Hepatoprotective effect of leaves of Erythroxylum monogynum *** paracetamol induced toxicity
Hepatoprotective effect of leaves of Erythroxylum monogynum *** paracetamol induced toxicity作者机构:Department of PharmacognosyBharati Vidyapeeth Deemed UniversityPoona College of Pharmacy
出 版 物:《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志(英文版))
年 卷 期:2013年第3卷第11期
页 面:877-881页
学科分类:1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题:Erythroxylum monogynum Hepatoprotection Paracetamol Silymarin
摘 要:Objective:To investigate the hepatoprotective activity of methanolic extract of leaves of Erythroxylum monogynum(***)on paracetamol induced ***:Methanolic extract of leaves of *** was given in doses of 100 mg/kg,200 mg/kg and 400 mg/kg for 7 d and toxicity was induced by paracetamol(2 mg/kg)on Day ***(50 mg/kg)was used as reference *** 24 h of toxicity induction blood samples were collected from retro-orbital plexsus and analyzed for serum parameters like serum glutamic pyruvic transaminase,serum glutamic oxaloacetate transaminse,alkaline phosphatase and total *** isolated were studied for histopathological ***:Phytochemical analysis of methanolic extract of *** leaves showed the presence of carbohydrates,flavonoids,phenols and *** administration of this extract restored the elevated levels serum markers as compared to toxic group which is also confirmed by the histopathological changes ***:The present study showed that methanolic extract of leaves of *** possess hepatoprotective action against paracetamol induced hepatotoxicity.