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解剖学研究 2024年第1期46卷 70-72页

作者：马延兵计胜峰肖新莉周劲松杨蓬勃西安交通大学医学部基础医学院人体解剖与组织胚胎学系陕西西安710061

硬脑膜骨化在临床影像学检查或神经外科手术中偶有发现,多为头部外伤后血肿机化所致。本文报道1例无明显诱因的多发硬脑膜骨化成年男性标本:一处位于右侧额顶部;一处位于大脑镰前部右侧;回顾硬脑膜骨化的相关文献,并展望临床中对于颅内... 详细信息

硬脑膜骨化在临床影像学检查或神经外科手术中偶有发现,多为头部外伤后血肿机化所致。本文报道1例无明显诱因的多发硬脑膜骨化成年男性标本:一处位于右侧额顶部;一处位于大脑镰前部右侧;回顾硬脑膜骨化的相关文献,并展望临床中对于颅内血肿诊疗的策略。

关键词：硬脑膜骨化钙化硬脑膜外血肿硬脑膜下血肿

GmNMHC5 may promote nodulation via interaction with GmGAI in soybean

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The Crop Journal 2022年第1期10卷 273-279页

作者： Wenting Wang Zhili Wang Wensheng Hou Li Chen Bingjun Jiang Wenya Ma Lijuan Bai Wenwen song Cailong Xu Tianfu han Yongjun Feng Cunxiang Wu School of Life Science Beijing Institute of TechnologyBeijing 100081China MARA Key Laboratory of Soybean Biology(Beijing) Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Soybean(Glycine max[L.]Merr.)is a food and oil crop whose growth and yield are influenced by root and nodule *** the present study,Gm NMHC5 was found to promote the formation of nodules in overexpressing *** contrast,the number of nodules in Gmnmhc5 edited with CRISPR/Cas9 decreased *** 35 S:Gm NMHC5 mutants,expression levels of genes involved in nodulation were significantly *** in vitro and in vivo biochemical analyses showed that Gm NMHC5 directly interacted with Gm GAI(a DELLA protein),and the content of gibberellin 3(GA_(3))in overexpressing mutants was lower than that in the wild *** results revealed that Gm NMHC5 participates in the classical GA signaling pathway,and may regulate the content of GA_3 to match the optimal concentration required for nodule formation,thereby promoting nodulation by directly interacting with Gm GAI.A model illustrating the mechanism by which Gm NMHC5 promotes soybean nodulation is presented.

关键词： Glycine max GmNMHC5 GmGAI Nodulation GA pathway

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水压驱动控制棒减速性能研究

原子能科学技术 2015年第5期49卷 825-831页

作者：秦本科许星星薄涵亮宋威清华大学核能与新能源技术研究院先进反应堆工程与安全教育部重点实验室北京100084

控制棒水压驱动线是一种新型的内置式控制棒驱动技术,控制棒水力减速装置是水压驱动线的关键部件之一,通过水力减速片和减速筒体的配合对控制棒进行减速,降低快速落棒末端的冲击速度,避免控制棒的变形和损坏。完成了水压驱动线快速落棒... 详细信息

控制棒水压驱动线是一种新型的内置式控制棒驱动技术,控制棒水力减速装置是水压驱动线的关键部件之一,通过水力减速片和减速筒体的配合对控制棒进行减速,降低快速落棒末端的冲击速度,避免控制棒的变形和损坏。完成了水压驱动线快速落棒减速实验,对减速过程机理进行了分析,在此基础上建立了水压驱动线快速落棒减速理论模型,理论模型的求解结果与实验结果符合很好,从而验证了理论模型的正确性。通过该模型对热态工况下水压驱动线的快速落棒性能进行了分析,为控制棒水压驱动线减速环节的设计和优化奠定了基础。

关键词：控制棒水压驱动线快速落棒控制棒水力减速装置减速片

血浆microRNA-206联合床旁超声膈肌功能预测老年机械通气患者撤机结果的价值

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中国现代医学杂志 2024年第4期34卷 58-65页

作者：吴魏芹韩香高利利赵红梅孙虹孙青松南京医科大学附属淮安第一医院急诊医学科江苏淮安223300

目的观察血浆microRNA-206(miRNA-206)与床旁超声膈肌功能联合预测老年机械通气患者撤机结果的价值。方法选取2020年6月—2023年6月在南京医科大学附属淮安第一医院急诊重症监护室住院的老年机械通气患者102例,根据撤机结果分为成功组... 详细信息

目的观察血浆microRNA-206(miRNA-206)与床旁超声膈肌功能联合预测老年机械通气患者撤机结果的价值。方法选取2020年6月—2023年6月在南京医科大学附属淮安第一医院急诊重症监护室住院的老年机械通气患者102例,根据撤机结果分为成功组、失败组。比较两组患者血浆miRNA-206、膈肌功能指标及一般资料;采用多因素逐步Logistic回归模型分析老年机械通气患者撤机结果的影响因素;绘制受试者工作特征(ROC)曲线分析血浆miRNA-206、床旁超声膈肌功能单独及联合对老年机械通气患者撤机结果的预测价值。结果102例患者撤机失败率为33.33%。与成功组比较,失败组膈肌增厚率(DTF)、膈肌活动度(DE)、血浆miRNA-206、白蛋白(Alb)水平降低(P<0.05),膈肌收缩速度(DCV)加快(P<0.05),膈肌浅快呼吸指数(DRSBI)、急性生理学和慢性健康状况评价Ⅱ(APACHEⅡ)评分、早期气管切开百分率升高(P<0.05),年龄增大(P<0.05)。多因素逐步Logistic回归分析结果显示:年龄[OR=1.089(95%CI:1.041,1.139)]、APACHEⅡ评分[OR=1.079(95%CI:1.029,1.131)]、miRNA-206[OR=0.663(95%CI:0.502,0.876)]、DTF[OR=0.587(95%CI:0.389,0.887)]、DE[OR=0.744(95%CI:0.584,0.947)]、DCV[OR=1.213(95%CI:1.059,1.389)]和DRSBI[OR=1.931(95%CI:1.029,3.622)]是老年机械通气患者撤机结果的影响因素(P<0.05)。ROC曲线分析结果显示,miRNA-206、DTF、DE、DCV、DRSBI预测老年机械通气患者撤机结果的最佳截断值分别为0.50、34.36%、9.60mm、1.50 cm/s、1.90次/(min·mm),敏感性分别为73.53%(95%CI:0.556,0.871)、67.65%(95%CI:0.495,0.826)、61.76%(95%CI:0.436,0.778)、70.59%(95%CI:0.525,0.849)、64.71%(95%CI:0.465,0.803),特异性分别为70.59%(95%CI:0.583,0.810)、73.53%(95%CI:0.614,0.835)、75.00%(95%CI:0.630,0.847)、72.06%(95%CI:0.599,0.823)、79.41%(95%CI:0.679,0.883),曲线下面积(AUC)分别为0.709、0.715、0.645、0.742、0.719;联合预测的敏感性为97.06%(95%CI:0.847,0.999),特异性为69.12%(95%CI:0.567,0.798),AUC为0.851。结论血浆miRNA-206联合床旁超声膈肌功能对老年机械通气患者撤机结果具有较高的预测价值。

关键词：机械通气撤机结果 microRNA-206 床旁超声膈肌功能

Ontogenetic trait variation and metacommunity effects influence species relative abundances during tree community assembly

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Plant Diversity 2022年第4期44卷 360-368页

作者： Yun-Yun He Kwansupa Srisombut Ding-Liang Xing Nanthan G.Swenson Mengesha Asefa Min Cao Xiao-Yang song han-Dong Wen Jie Yang CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla666303YunnanChina University of Chinese Academy of Sciences Beijing100049China School of Ecological and Environmental Sciences East China Normal UniversityShanghai200241China Department of Biological Sciences University of Notre DameNotre DameIN46556USA Center of Plant Ecology Core Botanical GardensChinese Academy of SciencesMengla666303YunnanChina

Predicting species abundance is one of the most fundamental pursuits of *** the information encoded in functional traits and metacommunities provides a new perspective to predict the abundance of species in *** applied a community assembly via trait selection model to predict quadrat-scale species abundances using functional trait variation on ontogenetic stages and metacommunity information for over 490 plant species in a subtropical forest and a lowland tropical forest in Yunnan,*** relative importance of trait-based selection,mass effects,and stochasticity in shaping local species abundances is evaluated using different null *** found both mass effects and trait selection contribute to local abundance *** selection was detectable at all studied spatial scales(0.04e1 ha),with its strength stronger at larger scales and in the subtropical *** contrast,the importance of stochasticity decreased with spatial scale.A significant mass effect of the metacommunity was observed at small spatial *** results indicate that tree community assembly is primarily driven by ontogenetic traits and metacommunity *** findings also demonstrate that including ontogenetic trait variation into predictive frameworks allows ecologists to infer ecological mechanisms operating in community assembly at the individual level.

关键词： Metacommunity Maximum entropy Ontogenetic trait variation Community assembly Trait-selected process

Role of mesocorticolimbic DA system in reinstatement induced by cue

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中国药理学与毒理学杂志 2018年第9期32卷 716-717页

作者： JING Man-yi han Xiao ZHAO Tai-yun LIU Wen-feng song Rui LI Jin Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Academy of Mililtary Sciences Beijing 100850 China

OBJECTIVE Dopamine(DA)plays important roles in Pavlovian conditioning by mediating reward,learning and *** the conditioning stimulation(CS) is the most important inducement for reinstatement in *** present study investigated the specific role of the DA projections to nucleus accumbens(NAc) and medial prefrontal cortices(mPFC) from ventral tegmental area(VTA) in reinstatement induced by ***(1)Optogenetic intracranial self-stimulation and ***-Cre transgenic mice received an injection of adeno-associated viral vectors encoding channelrhodopsin2(ChR2) or control vector into the VTA resulting in the selective expression of these opsins in DA ***,we stimulated the VTA,NAc(core and shel) or mP FC [prelimbic cortex(PL) and infralimbic cortex(IL)] via an optical *** the reinforcement test,the mice with ChR2 learned instrumental responses corresponding to the delivery of photostimulation into the VTA with multiple frequencies and during time;in the reinstatement phase,stimulation of the DA projections to NAc(core or shell) or mPFC(IL and PL) from VTA to induce reinstatement after 2 weeks of extinction of self-stimulation.(2)Reinstatement in cocaine *** encoding ChR2 or hM4 Di were injected into VTA of DAT-Cre transgenic *** mice with ChR2 and hM4 Di in DA neurons were trained to establish self-administration of *** 2 weeks of extinction,laser stimulation of the DA projections to NAc(core or shel) or mP FC(IL and PL) was conducted to induce *** that,Clozapine was injected in NAc core to test the impacts of VTA-NAc core depression on the reinstatement induced by cue.(3) Photometry of VTA DA neurons in ***-Cre transgenic mice were received an injection of AAV-DIO-Gcamp6 m into *** cocaine self-administration and extinction,mice with Gcamp6 m were challenged by cue(paired with cocaine previously) and the photometry of VTA DA neurons was conducted dur

关键词： dopamine ventral tegmental area nucleus accumbens core and shell medial prefrontal cortex self-stimulation reinstatement

血清趋化素和半乳糖凝集素3水平对心房颤动并发左心房纤维化有预测价值

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内科急危重症杂志 2024年第1期30卷 43-46,92页

作者：黄博雅柏松李津曹玉萍张国彦张会芳保定市第一中心医院急诊科河北保定071000

目的:探讨血清趋化素(chemerin)、半乳糖凝集素3 (gal-3)水平对心房颤动并发左心房纤维化的预测价值。方法:收集138例首次进行导管射频消融手术治疗的心房颤动患者,根据低电压区(LVAS)占左心房总面积范围,将患者分为LVAS1,P<0.05)。血清... 详细信息

目的:探讨血清趋化素(chemerin)、半乳糖凝集素3 (gal-3)水平对心房颤动并发左心房纤维化的预测价值。方法:收集138例首次进行导管射频消融手术治疗的心房颤动患者,根据低电压区(LVAS)占左心房总面积范围,将患者分为LVAS1,P<0.05)。血清chemerin水平截断值为147.26 ng/mL时,预测心房颤动并发左心房纤维化的ROC曲线下面积(AUC)为0.73,此时灵敏度和特异性分别为76.25%、69.33%;血清Gal-3水平截断值为56.39 pg/mL时,AUC为0.71,此时灵敏度和特异性分别为74.46%、68.29%,二者联合检测的AUC为0.77,此时灵敏度和特异性分别为79.37%、69.28%。结论:心房颤动并发左心房纤维化患者血清chemerin、Gal-3水平与左心房纤维化呈正相关关系,其水平对预测心房颤动并发左心房纤维化具有较好预测价值。

关键词：血清趋化素半乳糖凝聚素-3 心房颤动左心房纤维化预测价值

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连云港动力泥沙场信息共享平台设计与实现

广州航海学院学报 2024年第2期32卷 7-11页

作者：宋瑞波赵志伟温永宁高正荣章卫胜连云港科谊工程建设咨询有限公司江苏连云港222042 南京师范大学地理科学学院江苏南京210023 南京水利科学研究院河流海岸研究所江苏南京210024

为满足连云港港信息化管理需求,运用Python数据库预处理技术和JavaScript云平台技术,采用C/S和B/S混合体系构建应用系统平台.系统采用前后端分离的方式开发:客户端主要针对PC端浏览器开发,采用HTML、CSS、Javascript开发;服务器端程序采... 详细信息

为满足连云港港信息化管理需求,运用Python数据库预处理技术和JavaScript云平台技术,采用C/S和B/S混合体系构建应用系统平台.系统采用前后端分离的方式开发:客户端主要针对PC端浏览器开发,采用HTML、CSS、Javascript开发;服务器端程序采用Java开发,使用Spring boot框架开发.平台操作简便,实现了港口相关数据可视化、历史数据的浏览和模拟数据展示等功能,满足港口航道管理信息现代化需求.

关键词：信息共享平台云平台技术动力泥沙场港口管理

Cloning and Sequence Analysis of cDNA Encoding MRJP3 of Apis cerana cerana

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Agricultural Sciences in China 2005年第9期4卷 707-713页

作者： SU song-kun ZHNEG Huo-qing CHEN Sheng-lu ZHONG bo-xiong Stefan Albert College of Animal Science Zhejiang University Hangzhou 310029 P.R.China Institute of Medical Radiation and Cell Research Würzburg 97078 Germany

By screening the worker （Apis cerana cerana） heads cDNA library using a fragment of the mrjp3 gene of Apis cerana as probe, 120 positive clones were obtained. The clone containing A. cerana cerana MRJP3 （AccMRJP3） cDNA was selected. Based on the sequencing of the inserts of the positive clone, a sequence of AccMRJP3 cDNA which is 1 887 bp long including a poly （A） tail was obtained. The AccMRJP3 cDNA encompassed an open-reading frame （ORF） with 1 779 bp encoding 593 amino acids. The un-translated regions （UTR） of the 5′ end and 3′end are 46 bp and 160 bp in length, respectively. Similar to AmMRJP3 and AdMRJP3, the putative AccMRJP3 also has a repetitive region. The comparison of the repetitive region of AccMRJP3, AmMRJP3 and AdMRJP3 shows some differences between them.

关键词： Apis cerana cerana MRJP3 Gene cloning Sequence analysis

胰岛素样生长因子结合蛋白2对高血糖环境诱导人足细胞凋亡的影响及机制研究

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解放军医学院学报 2024年第6期45卷 610-617页

作者：王晓晨迟坤杜军霞宋晨雯丁潇楠冀雨薇张可颖张益帆韩秋霞傅博洪权朱晗玉解放军总医院第一医学中心肾脏病医学部肾脏疾病全国重点实验室国家慢性肾病临床医学研究中心肾脏疾病研究北京市重点实验室北京100853 北京朝阳医院肾内科北京100020

背景糖尿病肾病患者日益增加,仍有患者在现有治疗中进展为终末期肾病,因此迫切需要新型治疗靶点。目的探讨胰岛素样生长因子结合蛋白2(insulin like growth factor binding protein 2,IGFBP2)对高血糖环境诱导人足细胞凋亡的影响及机制... 详细信息

背景糖尿病肾病患者日益增加,仍有患者在现有治疗中进展为终末期肾病,因此迫切需要新型治疗靶点。目的探讨胰岛素样生长因子结合蛋白2(insulin like growth factor binding protein 2,IGFBP2)对高血糖环境诱导人足细胞凋亡的影响及机制。方法体外培养的人足细胞随机分为正常血糖(normal glucose,NG)组(5 mmol/L)以及高血糖(high glucose,HG)24 h组、HG 48 h组、HG 72 h组(30 mmol/L)。采用RT-qPCR法检测IGFBP2、肿瘤坏死因子α(tumor necrosis factor,TNF-α)和细胞间黏附分子-1(intercellular cell adhesion molecule-1,ICAM-1)mRNA表达水平,Western blot检测IGFBP2和Cleaved Caspase 3蛋白表达水平,以此确定后续实验HG处理的最佳时间点。将IGFBP2小干扰RNA转染进入足细胞并分为NG组、阴性对照干预组(NG-NC-siRNA)、IGFBP2敲低siRNA干预组(NG-IGFBP2-siRNA1、NG-IGFBP2-siRNA2、NG-IGFBP2-siRNA3),RT-qPCR检测IGFBP2 mRNA表达水平,选择敲低效率最高的IGFBP2-siRNA用于后续实验。根据实验内容将足细胞随机分为:(1)NG组和HG组;(2)NG组和NG+125 ng/mL rhIGFBP2组;(3)HG组和HG-IGFBP2-siRNA组。(1)(2)(3)均通过RT-qPCR检测TNF-α和ICAM-1 mRNA表达水平,JC-1染色法检测线粒体膜电位,共聚焦显微镜检测线粒体超氧化物和活性氧荧光强度,流式细胞术检测细胞凋亡率。结果随HG处理时间增加,RT-qPCR结果显示IGFBP2、TNF-α和ICAM-1 mRNA水平随时间升高,Western blot结果显示IGFBP2和Cleaved Caspase 3蛋白水平随时间升高。与NG组比较,RT-qPCR结果显示IGFBP2、TNF-α和ICAM-1均在HG 72 h时mRNA水平最高(P0.05),NG-IGFBP2-siRNA2组IGFBP2 mRNA表达水平最低(P<0.05),敲除效率最高,因此选择IGFBP2-siRNA2进行后续实验。与NG组相比较,HG组线粒体膜电位绿/红色荧光强度比值、线粒体超氧化物和活性氧荧光强度以及细胞凋亡率均增强(P<0.05)。与NG组相比较,NG+125 ng/mL rhIGFBP2组的TNF-α和ICAM-1 mRNA水平、线粒体膜电位绿/红色荧光强度比值、线粒体超氧化物和活性氧荧光强度以及细胞凋亡率均升高(P<0.05)。与HG组相比较,HG-IGFBP2-siRNA组的TNF-α和ICAM-1 mRNA表达水平、线粒体膜电位绿/红色荧光强度比值、线粒体超氧化物和活性氧荧光强度以及细胞凋亡率均降低(P<0.05)。结论敲除IGFBP2后通过减弱高血糖处理下的线粒体功能紊乱和氧化应激降低人足细胞凋亡,因此抑制IGFBP2的表达有望成为糖尿病肾病的潜在治疗策略。

关键词：胰岛素样生长因子结合蛋白2 线粒体损伤氧化应激细胞凋亡糖尿病肾病