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Extent of lymphadenectomy has no impact on postoperative complications after gastric cancer surgery in Sweden

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Chinese Journal of Cancer Research 2017年第4期29卷 313-322页

作者： chih-han kung huan song weimin ye magnus nilsson jan johansson ioannis rouvelas tomoyuki irino lars lundell jon a tsai mats lindblad Department of Surgery Skane University Hospital and Lund University Faculty of Medicine Department of Clinical Sciences 221 00 Lund Sweden

Objective： Curative gastric cancer surgery entails removal of the primary tumor with adequate margins including regional lymph nodes. European randomized controlled trials with recruitment in the 1990＇s reported increased morbidity and mortality for D2 compared to D 1. Here, we examined the extent of lymphadenectomy during gastric cancer surgery and the associated risk for postoperative complications and mortality using the strengths of a population-based study. Methods： A prospective nationwide study conducted within the National Register of Esophageal and Gastric Cancer. All patients in Sweden from 2006 to 2013 who underwent gastric cancer resections with curative intent were included. Patients were categorized into DO, D I, or D I ＋/D2, and analyzed regarding postoperative morbidity and mortality using multivariable logistic regression. Results： In total, 349 （31.7%） patients had a DO, 494 （44.9%） DI, and 258 （23.4%） DI＋/D2 lymphadenectomy. The 30-d postoperative complication rates were 25.5%, 25.1% and 32.2 % （DO, D I and D1 ＋/D2, respectively）, and 90-d mortality rates were 8.3%, 4.3 % and 5.8%. After adjustment for confounders, in mukivariable analysis, there were no significant differences in risk for postoperative complications between the lymphadenectomy groups. For 90-d mortality, there was a lower risk for D1 vs. DO. Conclusions： The majority of gastric cancer resections in Sweden have included only a limited lymphadenectomy （DO and DI）. More extensive lymphadenectomy （DI＋/D2） seemed to have no impact on postoperative morbidity or mortality.

关键词： Gastric cancer lymphadenectomy national database mortality complications

A novel method for geometric quality assurance of rock joint replicas in direct shear testing-Part 2:Validation and mechanical replicability

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第9期15卷 2209-2223页

作者： J.Larsson F.johansson D.Mas Ivars E.Johnson M.Flansbjer N.W.Portal Division of Material and Production Department of Chemistry and Applied MechanicsResearch Institutes of Sweden(RISE)Brinellgatan 4Borås50115Sweden Division of Soil and Rock Mechanics Department of Civil and Architectural EngineeringRoyal Institute of Technology(KTH)Brinellvägen 23Stockholm10044Sweden Swedish Nuclear Fuel and Waste Management Co.(SKB) SolnaSweden

Each rock joint is unique by nature which means that utilization of replicas in direct shear tests is required in experimental parameter ***,a method to acquire knowledge about the ability of the replicas to imitate the shear mechanical behavior of the rock joint and their dispersion in direct shear testing is *** this study,a novel method is presented for geometric quality assurance of *** aim is to facilitate generation of high-quality direct shear testing data as a prerequisite for reliable subsequent analyses of the *** Part 1 of this study,two quality assurance parameters,smf and V_(Hp100),are derived and their usefulness for evaluation of geometric deviations,*** reproducibility,is *** Part 2,the parameters are validated by showing a correlation between the parameters and the shear mechanical behavior,which qualifies the parameters for usage in the quality assurance *** results from direct shear tests presenting comparisons between replicas and the rock joint show that replicas fulfilling proposed threshold values of σ_(mf)same areas as in the rock *** wear is slightly larger in the rock joint and therefore the discrepancy in peak shear strength derives from differences in material properties,possibly from differences in *** is shown by application of the suggested method that the quality assured replicas manufactured following the process employed in this study phenomenologically capture the shear strength characteristics,which makes them useful in parameter studies.

关键词： Three-dimensional(3D)scanning Contact area measurements Direct shear testing Geometric quality assurance Mechanical replicability Replicas Rock joint

Insomnia is associated to depressive symptoms in patients with chronic heart failure

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Open Journal of Nursing 2013年第1期3卷 33-41页

作者： Peter johansson Anders Brostrom Department of Cardiology Linkoping University HospitalLinkopingSweden Department of Medicine and Care Division of Cardiovascular MedicineFaculty of Health SciencesLinkoping UniversityLinkopingSweden Division of Clinical Neurophysiology Linkoping University HospitalLinkopingSweden Department of Neuroscience and Locomotion Faculty of Health SciencesLinkoping UniversityLinkopingSweden

Introduction: Insomnia and depressive symptoms are common among patients with chronic heart failure (HF). Aim: The aim was to describe the prevalence of insomnia and depressive symptoms, as well as to examine the association between insomnia and depressive symptoms in patients with HF. Method: A crosssectional descriptive study including 212 patients with HF. All patients responded to questionnaires regarding sleeping difficulties (Uppsala Sleep Inventory-Chronic Heart Failure), daytime sleepiness (Epworth Sleepiness Scale) and depressive symptoms (The Mental Health Scale). Results: Patients with depressive symptoms (34%) had, compared to those without, significantly more major complaints of insomnia as indicated by the sub-types;non-restorative sleep (66% vs. 32%, p < 0.0001), difficulty in maintaining sleep (35% vs. 16%, p = 0.003), difficulty in initiating sleep (29% vs. 14%, p = 0.009) and early morning awakenings (25% vs. 10%, p = 0.004). The odds ratio (OR) to suffer from depressive symptoms;were for;non-restorative sleep 5.2 (CI 95%, 2.2 - 12.3), difficulties maintaining sleep 2.5 (CI 95%, 1.2 - 4.9), difficulties in initiating sleep 2.2 (CI 95%, 1.1 - 4.4) and early morning awakenings 2.4 (CI 95%, 1.1 - 5.4). When categorising insomnia into three severity groups, 1) non insomnia, 2) mild insomnia, and 3) severe insomnia, the OR for depressive symptoms for the mild insomnia and severe insomnia group were 2.2 (CI 95%, 1.1 - 4.2) and 7.4 (CI 95%, 2.4 - 22.8) respectively, compared to the non insomnia group. Conclusion: Insomnia is independently associated to depressive symptoms. Assessment of depressive symptoms and insomnia in patients with HF is important since treatment could be targeted to depressive symptoms only and/or to the sleep disturbance.

关键词： Congestive Heart Failure Insomnia Disorders Depressive Symptoms

Rectal nitric oxide as biomarker in the treatment of inflammatory bowel disease: Responders versus nonresponders

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World Journal of Gastroenterology 2006年第21期12卷 3386-3392页

作者： Tryggve Ljung Sofie Lundberg Mark Varsanyi Catharina johansson Peter T Schmidt Max Herulf Jon O Lundberg Per M Hellstr(o|¨)m Department of Gastroenterology and Hepatology Karolinska University Hospital Site SolnaStockholmSweden Department of Physiology and Pharmacology Karolinska Institutet StockholmSweden

AIM： To explore rectal nitric oxide （NO） as biomarker of treatment response in ulcerative colitis （UC） and Crohn＇s disease （CD）, and examine relationships between rectal NO, mucosal expression of NO synthases （NOS）, and pro-inflammatory cytokines. METHODS： Twenty-two patients with UC and 24 with CD were monitored during steroid treatment. Rectal NO levels were measured and clinical activities were assessed on days 1, 3, 7 and 28. Mucosal presence of NOS and pro-inflammatory cytokines were analyzed by immunohistochemistry and RT-PCR. RESULTS： Active UC and CD displayed markedly increased rectal NO levels （10950 ± 7610 and 5 040 ± 1 280 parts per billion （ppb）, respectively） as compared with the controls （154 ± 71 ppb, P 〈 0.001）. Rectal NO correlated weakly with disease activity in both UC and CD （r = 0.34 for UC and r = 0.48 for CD, P 〈 0.01）. In 12 patients, a steroid-refractory course led to colectomy. These patients had only slightly increased NO levels （UC： 620 ± 270 ppb; CD： 1260 ± 550 ppb） compared to those with a therapeutic response （UC： 18860 ± 530 ppb, P 〈 0.001, CD： 10060 ± 3200 ppb, P 〈 0.05）. CONCLUSION： Rectal NO level is a useful biomarker of treatment response in IBD as low NO levels predicts a poor clinical response to steroid treatment.

关键词： Crohn's disease CytokJnes Nitric oxide Steroids Ulcerative colitis

Effects of Alternative Nitrogen Management Regimes on Production of Eucalyptus in Tropics and Sub-tropics

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Journal of Agricultural Science and Technology(B) 2014年第5期4卷 341-351页

作者： Moses Otuba johansson Karl-Erik Nabuin Zonal Agricultural Research and Development Institute Soroti 256 Uganda Department of Forest Products Faculty of Forest Sciences Swedish University of Agricultural Sciences Uppsala SE75007Sweden

This paper presents the effects of alternative nitrogen management regimes on production of Eucalyptus in tropics and sub-tropics carried out in autumn, 2011. The aim of the study was to review alternative nitrogen management regimes that could enhance the positive effects and reduce negative effects of different Eucalyptus species in the perspective of smallholders. Literature review was used to survey the alternative nitrogen management regimes on eucalyptus trees. There was a significant improvement （P ≤ 0.01） in mean annual increment （MAI） as measured at seven years of Eucalyptus tereticornis in the plots planted with only legume, pueraria and stylosanthes, compared to that of the control on altitude 150 m and rainfall of 2,000 mm at the age of seven years, The MAI of Eucalyptus urophylla and Eucalyptus camaldulensis in plots planted with beans and rice shows a significant improvement （P ≤ 0.05） over the control treatment. Only the plots treated with nitrogen fertilizer 550 kg/ha showed significant improvement （P ≤ 0.05） in terms of MAI of Eucalyptus nitens, compared to the control treatment. In general, it can be concluded that as these alternative management regimes enhance productivity of Eucalyptus woodlots, the challenge for the small-scale farmers is on how to manage them sustainably. Therefore, forest policies that take consideration of increasing production of Eucalyptus and managing biodiversity with reference to these alternative management regimes should be developed in tropics and sub-tropics.

关键词： Eucalyptus legumes management nitrogen sub-tropics tropics.

APPLICATION OF ISOTHERMAL CALORIMETRY IN STUDIES OF CEMENT HYDRATION

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APPLICATION OF ISOTHERMAL CALORIMETRY IN STUDIES OF CEMENT H...

New frequency counting principle improves resolution

第五届水泥与混凝土国际会议

作者： Peter johansson Thermometric AB Spjutvgen 5ASE-175 61 JrfllaSweden

The rate and mechanism for cement hydration is important since it will affect the properties of the final product. The hydration process is known to be highly exothermic, i.e. heat is produced. The heat flow, expressed in W (J·s-1), reflects the rate of the overall hydration process, which can be monitored using TAM Air, an eight-channel heat conduction calorimeter. In this presentation some functional aspects and performance of TAM Air is discussed with special emphasis on cement hydration.

关键词： heat conduction calorimetry isothermal TAM Air cement hydration Portland temperature dependence Arrhenius

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New frequency counting principle improves resolution

A crowd-sourced genomic project to assess hybrid content in a rare avian vagrant(Azure Tit Cyanistes cyanus(Pallas,1770))

2009全国时间频率学术会议

作者： Staffan johansson Marketing Manager at Pendulum Instruments AB BrommaSweden

自从第一台频率计数器问世以来,频率计数器的发展经过了以下几个阶段:第一阶段:20世纪70年代以前传统的频率计数器第二阶段:20世纪80年代倒数频率计数器（周期测量+取倒数求频率）第三阶段:20世纪90年代内插法倒数频率计数器第四阶段:2... 详细信息

自从第一台频率计数器问世以来,频率计数器的发展经过了以下几个阶段:第一阶段:20世纪70年代以前传统的频率计数器第二阶段:20世纪80年代倒数频率计数器（周期测量+取倒数求频率）第三阶段:20世纪90年代内插法倒数频率计数器第四阶段:2000年以来采用回归分析的连续时间标记频率计数器本文介绍了频率计数器的设计与基本原理,并分析了最近几代频率计数器在测量技术与原理上的发展过程。本文同时介绍了瑞典Pendulum Instruments AB公司最新推出的CNT-90高分辨率时间间隔分析仪/计数器/分析仪,并以CNT-90为例子介绍了目前市场上最为先进的频率计数器测量技术。连续时间标记技术的优点将在本文中被讨论,这些优点包括使用回归分析来减小测量噪声的干扰并将频率测量分辨率提高到12位/1s测量时间。连续时间标记技术的另外一个应用实例便是零死区时间背靠背测量功能,此时测量之间的死区时间为零,被测信号的任何一个周期都不会被丢失。正是因为有了零死区时间背靠背测量功能,测量结果才能被用来正确的计算阿伦方差（Allan Deviation）。

关键词：时间标记(Time-stamping) 线性回归(linear regression)

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Avian Research 2023年第4期14卷 545-552页

作者： Martin Irestedt Filip Thorn Per G.P.Ericson Hein van Grouw Yaroslav A.Red'kin Alexander Hellquist Frank johansson Johan A.A.Nylander Department of Bioinformatics and Genetics Swedish Museum of Natural HistoryStockholmSweden Department of Zoology Stockholm University Sweden Bird Group Department of Life SciencesNatural History MuseumTringUnited Kingdom Zoological Museum Lomonosov Moscow State UniversityMoscowRussia Institute of Biological Problems of Cryolithozone SB RAS YakutskRussia Department of Women's and Children's Health Uppsala UniversitySweden Department of Ecology and Genetics Uppsala UniversityUppsalaSweden

The aim of this study was to correlate plumage variation with the amount of genomic hybrid content in hybrids between Azure Tits Cyanistes cyanus(Pallas,1770)and European Blue Tit Cyanistes caeruleus(Linnaeus,1758),by re-sequencing the genomes of museum specimens of non-hybrids and presumed hybrids with varying *** project was funded by crowdsourcing and initiated when two presumed Azure Tits,observed by hundreds of Swedish birdwatchers,were rejected as hybrids based on minor plumage deviations assumed to indicate hybrid contents from the European Blue *** results confirm that hybrids with intermediate plumages,so called Pleske’s Tits,are first generation hybrids(F1 hybrids).Individuals,whose plumages are similar to Azure Tits,but assessed as hybrids based on minor plumage deviations,are all backcrosses but vary in their degree of hybrid ***,some individuals morphologically recognized as pure Azure Tits expressed similar degrees of hybrid *** results indicate that:(1)hybrid content may be widespread in Azure Tits in the western part of its habitat distribution;(2)plumage deviation in backcrosses is not linearly correlated with the genetic degree of hybrid origin;and(3)all Azure Tits observed in Europe outside its natural distribution may have some degree of hybrid *** therefore suggest that it is very difficult to phenotypically single out hybrids beyond first generation *** argue that decreased sequencing costs and improved analytical tools open the doors for museomic crowd-sourced projects that may not address outstanding biological questions but have a major interest for lay citizens such as birdwatchers.

关键词： Crowdsourcing Cyanistes cyanus Hybridization Museomics

Process Adaption of a Small WWTP Operated at Low Loading Conditions for Substantial Energy Savings

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Journal of Water Resource and Protection 2020年第6期12卷 472-479页

作者： Stig Morling Sweco Roland johansson Pireva Sweco Environment AB Stockholm Sweden

The very long tradition of the activated sludge treatment model within the water industry has demonstrated very versatile possibilities to adopt the operation mode for different enhancements. By looking into other treatment models within the activated sludge family it is possible to find alternatives for the operation. This paper concentrates on the possibilities to improve even small WWTP with respect to energy savings. The small plant in Northern Sweden, called Rosvik WWTP, is given as an example. Some important findings related to the intermittent aeration mode may be summarized as follows: 1) An energy savings for the operation of the small WWTP with respect to aeration needs that resulted in a decrease of the energy power supply by more than 35%, as compared with the previous operation based on continuous aeration;2) The up to date effluent levels with respect to the main pollutants have remained at very good levels in 2020, P-level averages 0.16 mg P/l versus consent level 0.5 mg P/l;COD-level 40 versus 70 mg/l and BOD7 9 versus 15 mg/l;3) Sometimes, also improved sludge settling characteristics have been observed, thus providing improved discharge figures;4) The potential to develop an enhanced biological phosphorus removal. There are however some needed conditions to accomplish these improvements: 1) Reliable on-line probes for both oxygen control, SS-concentration control and optionally also for nitrogen control;2) A flexible automation system that allows the needed process modifications to take place;3) And finally, very important dedicated and competent plant operators, with the needed curiosi

关键词： Activated Sludge Low Load Energy Savings Phosphorus Removal Inter-mittent Operation