Mechanical characterization of rose bengal and green light crosslinked collagen scaffolds for regenerative medicine
作者机构：Department of Orthopedics and TraumatologyBiomaTiCSUniversity Medical CenterJohannes Gutenberg UniversityLangenbeckstraße 1Mainz 55131Germany Clemens-Schopf-Institute of Organic Chemistry and BiochemistryTechnical University of DarmstadtAlarich-Weiss-Straße 4Darmstadt 64287Germany Berufsakademie Sachsen—Staatliche Studienakademie GlauchauUniversity of Cooperative EducationKopernikusstraße 51Glauchau 08371Germany
出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)
年 卷 期：2021年第8卷第6期
页 面：185-198页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程]
基 金：supported by the Deutsche Forschungsgemeinschaft(Project number:400569699)
主 题：collagen type I collagen laminates rose bengal and green light crosslinking thickness analysis micro tensile testing cell-collagen interactions
摘 要：Collagen is one of the most important biomaterials for tissue engineering *** its excellent biocompatibility,it shows the non-negligible disadvantage of poor mechanical *** crosslinking with rose bengal and green light(RGX)is an appropriate method to improve this *** development of collagen laminates is helpful for further adjustment of the mechanical properties as well as the controlled release of incorporated *** this study,we investigate the impact of crosslinking and layering of two different collagen scaffolds on the swelling behavior andmechanical behavior inmicro tensile tests to obtain information on its wearing comfort(stiffness,strength and ductility).The mechanical stability of the collagen material after degradation due to cell contact is examined using thickness *** is no linear increase or decrease due to layering homologous ***,a decrease in elongation at break,Young’s modulus and ultimate tensile strength are measured when the untreated monolayer is compared to the crosslinked ***,we can detect a connection between stability and cell *** results show that with variation in number and type of layers,collagen scaffolds with tailored mechanical properties can be *** a multi-layered structure enables the release of biomolecules into inner or outer layers for biomedical applications.
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