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Factors influencing intercellular spaces in the rat esophageal epithelium

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World Journal of Gastroenterology 2010年第9期16卷 1063-1069页

作者： Dong-Hong Zhang,Li-Ya Zhou,Xiu-Yun Dong,Rong-Li Cui,Yan Xue,san-ren lin,Department of Gastroenterology,Peking University Third Hospital,Beijing 100191,China Department of Gastroenterology Peking University Third Hospital No. 49 Huayuanbei Road Beijing 100191 China. liyazhou@***

AIM:To evaluate the effect of acute stress,hydrochloric acid,ethanol,aspirin,and prednisolone on the intercellular spaces of the esophageal ***:Part -RESULTS:(1) The f ive damaging factors produced no lesions or inflammation in esophageal mucosa of rats under either gross or routine histological *** epithelial intercellular space diameters in stress and aspirin groups were significantly greater,nearly three or two-fold respectively,than those in their corresponding control groups (stress model:0.38 ± 0.05 μm vs 0.13 ± 0.02 μm,P 0.05;ethanol model:0.25 ± 0.10 μm vs 0.19 ± 0.05 μm,P > 0.05;prednisolone model:0.20 ± 0.03 μm vs 0.14 ± 0.03 μm,P > 0.05);and (2) No significant difference in the intercellular space diameters was observed between the group pretreated with esomeprazole and the control group,in both the stress and aspirin models (stress model:0.35 ± 0.05 μm vs 0.37 ± 0.05 μm,P > 0.05;aspirin model:0.24 ± 0.02 μm vs 0.27 ± 0.03 μm,P > 0.05).CONCLUSION:Acute stress and aspirin can induce DIS of the esophageal epithelium in rats,and it is not correlated with acid reflux.

关键词： Esophagus Dilated intercellular spaces Stress,acute Aspirin Reflux,acid

A randomized,double-blind,placebo-controlled trial assessing the efficacy and safety of tegaserod in patients from China with chronic constipation

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World Journal of Gastroenterology 2007年第5期13卷 732-739页

作者： san-ren lin Mei-Yun Ke Jin-Yan Luo Yao-Zong Yuan Ji-Yao Wang Shelley diTommaso Verena Walter Jiaqing Huang The 3rd Hospital Beijing Medical University Beijing China Peking Union Medical College Hospital BeijingChina The 2nd Hospital of Xian Jiaotong University Shanxi China Shanghai Ruijin Hospital Shanghai China Shanghai Zhongshan Hospital Shanghai China Novartis Pharma AG Basel Switzerland Novartis Pharmaceuticals Corp East HanoverNew Jersey United States

AIM： To evaluate the efficacy and safety of tegaserod, 6 mg twice daily （b.i.d.）, in men and women with chronic constipation （CC） from China. METHODS： This was a multicenter, double-blind, placebo-controlled study. Following a 2-wk treatmentfree baseline period, patients were randomized to receive either tegaserod （6 mg b.i.d.） or placebo （b.i.d.） for 4 wk. An analysis of covariance with repeated measures was used to determine the overall effect of treatment for the primary efficacy variable; the change from baseline in the number of complete spontaneous bowel movements （CSBMs） during the 4-wk treatment period. Secondary efficacy endpoints included other measures of response in terms of CSBMs, and patients＇ daily and weekly assessment of bowel habits. Safety was also assessed, based on the incidence and severity of adverse events （AEs）. RESULTS： A total of 607 patients were randomized to receive either tegaserod （n = 304） or placebo （n = 303）. Tegaserod treatment resulted in a rapid and significant increase from baseline in the adjusted mean number of CSBMs per week over wk 1-4 compared with placebo （1.39 vs 0.91, P = 0.0002）. A statistically significant difference in favor of tegaserod was also observed for a mean increase ≥ 1 CSBM/wk over wk 1-4 （47.7% vs 35.0%, tegaserod vs placebo, respectively, P = 0.0018） and for the absolute number of≥ 3 CSBMs/wk over wk 1-4 （25.0% vs 14.5%, tegaserod vs placebo, respectively, P = 0.0021）. Improvements in other symptoms of CC were also seen in the tegaserod group, including improved stool form and reduced straining. In addition, more patients in the tegaserod group reported satisfactory relief from their constipation symptoms. The frequency and severity of AEs was comparable between tegaserod and placebo groups, with the exception of a greater incidence of diarrhea in patients receiving tegaserod （3.6%） compared with placebo （1.7%）. CONCLUSION： Tecjaserod treatment improved multiple symptoms of CC and was associated with a fa

关键词： Chronic constipation tegaserod China Complete spontaneous bowel movement Placebocontrolled Stool

Eradication of H pylori infection in a rural population: One-day quadruple therapy versus 7-day triple therapy

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World Journal of Gastroenterology 2006年第24期12卷 3915-3918页

作者： Lian Zhang lin Shen Jun-ling Ma Kai-Feng Pan Wei-Dong Liu Jie Li Shu-Dong Xiao san-ren lin Meinhard Classen Wei-Cheng You Department of Cancer Epidemiology Peking University School of Oncology Beijing Cancer Hospital and Institute Beijing 100036 China Department of Internal Medicine PekingUniversity School of Oncology Beijing Cancer Hospital and Institute Beijing 100036 China linqu Public Health Bureau Linqu Shandong 262600 China Shanghai Institute for Digestive Disease Shanghai China The Third Hospital of Peking University Beijing China Technical University Munich Germany

AIM： To compare the one-day quadruple therapy with a standard 7-d triple therapy for H pylori eradication in a rural population of China. METHODS： A total of 396 patients with 13C-urea breath test positive for H pylori were assigned into two groups： 239 patients received one-day quadruple therapy （amoxicillin 2000 mg qid; metronidazole 500 mg qid; bismuth citrate 900 mg qid and lansoprazole 60 mg once daily） and 157 patients received 7-d standard triple therapy （amoxicillin 1000 mg bid; clarithromycin 500 mg bid and lansoprazole 30 mg bid）. All the patients underwent a 13C-UBT to assess the eradication of Hpylori infection six weeks after treatment. RESULTS： Two hundred and twenty-nine patients completed the one-day therapy （95.8%） and 148 patients completed the 7-d therapy （94.2%）. The oneday therapy eradicated H pylori infection in 64 patients （27.95%）. In contrast, 103 patients （69.59%） were Hpylori negative after the 7-d therapy （P 〈 0.01）. CONCLUSION： This pilot study suggests there is no beneficial effect of the one-day therapy in treatment ofHpylori infection compared with the 7-d standard therapy.

关键词： Eradication H pylori infection Quadrupletherapy Triple therapy

Effect of Heficobacter pylori Eradication on Reflux Esophagitis Therapy： A Multi-center Randomized Control Study

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Chinese Medical Journal 2015年第8期128卷 995-999页

作者： Yan Xue Li-Ya Zhou san-ren lin Xiao-Hua HOU Zhao-Shen Li Min-Hu Chen Xiu-E Yan ling-Mei Meng Jing Zhang Jing-Jing Lu Department of Gastroenterology Peking University Third Hospital Beijing 100191 China Department of Gastroenterology Wuhan Union Hospital Tongji Medical College Huazhong University of Science and Technology Huhan Hubei 430022 China Department of Gastroenterology Shanghai Changhai Hospital Shanghai 200433 China Department of Gastroenterology The First Affiliated Hospital Sun Yat-Sen University Guangzhou Guangdong 510080 China

Background： Helicohacterpylori （H. pylori） frequently colonizes the stomach. Gastroesophageal reflux disease （GERD） is a common and costly disease. But the relationship ofH. pylori and GERD is still unclear. This study aimed to explore the effect ofH. *** and its eradication on reflux esophagitis therapy. Methods： Patients diagnosed with reflux esophagitis by endoscopy were enrolled; based on rapid urease test and Warth-Starry stain, they were divided into H. pylori positive and negative groups. H. pylori positive patients were randomly given H. pylori eradication treatment for 10 days, then esomeprazole 20 mg bid for 46 days. The other patients received esomeprazole 20 mg bid therapy for 8 weeks. After treatment, three patient groups were obtained： H. pylori positive eradicated, H. pylori positive uneradicated, and H. pylori negative. Before and after therapy, reflux symptoms were scored and compared. Healing rates were compared among groups. The x2 test and t-test were used, respectively, for enumeration and measurement data. Results： There were 176 H. pylori positive （with 92 eradication cases） and 180 negative cases. Healing rates in the H. pylori positive eradicated and H. pylori positive uneradicated groups reached 80.4% and 79.8% （P = 0.911）, with reflux symptom scores of 0.22 and 0.14 （P = 0.588）. Healing rates of esophagitis in the 14. pylori positive uneradicated and H. pylori negative groups were, respectively, 79.8% and 82.2% （P = 0.848）; reflux symptom scores were 0.14 and 0.21 （P = 0.546）. Conclusions： Based on esomeprazole therapy, H. pylori infection and eradication have no significant effect on reflux esophagitis therapy.

关键词： Gastroesophageal Reflux Disease Helicobacter pylori Reflux Esophagitis Therapy

Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He Jie Peng Qingyun lin Meng Li Weibin Chen Pei Liu Tao Huang Zhencheng Huang Yuying Liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong ren Xiaoping Ouyang Jianhong Liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

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反流性食管炎与幽门螺杆菌感染的关系

世界华人消化杂志 2008年第2期16卷 171-174页

作者：李渊周丽雅林三仁金珠崔荣丽何平平北京大学第三医院消化科北京市100083 北京大学医学部公共卫生学院流行病与生物统计教研室北京市100083

目的:研究反流性食管炎(reflux esophagitis,RE)患者幽门螺杆菌(H pylori)感染率,感染程度与定植部位及胃炎的活动度,并对比H pylori阳性与阴性的RE患者食管炎症的严章程度.方法:选取从2007-01/03在我科行胃镜检查证实的RE患者89例,按... 详细信息

目的:研究反流性食管炎(reflux esophagitis,RE)患者幽门螺杆菌(H pylori)感染率,感染程度与定植部位及胃炎的活动度,并对比H pylori阳性与阴性的RE患者食管炎症的严章程度.方法:选取从2007-01/03在我科行胃镜检查证实的RE患者89例,按年龄、性别进行配对的方式随机抽取无反流对照组89例,对比两组H pylori感染率,感染部位,感染程度的差异,并比较RE组中H pylori阳性与阴性患者食管炎症的严重程度.结果:RE组与对照组H pylori感染率无统计学差异(P=0.137),但RE组H pylori感染程度较对照组轻(P_(胃体)=0.024,P_(胃窦)=0.000),且RE组胃体炎症严重程度较对照组轻(P=0.001);H pylori阳性与阴性的RE患者发生洛杉矾(LA)C级分别占8.3%和18.5%,D级分别占4.2%和12.3%,但食管炎症的轻重程度无显著性差异(P=0.353).结论:H pylori的感染程度及胃体胃炎的活动性与RE的形成有负相关性.

关键词：幽门螺杆菌反流性食管炎胃炎

Sub-pixel high precision dimensional measurement method for aero-engine hollow turbine blade based on industrial computed tomography image

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China Foundry 2022年第4期19卷 307-320页

作者： Ya-nan Wang san-san Shuai Xing-fu ren Tong-tong Hu Jiang Wang Zhong-ming ren State Key Laboratory of Advanced Special Steel School of Materials Science and EngineeringShanghai UniversityShanghai 200444China

Aero-engine hollow turbine blades are work under prolonged high temperature,requiring high dimensional *** profile and wall thickness are important parameters to ensure the comprehensive performance of blades,which need to be measured accurately during manufacturing *** this study,a high accuracy industrial computed tomography(ICT)measuring method was developed based on standard cylindrical pin and ring workpieces of different *** ICT with cubic spline interpolation,a sub-pixel accuracy was achieved in measuring the dimension of *** with the traditional and whole-pixel level image measurement method,the cubic spline interpolation algorithm has the advantages of high accuracy in image edge detection and thus high accuracy of dimensional ***,the technique was employed to measure the profile and wall thickness of a typical aerospace engine turbine blade,and an accuracy higher than 0.015 mm was obtained.

关键词： dimensional accuracy industrial computed tomography cubic spline interpolation sub-pixel accuracy

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亚太地区胃食管反流病的处理共识:更新版

胃肠病学 2008年第7期13卷 421-436页

作者： Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann sanjay Nandurkar san ren lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 Changi General Hospital Mayo Clinic College of Medicine Rochester University of Arizona Health Sciences Center University of Malaya University of Sydney McMaster University Medical Center Tohoku University Hospital Royal Adelaide Hospital Monash University The Third Hospital Peking University Queen Mary Hospital Prince of Wales Hospital University of Indonesia Korea University College of Medicine University of santo Tomas National University Hospital Siriraj Hospital

背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,... 详细信息

背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。

关键词：共识糜烂性食管炎非糜烂性反流病

Globally Proper Saddle Point in Ic-Cone-Convexlike Set-Valued Optimization Problems

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Acta Mathematica Sinica,English Series 2009年第11期25卷 1921-1928页

作者： Guo lin YU san Yang LIU Institute of Information and Systems Science The North University for Ethnics Yinchuan 750021 P. R. China Department of Applied Mathematics Xidian University Xi'an 710071 P. R. China

The existence conditions of globally proper efficient points and a useful property of ic- cone-convexlike set-valued maps are obtained. Under the assumption of the ic-cone-convexlikeness, the optimality conditions for globally proper efficient solutions are established in terms of Lagrange multipliers. The new concept of globally proper saddle-point for an appropriate set-valued Lagrange map is introduced and used to characterize the globally proper efficient solutions. The results which are obtained in this paper are proven under the conditions that the ordering cone need not to have a nonempty interior.

关键词： set-valued map ic-cone-convexlikeness globally proper efficiency saddle point