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Hepatoprotective effect of leaves of Erythroxylum monogynum *** paracetamol induced toxicity

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Asian Pacific Journal of Tropical Biomedicine 2013年第11期3卷 877-881页

作者： sabeena Hussain Syed Ajay Gajanan Namdeo Department of Pharmacognosy Bharati Vidyapeeth Deemed UniversityPoona College of Pharmacy

Objective:To investigate the hepatoprotective activity of methanolic extract of leaves of Erythroxylum monogynum(***)on paracetamol induced ***:Methanolic extract of leaves of *** was given in doses of 100 mg/kg,200 mg/kg and 400 mg/kg for 7 d and toxicity was induced by paracetamol(2 mg/kg)on Day ***(50 mg/kg)was used as reference *** 24 h of toxicity induction blood samples were collected from retro-orbital plexsus and analyzed for serum parameters like serum glutamic pyruvic transaminase,serum glutamic oxaloacetate transaminse,alkaline phosphatase and total *** isolated were studied for histopathological ***:Phytochemical analysis of methanolic extract of *** leaves showed the presence of carbohydrates,flavonoids,phenols and *** administration of this extract restored the elevated levels serum markers as compared to toxic group which is also confirmed by the histopathological changes ***:The present study showed that methanolic extract of leaves of *** possess hepatoprotective action against paracetamol induced hepatotoxicity.

关键词： Erythroxylum monogynum Hepatoprotection Paracetamol Silymarin

Role of Media in Provoking Cigarette Smoking among Adolescents in Urban Nepal

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Health 2015年第1期7卷 98-105页

作者： Sushma Dahal sabeena Maharjan Raj Kumar Subedi Juna Maharjan Department of Public Health Central Institute of Science and Technology (CIST College) Kathmandu Nepal Department of Social Science Tribhuwan University Kathmandu Nepal Lumanti Support Group for Shelter Kathmandu Nepal

At current era of globalization, media is the double edged sword that is important both for health education as well as the stimulation of unhealthy behaviour. In Nepal, though there is ban on most forms of advertising, it is not clear about placement of tobacco advertisement in TV, films and other forms of media. Studies about cigarette smoking and its association with media are inadequate in Nepal. The objective of this study was to explore the role of media in cigarette smoking habit of adolescents in Nepal. A cross-sectional study was conducted among 394 adolescent students by using questionnaire method in 3 randomly selected colleges of Kathmandu district, Nepal. Data were analysed by using bivariate and multinomial logistic regression analysis. Statistically significant relationship at 95% CI was found between cigarette smoking status and media related variables like: seeing cigarette advertisement, reading fashion magazine, attending musical program sponsored by cigarette companies, watching movies in cinema hall, liking heavy metal/hard rock music, television watching time and desire to smoke if favourite artist smokes. Multinomial logistic regression showed that those with high receptivity to cigarette advertisement were likely to be current smokers (OR = 71.416, CI: 8.796 - 579.823) and ever smokers (OR = 9.582, CI: 2.201 - 41.714) compared to never smokers. About 79% of respondents agreed that media teaches different ways of smoking to its audiences. Different forms of media including cinema, music, magazines, television, games and music sponsorship are found to be important predictors for smoking status of college students in urban Nepal. Thus smoking prevention activities should consider role of media in smoking provocation among adolescents.

关键词： Adolescents Cigarette Advertisement Media Provocation Smoking

Bioactive molecules from terrestrial and seafood resources in hypertension treatment:focus on molecular mechanisms and targeted therapies

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Natural Products and Bioprospecting 2023年第1期13卷 214-246页

作者： Md.Rezaul Islam Puja Sutro Dhar Shopnil Akash sabeena Hussain Syed Jeetendra Kumar Gupta Kumaraswamy Gandla Muniya Akter Abdur Rauf Hassan A.Hemeg Yasir Anwar Bassam Oudh Aljohny Polrat Wilairatana Department of Pharmacy Faculty of Allied Health SciencesDaffodil International UniversityDaffodil Smart CityBiruliaSavarDhaka 1216Bangladesh School of Pharmacy Vishwakarma UniversitySurvey No 234Kondhwa Main RdLaxmi NagarBetal NagarKondhwaPuneMaharashtra 411048India Institute of Pharmaceutical Research GLA UniversityMathuraUttar PradeshIndia Department of Pharmaceutical Analysis Chaitanya(Deemed to Be University)Himayath NagarHyderabadTelangana 500075India Department of Chemistry University of SwabiAnbarKhyber Pakhtunkhwa 23561Pakistan Department of Medical Laboratory Technology College of Applied Medical SciencesTaibah UniversityAl-Medinah Al-MonawaraSaudi Arabia Department of Biological Sciences Faculty of ScienceKing Abdulaziz UniversityJeddah 21441Kingdom of Saudi Arabia Department of Clinical Tropical Medicine Faculty of Tropical MedicineMahidol UniversityBangkok 10400Thailand

Hypertension(HTN),a complex cardiovascular disease(CVD),significantly impacts global health,prompting a growing interest in complementary and alternative therapeutic *** review article seeks to provide an up-to-date and thorough summary of modern therapeutic techniques for treating HTN,with an emphasis on the molecular mechanisms of action found in substances found in plants,herbs,and *** molecules have been a significant source of novel therapeutics and are crucial in developing and testing new HTN *** advances in science have made it possible to understand the complex molecular mechanisms underlying blood pressure(BP)-regulating effects of these natural substances ***,flavonoids,alkaloids,and peptides are examples of bioactive compounds that have demonstrated promise in influencing several pathways involved in regulating vascular tone,reducing oxidative stress(OS),reducing inflammation,and improving endothelial *** article explains the vasodilatory,diuretic,and renin-angiotensin-aldosterone system(RAAS)modifying properties of vital plants such as garlic and olive *** from plants are the primary in traditional drug development as models for novel antihypertensive drugs,providing diverse strategies to combat HTN due to their biological *** review also discusses the functions of calcium channel blockers originating from natural sources,angiotensin-converting enzyme(ACE)inhibitors,and nitric oxide(NO)*** seafood components in this study demonstrates the increased interest in using bioactive chemicals originating from marine sources to treat ***-3 fatty acids,peptides,and minerals obtained from seafood sources have anti-inflammatory,vasodilatory,and antioxidant properties that improve vascular health and control ***,we discussed the multiple functions of bioactive molecules and seafood components in the treatment of HTN.

关键词： Antihypertensive Plants Bioactive molecules Seafood Hypertension

Folic acid supplementation inhibits recurrence of colorectal adenomas:A randomized chemoprevention trial

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World Journal of Gastroenterology 2008年第28期14卷 4492-4498页

作者： Richard Jaszewski sabeena Misra Martin Tobi Nadeem Ullah Jo Ann Naumoff Omer Kucuk Edi Levi Bradley N Axelrod Bhaumik B Patel Adhip PN Majumdar John D Dingell Veterans Affairs Medical Center Karmanos Cancer InstituteDepartment of Internal MedicineWayne State University School of MedicineDetroitMI 48201United States

AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps. METHODS: In the current double-blind, placebo-controlled trial at this VA Medical Center, patients with colorectal adenomas were randomly assigned to receive either a daily 5 mg dose of folic acid or a matched identical placebo for 3 years. All polyps were removed at baseline colonoscopy and each patient had a follow up colonoscopy at 3 years. The primary endpoint was a reduction in the number of recurrent adenomas at 3 years. RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group. Recurrence of adenomas at 3-year was compared between the two groups. The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group. Patients below 70 years of age and those with left-sided colonicadenomas or advanced adenomas responded better to folic acid supplementation. CONCLUSION: High dose folic acid supplementation is associated with a signif icant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia.

关键词： Folic acid Adenoma, Colorectal cancer

Effect of Gastrointestinal Protease Digestion on Bioactivity of Marine Peptides

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Journal of Agricultural Science and Technology(B) 2014年第1期4卷 74-84页

作者： Ida-Johanne Jensen Lisa Lystbek Andersen Carlo Gunnar Ossum Greta Jakobsen Cristian De Gobba sabeena Farvin Koduvayur Habeebullah Inez Johansson Else Hoffmann Edel Oddny Elvevoll Flemming Jessen Henrik Hauch Nielsen Faculty of Bioscience Fisheries and Economics Norwegian College of FisheO Science UniversiO of Tromso Tromso 9037Norway Division ofIndustrial Food Research National Food Institute DTU-Food Technical University qf Denmark Lyngby DK-2800Denmark Department of Biology Cell and Developmental Biology Universitv of Copenhagen Copenhagen 2100 Denmark Marinova ApS Adelvej 11 Lem St. 6940 Denmark Department of Food Science University o[Copenhagen Frederiksberg C 1958 Denmark

Focus in nutritional science has turned towards components in, or added to, foods that may possess health beneficial activities beyond the classical nutritional value, namely functional food. Bioactive peptides are examples of such components. In vitro studies on bioactivities have mainly been executed without concerning subsequent digestion after intake and the aim of this work was hence to investigate how the in vitro antioxidative, antihypertensive and caspase activating activities of peptides are affected by digestion with gastrointestinal （GI） proteases. Five different fish protein hydrolysates were chosen to study the effect of in vitro digestion on bioactivity. The protein concentration decreased in all samples during digestion and the molecular weight distribution of the peptides shifted towards lower values. Thus, in vitro digestion with GI proteases resulted in a further degradation of the peptides obtained by hydrolysis. The antihypertensive effect increased in all samples after digestion with GI proteases whereas the antioxidative capacity decreased. The effect on the caspase activity depended on the proteases used in the preparation of hydrolysates. In conclusion, the caspase activity and antihypertensive activity are maintained during digestion with GI proteases, while the antioxidative capacity seems to be reduced.

关键词： Antioxidative ACE in vitro caspase bioactivity marine peptides.