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Journal of Systems Science and Systems Engineering 2016年第3期25卷 370-397页

作者： Jinhong Zhong Feng chu Chengbin chu Shanlin Yang School of Management Hefei University of Technology Hefei 230009 China Laboratoire IBISC Universite d'Evry-Val d'Essone France Laboratoire Genie Industriel Ecole Centrale Paris France Key Laboratory of Process Optimization and Intelligent Decision-making of Ministry of Education Hefei China

this paper addresses a dynamic lot sizing problem with bounded inventory and stockout where both no backlogging and backlogging allowed cases are considered. the stockout option means that there is outsourcing in a period only when the inventory level at that period is non-positive. the production capacity is unlimited and production cost functions are linear but with fixed charges. the problem is that of satisfying all demands in the planning horizon at minimal total cost. We show that the no backlogging case can be solved in O（t^2） time with general concave inventory holding and outsourcing cost functions where t is the length of the planning horizon. the complexity can be reduced to O（t） when the inventory holding cost functions are also linear and have some realistic properties, even if the outsourcing cost functions remain general concave functions. When the inventory holding and outsourcing cost functions are linear, the backlogging case can be solved in O（ t^3 logt） time whether the outsourcing level at each period is bounded by the sum of the demand of that period and backlogging level from previous periods, or only by the demand of that period.

关键词： Dynamic lot sizing problem bounded inventory outsourcing backlogging stockout,dynamic programming

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中美老年专科临床药师培训项目比较分析

中国药房 2024年第14期35卷 1781-1785页

作者：刘琛褚燕琦白向荣首都医科大学宣武医院药剂科北京100053

目的比较中美两国老年专科临床药师培训项目的基本情况,为我国老年专科临床药师培训项目的进一步优化提供参考。方法查询美国卫生系统药师协会(ASHP)和中国医院协会官方网站,检索并收集中美两国老年专科临床药师培训项目的培训大纲、... 详细信息

目的比较中美两国老年专科临床药师培训项目的基本情况,为我国老年专科临床药师培训项目的进一步优化提供参考。方法查询美国卫生系统药师协会(ASHP)和中国医院协会官方网站,检索并收集中美两国老年专科临床药师培训项目的培训大纲、机构类型/规模、招生人数、培训内容、申请条件、考核标准等资料和数据,采用Excel软件进行统计分析。结果与结论截至2024年1月12日,美国ASHP共开展毕业后第2年老年专科临床药师培训项目24个,可招收25人,并提供相应薪酬;培训基地涉及医院、药学院,规模不一;申请人需获得药学博士学位、完成毕业后第1年培训。ASHP就基础患者照护、高级患者照护、领导力和管理能力、知识的教育教学传播能力四大必备技能设计了详细的培训目标,各培训基地可结合自身特点,适当增设学术技能、长期照护技能等可选技能,制订学员轮转计划,并在培训过程的多个时间节点进行考核、评估。我国共开展老年专科临床药师培训项目5个,可招收15人,不提供薪酬;培训基地均为三级甲等医院,规模较大;申请人需要获得本科及以上学位,并根据所学专业和学位的不同,对其有不同的工作年限要求。中国医院协会药事专业委员会设置了详细的培训大纲,就理论知识、实践技能、科研思维等提出了具体的培训目标,在入组时、规定内容培训完成时和结业时由培训基地组织考核、评估。参考美国的项目开展经验,建议带教老师针对不同层次的学员开展差异化的知识和技能培训,灵活安排轮转科室,要求学员尽可能独立开展工作并深入参与临床教学、科研工作,安排多次、多种形式的考核、考察,及时调整学习方案,全面提升学员能力。

关键词：老年专科临床药师培训项目毕业后教育

Symmetry and Period-Adding Windows in a Modified Optical Injection Semiconductor Laser Model

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Chinese Physics Letters 2012年第1期29卷 1-4页

作者： LI Xian-Feng Andrew Y-t.Leung chu Yan-Dong Department of Mathematics Lanzhou Jiaotong UniversityLanzhou 730070 Department of Civil and Architectural Engineering City University of Hong KongHong Kong

Hierarchical structural symmetry of periodic islands embedded in the chaotic region of modified optical injection semiconductor lasers(MOISLs)is expounded upon in phase *** onset of the bifurcation cascade shows remarkable accumulation *** cascade follows a specific period-adding ***-similarities and infinite spiral nestings shrinking beyond a certain point of the periodic hub are revealed to affirm the existence of self-organized distribution of periodicity and chaos in phase diagrams.

关键词： periodic bifurcation symmetry

the role of Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma

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Virologica Sinica 2015年第2期30卷 107-121页

作者： Chi Man tsang sai Wah tsao Department of Anatomy Li Ka Shing Faculty of Medicine University of Hong Kong Hong Kong SAR China

Nasopharyngeal carcinoma(NPC) is closely associated with Epstein-Barr virus(EBV) infection. EBV episomes are detected in almost all NPC cells. the role of EBV in NPC pathogenesis has long been postulated but remains enigmatic. In contrast to infection of B lymphocytes, EBV infection does not directly transform nasopharyngeal epithelial cells into proliferative clones with malignant potential. EBV infection of normal pharyngeal epithelial cells is predominantly lytic in nature. Genetic alterations in premalignant nasopharyngeal epithelium, in combination with inflammatory stimulation in the nasopharyngeal mucosa, presumably play essential roles in the establishment of a latent EBV infection in infected nasopharyngeal epithelial cells during the early development of NPC. Establishment of latent EBV infection in premalignant nasopharyngeal epithelial cells and expression of latent viral genes, including the BARt transcripts and BARt-encoded micro RNAs, are crucial features of NPC. Expression of EBV genes may drive further malignant transformation of premalignant nasopharyngeal epithelial cells into cancer cells. the difficulties involved in the establishment of NPC cell lines and the progressive loss of EBV epsiomes in NPC cells propagated in culture strongly implicate the contribution of host stromal components to the growth of NPC cells in vivo and maintenance of EBV in infected NPC cells. Defining the growth advantages of EBV-infected NPC cells in vivo will lead to a better understanding of the contribution of EBV infection in NPC pathogenesis, and may lead to the identification of novel therapeutic targets for NPC treatment.

关键词： Epstein-Barr virus(EBV) nasopharyngeal carcinoma latent infection pathogenesis inflammation

Analysis of Higher Order Channel Dropping tunneling Processes in Photonic Crystals

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Chinese Physics Letters 2000年第10期17卷 737-739页

作者： FU Jian HE sai-Ling Centre for Optical and Electromagnetic Research State Key Laboratory for Modern Optical InstrumentationZhejiang UniversityHangzhou 310027

A theoretical analysis is given for a higher order channel drop tunneling structure composed of two horizontal channels and a resonator system with two vertical multi-mode cavities in a two- or three-dimensional photonic crystal. Criteria for a complete transfer are derived for the application of wavelength division multiplexing. Compared to the resonator system with two single-mode cavities or a single multi-mode cavity, the present resonator system improves the transport properties.

关键词： resonator properties. Crystal

Portable spirometer-based pulmonary function test willingness in China: A nationwide cross-sectional study from the "Happy Breathing Program"

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中华医学杂志(英文版) 2024年第14期137卷 1695-1704页

作者： Qi Weiran Huang Ke Chen Qiushi Jiao Lirui Yu Fengyun Yu Yiwen Niu Hongtao Li Wei Fang Fang Lei Jieping chu Xu Li Zilin Geldsetzer Pascal B?rnighausen till Chen Simiao Yang ting Wang Chen Department of Health Economics and Health Policy School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Pulmonary and Critical Care Medicine National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and Multimorbidity National Clinical Research Center for Respiratory Diseases Institute of Respiratory Medicine Chinese Academy of Medical Sciences Center of Respiratory Medicine China-Japan Friendship Hospital Beijing China the Harold and Inge Marcus Department of Industrial and Manufacturing Engineering The Pennsylvania State University University Park PA USA Department of Health Policy and Management Gillings School of Global Public Health University of North Carolina at Chapel Hill Chapel Hill NC USA Heidelberg Institute of Global Health (HIGH) Faculty of Medicine and University Hospital Heidelberg University Heidelberg Germany Administration Office of Medical Reform and Development China-Japan Friendship Hospital Beijing China Data and Project Management Unit Institute of Clinical Medical Sciences China-Japan Friendship Hospital Beijing China Department of Statistics School of Mathematics and Statistics Northeast Normal University Changchun Jilin China Chan Zuckerberg Biohub Stanford University School of Medicine San Francisco CA USA Division of Primary Care and Population Health Department of Medicine Stanford University School of Medicine Stanford CA USA Harvard Center for Population and Development Studies Harvard T.H. Chan School of Public Health Harvard University Cambridge MA USA

Background: Understanding willingness to undergo pulmonary function tests (PFts) and the factors associated with poor uptake of PFts is crucial for improving early detection and treatment of chronic obstructive pulmonary disease (COPD). this study aimed to understand willingness to undergo PFts among high-risk populations and identify any barriers that may contribute to low uptake of ***: We collected data from participants in the "Happy Breathing Program" in China. Participants who did not follow physicians’ recommendations to undergo PFts were invited to complete a survey regarding their willingness to undergo PFts and their reasons for not undergoing PFts. We estimated the proportion of participants who were willing to undergo PFts and examined the various reasons for participants to not undergo PFts. We conducted univariable and multivariable logistic regressions to analyze the impact of individual-level factors on willingness to undergo ***: A total of 8475 participants who had completed the survey on willingness to undergo PFts were included in this study. Out of these participants, 7660 (90.4%) were willing to undergo PFts. Among those who were willing to undergo PFts but actually did not, the main reasons for not doing so were geographical inaccessibility (n = 3304, 43.1%) and a lack of trust in primary healthcare institutions (n = 2809, 36.7%). Among the 815 participants who were unwilling to undergo PFts, over half (n = 447, 54.8%) believed that they did not have health problems and would only consider PFts when they felt unwell. In the multivariable regression, individuals who were ≤54 years old, residing in rural townships, with a secondary educational level, with medical reimbursement, still working, with occupational exposure to dust, and aware of the abbreviation "COPD" were more willing to undergo ***: Willingness to undergo PFts was high among high-risk populations. Policymakers may consider implementing strategies suc

关键词： Chronic obstructive pulmonary disease Pulmonary function tests Willingness to undergo pulmonary function tests Population medicine

Benefciation studies on recovery and in-depth characterization of ilmenite from red sediments of badlands topography of Ganjam District,Odisha,India

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International Journal of Mining Science and technology 2013年第5期23卷 725-731页

作者： t.Laxmi Satya sai Srikant D.S.Rao R.Bhima Rao Mineral Processing Department CSIR-Institute of Minerals and Materials Technology Department of Electronics and Communication Engineering SRM University Aryan College of Engineering and technology

this paper deals with the recovery of ilmenite mineral from red sediments of badlands topography and suggested flowsheet with material *** results of these investigations reveal that the red sediment samples contain 33.2%total heavy mineral,in which ilmenite mineral concentrate is 28.71%(by weight).the ilmenite concentrate recovered from red sediment sample by physical benefciation process,which included scrubbing,desliming,gravity concentration,magnetic and electrostatic separation,contains 99.41%grade with 97.3%*** ilmenite mineral concentrate recovered from red sediments is also suitable for industrial *** characterization studies on ilmenite reveal that the tiO2percentage is marginally increasing from 46.69%to 47.86%with increasing magnetic intensity from0.46 to 1.55 t.

关键词： Red sediments Badlands topography Ilmenite Benefciation Characterization

鄂东南铁铜金钨钼多金属矿集区基底属性:来自继承锆石年龄和Hf同位素的约束

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西北地质 2024年第5期57卷 283-297页

作者：谢应波褚刚罗华郭盼湖北省地质调查院湖北武汉430034 江西省景德镇市建筑设计院有限公司江西景德镇333001

长江中下游成矿带鄂东南矿集区的基底存在统一的川中式基底和北部川中式基底、南部江南式基底的争议。笔者对灵乡岩体西段闪长玢岩开展锆石U-Pb定年和Hf同位素分析,结果显示闪长玢岩的锆石具有复杂的组成与来源:最年轻的4颗锆石加权平... 详细信息

长江中下游成矿带鄂东南矿集区的基底存在统一的川中式基底和北部川中式基底、南部江南式基底的争议。笔者对灵乡岩体西段闪长玢岩开展锆石U-Pb定年和Hf同位素分析,结果显示闪长玢岩的锆石具有复杂的组成与来源:最年轻的4颗锆石加权平均年龄为(141±4)Ma,结合前人测年结果推测其可作为闪长玢岩的成岩年龄;其余16颗锆石具有较为宽泛的年龄(217~2550 Ma)和Hf同位素组成(εHf(t)=-11.2~11.7)。进一步结合前人获得的鄂东南矿集区岩浆岩继承锆石数据,分别对比川中式基底崆岭杂岩、江南式基底梵净山群及下江群的锆石数据,发现其与崆岭杂岩具有明显差异,但和梵净山群及下江群具有高度相似性。并且鄂东南矿集区岩浆岩继承锆石和梵净山群、下江群均记录了~1.5 Ga地壳增生事件。结合区域地球物理特征,笔者认为鄂东南矿集区南部为江南式基底,北部为川中式基底,两者的分界线大致为灵乡-大冶-网湖一线。

关键词：川中式基底江南式基底继承锆石鄂东南矿集区长江中下游成矿带

构建急性主动脉夹层患者发生急性肾损伤的临床预测模型

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现代生物医学进展 2024年第14期24卷 2613-2618,2633页

作者：李素华陈思思黄萱褚雪倩李欣赛陆晨省部共建中亚高发病成因与防治国家重点实验室新疆医科大学第一附属医院肾脏疾病中心新疆乌鲁木齐830054 新疆维吾尔自治区肾脏病研究所新疆乌鲁木齐830054 兰州大学第一医院甘肃兰州730013 新疆肾脏替代治疗临床医学研究中心新疆乌鲁木齐830054

目的:分析单中心近3年急性主动脉夹层(AAD)患者的临床资料,构建不同分型AAD患者发生急性肾损伤的临床预测模型,以期指导相关临床医生早期诊断及预防AKI。方法:回顾性收集2019年1月至2021年12月在新疆医科大学第一附属医院住院并确诊为... 详细信息

目的:分析单中心近3年急性主动脉夹层(AAD)患者的临床资料,构建不同分型AAD患者发生急性肾损伤的临床预测模型,以期指导相关临床医生早期诊断及预防AKI。方法:回顾性收集2019年1月至2021年12月在新疆医科大学第一附属医院住院并确诊为急性主动脉夹层患者的临床资料,将其按照CtA影像学结果分为A型和B型患者,按照KDIGO标准又将其分别分为AKI组及非AKI组。比较两组间术前临床资料差异,用二元Logistic回归筛出AAD-AKI的独立预测因子,并构建Logistic临床预测模型。通过绘制各独立预测因子及联合诊断的ROC曲线,评估预测模型对夹层患者发生AKI的诊断价值。结果:多因素Logistic回归分析表明:收缩压、白细胞、入院首次肌酐是tAAAD患者发生AKI的独立预测因子(PtAAAD-AKI预测模型Logit(P)=-5.189+0.019*收缩压+0.109*白细胞+0.012*入院首次肌酐。而tBAAD患者独立预测因子为乳酸浓度、入院首次肌酐、肾脏灌注不良,其预测模型为Logit(P)=-2.976+0.295*乳酸浓度+0.042*入院首次肌酐+0.655*肾脏灌注不良。结论:A型和B型患者发生AKI的最佳单因子预测指标均是入院首次肌酐,由于不同类型的夹层导致患者发生AKI机制也不完全相同,因此根据上述这些预测因子我们构建的临床模型并且发现有良好的预测效价,可为临床医生诊断提供依据。

关键词：急性主动脉夹层急性肾损伤预测因子和模型

超高效液相色谱-串联质谱法快速检测预制调理羊肉串中15种杂环胺

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食品安全质量检测学报 2024年第4期15卷 49-58页

作者：王露露罗娇依冯赛赛曹进孙姗姗国家市场监督管理总局食品质量与安全重点实验室中国食品药品检定研究院北京100050 山西师范大学食品科学学院太原030000

目的基于超高效液相色谱-串联质谱法(ultra performance liquid chromatography-tandem mass spectroscopy,UPLC-MS/MS)建立预制调理烤制羊肉串样品中15种杂环胺(heterocyclic aromatic amines,HAAs)的高通量快速检测方法。方法将预制调理羊肉串烤制后,对固相萃取柱萃取法(Oasis PRiME HLB柱和OasisMCX柱)、分散固相萃取法(QuEChERS)的净化效率进行评估;得到净化物后经t3色谱柱(150 mm×2.1 mm,1.8μm)分离,以乙腈和15 mmol/L甲酸铵溶液为流动相,梯度洗脱分离,采用串联三重四极杆质谱法对15种HAAs进行定量分析。结果在一定检测范围内,15种HAAs的线性良好,相关系数(r^(2))在0.9979~0.9997之间,检出限和定量限分别是0.002~0.017 ng/g和0.008~0.050 ng/g,加标回收率为81.3%~113.2%,相对标准偏差(relative standard deviations,RSDs)不大于11.9%。结论该方法前处理效率高,灵敏度高,重现性好,可用于预制调理烤制羊肉串样品中15种HAAs的快速检测,为日后建立预制食品国家标准与法规提供方法依据。

关键词：预制调理羊肉串杂环胺超高效液相色谱-串联质谱法 QuEChERS法