heuy Dong Department of Mechanical Engineering Andong National UniversityAndong36729Republic of Korea CAD-IT korea Co. Ltd.Seoul08591Republic of Korea

The oscillatory response of multiple shock waves to downstream perturbations in a supersonic flow is studied numerically in a rectangular *** shock waves are formed inside the duct at a shock Mach number of *** duct has an exit height of H,and the effect of duct resonance on multiple shock oscillations is investigated by attaching exit ducts of lengths 0H,50H,and *** downstream disturbance frequency varied from 10 Hz to 200 Hz to explore the oscillation characteristics of the multiple shock *** oscillatory response of shock waves under self-excited and forced oscillation conditions are analyzed in terms of wall static pressure,shock train leading-edge location,shock train length,and the size of the separation *** extent of the initial shock location increases with an increase in exit duct length for the self-excited oscillation *** analysis of the shock train leading edge and the spectral analysis of wall static pressure variations are *** variation in the shock train length is analyzed using the pressure ratio method for self-excited as well as forced *** RMS amplitude of the normalized shock train length(ζ_(ST))increases with an increase in the exit duct length for the self-excited oscillation *** the downstream perturbation frequency is increased,ζ_(ST)is decreased for exit duct *** all exit duct designs and downstream forcing frequencies,the size of the separation bubble grows and shrinks during the shock oscillations,demonstrating the dependence on duct resonance and forced oscillations.

关键词： shock train downstream disturbance supersonic flow shock wave boundary layer interaction duct resonance flow separation

Impact of Fin Arrangement on Heat Transfer and Melting Characteristics of Phase Change Material

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Journal of Thermal Science 2024年第2期33卷 435-456页

作者： Arun UNIYAL Yogesh k.PRAJAPATI Department of Mechanical Engineering National Institute of Technology UttarakhandSrinagar(Garhwal)246174India Department of Mechanical Engineering BIT SindriDhanbadJharkhand828123India

Present work investigates the heat transfer and melting behaviour of phase change material(PCM) in six enclosures(enclosure-1 to 6) filled with paraffin *** enclosures are equipped with distinct arrangements of the fins while keeping the fin's surface area equal in each *** analysis has been presented to recognize the suitable fin arrangements that facilitate improved heat transfer and melting rate of the *** wall of the enclosure is maintained isothermal for the temperature values 335 k,350 k and 365 *** length of the enclosure including fins is ranging between 0 and *** have been illustrated through the estimation of important performance parameters such as energy absorbing capacity,melting rate,enhancement ratio,and Nusselt *** has been found that melting time(to melt 100% of the PCM) is 60.5%less in enclosure-2(with two fins of equal length) as compared to the enclosure-1,having no *** the fin surface area equal,if the longer fin is placed below the shorter fin(enclosure-3),melting time is further decreased by 14.1% as compared to ***,among all the configurations,enclosure-6 with wire-mesh fin structure exhibits minimum melting time which is 68.4% less as compared to the *** on the findings,it may be concluded that fins are the main driving agent in the enclosure to transfer the heat from heated wall to the *** design and positioning of the fins improve the heat transfer rate followed by melting of the PCM in the entire area of the *** of the favourable vortices and natural convection current in the enclosure accelerate the melting phenomenon and help to reduce charging time.

关键词： phase change material enclosure fin melting fraction energy storage heat transfer

Radiative heat transfer analysis of a concave porous fin under the local thermal non-equilibrium condition:application of the clique polynomial method and physics-informed neural networks

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Applied Mathematics and Mechanics(English Edition) 2024年第9期45卷 1613-1632页

作者： k.CHANDAN k.kARTHIk k.V.NAGARAJA B.C.PRASANNAkUMARA R.S.VARUN kUMAR T.MUHAMMAD Amrita School of Artificial Intelligence Amrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia Department of Studies in Mathematics Davangere UniversityDavangere 577002KarnatakaIndia Computational Science Lab Amrita School of EngineeringAmrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia Department of Pure and Applied Mathematics School of Mathematical SciencesSunway UniversityPetaling Jaya 47500Malaysia Department of Mathematics College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia

The heat transfer through a concave permeable fin is analyzed by the local thermal non-equilibrium(LTNE)*** governing dimensional temperature equations for the solid and fluid phases of the porous extended surface are modeled,and then are nondimensionalized by suitable dimensionless ***,the obtained nondimensional equations are solved by the clique polynomial method(CPM).The effects of several dimensionless parameters on the fin's thermal profiles are shown by graphical ***,the current study implements deep neural structures to solve physics-governed coupled equations,and the best-suited hyperparameters are attained by comparison with various network *** results of the CPM and physicsinformed neural network(PINN)exhibit good agreement,signifying that both methods effectively solve the thermal modeling problem.

关键词： heat transfer fin porous fin local thermal non-equilibrium(LTNE)model physics-informed neural network(PINN)