Factors influencing intercellular spaces in the rat esophageal epithelium
Factors influencing intercellular spaces in the rat esophageal epithelium作者机构：Department of Gastroenterology Peking University Third Hospital No. 49 Huayuanbei Road Beijing 100191 China. liyazhou@***
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2010年第16卷第9期
页 面：1063-1069页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Esophagus Dilated intercellular spaces Stress,acute Aspirin Reflux,acid
摘 要：AIM:To evaluate the effect of acute stress,hydrochloric acid,ethanol,aspirin,and prednisolone on the intercellular spaces of the esophageal ***:Part -RESULTS:(1) The f ive damaging factors produced no lesions or inflammation in esophageal mucosa of rats under either gross or routine histological *** epithelial intercellular space diameters in stress and aspirin groups were significantly greater,nearly three or two-fold respectively,than those in their corresponding control groups (stress model:0.38 ± 0.05 μm vs 0.13 ± 0.02 μm,P 0.05;ethanol model:0.25 ± 0.10 μm vs 0.19 ± 0.05 μm,P 0.05;prednisolone model:0.20 ± 0.03 μm vs 0.14 ± 0.03 μm,P 0.05);and (2) No significant difference in the intercellular space diameters was observed between the group pretreated with esomeprazole and the control group,in both the stress and aspirin models (stress model:0.35 ± 0.05 μm vs 0.37 ± 0.05 μm,P 0.05;aspirin model:0.24 ± 0.02 μm vs 0.27 ± 0.03 μm,P 0.05).CONCLUSION:Acute stress and aspirin can induce DIS of the esophageal epithelium in rats,and it is not correlated with acid reflux.
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