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Fulminant myocarditis induced by SARS-CoV-2 infection without severe lung involvement:insights into COvID-19 pathogenesis

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Journal of Genetics and Genomics 2024年第6期51卷 608-616页

作者： Han Du Zhongtao Du Liang Wang Hong Wang Mingjun Jia Chunge Zhang Yun Liu Cheng Zhang Ya Zhang Ruifeng Zhang shuang Zhang Ning Zhang Zhenghai Ma Chen Chen Wenjun Liu Hui Zeng George F.gao Xiaotong Hou Yuhai Bi College of Life Science and Technology Xinjiang UniversityUrumchiXinjiang 830046China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China Beijing Anzhen Hospital Capital Medical UniversityBeijing 100029China College of Veterinary Medicine Shanxi Agricultural UniversityTaiyuanShanxi 030031China University of Chinese Academy of Sciences Beijing 100049China Beijing Shijitan Hospital Capital Medical UniversityBeijing 100038China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection often leads to pulmonary *** sequelae,including myocarditis and heart failure,have also been ***,the study presents two fulminant myocarditis cases infected by SARS-CoV-2 exhibiting remarkable elevation of cardiac biomarkers without significant pulmonary injury,as determined by imaging *** staining reveals the viral antigen within cardiomyocytes,indicating that SARSCoV-2 could directly infect the *** full viral genomes from respiratory,anal,and myocardial specimens are obtained via next-generation *** analyses of the whole genome and spike gene indicate that viruses in the myocardium/pericardial effusion and anal swabs are closely related and cluster together yet diverge from those in the respiratory *** addition,unique mutations are found in the anal/myocardial strains compared to the respiratory strains,suggesting tissue-specific virus mutation and *** findings indicate genetically distinct SARS-CoV-2 variants have infiltrated and disseminated within myocardial tissues,independent of pulmonary injury,and point to different infection routes between the myocardium and respiratory tract,with myocardial infections potentially arising from intestinal *** findings highlight the potential for systemic SARS-CoV-2 infection and the importance of a thorough multi-organ assessment in patients for a comprehensive understanding of thepathogenesisof COVID-19.

关键词： COVID-19 SARS-CoV-2 Fulminant myocarditis Myocardium Infection

基于分子链演化的NEPE推进剂基体超弹本构模型

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含能材料 2024年第5期32卷 518-527页

作者：刘俊梁爽刘向阳郜婕华中科技大学航空航天学院湖北武汉430070 北京理工大学宇航学院北京100081 中国航天科技集团有限公司四院四十一所陕西西安710025

为了揭示硝酸酯增塑聚醚(NEPE)推进剂基体内高分子链结构演化与超弹性力学行为间的构效关系,采用多尺度方法,对复杂变形状态下NEPE推进剂基体内的高分子链演化过程及其表征模型进行了研究。首先,在基体黏合剂、固化剂和增塑剂等组分微... 详细信息

为了揭示硝酸酯增塑聚醚(NEPE)推进剂基体内高分子链结构演化与超弹性力学行为间的构效关系,采用多尺度方法,对复杂变形状态下NEPE推进剂基体内的高分子链演化过程及其表征模型进行了研究。首先,在基体黏合剂、固化剂和增塑剂等组分微观模型的基础上,通过对基体体系的分子动力学模拟,发展了描述复杂变形状态下交联链和自由链构形演化的动力学模型。随后,基于统计力学理论对系统自由能中交联链和自由链演化的贡献进行了定量表征,并建立了考虑高分子链交联、缠结效应的超弹本构模型。最后,结合NEPE推进剂基体胶片准静态拉伸实验数据对本构模型进行了验证。结果表明,相较于经典Arruda-Boyce超弹本构模型,基于物理机制的本构模型中本构参数具有真实的物理意义,可以通过物化实验进行参数标定,能较好地预测复杂变形状态下的基体超弹性行为,从而为推进剂基体力学性能的调控和组分优化提供模型支持。

关键词：推进剂基体超弹性本构模型物理机制分子动力学高分子链密度

Current status of nerve infiltration by skip metastases in colorectal cancer

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Oncology and Translational Medicine 2024年第3期10卷 126-131页

作者： Jie Zhou Yan-Wei gao Ya-Dong Ji Ri-Na Su shuang Zhang Ze-He Li Inner Mongolia Medical University Hohhot 010000Inner MongoliaChina Abdominal Tumor Surgery Inner Mongolia Autonomous Region People’s HospitalHohhot 010017Inner MongoliaChina Baotou Medical College Baotou 014000Inner MongoliaChina Gastroenterology Department Arongqi People’s HospitalHulun Buir 021000Inner MongoliaChina

Colorectal cancer(CRC)is a prevalent malignant tumor,with the global new cases reaching 1.9316 million and deaths reaching 935,200 in *** China,therewere 555,500 new cases of CRC,with an age-standardized incidence rate of 24.07 per 10million,and 286,200 *** accounts for approximately 30%of new cases and deaths from CRC worldwide,with East Asia accounting for over 75%.Initially,CRC presents as local tumor growth,but it has the potential to spread to other body parts over *** infiltration(PNI)is a relatively less discussed route of diffusion,yet it plays a crucial role in the progression and prognosis of *** often occurs alongside local lymph nodes and distant metastases,posing challenges for treatment and *** symptoms,radiographic findings,and histopathological examination can be used to diagnose PNI with *** commonly include local pain,paresthesia,andmotor *** helps identify the mass’s location and relationship to nerves,whereas histopathological examination confirms the *** of PNI skipmetastases is similar to other CRC metastases,including surgical resection,chemotherapy,radiotherapy,and targeted *** resection is the primary therapeutic approach,but the wider range of metastasis in PNI skip transfer may limit its *** cases where surgical resection is not possible,chemotherapy,radiotherapy,and targeted therapy are used to control tumor *** conclusion,PNI skip metastases increase the risk of poor prognosis for CRC,requiring a comprehensive approach with multiple treatments to prevent disease *** detection and treatment are vital to improving prognosis.

关键词： Neve invasion in colorectal Skip metastases Perineural infiltration

静电纺丝紫苏醛/甲基-β-环糊精包合物纳米纤维的制备与表征

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精细化工 2024年第4期41卷 820-828页

作者：张杨李晓明胡芬高爽东北农业大学文理学院黑龙江哈尔滨150030

为提高紫苏醛(PA)的热稳定性和水溶性,扩展其应用,以甲基-β-环糊精(MβCD)为主体分子,PA为客体分子,通过静电纺丝技术制备了PA/MβCD包合物(PA/MβCD-IC)纳米纤维(PA/MβCD-IC-NF)。采用SEM、1HNMR、XRD、TGA、FTIR和分子模拟对PA/MβC... 详细信息

为提高紫苏醛(PA)的热稳定性和水溶性,扩展其应用,以甲基-β-环糊精(MβCD)为主体分子,PA为客体分子,通过静电纺丝技术制备了PA/MβCD包合物(PA/MβCD-IC)纳米纤维(PA/MβCD-IC-NF)。采用SEM、1HNMR、XRD、TGA、FTIR和分子模拟对PA/MβCD-IC-NF进行了表征和分析,测试了其相溶解度,评价了其抗氧化活性和抑菌性能。结果表明,PA已被成功地包裹在MβCD空腔中,形成PA/MβCD包合物;PA/MβCD-IC-NF为非晶体结构,直径分布较均匀且表面光滑,平均直径为(134±60)nm。质量浓度为12 g/L的PA/MβCD-IC-NF(2 cm×2 cm)在1 s内可完全溶解。与PA相比,PA/MβCD-IC-NF中PA的热稳定性和水溶性都显著提高。PA/MβCD-IC-NF的抗氧化活性明显高于PA,对大肠杆菌与金黄色葡萄球菌的抑制率分别为96.2%±0.1%和94.0%±0.3%。

关键词：静电纺丝紫苏醛甲基-β-环糊精包合物纳米纤维功能材料

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远程康复对学龄前功能性构音障碍儿童的疗效分析

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中国儿童保健杂志 2024年第2期32卷 223-227页

作者：贾玉凤李阳张双高淑芝高静云李爽唐山市妇幼保健院儿童康复科河北唐山063000

目的观察远程康复方案对学龄前功能性构音障碍(FAD)儿童构音清晰度的影响,为远程康复在学龄前FAD儿童中的应用提供临床实践参考。方法选取2022年3月—2023年3月在唐山市妇幼保健院儿童康复科门诊就诊并诊断为FAD的学龄前儿童66例,采用... 详细信息

目的观察远程康复方案对学龄前功能性构音障碍(FAD)儿童构音清晰度的影响,为远程康复在学龄前FAD儿童中的应用提供临床实践参考。方法选取2022年3月—2023年3月在唐山市妇幼保健院儿童康复科门诊就诊并诊断为FAD的学龄前儿童66例,采用随机数字表法分为远程康复组(n=32)和对照组(n=34),对照组给予常规家庭康复指导,远程康复组应用远程康复方案,治疗时间为3个月。所有儿童分别在治疗前和治疗3个月后采用汉语构音能力评定词表进行评定。结果治疗3个月后,远程康复组和对照组儿童构音清晰度均较治疗前显著改善(t=12.165、12.986,P0.05)。结论远程康复方案可以改善学龄前FAD儿童的构音清晰度,尤其适用于轻中度学龄前FAD儿童。

关键词：功能性构音障碍学龄前儿童远程康复言语治疗

Predicting the Mechanical Behavior of a Bioinspired Nanocomposite through Machine Learning

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1299-1313页

作者： Xingzi Yang Wei gao Xiaodu Wang Xiaowei Zeng Department of Mechanical Engineering University of Texas at San AntonioSan AntonioTX78249USA Department of Mechanical Engineering Texas A&M UniversityCollege StationTX77843USA

The bioinspired nacre or bone structure represents a remarkable example of tough,strong,lightweight,and multifunctional structures in biological materials that can be an inspiration to design bioinspired high-performance *** bioinspired structure consists of hard grains and soft material *** the material interface has a very low volume percentage,its property has the ability to determine the bulk material *** learning technology nowadays is widely used in material science.A machine learning model was utilized to predict the material response based on the material interface properties in a bioinspired *** model was trained on a comprehensive dataset of material response and interface properties,allowing it to make accurate *** results of this study demonstrate the efficiency and high accuracy of the machine learning *** successful application of machine learning into the material property prediction process has the potential to greatly enhance both the efficiency and accuracy of the material design process.

关键词： Bioinspired nanocomposite computational model machine learning finite element material interface

人胚胎来源细胞在生物医药领域的应用历史及研究和监管进展

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中国科学院院刊 2024年第2期39卷 388-396页

作者：高建超彭耀进韦薇鲁爽高晨燕国家药品监督管理局药品审评中心北京100022 中国科学院动物研究所北京100101 中国科学院大学北京100049 北京干细胞与再生医学研究院北京100101

自20世纪60年代人类首次利用流产胎儿组织建立人二倍体细胞系(HDCs)以来,人胚胎来源的细胞就被广泛应用于生物医学研究领域,为提高人类健康水平作出了重大贡献。近年来,包括人胚干细胞在内的人多能干细胞在再生医学领域展现出巨大的治... 详细信息

自20世纪60年代人类首次利用流产胎儿组织建立人二倍体细胞系(HDCs)以来,人胚胎来源的细胞就被广泛应用于生物医学研究领域,为提高人类健康水平作出了重大贡献。近年来,包括人胚干细胞在内的人多能干细胞在再生医学领域展现出巨大的治疗潜力,并受到各国政府和社会公众的高度关注。同时,由于历史文化、宗教信仰、伦理道德等多方面的因素,人胚胎来源细胞的研究和应用一直存在较大争议。文章通过介绍人胚胎来源细胞在生物医药领域研究应用的历史和进展,探究不同国家监管制度的演进,以期为完善我国对该领域的监管框架和技术要求提供有益参考。

关键词：人胚胎来源细胞人胚干细胞伦理监管

GRB 210610B:The Internal and External Plateau as Evidence for the Delayed Outflow of Magnetar

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Research in Astronomy and Astrophysics 2024年第7期24卷 170-180页

作者： Yi-Ning Wei Xiang-gao Wang Da-Bin Lin Wei-Kang Zheng Liang-Jun Chen Sheng-Yu Yan shuang-Xi Yi Qi Wang Zi-Min Zhou Hui-Ya Liu En-Wei Liang Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China GXU-NAOC Center for Astrophysics and Space Sciences Nanning 530004China Department of Astronomy University of CaliforniaBerkeleyCA 94720-3411USA Department of Physics and Tsinghua Center for Astrophysics(THCA) Tsinghua UniversityBeijing 100084China School of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China

After launching a jet,outflows of magnetar were used to account for the achromatic plateau of afterglow and the early X-ray flux plateau known as“internal plateau”.The lack of detecting magnetic dipole emission together with the energy injection feature in a single observation poses confusion until the long gamma-ray burst(GRB)210610B is *** 210610B is presented with an optical bump following an early X-ray plateau during the afterglow *** plateau followed by a steep decline flux overlays in the steadily decaying X-ray flux with indexα_(X,1)~2.06,indicating an internal origin and that can be fitted by the spin-down luminosity law with the initial plateau luminosity log_(10)L_(X)~48.29 erg s~(-1)and the characteristic spin-down timescale T~2818 s.A subsequent bump begins at~4000 s in the R band with a rising indexα_(R,1)~-0.30 and peaks at~14125 s,after which a decay indexα_(R,2)~0.87 and finally transiting to a steep decay withα_(R,3)~1.77 achieve the closure relation of the external shock for the normal decay phase as well as the magnetar spin-down energy injection phase,provided that the average value of the photon indexΓ_γ=1.80 derived from the spectral energy distributions(SEDs)between the X-ray and optical *** closure relation also works for the late X-ray *** to the traditional picture of GRB,the outflow powers the early X-ray plateau by dissipating energy internally and collides with the leading decelerating blast burst as time goes on,which could interpret the exotic feature of GRB *** carry out a Markov Chain Monte Carlo simulation and obtain a set of best parameters:■.The artificial light curve can fit the afterglow data *** that,we estimated the average Lorentz factor and the X-ray radiation efficiency of the later ejecta are 35%and 0.13%,respectively.

关键词： (stars)gamma-ray burst individual(GRB 210610B)-(stars)gamma-ray burst general-stars jets

全球视角下中国城镇化进程及其碳排放效应的比较研究

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地理科学 2024年第2期44卷 204-215页

作者：高爽王少剑莫惠斌中山大学地理科学与规划学院广东省城市化与地理环境空间模拟重点实验室广东广州510006 武汉大学城市设计学院湖北武汉430072

高质量的城镇化发展模式是中国实现现代化和低碳绿色发展转型的关键。本文利用1990―2020年世界195个国家(地区)的面板数据,从人口、空间、经济、社会4个维度测度各个国家(地区)的综合城镇化水平,并基于STIRPAT模型和EKC理论对比分析中... 详细信息

高质量的城镇化发展模式是中国实现现代化和低碳绿色发展转型的关键。本文利用1990―2020年世界195个国家(地区)的面板数据,从人口、空间、经济、社会4个维度测度各个国家(地区)的综合城镇化水平,并基于STIRPAT模型和EKC理论对比分析中国及不同收入群体国家城镇化对碳排放的影响机制。研究结果表明:①世界各国(地区)的综合城镇化水平整体呈现出增长的趋势,其中亚洲和欧洲地区的提升最为明显,中国的综合城镇化水平则呈现出起步低、速度快的发展趋势。②世界各国(地区)的城镇化发展质量正在稳步提升,综合城镇化的发展质量与区域的发展阶段具有密切的相关性,高收入国家(地区)的城镇化发展主要是由经济城镇化和社会城镇化主导的,而低收入国家(地区)城镇化的主导类型则是人口城镇化和空间城镇化,中国的城镇化进程逐渐从以城镇人口带动的“量”转变为协调发展的“质”,但仍与发达国家存在较大差距。③高收入、高城镇化和低收入国家(地区)综合城镇化与人均碳排放上存在“倒U型”曲线关系,中低收入、中高城镇化和低城镇化国家(地区)存在“U型”曲线关系,目前中国还处于人均碳排放随着综合城镇化水平的提升而上升的阶段,“倒U”曲线拐点还未出现,推动经济城镇化和社会城镇化水平的提升则是实现碳达峰的关键。因此,未来中国需要协调城镇化发展、居民生活水平提升和节能减排之间的关系,在提高城镇化质量的同时降低城镇化对碳排放的贡献。

关键词：综合城镇化人均碳排放国际比较低碳发展中国