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Stem cells therapy for regenerative medicine:Principles of present and future practice

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Journal of Biomedical Science and Engineering 2014年第2期7卷 49-57页

作者： Jose A.Andrades Jose Becerra Ramon Munoz-Chápuli salvador martínez Angel Raya Javier García-Sancho Jose M.Moraleda Laboratory of Bioengineering and Tissue Regeneration(LABRET) Department of Cell BiologyGenetics and PhysiologyFaculty of SciencesIBIMAUniversity of MálagaMálagaSpain Networking Biomedical Research Center in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)MálagaSpain Andalusian Centre for Biotechnology and Nanomedicine(BIONAND) Parque Tecnológico de AndalucíaCampanillasMálagaSpain Department of Animal Biology Faculty of SciencesUniversity of MálagaMálagaSpain Institute of Neurosciences University of Miguel HernándezAlicanteSpain Control of Stem Cell Potency Group Institut for Bioengineering of Catalonia(IBEC)BarcelonaSpain Institucio Catalana de Recerca i Estudis Avancats(ICREA) P.Lluís CompanysBarcelonaSpain Institute of Molecular Biology and Genetics(IBGM) University of ValladolidValladolidSpain Unit of Transplant and Cell Therapy University of MurciaIMIBUniversity Clinic Hospital Virgen de la ArrixacaEl PalmarMurciaSpain

The characterization and isolation of various stem cell populations, from embryonic to tissue-derived stem cells and induced pluripotent stem cells (iPSCs), have led to a rapid growth in the field of stem cell research and its potentially clinical application in the field of regenerative medicine and tissue repair. Stem cell therapy has recently progressed from the preclinical to the early clinical trial arena for a variety of diseases states, although further knowledge on action mechanisms, long-term safety issues, and standardization and characterization of the therapeutic cell products remains to be thoroughly elucidated. In this paper we summarize the current state of the art of basic and clinical research that were highlighted at the 2012 meeting of the Spanish Cell Therapy Network. This includes the current research involving in genomic and transcriptomic characterization of selected stem cell populations, studies of the role of resident and transplanted stem cells during tissue regeneration and their mechanism of action, improved new strategies of tissue engineering, transplantation of mesenchymal stem cells (MSCs) in different animal models of disease, disease correction by iPSCs, and preliminary results of cell therapy in human clinical trials.

关键词： Spanish Cell Therapy Network Stem Cell Cell Therapy Tissue Engineering Regenerative Medicine

Optimizing urban traffic control using a rational agent

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第12期15卷 1123-1137页

作者： salvador IBARRA-martínez José A.CASTN-ROCHA Julio LARIA-MENCHACA Engineering School Autonomous University of Tamaulipas

This paper is devoted to developing and evaluating a set of technologies with the objective of designing a methodology for the implementation of sophisticated traffic lights by means of rational agents. These devices would be capable of optimizing the behavior of a junction with multiple traffic signals, reaching a higher level of autonomy without losing reliability, accuracy, or efficiency in the offered services. In particular, each rational agent in a traffic signal will be able to analyze the requirements and constraints of the road, in order to know its level of demand. With such information, the rational agent will adapt its light cycles with the view of accomplishing more fluid traffic patterns and minimizing the pollutant environmental emissions produced by vehicles while they are stopped at a red light, through using a case-based reasoning(CBR) adaptation. This paper also integrates a microscopic simulator developed to run a set of tests in order to compare the presented methodology with traditional traffic control methods. Two study cases are shown to demonstrate the efficiency of the introduced approach, increasing vehicular mobility and reducing harmful activity for the environment. For instance, in the first scenario, taking into account the studied traffic volumes, our approach increases mobility by 23% and reduces emissions by 35%. When the roads are managed by sophisticated traffic lights, a better level of service and considerable environmental benefits are achieved, demonstrating the utility of the presented approach.

关键词： Rational agents Traffic light control Optimization Traffic mobility

Ambroxol,the cough expectorant with neuroprotective effects

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Neural Regeneration Research 2024年第11期19卷 2345-2346页

作者： Kristin Patzwaldt salvador Castaneda-Vega Werner Siemens Imaging Center Department of Preclinical Imaging and RadiopharmacyEberhard Karls University TuebingenTuebingenGermany Department of Nuclear Medicine and Clinical Molecular Imaging University Clinic TuebingenTuebingenGermany

Ambroxol hydrochloride(2-amino-3,5-dibromo-N-methylbenzylamine hydrochloride)has been used as a mucolytic agent in the treatment of respiratory diseases since the late 1970s.Its effects on mucus membranes such as mucus disruption,increased mucus production,and low toxicity profile were addressed in its original German patent in 1966.These first described properties have kept Ambroxol available worldwide and over the counter in the pharmaceutical market to this day.

关键词： protective agent German

Small molecules to target tau amyloid aggregation

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Neural Regeneration Research 2024年第3期19卷 509-511页

作者： Zoe Manglano-Artuñedo Samuel Peña-Díaz salvador Ventura Institut de Biotecnologia i Biomedicina Universitat Autònoma de BarcelonaBellaterraSpain

Protein aggregation has been linked with many neurodegenerative diseases,such as Alzheimer’s disease(AD)or Parkinson’s disease.AD belongs to a group of heterogeneous and incurable neurodegenerative disorders collectively known as tauopathies.They comprise frontotemporal dementia,Pick’s disease,or corticobasal degeneration,among others.The symptomatology varies with the specific tau protein variant involved and the affected brain region or cell type.However,they share a common neuropathological hallmark-the formation of proteinaceous deposits named neurofibrillary tangles.Neurofibrillary tangles,primarily composed of aggregated tau(Zhang et al.,2022),disrupt normal neuronal functions,leading to cell death and cognitive decline.

关键词： tau degeneration aggregation

Atypical Variations of Water Conductivity Prior to Tectonic Earthquakes

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International Journal of Geosciences 2015年第12期6卷 1367-1385页

作者： Fidel martínez-García Arturo Colín-Cruz salvador Adame-martínez Jorge J. Ramírez-García Center of Proposed Drafts of the South Pacific Federal Electricity Commission Cuernavaca Morelos Mexico State Mexico Faculty of Chemistry Autonomous University of Mexico State Toluca de Lerdo Mexico State Mexico Faculty of Urban and Regional Planning Autonomous University of Mexico State Toluca de Lerdo Mexico State Mexico

Within the framework of precursor events related to earthquakes, this paper analyzes the possible effect on the aquatic environment of the surrounding energy that accompanies earthquakes, particularly in the area where oceanic and continental plates collide (Cocos Plate and North American Plate, south of Mexico). As a preamble, the types of precursor events, characteristics, and their possible origin are described. A project was designed under the assumption that in areas with high frequency and intensity seismicity there is an electrical and electromagnetic potential promoter which is detectable and assessable indirectly by measuring water conductivity behavior, which also may have atypical variations of data;the outcome of intensive conductivity monitoring in different settings, natural as well as manmade (wellsprings, artesian well and a cistern), are presented herein. The results of the conductivity monitoring for seven months, highlight two patterns in data behavior: one pattern shows the subtle dependence of data behavior on the geographic location of data monitoring instruments, revealing that could have a slight relationship between areas with increased seismic frequency and intensity and the presence of atypical conductivity variations. Another pattern reveals the possible relationship between atypical variations in conductivity and subsequent earthquake events;a total of 241 seismic events were analyzed and 59 of them are provided as evidence related with patterns mentioned.

关键词： Earthquakes Precursor Events Natural Water Conductivity Subduction Plates Cocos Plate Electromagnetic Fields Earth’s Electromagnetic Pulses

Recent Developments in Metallic Degradable Micromotors for Biomedical and Environmental Remediation Applications

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Nano-Micro Letters 2024年第3期16卷 1-35页

作者： Sourav Dutta Seungmin Noh Roger Sanchis Gual Xiangzhong Chen salvador Pané Bradley J.Nelson Hongsoo Choi Department of Robotics and Mechatronics Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea DGIST‑ETH Microrobotics Research Center DGISTDaegu 42988Republic of Korea Multi‑Scale Robotics Lab Institute of Robotics and Intelligent SystemsETH Zurich8092 ZurichSwitzerland Institute of Optoelectronics State Key Laboratory of Photovoltaic Science and TechnologyShanghai Frontiers Science Research Base of Intelligent Optoelectronics and PerceptionFudan UniversityShanghai 200433People’s Republic of China

Synthetic micromotor has gained substantial attention in biomedicine and environmental remediation.Metal-based degradable micromotor composed of magnesium(Mg),zinc(Zn),and iron(Fe)have promise due to their nontoxic fuel-free propulsion,favorable biocompatibility,and safe excretion of degradation products Recent advances in degradable metallic micromotor have shown their fast movement in complex biological media,efficient cargo delivery and favorable biocompatibility.A noteworthy number of degradable metal-based micromotors employ bubble propulsion,utilizing water as fuel to generate hydrogen bubbles.This novel feature has projected degradable metallic micromotors for active in vivo drug delivery applications.In addition,understanding the degradation mechanism of these micromotors is also a key parameter for their design and performance.Its propulsion efficiency and life span govern the overall performance of a degradable metallic micromotor.Here we review the design and recent advancements of metallic degradable micromotors.Furthermore,we describe the controlled degradation,efficient in vivo drug delivery,and built-in acid neutralization capabilities of degradable micromotors with versatile biomedical applications.Moreover,we discuss micromotors’efficacy in detecting and destroying environmental pollutants.Finally,we address the limitations and future research directions of degradable metallic micromotors.

关键词： Magnesium Zinc Iron Biodegradable microrobot Biomedical Environmental

Design and redesign journey of a drug for transthyretin amyloidosis

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Neural Regeneration Research 2025年第4期20卷 1096-1097页

作者： Francisca Pinheiro salvador Ventura Institut de Biotecnologia i Biomedicina Departament de Bioquímica i Biologia MolecularUniversitat Autònoma de BarcelonaBellaterraSpain

The misfolding and subsequent aggregation of proteins into amyloid fibrils underlie the onset of a variety of human disorders collectively known as amyloidosis.Transthyretin(TTR)is one of the>30 amyloidogenic proteins identified to date and is associated with a group of highly debilitating and life-threatening disorders called TTR amyloidosis(ATTR).ATTR comprises senile systemic amyloidosis,which is linked to wild-type(WT)TTR aggregation,and hereditary ATTR,a dominantly inherited disorder caused by the deposition of one of over 130 TTR genetic variants.Senile systemic amyloidosis is a prevalent age-related amyloidosis,affecting up to 25%of the population over 80 years of age,and is characterized by the build-up of TTR fibrils in the myocardium.Regarding hereditary ATTR,the clinical presentation is highly heterogeneous,primarily affecting the peripheral nervous system(familial amyloid polyneuropathy-FAP)or the heart(familial amyloid cardiomyopathy).In rare cases,aggregation develops in the central nervous system,giving rise to a phenotype known as familial leptomeningeal amyloidosis(Carroll et al.,2022).

关键词： amyloid aggregation senile

Hepatic rupture secondary to HELLP syndrome: outcomes in three cases

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World Journal of Emergency Medicine 2024年第1期15卷 56-58页

作者： salvador Gomez-Carro Ruben R.Lozano-Salazar Kassandra Santos-Zaldívar Victor Andres Villasuso-Alcocer Nina Méndez-Domínguez O'Horan General Hospital Merida 97000Mexico Highly Specialized Hospital of the Yucatan Peninsula Merida 97134Mexico National Institute of Perinatology.Mexico City 11000 Mexico

Hypertensive disorders of pregnancy,including chronic hypertension,gestational hypertension,and preeclampsia,are the most common complications in pregnant women,affecting approximately 15%of pregnancies.[1,2]Hemolysis,elevated liver enzymes,and low platelet count(HELLP syndrome)can occur in 0.2%-0.6%of all pregnancies,and 10%-15%of patients are diagnosed with preeclampsia.[3,4]Among its severe complications,liver hematoma is remarkable and may lead to liver rupture.Prompt identification of HELLP syndrome is crucial for proper therapeutic management and to avoid fatal outcomes[4,5]since when a hepatic hematoma occurs,the risk of rupture increases to 12%.[3,5]

关键词： rupture HELLP hypertension pregnancy

Evaluation of Prediction Algorithms in the Student Dropout Problem

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Journal of Computer and Communications 2020年第3期8卷 20-27页

作者： Luis Earving Lee salvador Ibarra martínez José Antonio Castán Rocha Jesús David Terán Villanueva Julio Laria Menchaca Mayra Guadalupe Trevino Berrones Emilio Castán Rocha Faculty of Engineering Autonomous University of TamaulipasTampicoTamaulipasMexico Tec NM/Madero Institute of Technology Madero CityTamaulipasMexico.

University dropout is a growing problem which, in recent years, is using computer techniques to assist in the detection process. The paper presents the evaluation of some prediction algorithms to detect a student with a high possibility of scholar desertion. The approach uses real data from past scholar periods to create a dataset with different information of the students (i.e., personal, economic, and academic records). The algorithms selected in the experimental phase were: J48 decision tree, K-near neighbors, and support vector machine. We use two similarity metrics to split the dataset with cases with at least 80% of similarity to evaluate each case. We use the data from 2010 to 2016 with real students’ information to predict if there exists the possibility of a real academic dropout in one test for a period. The results show that the J48 algorithm reaches a better performance in both experiments. Besides, the tree generated for each student is taken as a path of attention, reaching around 88% of effectiveness. Finally, the conclusions argue the contributions of the paper and propose a future line of research.

关键词： Student Dropout Prediction Algorithms J48 K-Near Neighbors Support Vector Machine