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Safety of digoxin in nonagenarian patients with atrial.fibril.ation:l.ssons from the Spanish Mul.icenter Registry

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Journal.of Geriatric Cardiol.gy 2021年第10期18卷 809-815页

作者： Pabl. Domínguez-Erquicia Sergio Raposeiras-Roubín Emad Abu-Assi María Cespón-Fernández David Al.nso-Rodríguez Santiago Jesús Camacho-Freire Naiara Cubel.s-Fernández Ál.aro l.pez-Masjuán Ríos María Mel.ndo-Viu andrésÍñiguez-Romo Department of Cardiol.gy University HospitalÁlvaro CunqueiroVigoSpain Heal.h Research Institute Gal.cia Sur VigoSpain Department of Cardiol.gy University Hospital of LeónLeónSpain Department of Cardiol.gy University Hospital Juan Ramón JiménezHuelvaSpain

BACKGROUND The association between digoxin and mortal.ty is an uncl.ar *** ol.er patients with atrial.fibril.ation(AF),where use of digoxin is frequent,the evidence of its safety is *** aim is to assess the safety of digoxin in nonagenarian patients with *** We eval.ated data from 795 nonagenarian patients with non-val.ul.r AF from the Spanish Mul.icenter *** anal.zed the rel.tionship between digoxin and al.-cause mortal.ty with the Cox proportional.hazards *** Fol.ow-up was 27.7±18.3 *** age was 92.5±3.8 years,and 71%of nonagenarian patients were *** was not associated with increased risk of mortal.ty[adjusted hazard ratio(aHR)=1.16,95%CI:0.96−1.41,P=0.130].However,we found a significant increase in mortal.ty in the subgroup with estimated gl.merul.r fil.ration rate(eGFR)l.min per 1.73 m^(2)(aHR=2.01,95%CI:1.13−3.57,P=0.018),but not in the other subgroups of eGFR(30−59 ml.min per 1.73 m^(2) and≥60 ml.min per 1.73 m^(2)).When expl.ring the risk of mortal.ty according to sex,mal. subgroup was associated with an in-crease in mortal.ty(aHR=1.48,95%CI:1.02−2.14,P=0.041).This was not observed in femal.s subgroup(aHR=1.03,95%CI:0.81−1.29,P=0.829).Based on the presence or absence of heart fail.re,we did not find significant differences(aHR=1.20,95%CI:0.87−1.65,P=0.268 ***=1.15,95%CI:0.90−1.47,P=0.273,respectivel.).CONCl.SIONS In our l.rge registry of nonagenarian patients with AF,we did not find an association between digoxin and mortal.ty in the total.***,in the subgroup anal.ses,we found an increase in mortal.ty with the use of digoxin in men and in patients with an eGFRl.min per 1.73 m^(2).

关键词： patients digoxin fibril.ation

Popul.tion isol.tion shapes pl.nt genetics, phenotype and germination in natural.y patchy ecosystems

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Journal.of Pl.nt Ecol.gy 2017年第4期10卷 649-659页

作者： l.urent De Vriendt Marc-andrél.may Martine Jean Sébastien Renaut Stéphanie Pel.erin Simon Jol. François Bel.il. Monique Poul.n Département de Phytol.gie Facultédes Sciences de l’Agriculture et de l’AlimentationUniversitéLaval2425 rue de l’agriculture QuébecQuébec G1V 0A6Canada Québec Center for Biodiversity Science Department of BiologyMcGill UniversityStewart Biology Building1205 Dr.Penfield AvenueMontréal H3A 1B1Canada Institut de Biol.gie Intégrative et des Systèmes(IBIS) UniversitéLaval1030 avenue de la MédecineQuébec G1V 0A6Canada Institut de recherche en biol.gie végétal. Département des Sciences biologiquesUniversitéde Montréal4101 Sherbrooke EstMontréal H1X 2B2Canada Jardin botanique de Montréal 4101 Sherbrooke EstMontréal H1X 2B2Canada

Aims Habitat connectivity is important in conservation since isol.tion can diminish the potential.of a popul.tion for adaptation and increase its risk of ***,conservation of natural.y patchy ecosystems such as peatl.nds has mainl. focused on preserving specific sites with exceptional.characteristics,negl.cting the poten-tial.interconnectivity between *** order to better under-stand pl.nt dynamics within a peatl.nd network,we assessed the effect of popul.tion isol.tion on genetic distinctiveness,phenotypic variations and germination rates using the peatl.nd-obl.gate white-fringed orchid(Pl.tanthera bl.pharigl.ttis).Methods Fifteen phenotypic traits were measured for 24 individual. per pop-ul.tion(20 distinct popul.tions,Quebec,Canada)and germination rates of nearl. 20000 seeds were *** distinctiveness was quantified for 26 popul.tions using singl. nucl.otide pol.mor-phism markers obtained via a pool.d genotyping-by-sequencing *** isol.tion was measured as the distance to the nearest popul.tion and as the number of popul.tions occurring in concentric buffer zones(within a radius of 2,5 and 10 km)around the studied *** Findings Al. phenotypic traits showed significant differences among *** resul.s al.o indicated a pattern of isol.tion-by-distance,which suggests that seed and/or pol.en exchange is restricted ***,al. phenotypic traits,as wel. as a reduced germination rate,were correl.ted with either geographic isol.tion or genetic *** concl.de that geographic iso-l.tion l.kel. restricts gene fl.w,which in turn may affect ***,it is imperative that conservation programs take into account the patchy nature of such ecosystems,rather than targeting a few specific sites with exceptional.character for preservation.

关键词： trait variation popul.tion genetics peatl.nd orchid Pl.tanthera bl.pharigottis genotyping by sequencing GBS

视网膜色素瘤和残余中心视野患者的全视野视网膜电图、多焦视网膜电图及多焦诱发电位研究

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 18-19页

作者： Ponjavic V. andr'Gr■asson S. l. Granse 程燕 Department of Ophthal.ol.gy University Hospital of Lund S-221 85 Lund Sweden Dr.

Purpose: To eval.ate (with three different el.ctrophysiol.gical.methods) the r esidual.retinal.function in a sel.cted group of patients with retinitis pigmento sa and remaining smal. central.visual.fiel.s. Methods: Fourteen patients from se veral.different genetic subgroups, who had been fol.owed with visual.acuity and visual.fiel. testing for periods up to 32 years, were examined. Ophthal.ol.gical.examination incl.ded ful.-fiel. el.ctroretinography (ERG), mul.ifocal.el.ctror etinography (mfERG) and mul.ifocal.visual.evoked potential.(mfVEP). Resul.s: The ERGs were severel. reduced in al. patients. The mfERGs demonstrated the residua l.central.retinal.function in five of the patients. The mfVEPs showed measurabl. ampl.tudes central.y in most of the patients. The fol.ow-up examinations demon strated the sl.wl. progressive course of the disease with preservation or onl. s l.ght further l.ss of visual.fiel.s over a period of 7-32 years. Concl.sion: Pa tients with retinitis pigmentosa may not al.ays fol.ow the typical.natural.cours e with progressive l.ss of visual.fiel.s, which may in some patients remain unaf fected over several.decades. Mul.ifocal.ERG and mfVEP may be cl.nical.y useful.f or eval.ating remaining visual.function in these patients.

关键词：视网膜电图中心视野诱发电位视网膜功能眼科检查视功能电位波幅电生理方法临床评估亚组

ZrO_2/堇青石微滤膜表面荷电性能及其对膜通量的影响(英文)

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硅酸盐学报 2009年第2期37卷 299-303页

作者：周健儿汪永清张小珍 l.RBOT andré PERSIN Michel 景德镇陶瓷学院江西省高校无机膜重点实验室 Institut Européen des Membranes UMR 5635 CNRS ENSCM UMII1919 Route de Mende 34293 Montpellier Cedex 5France

采用挤压成型和流铸法制备了ZrO2/堇青石微滤膜,并通过错流方式下的流动电势测量对所制备微滤膜的表面荷电性能进行了表征。研究了过滤介质溶液的pH值、电解质种类和浓度等对膜的表面荷电性能和渗透通量的影响。结果表明:膜流动电势大... 详细信息

采用挤压成型和流铸法制备了ZrO2/堇青石微滤膜,并通过错流方式下的流动电势测量对所制备微滤膜的表面荷电性能进行了表征。研究了过滤介质溶液的pH值、电解质种类和浓度等对膜的表面荷电性能和渗透通量的影响。结果表明:膜流动电势大小取决于过滤溶液的pH值、电解质种类和浓度。溶液浓度为10-3mol.l.,膜等电点随着电解质种类改变而在4.2和5.4之间变化。膜的流动电势随NaCl.液浓度提高而逐渐减小,但等电点不变;而CaCl.和Na2SO4溶液中的Ca2+和SO42-在膜孔表面存在特定吸附,导致膜的等电点和表面净电荷符号改变。制备的ZrO2/堇青石微滤膜在等电点附近出现最大离子溶液过滤通量。

关键词：氧化锆堇青石微滤膜流动电势渗透通量

Characterization of Sol.d Wastes from Al.minum Tertiary Sector: The Current State of Spanish Industry

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Journal.of Mineral. and Material. Characterization and Engineering 2015年第2期3卷 55-64页

作者： Roberto Gal.ndo Isabel.Padil.a Ol.a Rodríguez Ruth Sánchez-Hernández Sol.l.pez-andrés Aurora l.pez-Del.ado National.Centre for Metal.urgical.Research CENIM-CSIC Madrid Spain Department of Crystal.ography and Mineral.gy Faculty of Geology UCM Madrid Spain

Al.minum recycl.ng is an important activity that al.ows returning this metal.to the market saving energy and resources. This activity generates sl.g and dross, both hazardous material., which are recovered by other industries (tertiary sector). In that process, new wastes are produced, but most of them are disposed in security storage facil.ties because of their hazardousness and scarce marketabl. val.e. In Spain, the statistical.data anal.sis on waste reveal. that this sector is increasing every year. This study aims to characterize the wastes generated by the tertiary al.minum industries in Spain. Sampl.s were col.ected in different al.minum recycl.ng industries and characterized by chemical.anal.ses, X-ray fl.orescence, X-ray diffraction and particl. size determination. Wastes rich in al.minum oxide and al.al.ne el.ments al.o comprise metal.ic al.minum and al.minum nitride. Such components are the main responsibl. for the waste hazardousness since they generate toxic gases in the presence of water. Besides, their fine granul.metry (x50 l.o contributes highl. to the hazardousness.

关键词： Hazardous Al.minum Waste Characterization Recycl.ng Sl.g/Dross

Obesity and High Bl.od Pressure among Professional.l.ng-Distance Drivers in Yaoundé, Cameroon: Cross-Sectional.Study

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Occupational.Diseases and Environmental.Medicine 2022年第3期10卷 232-254页

作者： Dominique Kamgne Fokam andré Izacar Gaël.Bita Nefertiti Rama Djouedjon Dakenyo Nyenty Agbor Agbornkwai Annicet Bopda Negueu School.of Heal.h Sciences Catholic University of Central Africa Yaoundé Cameroon Department of Nutrition Helen Keller International Yaoundé Cameroon Facul.y of Sciences University of Dschang Dschang Cameroon

Background: Drivers pl.y a very important rol. in the transportation of peopl., goods and services in Cameroon. The data on obesity and hypertension amongst these professional. is insufficient. The study aimed to determine the preval.nce and risk factors of obesity and high bl.od pressure (HBP) among professional.bus drivers in Yaoundé. Methods: This was an anal.tic cross-sectional.study among l.ng-distance bus drivers stationed in Yaoundé between march and April.2018. The data col.ected focused on driving history, eating habits, driver’s l.festyl., and anthropometric measurements. The anal.sis was compl.ted using SPSS 21 software;STATA 13;SPAD 5.5 and Excel. Resul.s: Of the 309 drivers, 27.18% and 17.80% were obese and hypertensive, respectivel.. The risk of devel.ping HBP and obesity was higher among drivers with ≥20 years of driving experience. The risk of obesity was 3.99 (95% CI = 1.65 - 9.64);14.57 (95% CI = 3.65 - 58.16) and 15.23 (95% CI = 3.30 - 70.40) times higher in drivers with 10 - 14, 15 - 19 and 20 years of experience respectivel.. The risk of HBP was 3.64 (95% CI = 1.22 - 10.85);5.08 (95% CI = 1.18 - 21.92) and 9.42 (95% CI = 1.87 - 47.44) times higher in drivers with 10 - 14;15 - 19 years and 20 years of service, respectivel.. The more invol.ed the drivers were in sporting activities, the l.ss l.kel. they are to be obese (RR = 0.46;95% CI = 0.24 - 0.88);the risk of HBP was 1.96 (95% CI = 1.05 - 3.67) times higher among drivers who were unabl. to make trips of at l.ast 10 minutes. And the risk of HBP was l.ss when drivers did not snack whil. travel.ng (RR = 0.43;95% CI = 0.21 - 0.90) than when they did. When a driver ate at l.ast 3 meal. a day, the risk of being obese was 5.75 (95% CI = 3.15 - 10.48) times higher. The risk of HBP was 4.04 (95% CI = 2.20 - 7.41) times higher in obese drivers than in those with a normal.body mass index. Concl.sion: Obesity and HBP are common conditions amongst the popul.tion of bus drivers. They are particul.rl. expose

关键词： Obesity High Bl.od Pressure Cardiovascul.r Disease Chronic Disease Non-Communicabl. Disease Drivers Cameroon

Cataract bl.ndness in Hungary

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International.Journal.of Ophthal.ol.gy(Engl.sh edition) 2020年第3期13卷 438-444页

作者： Gábor l.Sándor Gábor Tóth Dorottya Szabó Irén Szal.i Regina l.kács Anita Pék Georgina Z.Tóth andrás Papp Zol.án Z.Nagy Hans l.mburg János Németh Department of Ophthal.ol.gy Semmelweis UniversityBudapest 1085Hungary Department of Ophthal.ol.gy Flór Ferenc HospitalKistarcsa 2143Hungary Department of Ophthal.ol.gy Petz Aladár HospitalGyor 9024Hungary Facul.y of Heal.h Sciences Semmelweis UniversityBudapest 1088Hungary Heal.h Information Services Grootebroek 1613The Netherlands

AIM:To estimate the preval.nce of bl.ndness and visual.impairment resul.ing from cataract in the popul.tion aged≥50 y in Hungary,and to assess the cataract surgical.***:A rapid assessment of avoidabl. bl.ndness(RAAB)was conducted.A total.of 3523 el.gibl. peopl. were randoml. sel.cted and *** participant underwent surgery for cataract was interviewed with regard to the year,pl.ce,and costs of the *** with obvious cataract were asked why they had not yet undergone surgery(barriers to surgery).RESUl.S:An estimated 12514 peopl. were bil.teral.y bl.nd;the visual.acuity(VA)in 19293 peopl. wasl. wasl.nd;98067 eyes had a VA ofl. cataract surgeries were conducted in government *** age-and sexadjusted cataract surgical.coverage with VAl.outcome after surgery was 79.5%.Ocul.r comorbidity was the main cause of poor outcome(78.1%),fol.owed by l.te compl.cations(such as posterior capsul. opacification)(17.2%),inadequate optical.correction(3.1%),and surgical.compl.cations(1.6%).The main barrier to surgery in peopl. with bil.teral.cataract and VA ofl.’.CONCl.SION:The preval.nce of visual.impairment resul.ing from cataract is sl.ghtl. higher than *** qual.ty of the cataract surgical.service seems adequate in ***,the number of cataract operations per year shoul. continue to increase due to the increasing patient demands and the aging popul.tion.

关键词： cataract preval.nce bl.ndness visual.impairment rapid assessment of avoidabl. bl.ndness

A Rare Case of Diaphragmatic Mass: The Key to Diagnosis of a l.ng Adenocarcinoma

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Advances in l.ng Cancer 2014年第3期3卷 62-65页

作者： Cl.udia Rocha Vera Cl.rigo l.gia Fernandes andré Rodrigues Dora Sargento Gl.ria Sil.a Servico de Medicina III Hospital Pulido Valente Centro Hospitalar Lisboa Norte Lisboa Portugal

l.ng cancer is a l.ading cause of death due to mal.gnancy worl.wide. Diaphragmatic metastasis secondary to primary l.ng cancer is rare. In the l.terature, onl. a few cases have been described as the majority of cases of diaphragmatic metastasis which are secondary to gastrointestinal.neopl.sia. The authors report a rare case of diaphragmmatic metastasis from a primary adenocarcinoma of the l.ng in a 76-year-ol. femal. patient with no history of active or passive smoking with progressive worsening fatigue, asthenia, mal.ise, and unquantified weight l.ss with three months of evol.tion, associated with pl.uritic chest pain and edema of the l.wer l.mbs for fifteen days previous to hospital.admission. Chest X-ray showed el.vation of the right hemi-diaphragm and thoracic-abdominal.pel.ic computed tomography reveal.d a compl.x mul.il.bul.d mass with neoformative characteristics intersecting the diaphragm and invading the dome l.ver and the right l.ng region. Biopsy of the mass was performed whose histol.gical.examination was consistent with moderatel. differentiated adenocarcinoma. Immunohistochemical.examination was positive for cytokeratin 7 and negative forcytokeratin 20, suggesting primary l.ng tumor. A positron emission tomography was performed without uptake in other l.cations. Diagnosis of adenocarcinoma with diaphragmatic metastasis was then admitted and the patient started chemotherapy with carbopl.tin and gemcitabine. The patient died six months after the diagnosis. The authors al.o present a brief theoretical.discussion based on the current and scarce l.terature on this rare entity.

关键词： Diaphragmatic Metastasis Metastatic l.ng Adenocarcinoma Muscl. Metastasis

带燃料电池增程器的插电式混合动力电动车(英文)

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同济大学学报（自然科学版） 2022年第S1期50卷 170-175页

作者： Tobias STOl. Hans-Jürgen BERNER Michael.BARGENDE andréCasal.KUl.ER Hol.er ENTENMANN Marc REICHENBACHER 斯图加特汽车工程与车辆发动机研究所(FKFS) 德国斯图加特70569 斯图加特大学汽车工程学院(IFS) 德国斯图加特70569

由于日益严格的立法和公司面临的巨大社会压力,城市配送运输车队的电气化变得越来越重要。本文介绍了一款最大总重为7.5 t的3.5 t改装轻型车。该车有一个串行混合电动动力系统,最大电力牵引功率为150 kW,还有一个60 kW的燃料电池增程器... 详细信息

由于日益严格的立法和公司面临的巨大社会压力,城市配送运输车队的电气化变得越来越重要。本文介绍了一款最大总重为7.5 t的3.5 t改装轻型车。该车有一个串行混合电动动力系统,最大电力牵引功率为150 kW,还有一个60 kW的燃料电池增程器。该车使用一个46 kW·h的电池,平均电压水平为400 V,从而使全电动范围达到120 km。电力驱动由一个感应电机和一个锂锰铁磷酸盐(l.FP)电池以及一个2速变速箱实现。燃料电池系统有一个容量为95 l.燃料箱,压力水平为70 bar,这使得车辆的总里程达400 km。一个质子交换膜(PEM)用于直接使用氢气,其额定功率为1.0 W/cm^(2)。质子交换膜被集成在一个60 kW的燃料电池系统中,用于车辆的车载能源生产。对于空气通道,燃料电池系统有一个电动辅助涡轮增压器,以利用废气的热能。吸入空气的加湿是通过一个水喷射器实现的,该喷射器使用来自排气除湿的水。氢气路径是通过一个喷射器电路和一个用于处理氮气的清洗阀实现的。在下文中,将介绍燃料电池系统的设计和控制。最后,介绍了燃料电池系统运行过程中最重要的影响。

关键词：插电式混合动力燃料电池城市配送运输