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World Journal of Gastroenterology 2019年第11期25卷 1289-1306页

作者： sang mi lee Hong Soo Kim sangheun lee Jeong Won lee Department of Nuclear Medicine Soonchunhyang University Cheonan Hospital Department of Internal Medicine Soonchunhyang University Cheonan Hospital Division of Hepatology Department of Internal medicineCatholic Kwandong University College of MedicineInternational St.Mary’s Hospital Institute for Health and Life Science Catholic Kwandong University College of MedicineInternational St.Mary’s Hospital Department of Nuclear Medicine Catholic Kwandong University College of MedicineInternational St.Mary’s Hospital

Hepatocellular carcinoma(HCC) is one of major causes of cancer mortality worldwide. For decades, ^(18)F-fluorodeoxyglucose(FDG) positron emission tomography(PET) has been widely used for staging, predicting prognosis, and detecting cancer recurrence in various types of malignant diseases. Due to low sensitivity of FDG PET for detecting intrahepatic HCC lesions, the clinical value of FDG PET in HCC patients has been limited. However, recent studies with diverse analytic methods have shown that FDG PET has promising role in aiding management of HCC patients. In this review, we will discuss the clinical role of FDG PET for staging, predicting prognosis, and evaluating treatment response in HCC. Further, we will focus on recent clinical studies regarding implication of volumetric FDG PET parameters, the significance of FDG uptake in HCC for selecting treatment and predicting treatment response, and the use of radiomics of FDG PET in HCC.

关键词： Hepatocellular carcinoma Fluorodeoxyglucose F18 Positron emission tomography Staging Prognosis

Clinical implication of FDG uptake of bone marrow on PET/CT in gastric cancer patients with surgical resection

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World Journal of Gastroenterology 2017年第13期23卷 2385-2395页

作者： Jeong Won lee Moon-Soo lee Il Kwon Chung Myoung Won Son Young Sin Cho sang mi lee Department of Nuclear Medicine Institute of Integrative MedicineCatholic Kwandong University College of MedicineInternational St.Mary's Hospital Department of Surgery Soonchunhyang University Hospital Division of Gastroenterology Department of Internal MedicineSoonchunhyang University Hospital Department of Nuclear Medicine Soonchunhyang University Hospital

AIM To determine the relationship between F-18 fluorodeoxyglucose(FDG) uptake of bone marrow(BM) on positron emission tomography/computed tomography(PET/CT) and clinical factors and to assess the prognostic value of FDG uptake of BM in gastric *** We retrospectively enrolled 309 gastric cancer patients who underwent staging FDG PET/CT and curative surgical resection. FDG uptake of primary tumor was visually classified as positive or negative FDG uptake. Mean FDG uptake of BM(BM SUV) and BM-to-liver uptake ratio(BLR) were measured. The relationships of BM SUV or BLR with clinical factors were evaluated. The prognostic values of BM SUV, BLR, and other clinical factors for predicting recurrence-free survival(RFS) and overall survival(OS) were *** Of 309 patients, 38 patients(12.3%) experienced cancer recurrence and 18 patients(5.8%) died. Patients with advanced gastric cancer, positive FDG uptake, and recurrence had higher values of BM SUV and BLR than those with early gastric cancer, negative FDG uptake, and no recurrence(P < 0.05). BM SUV and BLR were significantly correlated with hemoglobin level, neutrophil-to-lymphocyte ratio, and platelet-tolymphocyte ratio(P < 0.05). On multivariate analysis, multiple tumors, T stage, lymph node metastasis, tumor involvement of resection margin, and BLR were significantly associated with RFS(P < 0.05). T stage, lymph node metastasis, hemoglobin level, and BLR were significantly associated with OS(P < 0.05). CONCLUSION BLR on PET/CT was an independent prognostic factor for RFS and OS in gastric cancer patients with curative surgical resection.

关键词： F-18 fluorodeoxyglucose Positron emission tomography Prognosis Bone marrow Gastric cancer

Breast cancer metastasizing to the stomach mimicking primary gastric cancer: A case report

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World Journal of Gastroenterology 2017年第12期23卷 2251-2257页

作者： Kwangil Yim sang mi Ro Jieun lee Department of Hospital Pathology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Division of Medical Oncology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Cancer Research Institute the Catholic University of Korea

Breast cancer with stomach metastasis rare with an incidence of 1% or less among metastatic breast cancer patients. We experienced a case of breast cancer metastasizing to the stomach in 65-year-old female patient. She experienced dyspepsia and poor oral intake before visiting the clinic. Diffuse infiltration with nodular mucosal thickening of the stomach wall was observed, suggesting advanced gastric cancer based on gross endoscopic finding. Spread of poorly cohesive tumor cells in the gastric mucosa observed upon hematoxylin and eosin stain resembled signet ring cell carcinoma, but diffuse positive staining for GATA3 in immunohistochemical stain allowed for a conclusive diagnosis of breast cancer metastasizing to the stomach. Based on the final diagnosis, systemic chemotherapy was administered instead of primary surgical resection. After 2 cycles of docetaxel administration, she showed a partial response based on abdominal computed tomography scan. This case is an unusual presentation of breast cancer metastasizing to the gastrointestinal tract.

关键词： Gastric cancer Breast cancer Metastasis Immunohistochemical stain GATA3 GCDFP-15

Brain activation induced by different strengths of hand grasp: a functional magnetic resonance imaging study

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Neural Regeneration Research 2020年第5期15卷 875-879页

作者： Hyeok Gyu Kwon Ju sang Kim mi Young lee Department of Physical Therapy College of Health ScienceEulji UniversityGyeonggiRepublic of Korea Department of Physical Therapy and Rehabilitation Yeungnam University HospitalDaeguRepublic of Korea Department of Physical Therapy College of Health and TherapyDaegu Haany UniversityGyeongsansiRepublic of Korea

mirror neuron system can be activated by observation and execution of an *** has an important function of action *** investigated brain activations in humans by observing the strength of a hand grasp using functional magnetic resonance *** right-handed healthy individuals,consisting of 10 males and 10 females,aged 22.40 ± 2.04 years,were recruited into this study from September to November 2017 via *** hand grasp task video showed a hand lightly grasping and releasing a ball *** hand grasp task video showed a hand tightly grasping and releasing a ball *** magnetic resonance imaging block design paradigm comprised five stimulation blocks alternating with five baseline *** blocks were presented with two stimulus tasks,consisting of a light grasp and a powerful *** of interest was defined around the inferior parietal lobule,inferior frontal gyrus,and superior temporal sulcus which have been called mirror neuron *** inferior parietal lobule,fusiform,postcentral,occipital,temporal,and frontal gyri were activated during light and powerful grasp *** BOLD signal response of a powerful grasp was stronger than that of a light *** results suggest that brain activation of the inferior parietal lobule,which is the core brain region of the mirror neuron system,was stronger in the powerful grasp task than in the light grasp *** believe that our results might be helpful for instructing rehabilitation of brain *** study was approved by the Institutional Review Board of Daegu Oriental Hospital of Daegu Haany University on September 8,2017 (approval ***-D-17020-PRO-01).

关键词： brain activation fMRI human brain inferior parietal lobule light grasp mirror neuron system powerful grasp

Cortical activation pattern during shoulder simple versus vibration exercises： a functional near infrared spectroscopy study

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Neural Regeneration Research 2017年第8期12卷 1294-1298页

作者： Sung Ho Jang sang Seok Yeo Seung Hyun lee sang Hyun Jin mi Young lee Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Daegu Republic of Korea Department of Physical Therapy College of Health Science Dankook University Cheonan-si Republic of Korea Robot System Research Division Daegu Gyeongbuk Institute of Science & Technology Daegu Republic of Korea Department of Physical Therapy College of Health and Therapy Daegu Haany University Gyeongsan-si Republic of Korea

To date, the cortical effect of exercise has not been fully elucidated. Using the functional near infrared spectroscopy, we attempted to compare the cortical effect between shoulder vibration exercise and shoulder simple exercise. Eight healthy subjects were recruited for this study. Two different exercise tasks（shoulder vibration exercise using the flexible pole and shoulder simple exercise） were performed using a block paradigm. We measured the values of oxygenated hemoglobin in the four regions of interest： the primary sensory-motor cortex（SM1 total, arm somatotopy, and leg and trunk somatotopy）, the premotor cortex, the supplementary motor area, and the prefrontal cortex. During shoulder vibration exercise and shoulder simple exercise, cortical activation was observed in SM1（total, arm somatotopy, and leg and trunk somatotopy）, premotor cortex, supplementary motor area, and prefrontal cortex. Higher oxygenated hemoglobin values were also observed in the areas of arm somatotopy of SM1 compared with those of other regions of interest. However, no significant difference in the arm somatotopy of SM1 was observed between the two exercises. By contrast, in the leg and trunk somatotopy of SM1, shoulder vibration exercise led to a significantly higher oxy-hemoglobin value than shoulder simple exercise. These two exercises may result in cortical activation effects for the motor areas relevant to the shoulder exercise, especially in the arm somatotopy of SM1. However, shoulder vibration exercise has an additional cortical activation effect for the leg and trunk somatotopy of SM1.

关键词： nerve regeneration functional near infrared spectroscopy cortical activation shoulder vibrationexercise flexible pole neural regeneration

Evaluation of the safety of hair essence containing 0.05% purified bee venom on the skin and eyes of rabbits

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Journal of Traditional Chinese Medicine 2020年第1期40卷 67-72页

作者： mi Kyung Lim Eun Hye Han sang Ho lee Jee Hee Kim R&D Center KoreaeundanGyeonggi-do 13207Republic of Korea

OBJECTIVE:To investigate the safety of hair essence containing 0.05%purified bee venom(HE-PBV)on the skin and eyes of New Zealand White ***:HE-PBV which contained 0.05%PBV,purified water,and glycerin,was used as the test *** skin-irritation test(SIT)and eye-irritation test(EIT)were conducted according to the Draize *** the SIT,HE-PBV(0.5 m L)dropped gauze was attached both intact and abraded skin for 24 *** other side of the skin was used as *** 24 and 72 h,the treatment site was observed and scored according to evaluation criteria for skin *** the EIT,the rabbits were divided into two groups:eye-washed(three rabbits)and non-eye-washed(six rabbits).HE-PBV(0.1 m L)was squirted into the right eye of *** left eye was untreated and used as a ***,20-30-s later,the eyes of rabbits in the eye-washed group were washed with^50 m L of physiologic(0.9%)salt ***,1,2,3,4 and 7 d after the start of the EIT,the eyes and behavior of the rabbits were *** degree of eye irritation elicited by HE-PBV was determined in three steps and then the criteria of the classification of eye-irritation ***:The SIT revealed erythema and edema at the site of HE-PBV *** 72 h,the body weight of rabbits was reduced slightly,but other symptoms(except erythema and edema)were not *** Primary Irritation Index score was0.6,and HE-PBV was deemed to be a slight *** EIT did not show mortality or body-weight fluctuation,but hyperemic conjunctiva and eyelid closure were noted after HE-PBV *** for these results,the score for the ophthalmic response on days 1,2,3,4 and 7 was 0,and HE-PBV was deemed to be a ***:These data suggest that HE-PBV did not elicit eye irritation,but was a slight irritant to the skin of rabbits;the latter slight would have been due to the excipients used in manufacture of the hair essence because PBV has been shown to be safe.

关键词： Alopecia Bee Venoms Hair essence Skin irritancy tests Eye irritancy tests Complementary therapies

Structural neural connectivity of the vestibular nuclei in the human brain:a diffusion tensor imaging study

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Neural Regeneration Research 2018年第4期13卷 727-730页

作者： Sung Ho Jang mi Young lee sang Seok Yeo Hyeok Gyu Kwon Department of Physical Medicine and Rehabilitation College of MedicineYeungnam University Department of Physical Therapy College of Health and TherapyDaegu Haany University Department of Physical Therapy College of Health SciencesDankook University Department of Physical Therapy College of Health SciencesCatholic University of Pusan

Many animal studies have reported on the neural connectivity of the vestibular nuclei（VN）.However,little is reported on the structural neural connectivity of the VN in the human *** this study,we attempted to investigate the structural neural connectivity of the VN in 37 healthy subjects using diffusion tensor tractography.A seed region of interest was placed on the isolated VN using probabilistic diffusion tensor *** was defined as the incidence of connection between the VN and each brain *** VN showed 100% connectivity with the cerebellum,thalamus,oculomotor nucleus,trochlear nucleus,abducens nucleus,and reticular formation,irrespective of *** the threshold of 5 streamlines,the VN showed connectivity with the primary motor cortex（95.9%）,primary somatosensory cortex（90.5%）,premotor cortex（87.8%）,hypothalamus（86.5%）,posterior parietal cortex（75.7%）,lateral prefrontal cortex（70.3%）,ventromedial prefrontal cortex（51.4%）,and orbitofrontal cortex（40.5%）,*** results suggest that the VN showed high connectivity with the cerebellum,thalamus,oculomotor nucleus,trochlear nucleus,abducens nucleus,and reticular formation,which are the brain regions related to the functions of the VN,including equilibrium,control of eye movements,conscious perception of movement,and spatial orientation.

关键词： nerve regeneration vestibular nuclei neural connectivity diffusion tensor tractography cerebellum oculomotor nucleus neural regeneration

Heuristic solution using decision tree model for enhanced XML schema matching of bridge structural calculation documents

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Frontiers of Structural and Civil Engineering 2020年第6期14卷 1403-1417页

作者： sang IPARK sang-Ho lee Department of Civil Environmental and Architectural EngineeringUniversity of Colorado at BoulderBoulderco 80309USA Department of"Civil and Environmental Engineering Yonsei UniversitySeoul 03722Korea

Research on the quality of data in a structural calculation document(SCD)is lacking,although the SCD ofa bridge is used as an essential reference during the entire lifecycle of the *** Schema matching enables qualitative improvement of the stored *** study aimed to enhance the applicability of XML Schema matching,which improves the speed and quality of information stored in bridge ***,the authors proposed a method of reducing the computing time for the schema matching of bridge *** computing speed of schema matching was increased by 13 to 1800 times by reducing the checking process of the ***,the authors developed a heuristic solution for selecting the optimal weight factors used in the matching process to maintain a high accuracy by introducing a decision *** decision tree model was built using the content elements stored in the SCD,design companies,bridge types,and weight factors as input variables,and the matching accuracy as the target *** inverse-calculation method was applied to extract the weight factors from the decision tree model for high-accuracy schema matching results.

关键词： structural calculation document bridge structure XML Schema matching weight factor data mining decision tree model

Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis

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Neural Regeneration Research 2024年第7期19卷 1584-1592页

作者： Jong mi Park Masoud Rahmati sang Chul lee Jae Il Shin Yong Wook Kim Department and Research Institute of Rehabilitation Medicine Yonsei University College of MedicineSeoulSouth Korea Department of Physical Education and Sport Sciences Faculty of Literature and Human SciencesLorestan UniversityKhoramabadIran Department of Pediatrics Yonsei University College of MedicineSeoulSouth Korea

Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease *** cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s *** stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of *** performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal *** searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,*** study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control *** use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the *** with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational *** the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a

关键词： animal animal experimentation mesenchymal stem cells models Parkinson’s disease stem cell transplantation

Correlation of microstructure with tensile behavior and properties of API X70 pipeline steels subjected to strain aging

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Journal of Iron and Steel Research International 2020年第3期27卷 319-324页

作者： sang-in lee Byoungchul Hwang Department of Materials Science and Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea

Variations in tensile behavior and properties after pre-strain and thermal aging were differently affected by strain aging phenomenon dependent on *** increasing polygonal ferrite fraction,decrement in uniform elongation is increased,and the increment in yield-to-tensile ratio is slightly decreased after pre-strain and thermal ***,it can be concluded that the polygonal ferrite has contradictory effects on strain aging resistance although the polygonal ferrite still contributes to improvement of uniform elongation after strain aging.

关键词： Steel microstructure Strain aging Deformability Pipeline