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Three novel missense germline mutations in different exons of MSH6 gene in Chinese hereditary non-polyposis colorectal cancer families

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World Journal of Gastroenterology 2007年第37期13卷 5021-5024页

作者： Shi-Yan Yan Xiao-Yan Zhou Xiang Du Tai-Ming Zhang Yong-Ming lu san-Jun Cai Xiao-Li Xu Bao-Hua Yu Heng-Hua Zhou Da-Ren Shi Department of Pathology Cancer Hospital/InstituteFudan University Department of Oncology Shanghai MedicalCollege Fudan University Shanghai 200032 China Department of Abdominal Surgery CancerHospital/Institute Fudan University Shanghai 200032 China

AIM: To investigate the germline mutations of MSH6 gene in probands of Chinese hereditary non-polyposis colorectal cancer (HNPCC) families fulfilling different clinical criteria. METHODS: Germline mutations of MSH6 gene were detected by PCR-based DNA sequencing in 39 unrelated HNPCC probands fulfilling different clinical criteria in which MSH2 and MLH1 mutations were excluded. To further investigate the pathological effects of detected missense mutations, we analyzed the above related MSH6 exons using PCR-based sequencing in 137 healthy persons with no family history. The clinicopathological features were collected from the Archive Library of Cancer Hospital, Fudan University and analyzed. RESULTS: Four germline missense mutations distributed in the 4th, 6th and 9th exons were observed. Of them, three were not found in international HNPCC databases and did not occur in 137 healthy controls, indicating that they were novel missense mutations. The remaining mutation which is consistent with the case H14 at c.3488A>T of exon 6 of MSH6 gene was also found in the controls, the rate was approximately 3.65% (5/137) and the type of mutation was not found in the international HNPCC mutational and SNP databases, suggesting that this missense mutation was a new SNP unreported up to date. CONCluSION: Three novel missense mutations and a new SNP observed in the probands of Chinese HNPCC families, may play an important role in the development of HNPCC.

关键词： Hereditary non-polyposis colorectal cancer MSH6 Missense mutation Colorectal cancer

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Identification of four novel mutations in the HNF-1A gene in Chinese early-onset and/or multiplex diabetes pedigrees

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Chinese Medical Journal 2006年第13期119卷 1072-1078页

作者： YANG Zhen WU Song-hua ZHENG Tai-shan lu Hui-juan XIANG Kun-san Shanghai Diabetes Institute Department of Endocrinology and Metabolism Shanghai No. 6 People＇s Hospital Shanghai Jiaotong University Shanghai 200233 China

Background Mutations in the hepatocyte nuclear factor-lA gene cause the type 3 form of maturity-onset diabetes of the young （MODY3）. This study was undertaken to determine mutations and sequence variations of the HN... 详细信息

关键词： maturity-onset diabetes of the young hepatocyte nuclear factor-1A gene direct sequencing

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Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats

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Acta Pharmacologica Sinica 2006年第9期27卷 1103-1110页

作者： Yu ZHOU san-hua FANG Yi-lu YE Li-sheng CHU Wei-ping ZHANG Meng-ling WANG Er-qing WEI~2 Department of Pharmacology,School of Medicine,Zhejiang University,Hangzhou 310031,China Department of Pharmacology School of Medicine Zhejiang University Hangzhou China

Aim:To investigate the effects of caffeic acid on early and delayed injuries afterfocal cerebral ischemia in rats,and the possible relation to ***:Transient focal cerebral ischernia was induced by middlecerebral artery occlusion in Sprague-Dawley *** acid(10 and 50 mg/kg)was ip injected for 5 d after *** brain injuries were observed,and thelevels of cysteinyl leukotrienes and leukotriene B4in the brain tissue ***:Caffeic acid(50 mg/kg)ameliorated neurological dysfunctionand neuron loss,and decreased infarct volume 24 h after ischemia;it attenuatedbrain atrophy,infarct volume,and particularly astrocyte proliferation 14 d *** addition,it reduced the production of leukotrienes(5-lipoxygenasemetabolites)in the ischemic hemispheres 3 h and 7 d after ***:Caffeic acid has protective effect on both early and delayed injuries after focalcerebral ischemia in rats;and this effect may partly relate to 5-lipoxygenaseinhibition.

关键词： caffeic acid focal cerebral ischemia neuron astrocyte 5-lipoxygenase leukotriene

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Identification of the hydrogen utilization pathway for the electrocatalytic hydrogenation of phenol

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Science China Chemistry 2021年第9期64卷 1586-1595页

作者： Ling Zhou Xiaorong Zhu Hui Su Hongzhen Lin Yanhong Lyu Xu Zhao Chen Chen Nana Zhang Chao Xie Yingying Li Yuxuan lu Jianyun Zheng Benrt Johannessen san Ping Jiang Qinghua Liu Yafei Li Yuqin Zou Shuangyin Wang State Key Laboratory of Chem/Bio-Sensing and Chemometrics Provincial Hunan Key Laboratory for Graphene Materials and DevicesCollege of Chemistry and Chemical Engineeringthe National Supercomputer Centers in ChangshaHunan UniversityChangsha410082China College of Chemistry and Materials Science Nanjing Normal UniversityNanjing210023China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei230026China i-LAB Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou215123China Department of Educational Science Hunan First Normal UniversityChangsha410205China Australian Synchrotron ClaytonVictoria3168Australia Western Australian School of Mines:Minerals Energy and Chemical Engineering and Fuels and Energy Technology InstituteCurtin UniversityPerthWA6102Australia

Electrochemical hydrogenation(ECH)of biomass-derived platform molecules is a burgeoning route for the sustainable utilization of ***,the noble-metal-catalyzed ECH of phenolic compounds suffers from intense competition with hydrogen evolution *** prepared Pt Rh bimetallic nanoparticles dispersed on highly ordered mesoporous carbon nanospheres,which improves the utilization efficiency of adsorbed hydrogen(H_(ad))to ECH in H-UPD region(>0 V ***).Further analysis reveals(i)the strong overlapping between the d-orbitals of Pt and Rh enhances specific adsorption of phenol;(ii)incorporation of Rh devotes an electronic effect on weakening the alloy-H_(ad)interaction to increase the FE of *** calculations confirm the selectivity difference and the ECH parallel pathways:cyclohexanol and cyclohexanone are formed via hydrogenation/dehydrogenation of the intermediate ^(*)C_(6)H_(10) *** findings deepen our fundamental understanding of the ECH process,and cast new light on exploration of highly efficient electrocatalysts for biomass upgrading.

关键词： electrohydrogenation aromatic hydrogenation biomass conversion Pt Rh alloy

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高效液相色谱-串联质谱法同时测定动物源性食品中全氟辛烷磺酸和全氟辛酸含量

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食品安全质量检测学报 2024年第10期15卷 217-223页

作者：张娇娇李璐涵柏明华惠利娜冯晖王三保许育民河南省食品工业科学研究所有限公司郑州450000 河南省信阳市鸡公山酒业有限公司信阳464000

目的建立一种同时测定动物源性食品中全氟辛烷磺酸(perfluorooctane sulfonate,PFOS)和全氟辛酸(perfluorooctanoic acid,PFOA)含量的高效液相色谱-串联质谱法的分析方法。方法从前处理过程和色谱条件两个方面进行优化,在不使用价格昂... 详细信息

目的建立一种同时测定动物源性食品中全氟辛烷磺酸(perfluorooctane sulfonate,PFOS)和全氟辛酸(perfluorooctanoic acid,PFOA)含量的高效液相色谱-串联质谱法的分析方法。方法从前处理过程和色谱条件两个方面进行优化,在不使用价格昂贵的同位素内标的情况下提取样品,流动相为0.05%甲酸-5mmol/L甲酸铵水溶液和甲醇,采用多反应监测模式进行分析检测,外标法定量。结果PFOS和PFOA含量在0.1~60.0ng/m L范围内线性良好,相关系数均大于0.997,PFOS和PFOA定量限分别为0.1μg/kg、0.01μg/kg,样品加标回收率在85%~110%之间,相对标准偏差均小于10%。该方法适用于检测国家认监委组织的CNCA-23-03(2023)能力验证样品,能力验证结果为满意。结论本方法前处理简单,且不使用价格昂贵的同位素内标,回收率高,精密度好,色谱峰分离效果佳,适用于动物源性食品中PFOS和PFOA的检测。

关键词：全氟辛烷磺酸全氟辛酸同位素内标高效液相色谱-串联质谱法

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Role of Fas/FasL Pathway-mediated Alveolar Macrophages Releasing Inflammatory Cytokines in Human Silicosis

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Biomedical and Environmental Sciences 2013年第11期26卷 930-933页

作者： YAO san Qiao HE Qin Cheng YUAN Ju Xiang CHEN Jie CHEN Gang lu Yao BAI Yu Ping ZHANG Chun Min YUAN Yang XU Ying Jun Department of Occupational and Environmental Health School of Public Health Hebei Union University Division of Pneumoconiosis School of Public Health China Medical University Department of Pneumoconiosis Beidaihe Sanitarium for China Coal Miners Department of Community Medicine Tangshan Workers’ Hospital

The role of Fas/Fas ligand （FasL） in mediating alveolar macrophage （AM）-derived inflammatory cytokines in 29 human lung silicosis patients and 6 controls was studied. It showed that the serum levels of IL-1β, TNF-a, IL-8, MIP-la, MCP-1, and TGF-β1 were higher in silicosis patients than in controls, and increased with the progression of silicosis except TGF-β1 and IL-8. TGF-β1, IL-8, MCP-1,

关键词： FasL AM

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Effects of Incretin-based Therapies on Weight-related Indicators among Patients with Type 2 Diabetes: A Network Meta-analysis

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Biomedical and Environmental Sciences 2020年第1期33卷 37-47页

作者： XU lu YU Shu Qing GAO Le HUANG Yi WU Shan Shan YANG Jun SUN Yi Xin YANG Zhi Rong CHAI san Bao ZHANG Yuan JI Li Nong SUN Feng ZHAN Si Yan Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Mathematics and Statistics University of Maryland Baltimore CountyBaltimore MD 21250MarylandUSA National Clinical Research Center of Digestive Diseases Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China The Primary Care Unit School of Clinical MedicineUniversity of CambridgeCambridge CB21TNUK Department of Endocrinology and Metabolism Peking University International HospitalBeijing 102206China Department of Clinical Epidemiology and Biostatistics McMaster UniversityHamilton L8S 4L8OntarioCanada Department of Endocrinology and Metabolism Peking University People’s HospitalBeijing 100044China

Objective To evaluate the effects of incretin-based therapies on body weight as the primary outcome,as well as on body mass index(BMI)and waist circumference(WC)as secondary *** Databases including Medline,Embase,the Cochrane Library,and ***(***)were searched for randomized controlled trials(RCTs).Standard pairwise meta-analysis and network meta-analysis(NMA)were both carried *** risk of bias(ROB)tool recommended by the Cochrane handbook was used to assess the quality of *** analysis,sensitivity analysis,meta-regression,and quality evaluation based on the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)were also *** A total of 292 trials were included in this *** with placebo,dipeptidyl-peptidase IV inhibitors(DPP-4 Is)increased weight slightly by 0.31 kg[95%confidence interval(CI):0.05,0.58]and had negligible effects on BMI and *** with placebo,glucagon-like peptide-1 receptor agonists(GLP-1 RAs)lowered weight,BMI,and WC by-1.34 kg(95%CI:-1.60,-1.09),-1.10 kg/m2(95%CI:-1.42,-0.78),and-1.28 cm(95%CI:-1.69,-0.86),*** GLP-1 RAs were more effective than DPP-4 Is in lowering the three ***,the effects of GLP-1 RAs on weight,BMI,and WC were favorable.

关键词： Body mass index Body weight Diabetes mellitus Dipeptidyl-peptidase IV inhibitors Glucagon-like peptide-1 receptor agonists Network meta-analysis Waist circumference

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Drug-coated balloons for the treatment of ostial left anterior descending or ostial left circumflex artery lesions:a patientlevel propensity score-matched analysis

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Journal of Geriatric Cardiology 2023年第10期20卷 716-727,I0001-I0005页

作者： Liang PAN Wen-Jie lu Zhan-Ying HAN san-Cong PAN Xi WANG Ying-Guang SHAN Meng PENG Xiao-Fei QIN Guo-Ju SUN Pei-Sheng ZHANG Jian-Zeng DONG Chun-Guang QIU Department of Cardiovascular Medicine the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Cardiology Jincheng People’s HospitalJinchengChina Department of Cardiology the Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

BACKGROUND Controversy exists as to the optimal treatment approach for ostial left anterior descending(LAD)or ostial left circumflex artery(LCx)***-coated balloons(DCB)may overcome some of the limitations of drug-eluting stents(DES).Therefore,we investigated the security and feasibility of the DCB policy in patients with ostial LAD or ostial LCx lesions,and compared it with the conventional DES-only *** We retrospectively enrolled patients with de novo ostial lesions in the LAD or LCx who underwent interventional *** were categorized into two groups based on their treatment approach:the DCB group and the DES *** treatment strategies in the DCB group involved the use of either DCB-only or hybrid strategies,whereas the DES group utilized crossover or precise stenting ***-year target lesion revascularization was the primary endpoint,while the rates of major adverse cardiovascular events,cardiac death,target vessel myocardial infarction,and vessel thrombosis were the secondary *** propensity score matching,we assembled a cohort with comparable baseline *** ensure result analysis reliability,we conducted sensitivity analyses,including interaction,and stratified *** Among the 397 eligible patients,6.25%of patients who were planned to undergo DCB underwent DES.A total of 108 patients in each group had comparable propensity scores and were included in the ***-year target lesion revascularization occurred in 5 patients(4.90%)and 16 patients(16.33%)in the DCB group and the DES group,respectively(odds ratio=0.264,95%CI:0.093–0.752,P=0.008).Compared with the DES group,the DCB group demonstrated a lower major adverse cardiovascular events rate(7.84%vs.19.39%,P=0.017).However,differences with regard to cardiac death,non-periprocedural target vessel myocardial infarction,and definite or probable vessel thrombosis between the groups were *** The utilization of

关键词： lesions balloon treatment

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云南勐海地区1∶5万水系沉积物地球化学特征及找矿预测

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地质与资源 2024年第2期33卷 169-177,168页

作者：卢文姬孔祥超张永三蓝信杰王明波付世兴张其凯中国冶金地质总局山东正元地质勘查院山东济南250000 山东省第三地质矿产勘查院山东烟台264000

勐海地区处于临沧-勐海(岩浆弧)Fe-Pb-Zn-Au-Ag-Sn-Sb-Ge-REE矿带,具有较好的找矿前景.在勐海地区1∶5万水系沉积物测量基础上,对区内29种元素分布特征、元素相关性、地球化学参数特征研究,圈定了5个组合异常和13个综合异常.其中,Ce-La-... 详细信息

勐海地区处于临沧-勐海(岩浆弧)Fe-Pb-Zn-Au-Ag-Sn-Sb-Ge-REE矿带,具有较好的找矿前景.在勐海地区1∶5万水系沉积物测量基础上,对区内29种元素分布特征、元素相关性、地球化学参数特征研究,圈定了5个组合异常和13个综合异常.其中,Ce-La-Y-Zr综合异常具有较好找矿前景;Au、As、Sb、Hg、W、P等元素离散程度较高,元素局部较富集,具有成矿的可能性.结合水系沉积物测量成果,圈定找矿远景区2处,为下一步找矿工作提供了地球化学依据.

关键词：水系沉积物地球化学异常稀土元素云南省

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QTL Analysis of Some Agronomic Traits in Rice Under Different Growing Environments

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Agricultural Sciences in China 2006年第1期5卷 15-22页

作者： HAN Long-zhi QIAO Yong-li ZHANG san-yuan CAO Gui-lan YE Chang-rong XU Fu-rong DAI lu-yuan YeJong-doo Koh Hee-jong Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China School of Plant Science College of Agriculture and Life Science Seoul National University Seoul 151-921 Korea Institute of Rice Research Jilin Academy of Agricultural Sciences Gongzhuling 136100 P.R.China Institute of Biotechnology and Germplasm Research Yunnan Academy of Agricultural Sciences Kunming 650205 P.R.China National Crop Experiment Station Rural Development Administration Suwon 441-857 Korea

The culm length, panicle length, spikelets per panicle and panicle exsertion were evaluated by using F2：3 population including 200 lines derived from the cross of indica and japonica Milyang 23/Jileng 1 under five different environments of Beijing （natural normal growing environment）, Kunming （natural cold environment）, Gongzhuling of China （cold water irrigation） and Chuncheon of Korea （natural normal growing environment and cold water irrigation）, and QTLs of these traits were analyzed by using SSR markers. The results showed that 44 QTLs related to these agronomic traits were detected under five different growing environments, and these QTLs have been located on 11 chromosomes except chromosome 9. The QTLs for qCLla, qCL1b, qCL5a, qCL6b, qPLla, qPL3a, qPL6b, qPL6c, qPL7b, qSP8b, qSPlc, qSP11a, qSP12, and qPE1 have been detected under more than two growing environments, and those that were little affected by environments, were stable QTLs. Among them, qCLla, qCLlb, qPLla, qSPlc, and qPE1 explained 24.2-55.2%, 22.7-39.9%, 12.5-27.7%, 14.4-33.5%, and 26.6-28.7% of observed phynotypic variation, respectively, which were major genes mainly appearing as overdominance. These QTLs cause the increase in action to culm length, panicle length, spikelets per panicle, and panicle exsertion under cold environment, showing that these QTLs were correlated with cold tolerance.

关键词： rice different growing environments agronomic traits QTLs

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