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Pathogens causing diarrhoea among Bangladeshi children with malignancy: Results from two pilot studies

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World Journal of Clinical Cases 2020年第2期8卷 276-283页

作者： sabina Karim Ferdousi Begum Afiqul Islam Monowar Ahmad Tarafdar Mamtaz Begum Md Johirul Islam Bushra Malik Md Shamim Ahsan Ameneh Khatami Harunor Rashid Department of Paediatric Haematology and Oncology National Institute of Cancer Research and HospitalMohakhaliDhaka 1212Bangladesh Department of Pediatric Hematology and Oncology Bangabandhu Sheikh Mujib Medical UniversityDhaka 1212Bangladesh Department of Community Medicine Z.H.Sikder Women’s Medical CollegeDhaka 1212Bangladesh Department of Cancer Epidemiology National Institute of Cancer Research and HospitalMohakhaliDhaka 1212Bangladesh National Centre for Immunisation Research and Surveillance The Children’s Hospital at WestmeadWestmeadNSW 2145Australia Medical Services Rangpur CantonmentRangpur 5400Bangladesh Department of Infectious Diseases and Microbiology The Children’s Hospital at WestmeadNSW 2145Australia Discipline of Child and Adolescent Health Faculty of Medicine and HealthUniversity of SydneyNSW 2145Australia

BACKGROUND Diarrhoea is a frequent symptom in children with cancer, and occurs due to a composite effect of underlying disease and immunosuppression consequent to therapy, malnutrition, and non-infective aetiologies such as mucositis. In a large proportion of cases, the aetiology of diarrhoea remains unknown but is often attributed to multiple pathogens including *** To identify and describe the pathogens causing diarrhoea in Bangladeshi children with *** Two cross-sectional pilot studies were conducted involving paediatric oncology patients with diarrhoea. Stool samples were collected from children who were hospitalised with or without being treated with chemotherapy during the study period, and had diarrhoea at any stage during their admission. In the first study,stool samples were tested by conventional microbiological methods and by polymerase chain reaction for parasites, and by immunoassays for Clostridium difficile. In the second study, conventional microbiology was conducted for bacteria and parasites including an enzyme-linked immunosorbent assay for Cryptosporidium antigen, and in a subset, immunoassays for Clostridium *** In the first study Giardia lamblia was detected in 68.5% of samples, Entamoeba histolytica in 13%, Cryptosporidium in 5.6%, non-toxigenic C. difficile in 22.4%, and other bacteria in 5.2%. In the second study, E. histolytica was detected in 10% of samples, Cryptosporidium in 4.3%, G. lamblia in 1.4%, C. difficile in 5.1%, and other bacteria in 5.7% of *** These pilot data suggest that parasites are important aetiologies of diarrhoea in Bangladeshi children with malignancy. While molecular diagnostic tools detect an array of stool pathogens with greater sensitivity, conventional diagnostic methods are also useful.

关键词： Bangladesh Cancer Child Cryptosporidium Gastroenteritis Parasite

Phenolics from grapefruit peels inhibit HMG-CoA reductase and angiotensin-I converting enzyme and show antioxidative properties in endothelial *** 926 cells

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Food Science and Human Wellness 2015年第2期4卷 80-85页

作者： Ayokunle O.Ademosun Ganiyu Oboh sabina Passamonti Federica Tramer Lovro Ziberna Aline Augusti Boligon Margareth Linde Athayde Functional Foods and Nutraceuticals Unit Department of BiochemistryFederal University of TechnologyAkureNigeria Department of Life Sciences University of Triestevia L.Giorgieri 134127 TriesteItaly Program of Post-Graduation in Pharmaceutical Sciences Federal University of Santa MariaCampus CamobiSanta MariaRS 97105-900Brazil

This study sought to investigate the possible mechanisms for the use of phenolic extracts from grapefruit peels in the management/prevention of cardiovascular *** effects of the phenolic extracts on key enzymes relevant to cardiovascular diseases[3-hydroxy-methyl-3-glutaryl coenzyme A reductase(HMG-CoA reductase)and angiotensin-I converting enzyme(ACE)],cellular antioxidant activity in human endothelial cells(*** 926)and radicals[1,1-diphenyl-2 picrylhydrazyl(DPPH)and 2,2-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)(ABTS)]scavenging abilities were *** phenolic contents of the extracts were investigated using HPLC–*** was no significant(P>0.05)difference in the HMG-CoA reductase inhibitory ability of the two extracts,while the bound phenolic extracts had a stronger ACE inhibitory ability than the soluble free *** extracts also showed intracellular antioxidant activity in human endothelial(*** 926)***,the bound phenolics had significantly higher radicals(DPPH*and ABTS*)scavenging abilities than the free *** HPLC analysis revealed the presence of flavonoids(quercetin and kaempferol),phenolics acids(resveratrol,gallic acid,ellagic acid and caffeic acid)and tannin(catechin).The cellular antioxidative properties and inhibition of enzymes relevant to the management of cardiovascular complications showed that grapefruit peels could be used as nutraceuticals for the management of such conditions.

关键词： prevention cardiovascular phenolic

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Water Service Provision in Owerri City, Nigeria

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Journal of Water Resource and Protection 2012年第7期4卷 497-506页

作者： Emmanuella C. Onyenechere sabina C. Osuji Department of Geography & Environmental Management Imo State University Owerri Nigeria Department of Urban & Regional Planning Imo State University Owerri Nigeria

The study investigates water service provision in Owerri-a Nigerian city. For the study both primary and secondary data were obtained and analysed. Secondary data were obtained from Imo State Water Corporation (ISWC) and the Works Department of Owerri Municipal Council. While, primary data were obtained from all the 17 wards that constitute Owerri city, i.e. the municipal area. Key informants were identified and interviewed using a structured interview schedule. The analysis of variance employed showed that there are significant differences in the water service provision pattern in the seventeen wards in Owerri city. The study found that though most residents of Owerri city rely heavily on commercial borehole owners and water tanker drivers/water peddlers for their daily supplies, the government through its SWA is in control, and there is an absence of a popularly acceptable regulatory framework/water policy. It recommends that Water decree 101 from 1993 (water legislation) be reviewed to address growing challenges. In order to enhance regular water supply at less cost, the study recommends that government should collaborate with the private sector and other community based organizations in a tripartite partnership. A new regulatory framework that will carry out government ownership and control of water resources and participatory aspects of water management should be produced by ISWC.

关键词： Boreholes Regulation State Water Agency Water Peddlers Water Policy

Reiterated homogenization of a laminate with imperfect contact:gain-enhancement of effective properties

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Applied Mathematics and Mechanics(English Edition) 2018年第8期39卷 1119-1146页

作者： F.E.ALVAREZ-BORGES J.BRAVO-CASTILLERO M.E.CRUZ R.GUINOVART-DIAZ L.D.PEREZ-FERNANDEZ R.RODRIGUEZ-RAMOS F.J.sabina Facultad de Matematica y Computacion Departamento de MatematicaUniversidad de La HabanaSan Lazaro y LHabana 4La HabanaCP 10400Cuba Departamento de Matematicas y Mecanica Universidad Nacional Autonoma de MexicoInstituto de Investigaciones en Matematicas Aplicadas y en Sistemas01000 CDMXAP 20-126M′exico Departamento de Engenharia Mecanica Universidade Federal do Rio de JaneiroPolitecnica/COPPECaixa Postal 68503Rio de JaneiroRJCEP 21941-972Brasil Departamento de Matematica e Estatistica Universidade Federal de PelotasCaixa Postal 354PelotasRio Grande do SulCEP 96010-900Brasil

A family of one-dimensional(1D) elliptic boundary-value problems with periodic and rapidly-oscillating piecewise-smooth coefficients is considered. The coefficients depend on the local or fast variables corresponding to two different structural scales. A finite number of imperfect contact conditions are analyzed at each of the scales. The reiterated homogenization method(RHM) is used to construct a formal asymptotic solution. The homogenized problem, the local problems, and the corresponding effective coefficients are obtained. A variational formulation is derived to obtain an estimate to prove the proximity between the solutions of the original problem and the homogenized problem. Numerical computations are used to illustrate both the convergence of the solutions and the gain of the effective properties of a three-scale heterogeneous 1D laminate with respect to their two-scale counterparts. The theoretical and practical ideas exposed here could be used to mathematically model multidimensional problems involving multiscale composite materials with imperfect contact at the interfaces.

关键词： reiterated homogenization method(RHM) imperfect contact variational formulation effective coefficient gain

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Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin

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Cellular & Molecular Immunology 2020年第4期17卷 380-394页

作者： Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag Institute of Immunology Section Molecular ImmunologyHeidelberg UniversityIm Neuenheimer Feld 30569120 HeidelbergGermany Institute of Human Genetics Department of Human Molecular Geneticsand nCounter Core FacilityHeidelberg UniversityIm Neuenheimer Feld 36669120 HeidelbergGermany Department of Dermatology Heidelberg UniversityIm Neuenheimer Feld 44069120 HeidelbergGermany

The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin *** psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal ***,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the ***,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains ***,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T *** activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/*** T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 *** particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/*** latter molecule initiated STAT1 signaling and IFN γproduction in T *** of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin ***,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases.

关键词： keratinocytes inflammatory skin diseases psoriasis human T cells costimulation CD2 LFA-1 nonprofessional antigenpresenting cells Th1 cells Th17 cells

阿尔茨海默病发病与淀粉样β蛋白1～42/α1-抗糜蛋白酶复合物及脂质代谢紊乱的关系

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中国临床康复 2005年第9期9卷 42-45,i002页

作者：孙永馨贾建平 sabina Janciauskiene 首都医科大学宣武医院神经内科 Wallenberg Lab Plan2University HospitalUMAS MalmSweden S-20502

目的:研究淀粉样β蛋白(Aβ)1～42与α1-抗糜蛋白酶(antichymotrypsin,ACT)形成的复合物对神经胶质瘤细胞(DK-MG)脂质代谢的影响,探索脂质代谢紊乱与阿尔茨海默病(Alzheimerdisease,AD)发病机制的相关性。方法:实验于2001-01/2002-03在... 详细信息

目的:研究淀粉样β蛋白(Aβ)1～42与α1-抗糜蛋白酶(antichymotrypsin,ACT)形成的复合物对神经胶质瘤细胞(DK-MG)脂质代谢的影响,探索脂质代谢紊乱与阿尔茨海默病(Alzheimerdisease,AD)发病机制的相关性。方法:实验于2001-01/2002-03在瑞典隆德大学附属马尔默医院Wallenberg实验室和首都医科大学宣武医院神经内科实验室完成,Aβ1～42与ACT溶液室温下以10∶1摩尔比混合孵育2h,琼脂糖凝胶电泳和Western-blot检测反应产物Aβ1～42/ACT。观察在Aβ1～42/ACT存在的条件下,细胞对低密度脂蛋白(low-densitylipoprotein,LDL)的摄取、降解和细胞内胆固醇的合成;红油O染色观察细胞内脂质的含量;RT-PCR检测LDL受体(LDLr)的mRNA表达水平。结果:Aβ1～42,ACT单克隆抗体染色证实Aβ1～42/ACT复合物的存在。与对照组细胞相比,Aβ1～42/ACT使细胞摄取LDL增加50%(t=10.30,P<0.01),胞内脂质颗粒增加20倍(t=6.84,P<0.05),LDLr的mR-NA水平增加48%(t=20.79,P<0.01)。相反,Aβ1～42,ACT单分子对上述脂质代谢过程没有显著影响。Aβ1～42,ACT,Aβ1～42/ACT对LDL降解、细胞内胆固醇的合成都没有影响。结论:Aβ1～42/ACT复合物使神经胶质细胞内的脂质累积增加,可能是LDLr表达上调增加LDL摄取的结果。脂质代谢紊乱是AD发病的假说之?

关键词：阿尔茨海默病淀粉样β蛋白 α1-抗糜蛋白酶脂蛋白类,LDL 脂类/代谢

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Ascites as a Symptom of a Rotavirus Infection—Case Report

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Advances in Infectious Diseases 2014年第2期4卷 73-76页

作者： sabina Wiecek Urszula Grzybowska-Chlebowczyk Halina Wos Department of Paediatrics Medical University of Silesia Katowice Poland

Rotaviruses (RV) are the most common cause of acute diarrhoea in children. The course of RV in-fections may vary from a mild to a serious course of diarrhoea with significant disturbances to the water-electrolyte and acid-base homeostasis and complications requiring hospitalisation. There are known cases of postinfectious enteropathy and severe cases may involve a complete villous atrophy and temporary intolerance to lactose in the course of rotavirus infection. Opinions on the changes in the permeability of the mucous of the small intestine in the result of ongoing inflammation are largely diverse. This study presents a very rare complication of a rotavirus infection which is ascites in a 3-month infant. It seems that the pathomechanism of ascites in presented patient is very complex and affected by other factors such as nutritional disorders, including hypoproteinemia and hypoalbuminemia and immunological factors.

关键词： Rotavirus Infection Ascites Children

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Green–Nature

装饰 2020年第3期 2-2页

作者： sabina Oberholzer Renato Tagli

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New Software for the Identification and Characterization of Peptides Generated during Fontina Cheese Ripening Using Mass Spectrometry Data

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Journal of Chemistry and Chemical Engineering 2012年第4期6卷 323-326页

作者： sabina Valentni Massimo Natale Elisa Ficarra Andrea Barmaz Institut Agricole Rdgional Rdg. La Rochbre 1/A Aosta 11100 Italy BioDigitalValley S.rl. via Carlo Viola 78 Pont Saint Martin （AO） 11026 Italy Department of Control and Computer Engineering Politecnico di Torino Torino 11029 Italy

The aim of this work was to design and implement a new bioinformatics software which is able to identify the protein peptides from the peaks which arise from in-source or MS/MS fragmentation. The oligopeptide fraction was extracted from Fontina cheese at different ages of ripening and subsequently analyzed by LC/MS/MS. On the resulting total ion chromatograms, the peptides were identified by a method based both on the in-source fragmentation detectable with a single-quadrupole mass analyzer and by a new software which was developed. This software performs an in-silieo digestion of the major milk proteins, it calculates all the possible peptide fragments which are generated by the loss of the first N- or C-terminal amino acids, and finally, it matches the experimental ion chromatogram with the in-silico which generated theoretical spectrum to identify the exact amino-acid protein sequence of the unknown oligopeptide. With this tool, the useful insights into the proteolytic processes which occur during Fontina cheese aging are obtained, which leads to a better knowledge about the functional features of the proteolysis end product.

关键词： Fontina PDO cheese ripening LC-MS/MS new bioinformatics software.