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Hyaluronic acid and its biomedical applications:A review

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Engineered Regeneration 2020年第1期1卷 102-113页

作者： Matthew Dovedytis Zhuo Jie Liu samuel Bartlett Department of Biomedical Engineering Stony Brook UniversityStony BrookNew York 11794United States

Hyaluronic acid is a naturally occurring biopolymer possessing numerous functions within the body including wound repair,cell migration,and cell *** to its versatility,hyaluronic acid has been a major component of biomedical research and has seen application in several fields such as tissue engineering and cancer treatments through a multitude of different *** review aims to outline hyaluronic acid’s role in the healing process while focusing on its myriad of forms and applications in the biomedical world.

关键词： Hyaluronic acid Wound healing Hydrogel Tissue engineering Regenerative medicine

Gerarda prevostiana(Eydoux and Gervais,1837)(Squamata:Serpentes:Homalopsidae),a New Snake for Borneo

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Asian Herpetological Research 2013年第1期4卷 76-78页

作者： Indraneil DAS Hans BREUER samuel SHONLEBEN Institute of Biodiversity and Environmental Conservation Universiti Malaysia

A new record of the homalopsid snake, Gerarda prevostiana is presented from a mangrove-dominated patch in the vicinity of Kampung Bako, Sarawak, East Malaysia, and this comprises the first published record from the Sundaic Island of Borneo. A possible second locality for the species is a ca. 6.68 km site to its northeast, Kampung Buntal, based on an unlocated museum specimen. The species is widespread in mainland Southeast Asia, with additional records to the west （the Indian Subcontinent） and east （the Philippines Archipelago）, but was previously unrecorded from the islands of the Sundas. The secretive habits of the species, including the occupancy of mud lobster （Thalassinia spp.） mounds in mostly inaccessible, swampy habitats may be a reason for its perceived rarity and few published records.

关键词： Gerarda prevostiana serpentes Squamata Homalopsidae Borneo new record

Characteristics of pupillo-accommodative functions according to time of onset,gender and age in tonic pupil

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 659-661页

作者： Kyung-Min Koh Ungsoo samuel Kim Department of Ophthalmology Kim's Eye Hospital Department of Ophthalmology Konyang University College of Medicine

AIMTo evaluate the characteristics of pupillo-accommodative functions in patients with idiopathic tonic pupil according to the time of onset, gender, and age.

关键词： tonic pupil accommodation cholinergic supersensitivity

Diagnosis of alcoholic liver disease

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World Journal of Gastroenterology 2014年第33期20卷 11684-11699页

作者： Cara Torruellas samuel W French Valentina Medici Division of Gastroenterology and Hepatology Department of Internal Medicine University of California Davis Sacramento CA 95817 United States Department of Pathology UCLA/Harbor Medical Center Torrance CA 90502 United States

Alcohol is a hepatotoxin that is commonly consumed worldwide and is associated with a spectrum of liver injury including simple steatosis or fatty liver, alcoholic hepatitis, fibrosis, and cirrhosis. Alcoholic liver disease(ALD) is a general term used to refer to this spectrum of alcohol-related liver injuries. Excessive or harmful alcohol use is ranked as one of the top five risk factors for death and disability globally and results in 2.5 million deaths and 69.4 million annual disability adjusted life years. All patients who present with clinical features of hepatitis or chronic liver disease or who have elevated serum elevated transaminase levels should be screened for an alcohol use disorder. The diagnosis of ALD can generally be made based on history, clinical and laboratory findings. However, the diagnosis of ALD can be clinically challenging as there is no single diagnostic test that confirms the diagnosis and patients may not be forthcoming about their degree of alcohol consumption. In addition, clinical findings may be absent or minimal in early ALD characterized by hepatic steatosis. Typical laboratory findings in ALD include transaminase levels with aspartate aminotransferase greater than alanine aminotransferase as well as increased mean cor-puscular volume, gamma-glutamyltranspeptidase, and IgA to IgG ratio. In unclear cases, the diagnosis can be supported by imaging and liver biopsy. The histological features of ALD can ultimately define the diagnosis according to the typical presence and distribution of hepatic steatosis, inflammation, and Mallory-Denk bodies. Because of the potential reversible nature of ALD with sobriety, regular screening of the general population and early diagnosis are essential.

关键词： Alcoholic liver disease Diagnosis Alcohol screening Histology Mallory-Denk bodies Prognosis

ADAM17/TACE:a key molecule in brain injury regeneration

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Neural Regeneration Research 2019年第8期14卷 1378-1379页

作者： samuel Dominguez-Garcia Carmen Castro Noelia Geribaldi-Doldan Area de Fisiologia Facultad de Medicina Universidad de Cadiz Cadiz Spain Instituto de Investigacion e Innovacion Biomedica de Cadiz (INIBICA) Universidad de Cadiz Cadiz Spain

It has been many years since "the tumor necrosis factor-a-converting enzyme”,also known as ADAM17/TACE, was described as "the enzyme that does it all” because of its role in neurodegenerative diseases and in several physiological processes including proteolysis, adhesion, intracellular signaling, migration and proliferation. ADAM17/TACE is an integral membrane protein that belongs to the disintegrin and metalloprotease (ADAM) family. Several years ago, Romero-Grimaldi et al.

关键词： ADAM17/TACE key molecule injury regeneration

SYNAPTIC INPUTS FROM RODS AND CONES TO HORIZONTAL CELLS IN THE TIGER SALAMANDER RETINA

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Science China Chemistry 1990年第8期33卷 946-954页

作者：杨雄里 WU samuel M. Shanghai Institute of Physiology Academia Sinica Shanghai 200031 PRC Cullen Eye Institute Baylor College of Medicins Houston Texas 77030 USA

Synaptic inputs from rods and cones to horizontal cells (HCs) were studied in the flatmounted isolated retinas of the tiger salamander. Voltage-intensity relations, spectral sensitivities and response waveforms of the rod, the cone, and the HC under dark- and light-adapted conditions were examined. HCs receive mixed inputs from rods and cones in both dark- and light-adapted retinas. The relative rod/cone input in HC_s depends on the intensity of stimulus and background illumination, and it varies from HC to HC.

关键词： retina horizontal cells photoreceptor cells synaptic inputs

Self-contained Capsubot Propulsion Mechanism

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International Journal of Automation and computing 2011年第3期8卷 348-356页

作者： M.Nazmul Huda samuel Oliver Wane Faculty of Computing Engineering and Technology Staffordshire University

In this paper, a self contained capsubot （capsule robot） propulsion mechanism is investigated. The proposed capsubot works on the principle of internal force-static friction. A modified linear DC motor is used to drive the capsubot. A novel acceleration profile is proposed for the moving part （linear cylinder） based on the principle. A significant feature of the proposed capsubot is that it is legless, wheelless, and trackless. The developed capsubot with a proposed propulsion mechanism demonstrates a very good average velocity. The propulsion mechanism has the potential to be used for the propulsion of a wireless-controlled self-propelling capsule endoscope. Simulation and experimental results demonstrate the performance of the self-contained capsubot with the proposed acceleration profile.

关键词： Capsubot internal force and static friction linear DC motor propulsion capsule endoscopy.

Ophiolites-Geodynamic and environmental implications:Preface

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Geoscience Frontiers 2020年第1期11卷 1-2页

作者： Emilio Saccani Vinod samuel M.Santosh Department of Physics and Earth Sciences Ferrara University44122FerraraItaly Department of Earth System Sciences Yonsei UniversitySeoulSouth Korea China University of Geosciences(Beijing) Beijing 100083China

Ophiolite studies over the decades have played a crucial role in better understanding of mid-ocean ridge and subduction zone processes,mantle dynamics and heterogeneity,fluid-rock interactions in both sub-oceanic and sub-arc upper mantle,and the mechanisms of continental growth in accretionary and collisional *** continued interest in ophiolites as a topic of multi-disciplinary research in Earth Sciences has resulted in a wealth of new data,syntheses,and ideas from ophiolites around the world.

关键词： mantle rock Earth

Centration axis in refractive surgery

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Eye and Vision 2015年第1期2卷 28-43页

作者： samuel Arba Mosquera Shwetabh Verma Colm McAlinden SCHWIND eye-tech-solutions KleinostheimGermany Recognized Research Group in Optical Diagnostic Techniques University of ValladolidValladolidSpain Department of Ophthalmology and Sciences of Vision University of OviedoOviedoSpain Flinders University AdelaideSouth AustraliaAustralia Wenzhou Medical University WenzhouZhejiangChina.

The human eye is an asymmetric optical system and the real cornea is not a rotationally symmetrical *** optical element in the eye has its own optical and neural *** the optimum center for laser ablation is difficult with many available *** explain the various centration approaches(based on these reference axes)in refractive surgery and review their clinical *** line-of-sight(LOS)(the line joining the entrance pupil center with the fixation point)is often the recommended reference axis for representing wavefront aberrations of the whole eye(derived from the definition of chief ray in geometrical optics);however pupil centration can be unstable and change with the pupil *** corneal vertex(CV)represents a stable preferable morphologic reference which is the best approximate for alignment to the visual ***,the corneal light reflex can be considered as non-constant,but dependent on the direction of gaze of the eye with respect to the light source.A compromise between the pupil and CV centered ablations is seen in the form of an asymmetric offset where the manifest refraction is referenced to the CV while the higher order aberrations are referenced to the pupil *** is a need for a flexible choice of centration in excimer laser systems to design customized and non-customized treatments optimally.

关键词： Centration Refractive surgery Optical axis Neural axis Corneal vertex Pupil centration Corneal light reflex Line of sight Angle Kappa Alpha Lambda Asymmetric offset