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Mechanical characterization of rose bengal and green light crosslinked collagen scaffolds for regenerative medicine

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Regenerative Biomaterials 2021年第6期8卷 185-198页

作者： Joy Braun Stefanie Eckes Michelle Fiona Kilb Dirk Fischer Claudia Eßbach Pol Maria Rommens Philipp Drees Katja Schmitz Daniela nickel Ulrike Ritz Department of Orthopedics and Traumatology BiomaTiCSUniversity Medical CenterJohannes Gutenberg UniversityLangenbeckstraße 1Mainz 55131Germany Clemens-Schopf-Institute of Organic Chemistry and Biochemistry Technical University of DarmstadtAlarich-Weiss-Straße 4Darmstadt 64287Germany Berufsakademie Sachsen—Staatliche Studienakademie Glauchau University of Cooperative EducationKopernikusstraße 51Glauchau 08371Germany

Collagen is one of the most important biomaterials for tissue engineering *** its excellent biocompatibility,it shows the non-negligible disadvantage of poor mechanical *** crosslinking with rose bengal and green light(RGX)is an appropriate method to improve this *** development of collagen laminates is helpful for further adjustment of the mechanical properties as well as the controlled release of incorporated *** this study,we investigate the impact of crosslinking and layering of two different collagen scaffolds on the swelling behavior andmechanical behavior inmicro tensile tests to obtain information on its wearing comfort(stiffness,strength and ductility).The mechanical stability of the collagen material after degradation due to cell contact is examined using thickness *** is no linear increase or decrease due to layering homologous ***,a decrease in elongation at break,Young’s modulus and ultimate tensile strength are measured when the untreated monolayer is compared to the crosslinked ***,we can detect a connection between stability and cell *** results show that with variation in number and type of layers,collagen scaffolds with tailored mechanical properties can be *** a multi-layered structure enables the release of biomolecules into inner or outer layers for biomedical applications.

关键词： collagen type I collagen laminates rose bengal and green light crosslinking thickness analysis micro tensile testing cell-collagen interactions

Validation of a Risk-Based Biomarker-Enhanced Scoring System for Lower Respiratory Tract Infections (OPTIMA I Basel)—An Observational Survey

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International Journal of Clinical Medicine 2013年第2期4卷 69-77页

作者： Richard X. Sousa Da Silva Frank Dusemund Christian nickel Roland Bingisser Andreas Huber Beat Müller Werner C. Albrich Department of Emergency Medicine University Hospital of Basel Basel Switzerland Department of Laboratory Medicine Kantonsspital Aarau Switzerland Medical University Department of the University of Basel Kantonsspital Aarau Switzerland

Background: Despiteits recommendation in management guide lines for community acquired pneumonia (CAP), the CURB65 score is frequently not followed for disposition decisions in clinical routine. We therefore proposed an improved CURB65 A score, supplemented by proadre nome dull in (ProADM) levels for patients with CAP and other lower respiratory tract infections (LRTIs). In this study, we vali dated this risk based biomarker enhanced disposition in patients with LRTIs presenting to the emergency department of the University Hospital of Basel. Methods: In this prospective observational cohort study of 85 patients presenting with LRTIs, site of care was decided by the physicians in charge according to their judgement. Retro spectively the CURB65 A score was calculated and a virtual disposition assigned. This was compared with the existing disposition in order to identify efficacy of the novel risk based biomarker enhanced disposition. Results: The novel disposition criteria considered 14 patients suitable for outpatient treatment compared to 11 in the current disposition (p = 0.5). It detected 7 patients to be best treated outside the hospital for nursing reasons, while the current disposition detected only 1 patient requiring geriatric care (p = 0.09). Further, it decreased regular hospitalizations considerably (32 vs. 64, p 0.001). Conclusions: The novel risk based biomarker enhanced disposition is an objective, safe and probably more efficient disposition system to identify outpatient treatment options than the current practice at the University Hospital of Basel.

关键词： Lower Respiratory Tract Infection Proadrenomedullin Biomarker-Enhanced Disposition CURb65-A-Score Outpatient Treatment

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全面计算变压器损耗的成本

变压器 1981年第2期 34-36页

作者： D.L.nickel 张子学

配电变压器损耗占电力系统全部变压器总损耗的40～45%。在全面计算电力系统经济性时,许多电力公司正试图注意从电力系统的投

关键词：成本财政管理负载系数变压器损耗负载变化负载损耗短路损耗涡流损耗磁损失电力公司配电变压器电力变压器无功损耗空载损耗平均

国际矿物学协会新矿物及矿物命名委员会(IMA CNMMN)多型后缀规范化

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矿物岩石地球化学通报 1993年第3期12卷 170-172页

作者： E.H.nickel 曹亚文 IMA CNMMN 新矿物及矿物命名专业委员会

国际矿物学协会新矿物及矿物命名委员会(IMA CNMMN)已经出版了关于矿物命名的若干准则,其中包括对矿物多型的命名法(如nickel和Mandarino,1987)。从根本上说,多型名称是由在矿物名(root name)后附加数字和字母,并将数字和字母用连字符(-... 详细信息

国际矿物学协会新矿物及矿物命名委员会(IMA CNMMN)已经出版了关于矿物命名的若干准则,其中包括对矿物多型的命名法(如nickel和Mandarino,1987)。从根本上说,多型名称是由在矿物名(root name)后附加数字和字母,并将数字和字母用连字符(-)与根矿物名连接起来而形成。附加的数字部分代表层的周期(layering periodicity);而字母部分以斜体书写,代表晶系。举例来说,Wurtzite-4H(纤锌矿-4H)是具有4倍于纤锌矿母体(wurtzite parent)c轴长度的同期之六方纤锌矿多型。

关键词：纤锌矿新矿物 IMA CNMMN 数字部分命名法 periodicity parent 轴长连字符晶系

LittlevGL不只是某些人的项目!——采访LittlevGL的开发者Gabor Kiss-Vamosi

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单片机与嵌入式系统应用 2020年第9期20卷 1-3页

作者： Mathias Claußen Jens nickel 君谦(译) 不详

如今,没有开源库和框架支撑,软件开发就无法正常进行。其中一些库诞生于年轻的私人软件爱好者为自己定制满足特定需求的代码功能。然后,这些项目变得越来越大,并且越来越专业。一个例子就是Gabor Kiss Vamosi开发的LittlevGL库,即使在小... 详细信息

如今,没有开源库和框架支撑,软件开发就无法正常进行。其中一些库诞生于年轻的私人软件爱好者为自己定制满足特定需求的代码功能。然后,这些项目变得越来越大,并且越来越专业。一个例子就是Gabor Kiss Vamosi开发的LittlevGL库,即使在小型RAM的16位微控制器中,它也能够实现触摸图形用户界面访问。在这次采访中,Gábor谈到了他广受欢迎的库的开发背景、一些有趣的细节以及未来的畅想。

关键词：图形用户界面软件开发 Gabor GL 开发背景开发者特定需求 RAM

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中国几个硫化镍矿床基本特征

吉林地质 1986年第4期 73-82页

作者：秦宽吉林镍业公司

中国已探明镍矿储量主要为岩浆硫化铜镍矿床(以下称硫化镍矿床),目前开采的镍矿均属这一矿床类型。因此,加强硫化镍矿床的总结工作有着重要意义。笔者曾考察了四川、云南等省几个镍矿,就蒐集到的资料对中国几个硫化镍矿床基本特征进行... 详细信息

中国已探明镍矿储量主要为岩浆硫化铜镍矿床(以下称硫化镍矿床),目前开采的镍矿均属这一矿床类型。因此,加强硫化镍矿床的总结工作有着重要意义。笔者曾考察了四川、云南等省几个镍矿,就蒐集到的资料对中国几个硫化镍矿床基本特征进行了初步总结。

关键词：硫化镍矿橄榄岩超基性岩致密块状矿床类型矿体规模基性均质混合岩岩相矿床成因类型

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亚洲视野中的秦兵马俑

古代墓葬美术研究 2011年第1期 23-40页

作者：倪克鲁陈亮伦敦大学亚非学院

…for all our knowledge of the way they were originally finished,we shrink from admitting that their prime effect must have been sheer realism.[1]1974年秦始皇陵墓陶俑、陶马等的发现激起学者持久的兴趣,此后,大量展览图录、专著和论文不断出版和发表。研究课题涉及陶俑在帝陵中的象征意义、宗教功能、陶俑作为写实性人物形象乃至肖像的风格特征、陶俑的制作方式及其原有着色,以及陶俑与考古学和历史学的关系等诸多方面。然而,与兵马俑以及在其他陪葬坑中所发现的文吏俑、乐舞俑、百戏俑相关的一个重要现象,至今却鲜有人论及,那就是,在这些陶俑制造之前的数个世纪,即东周时期,人物雕像很少放置在墓葬中,也绝少在公共场所使用。

关键词：大量风格特征制作功能图录象征意义写实性帝陵

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中国古代砖材及早期亚洲跨区域的互动与交流

古代墓葬美术研究 2017年第1期 298-314页

作者：倪克鲁李尔吾维也纳大学

黏土、陶制建材的出现本文所涉及的砖指陶制的建筑材料,这些材料构成了诸如墙体及拱顶这些结构的一部分。本文中的瓦指没有结构功能的陶制材料,它们只被用于保护由其他材料构筑而成的屋顶、墙壁以及地板的表面等。总体来讲,陶制材料最... 详细信息

黏土、陶制建材的出现本文所涉及的砖指陶制的建筑材料,这些材料构成了诸如墙体及拱顶这些结构的一部分。本文中的瓦指没有结构功能的陶制材料,它们只被用于保护由其他材料构筑而成的屋顶、墙壁以及地板的表面等。总体来讲,陶制材料最早以瓦、砖和管道的形式出现在史前建筑中。泥坯砖的出现通常在此之前。在西亚地区,这种极简的人造建材可上溯至公元前9千纪[1]。在印度北部,最早的泥坯砖出现在公元前7千纪。在美索不达米亚,焙烤而成的砖出现于公元前4千纪。

关键词：空心砖工匠们子母砖跨区域

Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation

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Bone Research 2018年第1期6卷 83-94页

作者： Heather A.Carey Blake E.Hildreth III Jennifer A.Geisler Mara C.nickel Jennifer Cabrera Sankha Ghosh Yue Jiang Jing Yan James Lee Sandeep Makam Nicholas A.Young Giancarlo R.Valiente Wael N.Jarjour Kun Huang Thomas J.Rosol Ramiro E.Toribio Julia F.Charles Michael C.Ostrowski Sudarshana M.Sharma Department of Cancer Biology and Genetics and Comprehensive Cancer Center The Ohio State University Wexner Medical Center College of Veterinary Medicine The Ohio State University Department of Biochemistry and Molecular Biology and Hollings Cancer Center Medical University of South Carolina Division of Rheumatology Immunology and Allergy Department of Medicine Brigham and Women’s Hospital and Harvard Medical School Division of Rheumatology and Immunology Department of Internal Medicine The Ohio State University Wexner Medical Center Department of Biomedical Informatics The Ohio State University Wexner Medical Center

Genome-wide association studies(GWASs) have been instrumental in understanding complex phenotypic traits. However, they have rarely been used to understand lineage-specific pathways and functions that contribute to the trait. In this study, by integrating lineage-specific enhancers from mesenchymal and myeloid compartments with bone mineral density loci, we were able to segregate osteoblast-and osteoclast(OC)-specific functions. Specifically, in OCs, a PU.1-dependent transcription factor(TF)network was revealed. Deletion of PU.1 in OCs in mice resulted in severe osteopetrosis. Functional genomic analysis indicated PU.1 and MITF orchestrated a TF network essential for OC differentiation. Several of these TFs were regulated by cooperative binding of PU.1 with BRD4 to form superenhancers. Further, PU.1 is essential for conformational changes in the superenhancer region of Nfatc1. In summary, our study demonstrates that combining GWASs with genome-wide binding studies and model organisms could decipher lineage-specific pathways contributing to complex disease states.

关键词： Genome-wide GWASs MITF