检索结果-南通市图书馆

Biomedical and Environmental Sciences 2018年第4期31卷 253-260页

作者： SUN Di ZHAO Xi LI Sha ZHANG Yan WU Na Qiong ZHU Cheng Gang GUO Yuan Lin GAO ying QING Ping LIU Geng DONG qian LI Jian Jun Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College

Objective Low-density lipoprotein cholesterol（LDL-C） has been well known as the risk factor of coronary artery disease（CAD）. However, the role of lipoprotein（a） [Lp（a）] in the development of CAD is of great interest but still controversial. Thus, we aim to explore the effect of Lp（a） on predicting the presence and severity of CAD in Chinese untreated patients, especially in combination with LDL-C. Methods We consecutively recruited 1,980 non-treated patients undergoing coronary angiography, among which 1,162.patients were diagnosed with CAD. Gensini score（GS） was used to assess the severity of CAD. Lp（a） was measured by immunoturbidimetric method. Results Patients with CAD had higher level of LDL-C and Lp（a） compared with non-CAD（P 〈 0.05）. Multivariable logistic regression revealed that Lp（a）〉 2.5 mg/L（highest tertile） predicted 1.437-fold risk for CAD（95% CI： 1.108-1.865, P = 0.006） and 1.480-fold risk for high GS（95% CI： 1.090-2.009, P = 0.012. respectively. Interestingly, concomitant elevated level of Lp（a） and LDL-C conferred the highest risk for both presence [OR = 1.845, 95% CI： 1.339-2.541, P 〈 0.001] and severity [OR = 1.736, 95% CI： 1.188-2.538, P = 0.004] of CAD. Conclusion Lipoprotein（a） is a useful marker for predicting the presence and severity of CAD, especially combined with LDL-C.

关键词： Lipoprotein(a) LDL-C Coronary artery disease Chinese

在线全文

学校读者我要写书评

暂无评论

基于积分制的物理学科育人探索

教学与管理 2024年第31期 54-57页

作者：邓李君张航英文海燕深圳市龙华区第二外国语学校广东深圳518100 深圳市福永中学广东深圳518000

从物理教学走向物理学科育人是新课标的必然要求,应把握物理学科育人指向全面发展的目标,从物理学科核心素养培育上升到育全人的“五育融合”培养的高度。实践上可以从系统论理念出发,以积分制为基础,在一学期的大周期内,通过目标有机... 详细信息

从物理教学走向物理学科育人是新课标的必然要求,应把握物理学科育人指向全面发展的目标,从物理学科核心素养培育上升到育全人的“五育融合”培养的高度。实践上可以从系统论理念出发,以积分制为基础,在一学期的大周期内,通过目标有机统整、内容方式融合、积分项目优化、评价多元全面的育人路径,并把握好教学注重情境化、评价注重人本性、数据注重智能化的策略,为基于物理学科的学生全面发展提供一条可行之路。

关键词：积分制 “五育融合” 物理教学学科育人

Penetration depth and concentration distribution for implanted heavy ions with low energies in plant seeds by SEM and EDS

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2001年第1期12卷 26-31页

作者： WANG Xin-Fu ZHOU Yun-Long ZHOU Hong-Yu LU Ting Wang Chao SU ying ZHU Guang-Hua WEN Chen-Lin LI Yong-Liang (Key Laboratory for Beam Technology and Material Modification of ministry of education, Institute of Low Energy Nuclear Physics, Beijing Norm Key Laboratory for Beam Technology and Material Modificationof ministry of education Institute of Low Energy Nuclear PhysicsBeijing Normal University Beijing Radiation Center Department of Biology Beijing Normal University Center for Analysis and Testing Beijing Normal University

The penetration depth and concentration distribution of implanted ions have been studied for low energy heavy ions implanted in the dry seeds of plant, such as peanut, mung beau, sunflower, wheat and radish seeds, etc. by SEM+EDS. The results .how that the maximum penetration depth is about 12.m for V+ with an energy 2.0 keV implanted in cotyledon of the peanut, 18pm, spin, 2.μm for V2. with 90 keV implanted in sunflower, wheat, radish seeds, respectively. The penetration depth of implanted Cu2. with 80 keV is about 90μm in the remainder funicle derivative of the mung beau seeds. The experimental result of the maximum penetration depth of implanted V+ in the peanut seeds was compared with the calculated value of the TRIM95.

关键词：离子移植渗透深度浓度分布植物种子

Effect of Vanadium Nitride(VN)Particles on Microstructure and Mechanical Properties of Extruded AZ31 Mg Alloy

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2023年第2期36卷 237-250页

作者： Wei Qiu Wen Xie Qi-feng Li Wei-ying Huang Li-Bo Zhou Wei Chen Jian Chen Yan-Jie Ren Mao-Hai Yao Ai-Hu Xiong Zhuo-Ran Zeng School of Energy and Power Engineering Changsha University of Science and TechnologyChangsha410114China Key Laboratory of Energy Efficiency and Clean Utilization The Education Department of Hunan ProvinceChangsha University of Science and TechnologyChangsha410114China Hunan Rare Earth Metal Material Research Institute Institute of Rare Earth Light AlloysChangsha410126China College of Engineering and Computer Science Australian National UniversityActonACT2601Australia

The effect of vanadium nitride(VN)particles additives on microstructure and mechanical properties of the extruded AZ31 Mg alloy was systematically *** experimental results revealed that the addition of 0.5 wt%VN decreased the average grain size of AZ31 Mg alloy from 6.4 to 4.9µ*** the increase in VN content,the refining effect would weaken because excessive VN particles would negatively affect the dynamic recrystallization process of the *** scanning electron microscopy and energy-dispersive spectroscopy indicated that AlN,VN and Al-V-N particles with different morphologies were distributed in the streamline along the extrusion direction during the extrusion *** mechanical properties of AZ31 Mg alloy vary with the addition of *** extruded AZ31+0.5 wt%VN Mg alloy possesses an excellent combination of high strength and *** yield strength and ultimate tensile strength of the extruded AZ31+0.5 wt%VN Mg alloy were increased without sacrificing *** is mainly due to the grain refinement caused by double-heterogeneous nucleation *** a further increase in VN content,the presence of excessive VN particles increases the stress concentration,and the initiation source of microcracks in the alloy during alloy deformation makes the cracks more easily propagated and results in a decrease in the ductility of the extruded alloy.

关键词： AZ31 Mg alloy Extrusion VN particles Microstructure Mechanical properties

大面积自组装金纳米颗粒超晶格薄膜的制备及光学特性研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

光电工程 2024年第6期51卷 12-20页

作者：黄信史作盐宋明霞虞应刘绍鼎太原理工大学新型传感器与智能控制教育部重点实验室山西太原030024 太原理工大学电子信息与光学工程学院山西太原030024

自组装贵金属纳米颗粒超晶格等离激元与光场的耦合能够激发极化激元模式,在增强光谱及传感等领域具有重要的应用前景。然而目前自组装方法制备超晶格薄膜层数较难控制,同时样品尺寸较小,限制了相关应用的发展。本文基于润湿增强的界面... 详细信息

自组装贵金属纳米颗粒超晶格等离激元与光场的耦合能够激发极化激元模式,在增强光谱及传感等领域具有重要的应用前景。然而目前自组装方法制备超晶格薄膜层数较难控制,同时样品尺寸较小,限制了相关应用的发展。本文基于润湿增强的界面自组装方法可快速、大面积制备单层密排纳米颗粒薄膜的特性,采用逐层堆叠方法制备了具有不同层数的大面积、均匀分布的金纳米颗粒超晶格薄膜样品。实验及计算透/反射光谱表明,所制备超晶格样品能够有效激发极化激元模式,同时高阶极化激元模式随着超晶格层数的增加也可被有效激发。此外,通过调整纳米颗粒尺寸也可有效调制极化激元模式的共振峰位。这些研究为制备大面积高质量纳米颗粒超晶格薄膜提供了一种有效的方案,有望用于高性能微纳光子器件的设计。

关键词：金纳米颗粒纳米颗粒超晶格时域有限差分法极化激元模式

中医护理技术在脑卒中便秘病人中的干预效果及其评价指标研究进展

在线全文

学校读者我要写书评

暂无评论

全科护理 2024年第13期22卷 2439-2443页

作者：王海迪宁佳丽陈祖琨袁自仙张莹李曼娜吴倩云南中医药大学 650500

介绍艾灸、穴位贴敷、腹部按摩、耳穴埋籽中医护理技术在脑卒中便秘病人中的应用现状,综述便秘症状评价指标、脑肠肽及中医证候积分在脑卒中便秘病人中的应用情况,以期为今后脑卒中便秘疗效观察指标的选择及中医护理技术的临床运用提供... 详细信息

介绍艾灸、穴位贴敷、腹部按摩、耳穴埋籽中医护理技术在脑卒中便秘病人中的应用现状,综述便秘症状评价指标、脑肠肽及中医证候积分在脑卒中便秘病人中的应用情况,以期为今后脑卒中便秘疗效观察指标的选择及中医护理技术的临床运用提供参考依据。

关键词：脑卒中中医护理技术便秘脑肠肽便秘症状评价指标综述

Development of mouse preimplantation embryos in space

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

National Science Review 2020年第9期7卷 1437-1446页

作者： Xiaohua Lei Yujing Cao Baohua Ma Yunfang Zhang Lina Ning Jingjing qian Liwen Zhang Yongcun Qu Tao Zhang Dehong Li Qi Chen Junchao Shi Xudong Zhang Chiyuan Ma ying Zhang Enkui Duan State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of Sciences University of Chinese Academy of Sciences Shanghai Institute of Technical Physics Chinese Academy of Sciences Division of Ionizing Radiation National Institute of Metrology College of Veterinary Medicine Northwest A&F University/Key Laboratory of Animal BiotechnologyMinistry of Agriculture

The development of life beyond planet Earth is a long-standing quest of the human race, but whether normal mammalian embryonic development can occur in space is still unclear. Here, we show unequivocally that preimplantation mouse embryos can develop in space, but the rate of blastocyst formation and blastocyst quality are compromised. Additionally, the cells in the embryo contain severe DNA damage, while the genome of the blastocysts developed in space is globally hypomethylated with a unique set of differentially methylated regions. The developmental defects, DNA damage and epigenetic abnormalities can be largely mimicked by the treatment with ground-based low-dose radiation. However,the exposure to simulated microgravity alone does not cause major disruptions of embryonic development,indicating that radiation is the main cause for the developmental defects. This work advances the understanding of embryonic development in space and reveals long-term extreme low-dose radiation as a hazardous factor for mammalian reproduction.

关键词： space-flight radiation microgravity preimplantation development DNA damage DNA methylation

PTFE包覆连续氧化铝纤维缝纫线的磨损行为

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

航空材料学报 2024年第4期44卷 68-76页

作者：孟影吴宁袁志清张一帆陈利天津工业大学纺织科学与工程学院天津300387 天津工业大学复合材料研究院先进纺织复合材料教育部重点实验室天津300387 石家庄海关技术中心石家庄050000

结合上浆及二维编织技术制备部分包覆结构F-3、F-4、F-5连续氧化铝纤维缝纫线,使用自研实验装置研究包覆结构对缝纫线与针孔间磨损行为的影响。使用3D轮廓仪表征不同包覆结构缝纫线的轮廓外观和摩擦作用下的损伤形态演变;通过拉伸性能测... 详细信息

结合上浆及二维编织技术制备部分包覆结构F-3、F-4、F-5连续氧化铝纤维缝纫线,使用自研实验装置研究包覆结构对缝纫线与针孔间磨损行为的影响。使用3D轮廓仪表征不同包覆结构缝纫线的轮廓外观和摩擦作用下的损伤形态演变;通过拉伸性能测试,表征缝纫线在不同摩擦次数下的强度保持率;通过磨断次数来评价缝纫线在不同实验参数下的磨损性能。结果表明:包覆工艺参数的变化影响缝纫线表面轮廓的起伏状态,导致磨损后断口产生的毛羽长度随着包覆纱根数的增多和编织节距的增加而增大;相比原纱和浆纱,缝纫线的耐磨性显著提高;随着摩擦次数的增加,缝纫线拉伸强度保持率均呈现快速下降后趋于平缓的趋势,当摩擦次数达到30次时,F-3、F-4、F-5缝纫线拉伸强度保持率分别为12.89%、2..82.、18.35%;随着摩擦距离、纱线张力的增加,摩擦角度的减小,缝纫线的磨断次数逐渐下降。

关键词：连续氧化铝纤维缝纫线磨损包覆结构

IFN-γ and indoleamine 2.3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

IFN-γ and indoleamine 2,3-dioxygenase signaling between don...

教师职业自我认知对专业自主发展意识的影响:职业信念与职业动机的链式中介作用

中国病理生理学会第十三届肿瘤、第十四届免疫专业委员会学术会议

作者： Lu ying Department of Pathophysiology,Shanghai Universities E-Institute for Chemical Biology,Key Laboratory of Cell Differentiation and Apoptosis of Chinese ministry of education,Shanghai Jiao Tong University School of Medicine(SJTU-SM)

Allogeneic hematopoietic stem cell transplantation(HSCT) can eradicate chemorefractory leukemia through the graft-versus-leukemia(GVL) activity of donor T ***,the clinical success ofallo-HSCT is limited by the graft-versus-host disease(GVHD) activity of donor T *** have reported previously that donor bone marrow precursors of plasmacytoid dendritic cells(pre-pDCs) can activate donor T cells toward T-helper 1 immune polarization in murine allogeneic *** optimize the GVL activity of these activated donor T cells and limit their graft versus host activity,we engineered the cellular constituents of an allogeneic hematopoietic

关键词： GVL and indoleamine 2.3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus IFN

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

陇东学院学报 2024年第1期35卷 116-121页

作者：杜军王明辉赵媛媛郭英英陇东学院教育与体育学院庆阳745000 西峰区塔头小学庆阳745000 北京师范大学庆阳附属学校庆阳745000

以72.名中小学教师为研究对象,运用《教师职业自我认知问卷》《教师职业信念问卷》《教师职业动机问卷》与《教师专业自主发展意识问卷》探讨了教师职业自我认知、职业信念、职业动机与专业自主发展意识之间的关系。研究发现:(1)教师职... 详细信息

以72.名中小学教师为研究对象,运用《教师职业自我认知问卷》《教师职业信念问卷》《教师职业动机问卷》与《教师专业自主发展意识问卷》探讨了教师职业自我认知、职业信念、职业动机与专业自主发展意识之间的关系。研究发现:(1)教师职业自我认知、职业信念、职业动机与专业自主发展意识之间显著正相关;(2.职业动机在教师职业自我认知与专业自主发展意识之间起着部分中介作用;(3)职业信念—职业动机在职业自我认知和专业自主发展意识之间起着链式中介作用。基于此,提出了加强教师职业认知教育,加强教师职业情感培养,提升教师职业理想等建议。

关键词：专业自主发展意识职业自我认知职业信念职业动机链式中介