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Multiomic investigation of Sugarcane mosaic virus resistance in sugarcane

The Crop Journal 2023年第6期11卷 1805-1815页

作者： Ricardo joséGonzaga Pimenta Alexandre Hild Aono Roberto Carlos Villavicencio Burbano Marcel Fernando da Silva Ivan Antônio dos Anjos Marcos Guimarães de Andrade Landell Marcos Cesar Gonçalves Luciana Rossini Pinto Anete Pereira de souza Centre for Molecular Biology and Genetic Engineering University of CampinasCampinasBrazil Gustavo Galindo Velasco Campus Littoral Polytechnic Superior SchoolGuayaquilEcuador Advanced Centre for Technological Research in Sugarcane Agribusiness Agronomic Institute of CampinasRibeirão PretoBrazil Plant Protection Research Centre Biological InstituteSão PauloBrazil department of Plant Biology Institute of BiologyUniversity of CampinasCampinasBrazil

Sugarcane mosaic virus(SCMV)is the main etiological agent of sugarcane mosaic disease,which affects sugarcane and other grass *** the extensive characterization of quantitative trait loci controlling resistance to SCMV in maize,the genetic basis of this trait in sugarcane is largely ***,a genome-wide association study was performed and machine learning coupled with feature selection was used for genomic prediction of resistance to SCMV in a diverse sugarcane *** single-nucleotide polymorphisms(SNPs)explained up to 29.9%of the observed phenotypic variance and a 73-SNP set predicted resistance with high accuracy,precision,recall,and F1 scores(the harmonic mean of precision and recall).Both marker sets were validated in additional sugarcane genotypes,in which the SNPs explained up to 23.6%of the phenotypic variation and predicted resistance with a maximum accuracy of 69.1%.Synteny analyses suggested that the gene responsible for the majority of SCMV resistance in maize is absent in sugarcane,explaining why this major resistance source has not been identified in this ***,using sugarcane RNA-Seq data,markers associated with resistance to SCMV were annotated,and a gene coexpression network was constructed to identify the predicted biological processes involved in *** network allowed the identification of candidate resistance genes and confirmed the involvement of stress responses,photosynthesis,and the regulation of transcription and translation in resistance to *** results provide a practical marker-assisted breeding approach for sugarcane and identify target genes for future studies of SCMV resistance.

关键词： Saccharum SCMV GWAS Machine learning RNA-Seq

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Antioxidant,hypolipidemic and hypoglycemic effect of red wine in wistar rats fed with obesogenic diet

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Food Bioscience 2022年第3期47卷 756-764页

作者： Cornélio Mucaca josé Henrique Tavares Filho Luciana Lima Arruda André Martins Galvão Maria Bernadete de Sousa Maia Eryka Maria dos Santos Alves Eryvelton de souza Franco Elizabeth do Nascimento department of Nutrition Center of Health SciencesFederal University of Pernambuco (UFPE)Cidade Universitaria50670-901RecifePEBrazil Rural Technology department Federal Rural University of Pernambuco (UFRPE)AD.Manoel de Medeiros Ave.s/nDois Irmãos52171-900RecifePEBrazil department of Physiology and Pharmacology Center of Biological SciencesFederal University of Pernambuco (UFPE)Cidade Universitaria50670-901RecifePEBrazil

The health benefits resulting from the usual ingestion of red wines have been studied in humans and ***,the evaluation of benefits in antioxidant,hypoglycemic and hypolipemic activity concomitant with the use of an obesogenic diet in adult Wistar rats has been little *** present study investigated the use of red wine derived from Northeast Brazil in adult rats fed with an obesogenic diet on antioxidant activity,glucose tolerance,adipose,glycemic and lipemic *** 45-day old male Wistar rats formed two groups:standard diet and westernized *** changes in body mass and glycemic levels,the animals were subdivided into six subgroups (n = 10 per group) and received water,red wine or hydroalcoholic solution by *** data reveal that the moderate and chronic use of red wine improves the glycemic,lipid and oxidative stress profile,being favorable in preventing the risk of cardiovascular diseases in rats fed with an obesogenic diet.

关键词： Dyslipidemia Obesity Rats Westernized diet Red wine

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COMBINING SINGULAR SPECTRUM ANALYSIS AND PAR(p) STRUCTURES TO MOdeL WIND SPEED TIME SERIES

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Journal of Systems Science & Complexity 2014年第1期27卷 29-46页

作者： MENEZES Moises Lima de souza Reinaldo Castro PESSANHA jos Francisco Moreira department of Statistics Fluminense Federal University ( UFI~ Brazil. Email: moisesAima@msn.com.SOUZA Reinaldo Castro Electrical Engineering department: Pontifical Catholic University of Rio de Janeiro (PUC-Rio) Brazil. Institute of Mathematics and Statistics State University of Rio de Janeiro (UERJ) Brazil.

单个光谱分析(SSA ) 是分解一时间的一种技术系列进一套部件，例如，趋势，泛音，和剩余。省掉剩余部件并且将其它，加起来时间系列能被弄平。这个过程被用来为巴西电消费和流动系列建模。同等(p) ，周期的 autoregressive 模型，广泛... 详细信息

单个光谱分析(SSA ) 是分解一时间的一种技术系列进一套部件，例如，趋势，泛音，和剩余。省掉剩余部件并且将其它，加起来时间系列能被弄平。这个过程被用来为巴西电消费和流动系列建模。同等(p) ，周期的 autoregressive 模型，广泛地在巴西在建模精力系列被使用了。这份报纸论述这个分解方法的一条途径，由适合 PAR (p) ，就它作为 multivariate SSA (MSSA ) 知道的 multivariate 版本而言。方法被用于在巴西东北区域在二个地点记录的二个风速度系列的向量。，与每个系列的 univariate 分解相比获得了结果，是远优异的，证明在二个系列之间的空间关联被 MSSA 分解舞台考虑。

关键词：奇异谱分析 PAR 风速结构时间序列分解方法自回归模型东北部地区

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A numerical assessment of two geometries for reducing elbow erosion

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Particuology 2020年第2期18卷 117-133页

作者： Carlos Antonio Ribeiro Duarte Francisco joséde souza Diego Nei Venturi Martin Sommerfeld department of Engineering Federal University of Goiás-Regional Catal(a)oAv.Dr.Lamartine Pinto de Avelar1120Catal(a)oGoiásBrazil School of Mechanical Engineering Federal University of Uberl(a)ndiaAv.Joāo Naves de(A)vila2121 Bloco 5PUberl(a)ndiaMinas GeraisBrazil Multiphase Flow Systems(MPS) Otto-von-Guericke-University MagdeburgZeppelinstraβe 1D-06130 Halle(Saale)Germany

Elbows in pneumatic conveying systems are normally prone to the erosive effects of conveyed *** are a number of solutions available to reduce such damage.A widely used geometric alternative for replacing the 90°elbow and reducing erosive wear is the plugged *** option,although less commonly used,is the vortex-chamber *** both cases,the effective reduction in erosion brought about is unclear,as it strongly depends on the operating *** present study assesses relative erosion among the plugged tee,vortex-chamber elbow,and standard elbow for a dilute gas-solid multiphase flow.A numerical model is employed to predict the penetration ratio and validated using experimental data for the plugged *** are run for the standard and vortex-chamber elbows and plugged tee under the same conditions to compare the mechanics involved and the relative erosion *** analysis uses variables relating to particle-wall interactions(impact angle,impact velocity,impact frequency)to illustrate the nature of the erosive process in each pipe *** general,the geometric configurations of both the plugged tee and vortex-chamber elbow promote changes in particle dynamics that reduce the rate of *** the basis of the relative erosion of the standard elbow,the plugged tee proves to be an interesting option in cases of a low mass loading,while the vortex-chamber elbow demonstrates its erosion reduction potential for higher mass loading ***,the advantages and disadvantages of each fitting are highlighted.

关键词： Relative erosion Plugged tee Erosion reduction Pipe fitting Computational fluid dynamics

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Multi-objective forest harvesting under sustainable and economic principles

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林业研究:英文版 2023年第5期34卷 1379-1394页

作者： Talles Hudson souza Lacerda Luciano Cavalcante de Jesus Franca Isáira Leite e Lopes Sammilly Lorrayne souza Lacerda Evandro OrfanóFigueiredo Bruno Henrique Groenner Barbosa Carolina souza Jarochinski e Silva Lucas Rezende Gomide Suzano SA Sao JoséDos CamposSao PauloBrazil Institute of Agricultural Sciences Federal University of Uberlandia–UFUMonte CarmeloMinas GeraisBrazil department of Forest Sciences Federal University of Lavras–UFLALavrasMinas GeraisBrazil Brazilian Agricultural Research Corporation–EMBRAPA Rio BrancoAcreBrazil department of Systems and Automation Federal University of Lavras–UFLALavrasMinas GeraisBrazil

Selective logging is well-recognized as an effective practice in sustainable forest ***,the ecological efficiency or resilience of the residual stand is often in *** time depends on operational variables,diversity,and forest *** logging is excellent but is open to *** may be resolved by mathematical programming and this study integrates the economic-ecological aspects in multi-objective function by applying two evolutionary *** function maximizes remaining stand diversity,merchantable logs,and the inverse of distance between trees for harvesting and log landings *** Brazilian rainforest database(566 trees)was used to simulate our 216-ha *** log landing design has a maximum volume limit of 500 *** nondominated sorting genetic algorithm was applied to solve the main optimization *** parallel,a sub-problem(p-facility allocation)was solved for landing allocation by a genetic *** frontier analysis was applied to distinguish the gradientsα-economic,β-ecological,andγ-*** expected,the solutions have high diameter changes in the residual stand(average removal of approximately 16 m^(3) ha^(-1)).All solutions showed a grouping of trees selected for harvesting,although there was no formation of large clearings(percentage of canopy removaldemographic rates of the remaining *** methodology should support projects of reduced impact logging by using spatial-diversity information to guide better practices in tropical forests.

关键词： Amazon rainforest management Computational intelligence Multi-objective functions Evolutionary computing

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Impact of multidrug resistance on the management of bacterial infections in cirrhosis

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World Journal of Clinical Cases 2023年第3期11卷 534-544页

作者： Carlos Terra Ângelo Zambam de Mattos Marcelo souza Chagas Andre Torres denusa Wiltgen Barbara Muniz souza Renata Mello Perez Gastroenterology-Liver Unit State University of Rio de JaneiroRio de Janeiro 20551-030Rio de JaneiroBrazil Liver Unit Casa de Saúde São José-Rede Santa CatarinaRio de Janeiro 22271-080Rio de JaneiroBrazil Alliance of Brazilian Centers for Cirrhosis Car The ABC GroupRio de Janeiro 20551-030Rio de JaneiroBrazil Liver Unit Federal Hospital of LagoaRio de Janeiro 22470-050Rio de JaneiroBrazil Graduate Program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Gastroenterology and Hepatology Unit Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Internal Medicine Federal Hospital of LagoaRio de Janeiro 22470-050Rio de JaneiroBrazil department of Internal Medicine Federal University of Health Sciences of Porto AlegrePorto Alegre 90020-090Brazil Hepatology Division Federal University of Rio de JaneiroRio de Janeiro 21941-617Rio de JaneiroBrazil IDOR D’Or Institute for Research and EducationRio de Janeiro 22281-100Rio de JaneiroBrazil

Patients with cirrhosis have an increased risk of infection and differently from other complications,that over the years are improving in their outcomes,infections in cirrhotic patients are still a major cause of hospitalization and death(up to 50%in-hospital mortality).Infections by multidrug-resistant organisms(MDRO)have become a major challenge in the management of cirrhotic patients with significant prognostic and cost-related *** one third of cirrhotic patients with bacterial infections is infected with MDR bacteria and their prevalence has increased in recent *** infections have a worse prognosis compared to infections by non-resistant bacteria because they are associated with lower rate of infection *** adequate management of cirrhotic patients with infections caused by MDR bacteria depends on the knowledge of some epidemiological aspects,such as the type of infection(spontaneous bacterial peritonitis,pneumonia,urinary tract infection and spontaneous bacteremia),bacteriological profile of antibiotic resistance at each health care unit and site of infection acquisition(community acquired,healthcare associated or nosocomial).Furthermore,regional variations in the prevalence of MDR infections determine that the choice of empirical antibiotic therapy must be adapted to the local microbiological *** treatment is the most effective measure to treat infections caused by ***,optimizing antibiotic prescribing is critical to effectively treat these *** of risk factors for multidrug resistance is essential to define the best antibiotic treatment strategy in each case and the choice of an effective empirical antibiotic therapy and its early administration is cardinal to reduce *** the other hand,the supply of new agents to treat these infections is very ***,specific protocols that include preventive measures must be implemented in order to limit the negative impact of this sev

关键词： Cirrhosis Infection Multidrug-resistance Bacterial Antibiotics Microbiota

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Effect of rare-earth oxides on properties of silicon nitride obtained by normal sintering and sinter-HIP

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Journal of Rare Earths 2012年第11期30卷 1177-1183页

作者： Cecilia C.Guedes-Silva Flávio Machado de souza Carvalho josé Carlos Bressiani Nuclear and Energy Research Institute-IPEN/CNEN Geoscience Institute-IGC/USP

This paper presented the microstructure, mechanical properties and oxidation behavior of silicon nitride obtained by both conventional sintering and sintering followed by hot isostatic pressing （HIP）. Silicon nitride with additives such as 5 wt.% Al2O3 and 5 wt.% Ln203 （Ln= La, La concentrate, Gd or La＋Gd） were studied. The results revealed that Gd203 additions increased the formation of elongated grains of β-Si3N4, the fracture toughness and oxidation resistance. La2O3 additions led to higher densification and hardness values, while addition of La2O3 concentrate promoted the formation of materials with intermediate properties, compared to the other studied compositions. Hot isostatic pressing increased the hardness but decreased the fracture toughness of the material, mainly because it allowed residual pores to close and also reduced the average aspect ratio of β-Si3N4 grains.

关键词： rare earths silicon nitride properties normal sintering sinter-HIP

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Characterization of goat whey proteins and their bioactivity and toxicity assay

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Food Bioscience 2022年第2期46卷 833-843页

作者： Maria Isabel Ferreira Campos Paula Perazzo de souza Barbosa Laura Junqueira Camargo Luciano Da Silva Pinto Bianca Mataribu Catarina Serr˜ao Luis Fernando Marques-Santos jos´e Hon´orio Lopes Julia Mariano Caju de Oliveira Carlos Alberto de Almeida Gadelha Tatiane Santi-Gadelha Programa de P´os-Graduaç˜ao em Ciˆencia e Tecnologia de Alimentos Universidade Federal da ParaíbaJo˜ao PessoaParaíbaBrazil departamento de Biologia Molecular Universidade Federal da ParaíbaJo˜ao PessoaParaíbaBrazil Centro de desenvolvimento Tecnol´ogico Universidade Federal de PelotasRio Grande do SulBrazil Programa de P´os-Graduaç˜ao em Ciˆencias da Nutriç˜ao Universidade Federal da ParaíbaJo˜ao PessoaParaíbaBrazil

Goat whey is an industry-discarded dairy by-product that has interesting nutritional value and a nutrient composition with important functional potential,where proteins have a high biological value and play an important role in the organism’s ***,the aim of this study was to identify,quantify,concentrate and investigate the capacity of goat whey proteins to perform different biological activities and to evaluate their acute *** proteins were quantified and identified by Bradford,Kjehdal and SDS-PAGE *** activity was performed against Listeria monocytogenes,Salmonella spp.,Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli microorganisms and showed MIC ranging from 15 to 120μg mL-1,with the highest inhibition for *** *** activity was performed against human malignant melanoma cells and their proliferation inhibition was up to 66.8%within 72 h of *** highest antioxidant capacity was obtained at concentration 2 mg that showed 29.69%of inhibition of DPPH radical *** acute toxicity test was performed using Artemia franciscana larvae in which whey proteins were able to preserve larval survival throughout ***,we can conclude that goat’s whey has proteins that can play a positive effect on health,with antimicrobial activity and without *** present study highlights the great potential of goat’s whey to be developed as a safe biopreservative or as a functional ingredient in the food industry.

关键词： Goat whey proteins Malignant cells Antimicrobial Antioxidant capacity Whey protein functionality

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COVID-19 impact in Crohn’s disease patients submitted to autologous hematopoietic stem cell transplantation

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World Journal of Hematology 2024年第1期11卷 1-8页

作者： Milton Artur Ruiz Roberto Luiz Kaiser Junior Lilian Piron-Ruiz Tainara souza Pinho Lilian Castiglioni Luiz Gustavo de Quadros department of Bone Marrow Transplantation Associação Portuguesa de BeneficênciaSão Josédo Rio Preto SP 15090470Brazil department of Surgery Kaiser Hospital DiaSão Josédo Rio Preto 08010-150São PauloBrazil department of Bone Marrow Transplantation Beneficência Portuguesa HospitalSão Josédo Rio Preto 15090470São PauloBrazil FAMERP Faculdade de Medicina de São Josédo Rio PretoSão Josédo Rio Preto 15090000São PauloBrazil Beneficência Portuguesa Hospital ABC Medical SchoolSão Bernardo 15015110São PauloBrazil

BACKGROUND Severe acute respiratory syndrome coronavirus 2 is the virus responsible for coronavirus disease 2019(COVID-19),a disease that has been blamed for inducing or exacerbating symptoms in patients with autoimmune ***'s disease(CD)is an inflammatory bowel disease that affects genetically susceptible patients who develop an abnormal mucosal immune response to the intestinal *** who underwent hematopoietic stem cell transplantation(HSCT)are considered at risk for *** To describe for the first time the impact of COVID-19 in CD patients who had undergone autologous,non-myeloablative *** In this descriptive study a series of 19 patients were diagnosed with positive *** two patients there were reports of the occurrence of two infectious *** related to HSCT,such as time elapsed since the procedure,vaccination status,CD status before and after infection,and clinical manifestations resulting from COVID-19,were *** Among the patients with COVID-19,three,who underwent Auto HSCT less than six months ago,relapsed and one,in addition to the CD symptoms,started to present thyroid impairment with positive *** one of the patients required hospitalization for five days to treat COVID-19 and remained in CD clinical *** patients reported late symptoms that may be related to *** were no deaths,and a statistical evaluation of the series of COVID-19 patients compared to those who did not present any infectious episode did not identify significant differences regarding the analyzed *** despite the change in CD status in three patients and the presence of nine patients with late symptoms,we can conclude that there was no significant adverse impact concerning COVID-19 in the evaluated patients who underwent HSCT to treat CD.

关键词： Inflammatory bowel disease Crohn disease SARS-CoV-2 COVID-19 Autologous hematopoietic stem cell transplantation Stem cell therapy

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Increasing pancreatic cancer is not paralleled by pancreaticoduodenectomy volumes in Brazil:A time trend analysis

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Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 79-86页

作者： Lucila M Perrotta de souza Jessica PL Moreira Homero S Fogaca josé Marcus Raso Eulálio Ronir R Luiz Heitor SP de souza department of Internal Medicine School of Medicine Federal University of Rio de Janeiro Institute of Public Health Studies (IESC) Federal University of Rio de Janeiro department of Surgery School of Medicine Federal University of Rio de Janeiro D’Or Institute for Research and Education

Background: Currently, surgical resection represents the only curative treatment for pancreatic cancer(PC), however, the majority of tumors are no longer resectable by the time of diagnosis. The aim of this study was to describe time trends and distribution of pancreaticoduodenectomies(PDs) performed for treating PC in Brazil in recent years. Methods: Data were retrospectively obtained from Brazilian Health Public System(namely DATASUS) regarding hospitalizations for PC and PD in Brazil from January 2008 to december 2015. PC and PD rates and their mortalities were estimated from DATASUS hospitalizations and analyzed for age, gender and demographic characteristics. Results: A total of 2364 PDs were retrieved. Albeit PC incidence more than doubled, the number of PDs increased only 37%. Most PDs were performed in men(52.2%) and patients between 50 and 69 years old(59.5%). Patients not surgically treated and those 70 years or older had the highest in-hospital mortality rates. The most developed regions(Southeast and South) as well as large metropolitan integrated municipalities registered 76.2% and 54.8% of the procedures, respectively. LMIM PD mortality fluctuated, ranging from 13.6% in 2008 to 11.8% in 2015. Conclusions: This study suggests a trend towards regionalization and volume-outcome relationships for PD due to PC, as large metropolitan integrated municipalities registered most of the PDs and more stable mortality rates. The substantial differences between PD and PC increasing rates reveals a limiting step on the health system resoluteness. Reduction in the number of hospital beds and late access to hospitalization, despite improvement in diagnostic methods, could at least in part explain these findings.

关键词： Pancreatic cancer Pancreaticoduodenectomy Time trend analysis Ecological study Hospitalization rates Mortality rates

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