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Crushed Gold Shell Nanoparticles Labeled with Radioactive Iodine as a Theranostic Nanoplatform for Macrophage-Mediated Photothermal Therapy

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Nano-Micro Letters 2019年第2期11卷 244-257页

作者： sang bong lee Jae-Eon lee Sung Jin Cho Jungwook Chin sang Kyoon Kim In-Kyu lee sang-Woo lee Jaetae lee Yong Hyun Jeon New Drug Development Center Daegu-Gyeongbuk Medical Innovation FoundationDaeguSouth Korea Department of Biomaterials Science College of Natural Resources and Life Science/Life and Industry Convergence Research InstitutePusan National UniversityPusanSouth Korea Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease Kyungpook National University HospitalDaegu 702-210South Korea Department of Nuclear Medicine Kyungpook National University HospitalDaegu 702-210South Korea Department of Internal Medicine Kyungpook National University School of MedicineDaegu 700-721South Korea Daegu-Gyeongbuk Medical Innovation Foundation Daegu 360-4South Korea [Laboratory Animal Center Daegu-Gyeongbuk Medical Innovation FoundationDaegu 360-4South Korea

Plasmonic nanostructure-mediated photothermal therapy(PTT) has proven to be a promising approach for cancer treatment,and new approaches for its effective delivery to tumor lesions are currently being *** study aimed to assess macrophage-mediated delivery of PTT using radioiodine-124-labeled gold nanoparticles with crushed gold shells(124I-Au@AuCBs) as a theranostic nanoplatform.124I-Au@AuCBs exhibited effective photothermal conversion effects both in vitro and in vivo and were efficiently taken up by macrophages without *** the administration of 124I-Au@AuCB-labeled macrophages to colon tumors,intensive signals were observed at tumor lesions,and subsequent in vivo PTT with laser irradiation yielded potent antitumor *** results indicate the considerable potential of 124I-Au@AuCBs as novel theranostic nanomaterials and the prominent advantages of macrophage-mediated cellular therapies in treating cancer and other diseases.

关键词： Photothermal therapy Radionuclide crushed gold shell nanoballs Macrophage-mediated delivery

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A new hemostatic clip for endoscopic surgery that can maintain blood flow after clipping

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World Journal of Gastroenterology 2014年第5期20卷 1325-1331页

作者： Kyoung Won Nam sang bong lee In Young Kim Kwang Gi Kim sang Jae Park Department of Biomedical Engineering Hanyang University Biomedical Engineering Branch National Cancer Center Center for Liver Cancer National Cancer Center

AIM: To develop a new hemostatic device for endoscopic surgery that can control the bleeding without completely occluding the bleeding vessel.

关键词： Vessel bleeding Hemostasis Hemostatic clip Laparoscopic surgery Endoscopic surgery

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Chemical and mechanical properties of stainless, environment-friendly, and nonflammable Mg alloys (SEN alloys): A review

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Journal of Magnesium and Alloys 2024年第3期12卷 841-872页

作者： Jong Un lee Hyun Ji Kim sang-Cheol Jin Ye Jin Kim Young Min Kim bong Sun You Jun Ho Bae Sung Hyuk Park Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Department of Materials Science and Metallurgical Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Missile Research Institute Agency for Defense DevelopmentDaejeon 34060Republic of Korea

This review article provides overall understanding of stainless,environment-friendly,and nonflammable Mg alloys(SEN alloys)recently developed at the Korea Institute of Materials *** alloys are produced by adding small amounts of Ca and Y(each<1 wt%)into commercial Mg–Al based alloys,resulting in exceptional ignition and corrosion resistances and impressive mechanical *** main advantages of SEN alloys are as follows.(1)A dense multi-oxide layer of SEN alloys comprising MgO,CaO,and Y_(2)O_(3) impedes the outward dispersion of Mg vapor and the inward penetration of O_(2) during oxidation,thereby enhancing the oxidation and ignition resistances.(2)The presence of Ca-and Y-based second-phase particles in SEN alloys can enhance their corrosion resistance because Ca-containing particles prevent the spread of corrosion,and the replacement of Al-containing particles with less noble ones containing Y(e.g.,Al–Mn–Y or Al–Y particles)retards corrosion.(3)The addition of minor amounts of Ca and Y renders excellent mechanical properties due to improved strengthening *** enhanced properties are attributed to more pronounced dynamic recrystallization and grain refining behaviors caused by the second-phase particles during extrusion.(4)Despite the presence of various types of second-phase particles,the fatigue properties of SEN9 alloys are similar to those of commercial AZ91 alloys.(5)Simultaneous introduction of Ca and Y suppresses the formation of Mg17Al12 discontinuous precipitates during aging,leading to the enhanced elongation of aged SEN alloys.(6)Adding mischmetal into the SEN9 alloy leads to a six-fold enhancement in ***,the studies conducted on SEN alloys demonstrate their excellent ignition and corrosion resistances and mechanical properties,which broaden the industrial applications of Mg alloys by addressing their inherent weaknesses.

关键词： SEN magnesium alloy Corrosion resistance Ignition resistance Mechanical properties Extrudability.

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Prevalence of nonalcoholic fatty liver disease in pediatrics and adolescents:a systematic review and meta-analysis

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World Journal of Pediatrics 2024年第6期20卷 569-580页

作者： Eun Joo lee Miyoung Choi sang bong Ahn Jeong-Ju Yoo Seong Hee Kang Yuri Cho Do Seon Song Hong Koh Dae Won Jeon Hye Won lee Department of Pediatrics Yonsei University College of MedicineSeoulKorea Clinical Evidence Research National Evidence-Based Healthcare Collaborating Agency(NECA)SeoulKorea Department of Internal Medicine Nowon Eulji Medical CenterEulji University College of MedicineSeoulKorea Department of Internal Medicine Soonchunhyang University Bucheon HospitalBucheonKorea Department of Internal Medicine Sangkye Paek HospitalInje University College of MedicineSeoulKorea Center for Liver and Pancreatobiliary Cancer National Cancer CenterGoyangKorea Department of Internal Medicine College of MedicineSt.Vincent's HospitalThe Catholic University of KoreaSuwonKorea Department of Internal Medicine Hanyang University College of MedicineSeoulKorea Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background As childhood obesity escalates worldwide,the prevalence of nonalcoholic fatty liver disease(NAFLD)in pediatric and adolescent populations is also ***,systematic studies and meta-analyses evaluating the prevalence of pediatric NAFLD remain *** The MEDLINE,Korean Medical Database(KMBASE),Embase,Global Health,and Cochrane Library databases were searched from January 1997 to April *** terms included NAFLD or steatosis;nonalcoholic or steatohepatitis;child(ren),adolescent,or teenager;and prevalence,incidence,or epidemiology.A random-effects meta-analysis model was used to estimate the prevalence of pediatric *** A total of 2116 publications were found,of which 62 were included in the *** them,27 reported the prevalence in the general population and 39 in the obese *** worldwide pooled prevalence of pediatric NAFLD was 13%[95%confidence interval(CI)9-18%]in the general population and 47%(95%CI 41%–53%)in the obese *** 16 studies in the general population and 18 in the obese population,NAFLD prevalence varied by *** the general population,the prevalence of NAFLD was 15%(95%CI 8%–23%)in males and 10%(95%CI 6%–15%)in *** the obese population,it was 54%(95%CI 46%–61%)in males and 39%(95%CI 30%–49%)in *** The global prevalence of pediatric NAFLD is rising in both the general and obese *** the increasing rates of childhood obesity,epidemiological studies on the prevalence and incidence of NAFLD are needed.

关键词： Meta-analysis Nonalcoholic fatty liver disease Pediatric Prevalence

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Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis

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Cellular & Molecular Immunology 2024年第3期21卷 227-244页

作者： Kang-Gu lee bong-Ki Hong Saseong lee Naeun lee Seung-Whan Kim Donghyun Kim Wan-Uk Kim Center for Integrative Rheumatoid Transcriptomics and Dynamics The Catholic University of KoreaSeoul 06591Republic of Korea Department of Biomedicine&Health Sciences The Catholic University of KoreaSeoul 06591Republic of Korea Department of Pharmacology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Bio-Medical Institute of Technology University of UlsanSeoul 05505Republic of Korea Department of Microbiology and Immunology Seoul National University College of MedicineSeoul 03080Republic of Korea Institute of Infectious Diseases Seoul National University College of MedicineSeoul 03080Republic of Korea Division of Rheumatology Department of Internal MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Transcriptional coactivators regulate the rate of gene expression in the *** receptor coactivator 6(NCOA6),a coactivator,has been implicated in embryonic development,metabolism,and cancer pathogenesis,but its role in innate immunity and inflammatory diseases remains ***,we demonstrated that NCOA6 was expressed in monocytes and macrophages and that its level was increased under proinflammatory ***,nuclear NCOA6 was found to translocate to the cytoplasm in activated monocytes and then become incorporated into the inflammasome with NLRP3 and ASC,forming cytoplasmic ***,NCOA6 associated with the ATP hydrolysis motifs in the NACHT domain of NLRP3,promoting the oligomerization of NLRP3 and ASC and thereby instigating the production of IL-1βand active *** note,Ncoa6 deficiency markedly inhibited NLRP3 hyperactivation caused by the Nlrp3^(R258W) gain-of-function mutation in *** ablation of Ncoa6 substantially attenuated the severity of two NLRP3-dependent diseases,folic-induced acute tubular necrosis and crystal-induced arthritis,in *** with these findings,NCOA6 was highly expressed in macrophages derived from gout patients,and NCOA6-positive macrophages were significantly enriched in gout macrophages according to the transcriptome profiling ***,NCOA6 is a critical regulator of NLRP3 inflammasome activation and is therefore a promising target for NLRP3-dependent diseases,including gout.

关键词： Nuclear receptor coactivator 6 Nuclear-to-cytoplasmic translocation NLRP3 inflammasome NACHT domain Gouty arthritis

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Trifunctional robust electrocatalysts based on 3D Fe/N-doped carbon nanocubes encapsulating Co4N nanoparticles for efficient battery-powered water electrolyzers

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Carbon Energy 2024年第6期6卷 124-139页

作者： Hyung Wook Choi Hongdae lee Jun Lu Seok Bin Kwon Dong In Jeong Beum Jin Park Jiwon Kim bong Kyun Kang Gun Jang Dae Ho Yoon Ho Seok Park SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Chemical Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Electronic Materials Devicesand Equipment EngineeringSoonchunhyang UniversityAsan CityChungnamRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

Herein,we have designed a highly active and robust trifunctional electrocatalyst derived from Prussian blue analogs,where Co_(4)N nanoparticles are encapsulated by Fe embedded in N-doped carbon nanocubes to synthesize hierarchically structured Co_(4)N@Fe/N-C for rechargeable zinc-air batteries and overall water-splitting *** confirmed by theoretical and experimental results,the high intrinsic oxygen reduction reaction,oxygen evolution reaction,and hydrogen evolution reaction activities of Co_(4)N@Fe/N-C were attributed to the formation of the heterointerface and the modulated local electronic ***,Co_(4)N@Fe/N-C induced improvement in these trifunctional electrocatalytic activities owing to the hierarchical hollow nanocube structure,uniform distribution of Co_(4)N,and conductive encapsulation by Fe/***,the rechargeable zinc-air battery with Co_(4)N@Fe/N-C delivers a high specific capacity of 789.9 mAh g^(-1) and stable voltage profiles over 500 ***,the overall water electrolyzer with Co_(4)N@Fe/N-C achieved better durability and rate performance than that with the Pt/C and IrO2 catalysts,delivering a high Faradaic efficiency of 96.4%.Along with the great potential of the integrated water electrolyzer powered by a zinc-air battery for practical applications,therefore,the mechanistic understanding and active site identification provide valuable insights into the rational design of advanced multifunctional electrocatalysts for energy storage and conversion.

关键词： battery-powered electrolyzers hierarchical structure Prussian blue analog trifunctional electrocatalyst zinc-air battery

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New reclosing scheme of distribution system for utilization of BESS using wavelet transform

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Journal of Central South University 2018年第1期25卷 78-83页

作者： PARK Keon-Woo KIM Chul-Hwan lee sang-Hyuk RHEE sang-bong College of Info.& Comm. Eng Sungkyunkwan UniversitySuwon16419Korea Department of Electrical and Electronic Engineering of Xi’an Jiaotong-Liverpool University (XJTLU) Suzhou 215123 China Department of Electrical Engineering Yeungnam University Gyeongsan 38541 Korea

This paper proposed the reclosing method in distribution system with battery energy storage system(BESS)using wavelet transform(WT).The proposed method performs the WT of load current and then calculates the absolute value of slope of detail *** mother wavelet used is db4of *** fault clearing is detected using the rapid increase of this *** the detection of fault clearing,the reclosing is *** verify the proposed method,various simulations according to the fault clearing times,fault resistances,and fault lengths are performed using *** simulation results show that fault clearing can be detected using proposed absolute value of slope of detail coefficient and hence the reclosing can be performed successfully.

关键词： distribution system electro-magnetic transient program reclosing battery energy storage system wavelet transform

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Effect of molybdenum on interfacial properties of titanium carbide reinforced Fe composite

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Journal of Materials Science & Technology 2022年第12期107卷 252-258页

作者： Seungchan Cho Junghwan Kim Ilguk Jo Jae Hyun Park Jaekwang lee Hyun-Uk Hong bong Ho lee Wook Ryol Hwang Dong-Woo Suh sang-Kwan lee sang-Bok lee Composites Research Division Korea Institute of Materials Science(KIMS)Changwon 51508South Korea Advanced Materials Engineering Dong-Eui UniversityBusan 47340South Korea Department of Aerospace and Software Engineering Gyeongsang National UniversityJinju 52828South Korea Department of Physics Pusan National UniversityBusan 46241South Korea Department of Materials Convergence and System Engineering Changwon National UniversityChangwon 51140South Korea Center for Core Research Facilities Daegu Gyeongbuk Institute of Science and TechnologyDaegu 42988South Korea School of Mechanical Engineering Gyeongsang National UniversityJinju 52828South Korea Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyGyeongbuk 37673South Korea

This study shows that the mechanical strength of the composite of Fe matrix and titanium carbide(Ti C)ceramic particles is significantly enhanced with addition of molybdenum(Mo) atoms. Ti C reinforced Fe(Fe-0.2C-7Mn) composites with and without Mo were fabricated by a liquid pressing infiltration(LPI)process and the effect of Mo on interfacial properties of TiC–Fe composite was investigated using atomic probe tomography(APT) analysis, molecular dynamics(MD) simulations, first-principle density functional theory(DFT), and thermodynamic calculations. First, DFT calculations showed that total energies of the Mo-doped Ti C–Fe superlattices strongly depend on the position of Mo defects, and are minimized when the Mo atom is located at the TiC/Fe interface, supporting the probable formation of MoC-like interphase at the TiC/Fe interface region. Then, APT analysis confirmed the DFT predictions by finding that about6.5 wt.% Mo is incorporated in the Ti C–Fe(Mo) composite and that sub-micrometer thick(Ti,Mo)C interphase is indeed formed near the interface. The MD simulations show that Mo atoms migrate to the Mo-free TiC–Fe interface at elevated temperatures and the mechanical strength of the interface is considerably enhanced, which is in good agreement with experimental observations.

关键词： Metal matrix composites(MMCs) Titanium carbide Fe matrix composite Infiltration Molybdenum Interfacial property

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Non-Invasive Measurements of Thickness of Superconductor Films by Using Two-Resonant-Mode Rutile Resonator

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Chinese Physics Letters 2010年第8期27卷 203-206页

作者： JUNG Ho sang YANG Woo Il lee Jae Hun SOHN Jae Min CHOO Kee Nam KIM bong Goo lee sang Young Department of Physics and Center for Wireless Transmission Technology Konkuk University Seoul 143-701 Korea Research Reactor Engineering Division Korea Atomic Energy Research Institute Daejeon 305-600 Korea

The film thickness should be known for extrazting the intrinsic surface resistance from the effective surface resistance as measured by using the dielectric resonator method. Thicknesses of 70 nm to 360 nm are measured for YBa2 Cu3 O7-δ films in a non-invasive way by using the two-resonant-mode dielectric resonator （TDR） method. A futile resonator with the respective resonant frequencies of 15.25-15.61 GHz and 15.10-15.37 GHz for the TE021 and the TE012 modes is used for this purpose. Differences between the values as measured by using the TDR technique and those measured by using a step profilometer appear to be less than 3%, which is smaller than the previous value of 5% as measured by using a 8. 6 GHz single-resonance mode futile resonator [lee et al. J. Korean Phys. Soc. 54（2009）1619]. Merits of using the TDR method are discussed.

关键词： THICKNESS measurement SUPERCONDUCTORS THIN films RUTILE DIELECTRIC resonators PROFILOMETER ELECTRIC resistance SURFACES (Technology)

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Graphene derivatives supported nanocatalysts for oxygen reduction reaction

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Chinese Journal of Catalysis 2015年第11期36卷 1799-1810页

作者： Ilkeun lee Ji bong Joo Mohammadreza Shokouhimehr 加利福尼亚大学河滨分校化学系美国韩国能源研究所低碳过程实验室韩国大田305-343 国立首尔大学工程学院化工和生物工程系韩国首尔151-741

Very recent progress on the graphene derivatives supported variable nanocatalysts for oxygen reduction reaction （ORR） in fuel cell is reviewed. First, common electrochemical techniques to characterize graphene-based electrocatalysts are mentioned. Second, recent updates on gra- phene-derived electrocatalysts are introduced. In this part, both electrochemical activity and stabil- ity of Pt catalysts can be improved when they are supported by reduced graphene oxide （RGO）. Other noble-metal catalysts including Pd, Au, and Ag showing comparable performance have been investigated. The stability of Pd catalyst is enhanced by RGO or few-layered graphene support. Syn- thetic approaches for Au or Ag catalysts supported on graphene oxide are discussed. In addition, non-noble transition metals in N4-chelate complexes can reduce oxygen electrochemically. Fe and Co are cheap alternative catalysts for ORR. In most cases, the stability and tolerance issues are overcome well, but their overall performances don＇t seem to surpass Pt/C catalyst yet,

关键词： Graphene Oxygen reduction reaction Electrocatalyst Nanocatalyst

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