视网膜色素瘤和残余中心视野患者的全视野视网膜电图、多焦视网膜电图及多焦诱发电位研究

作     者：Ponjavic V. Andr'Gr■asson S. L. Granse 程燕 

作者机构：Department of Ophthalmology University Hospital of Lund S-221 85 Lund Sweden Dr. 

出 版 物：《世界核心医学期刊文摘（眼科学分册）》 (Digest of the World Core Medical Journals:Ophthalmology)

年 卷 期：2005年第1卷第5期

页      面：18-19页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：视网膜电图 中心视野 诱发电位 视网膜功能 眼科检查 视功能 电位波幅 电生理方法 临床评估 亚组 

摘      要：Purpose: To evaluate (with three different electrophysiological methods) the r esidual retinal function in a selected group of patients with retinitis pigmento sa and remaining small central visual fields. Methods: Fourteen patients from se veral different genetic subgroups, who had been followed with visual acuity and visual field testing for periods up to 32 years, were examined. Ophthalmological examination included full-field electroretinography (ERG), multifocal electror etinography (mfERG) and multifocal visual evoked potential (mfVEP). Results: The ERGs were severely reduced in all patients. The mfERGs demonstrated the residua l central retinal function in five of the patients. The mfVEPs showed measurable amplitudes centrally in most of the patients. The follow-up examinations demon strated the slowly progressive course of the disease with preservation or only s light further loss of visual fields over a period of 7-32 years. Conclusion: Pa tients with retinitis pigmentosa may not always follow the typical natural cours e with progressive loss of visual fields, which may in some patients remain unaf fected over several decades. Multifocal ERG and mfVEP may be clinically useful f or evaluating remaining visual function in these patients.