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Expression of multidrug resistance proteins in retinoblastoma

International Journal of Ophthalmology(English edition) 2017年第11期10卷 1655-1661页

作者： Swati Shukla Arpna Srivastava Sunil Kumar Usha singh sandeep Goswami Bhavna Chawla Mandeep singh Bajaj Seema Kashyap Jasbir Kaur Department of Ocular Biochemistry Dr. Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences New Delhi 110029 India Oculoplasty & Pediatric Opthalmology Services Dr. Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences New Delhi 110029 India Department of Ocular Pathology Dr. Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences New Delhi 110029 India

AIM： To elucidate the mechanism of multidrug resistance in retinoblastoma, and to acquire more insights into in vivo drug ***： Three anticancer drug resistant Y79 human RB cells were generated against vincristine, etoposide or carboplatin, which are used for conventional chemotherapy in RB. Primary cultures from enucleated eyes after chemotherapy（PCNC） were also prepared. Their chemosensitivity to chemotherapeutic agents（vincristine, etoposide and carboplatin） were measured using MTT assay. Western blot analysis was performed to evaluate the expression of p53, Bcl-2 and various multidrug resistant proteins in retinoblastoma ***： Following exposure to chemotherapeutic drugs, PCNC showed less sensitivity to drugs. No significant changes observed in the p53 expression, whereas Bcl-2 expression was found to be increased in the drug resistant cells as well as in PCNC. Increased expression of P-glycoprotein（P-gp） was observed in drug resistant Y79 cells; however there was no significant change in the expression of P-gp found between primary cultures of primarily enucleated eyes and PCNC. Multidrug resistance protein 1（Mrp-1） expression was found to be elevated in the drug resistant Y79 cells as well as in PCNC. No significant change in the expression of lung resistance associatedprotein（Lrp） was observed in the drug resistant Y79 cells as well as in ***： Our results suggest that multidrug resistant proteins are intrinsically present in retinoblastoma which causes treatment failure in managing retinoblastoma with chemotherapy.

关键词： retinoblastoma chemotherapy multidrug resistance multidrug resistance associated proteins

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Isolated tuberculous splenic abscess in an immunocompetent individual

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Asian Pacific Journal of Tropical Medicine 2011年第1期4卷 81-82页

作者： Parveen rana Kundu SK Mathur Sunita singh Amrita Duhan Garima Aggarwal Rajeev Sen Department of Pathology Pt.B.D.Sharma PGIMSIndia

Tuberculosis(TB) of the spleen is an extremely rare clinical entity particularly among immunocompetent *** report a case of isolated tuberculous abscess of spleen in a 13- years- old *** primary focus of infection was detected in lungs or any other *** patient was treated by splenectomy after a therapeutic failure with standard antituberculous medication.

关键词： Spleen Tuberculosis Abscess

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An unusual cause of simultaneous common bile and pancreatic duct dilation

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Gastroenterology Report 2015年第3期3卷 258-261页

作者： Puneet Chhabra Surinder singh rana Vishal Sharma Ravi Sharma Rajesh Gupta Deepak Kumar Bhasin Department of Gastroenterology Postgraduate Institute of Medical Education and Research(PGIMER)ChandigarhIndia Department of Surgery Postgraduate Institute of Medical Education and Research(PGIMER)ChandigarhIndia

Simultaneous dilation of both the common bile duct and the pancreatic duct(double-duct sign)is usually because of ampullary or pancreatic *** we report an unusual cause of double-duct dilation;we describe the case of a 49-year-old female who developed afferent loop syndrome after pylorus-preserving pancreaticoduodenectomy:crosssectional imaging of the abdomen revealed a double-duct sign.

关键词： afferent loop syndrome pylorus preserving pancreaticoduodenectomy

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Analysis and Predictions of Spread, Recovery, and Death Caused by COVID-19 in India

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Big Data Mining and Analytics 2021年第2期4卷 65-75页

作者： Rajani Kumari sandeep Kumar Ramesh Chandra Poonia Vijander singh Linesh Raja Vaibhav Bhatnagar Pankaj Agarwal Department of Information Technology and Computer Application JECRC UniversityJaipurRajasthan 303905India Bangalore Karnataka 560029India with Amity University Rajasthan JaipurRajasthan 303002India University Jaipur Rajasthan 303007India

The novel coronavirus outbreak was first reported in late December 2019 and more than 7 million people were infected with this disease and over 0.40 million worldwide lost their lives. The first case was diagnosed on30 January 2020 in India and the figure crossed 0.24 million as of 6 June 2020. This paper presents a detailed study of recently developed forecasting models and predicts the number of confirmed, recovered, and death cases in India caused by COVID-19. The correlation coefficients and multiple linear regression applied for prediction and autocorrelation and autoregression have been used to improve the accuracy. The predicted number of cases shows a good agreement with 0.9992 R-squared score to the actual values. The finding suggests that lockdown and social distancing are two important factors that can help to suppress the increasing spread rate of COVID-19.

关键词： COVID-19 regression correlation machine learning prediction

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Development of a set of SSR markers for genetic polymorphism detection and interspecific hybrid jute breeding

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The Crop Journal 2017年第5期5卷 416-429页

作者： Dipnarayan Saha Rajeev singh rana Sukla Chakraborty Subhojit Datta Arroju Anil Kumar Asim Kumar Chakraborty Pran Gobinda Karmakar Division of Crop Improvement Indian Council of Agricultural Research (ICAR)-Central Research Institute for Jute and Allied Fibers

Corchorus capsularis(white jute) and C. olitorius(dark jute) are the two principal cultivated spedes of jute that produce natural bast fiber of commercial importance. We have identified 4509 simple sequence repeat(SSR) loci from 34,163 unigene sequences of C. capsularis to develop a non-redundant set of 2079 flanking primer pairs. Among the SSRs, trinudeotide repeats were most frequent(60%) followed by dinucleotide repeats(37.6%). Annotation of the SSR-containing unigenes revealed their putative functions in various biological and molecular processes, including responses to biotic and abiotic signals. Eighteen expressed gene-derived SSR(eSSR) markers were successfully mapped to the existing single-nucleotide polymorphism(SNP) linkage map of jute,providing additional anchor points. Amplification of 72% of the 74 randomly selected primer pairs was successful in a panel of 24 jute accessions, comprising five and twelve accessions of *** and C. olitorius, respectively, and seven wild jute spedes. Forty-three primer pairs produced an average of 2.7 alleles and 58.1% polymorphism in a panel of 24 jute accessions. The mean PIC value was 0.34 but some markers showed PIC values higher than 0.5, suggesting that these markers can efficiently measure genetic diversity and serve for mapping of quantitative trait loci(QTLs) in jute. A primer polymorphism survey with parents of a wide-hybridized population between a cultivated jute and its wild relative revealed their efficacy for interspecific hybrid identificatioii. For ready accessibility of jute eSSR primers, we compiled all information in a user-friendly web database, JuteMarkerdb(http://***/) for the first time in *** eSSR resource in jute is expected to be of use in characterization of germplasm, interspecific hybrid and variety identification, and marker-assisted breeding of superior-quality jute.

关键词： Database Genic-SSR Jute Interspecific hybrid identification Unigene sequences

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Changes in soil biochemical indicators at different wheat growth stages under conservation-based sustainable intensification of rice-wheat system

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Journal of Integrative Agriculture 2018年第8期17卷 1871-1880页

作者： Tanushree Bera sandeep Sharma H.S.Thind Yadvinder-singh H.S.Sidhu M.L.Jat Department of Soil Science Punjab Agricultural University Borlaug Institute for South Asia (BISA) International Maize and Wheat Improvement Center (CIMMYT) CIMMYT National Agricultural Science Complex

Soil microbes play critical roles in soil biogeochemistry, soil biological health and crop productivity. The current study evaluated the effects of tillage and residue management on changes in soil biochemical indicators at different growth stages of wheat after 5 years of rice-wheat system. Nine treatment combinations of tillage, crop establishment and crop residue management included three main plot treatments applied to rice:(1) conventional till direct dry seeded rice(CTDSR),(2) zero till direct dry seeded rice(ZTDSR), and(3) conventional puddled manual transplanted rice(CTPTR) and three subplot treatments in subsequent wheat:(1) conventional tillage with rice residue removed(CTW-R),(2) zero tillage with rice residue removed(ZTW-R) and(3) zero tillage with rice residue retained as surface mulch(ZTW+R). Irrespective of rice treatments, ZTW+R treatment had higher soil biochemical indicators compared with ZTW-R and CTW-R at all the growth stages of wheat. Generally, all the biochemical indicators were the highest at the flowering stage of wheat. Residual effect of rice treatments was also significant on biochemical quotients in wheat, which were the highest under ZTDSR followed by CTDSR and CTPTR. The present study provided three sensitive and reliable biochemical indicators(microbial biomass, basal soil respiration and microbial quotient) which respond rapidly to change in tillage and residue management practices in RWS of South Asia.

关键词： microbial metabolic quotients tillage practices residue retention cropping system

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Model of Preformed Hole-Pairs in c-Axis Transport in Cuprate Superconductors

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World Journal of Condensed Matter Physics 2012年第4期2卷 228-236页

作者： rana Janardan singh Department of Physics Aligarh Muslim University Aligarh India.

Model of hole-pairs in electrical transport along ab plane in cuprate superconductors has already been proposed. It has been found to be in the shape of 3dx2–y2 orbital of an electron in an atom. This time, model of hole-pairs in transport along c-axis in cuprate superconductors is proposed. In ab-plane, hole-pairs are formed along CuO2 plane;one hole-pair covering 9 - 10 two dimensional CuO2 unit cells in 3dx2–y2 configuration. In the investigation of c-axis hole-pairs, cuprate superconductors have been sub-divided into three categories depending on the number of CuO2 planes/formula unit. There is a little different treatment for finding out the order parameter in each category. Coherence lengths along ab-planes are of the order of a few tens of Angstroms, whereas along c-axis, they are less than even their a-, b-lattice constants. In cuprates with 2 or 3 CuO2 planes, the order parameter is of 3dz2–x2 type in zx-plane with lobes along both the axes much constrained. For cuprates with a single CuO2 layer, the order parameter is of 3dx2–y2 type, but its dimensions are less than a-, b-lattice constants.

关键词： Cuprate Superconductors Preformed Hole-Pairs Electron Paramagnetic Resonance 41 meV Peak in Neutron Diffraction

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High-yield synthesis and liquid-exfoliation of two- dimensional belt-like hafnium disulphide

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Nano Research 2018年第1期11卷 343-353页

作者： Harneet Kaur sandeep Yadav Avanish K. Srivastava Nidhi singh Shyama Rath Jorg J. Schneider Om P. Sinha Ritu Srivastava National Physical Laboratory Council of Scientific and Industrial Research Dr. K. S. Krishnan Road New Delhi I I O012 India Academy of Scientific and Innovative Research NPL New Delhi 110012 India Technische Universitat Darmstadt Eduard-ZintMnstitut f~r Anorganische und Physikalische Chemie 12 105 117 Alarich-Weiss-Str 12 64287 Darmstadt Germany DepartmentofPhysics andAstrophysics University of Delhi Delhi 110007 India Amity Institute of Nanotechnology Amity University UP Sector 125 Noida Uttar Pradesh 201313 India

Producing environmentally stable monolayers and few-layers of hafnium disulphide （HfS2） with a high yield to reveal its unlocked electronic and optoelectronic applications is still a challenge. HfS2 is a layered two-dimensional material of group-IV transition metal dichalcogenides. For the first time, we demonstrate a simple and cost-effective method to grow layered belt-like nanocrystals of HfS2 with a notably large interlayer spacing followed by their chemical exfoliation. Various microscopic and spectroscopic techniques confirm that these as-grown crystals exfoliate into single or multiple layers in a few minutes using solvent assisted ultrasonification method in N-cyclohexyl-2- pyrrolidone. The exfoliated nanosheets of HfS2 exhibit an indirect bandgap of 1.3 eV with high stability against surface degradation. Furthermore, we demonstrate that these nanosheets hold potential for electronic applications by fabricating a field-effect transistor based on few-layered HfS2, exhibiting a field-effect mobility of 0.95 cm2/（V.s） with a high on/off current modulation ratio of 10,000 in ambient conditions. The method is scalable and has a potential significance for both academic and industrial purposes.

关键词： two-dimensionalmaterials hafnium disulphide nano-crystals liquid-phase exfoliation environment-stabili~ field-effect transistor

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Piecewise linear programming approach to solve multi-objective matrix games with I-fuzzy goals

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Journal of Control and Decision 2021年第1期8卷 1-13页

作者： sandeep Kumar Department of Mathematics Ch.Charan Singh UniversityMeerut 250004Uttar PradeshIndia

The intuitionistic fuzzy set(I-fuzzy set)plays an effective role in game theory when players face‘neither this nor that’situation to set their *** study presents a maxmin–minmax solution to multi-objective two person zero-sum matrix games with I-fuzzy *** this article,a class of piecewise linear membership and non-membership functions for I-fuzzy goals is *** functions are more effective in real games because marginal rate of increase(decrease)of such membership functions(non-membership functions)is different in different intervals of tolerance ***,one numerical example is given to examine the effectiveness and advantages of the proposed results.

关键词： Intuitionistic fuzzy set multi-objective matrix game I-fuzzy goals maxmin-minmax solution piecewise linear function

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Ultra-performance liquid chromatography electrospray ionization-tandem mass spectrometry method for the simultaneous determination of itraconazole and hydroxy itraconazole in human plasma

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Journal of Pharmaceutical Analysis 2014年第5期4卷 316-324页

作者： Ashish Dwivedi Bhupinder singh sandeep Sharma R.S.Lokhandae Naveen Dubey Bioanalytical Department Jubilant Life SciencesC-46Sector 62Noida 201307India Jaipur National University JaipurIndia

A highly sensitive, selective, and precise ultra-performance liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous quantification of itraconazole and hydroxy itraconazole in human plasma by a single liquid-liquid extraction step. The precursor to product ion transitions of m/z 705.3/392.3, m/z 721.2/408.3 and m/z 708.2/435.4 were used to detect and quantify itraconazole, hydroxy itraconazole and itraconazole-d3 respectively. The lower limit of quantitation was found to be 0.500 ng/mL for itraconazole and 1.00 ng/mL for hydroxy itraconazole. The mean recoveries for itraconazole and hydroxy itraconazole were found to be 100.045% and 100.021%, respectively. This developed method with a chromatographic run time of 2.0 min was successfully applied to a bioequivalence study of 100 mg itraconazole capsule.

关键词： Itraconazole,Hydroxy itraconazole,Ultra-performance liquidchromatography, Human plasma Simultaneous analysis

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