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Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

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Genes & Diseases 2024年第1期11卷 67-71页

作者： s.uvik kar Andrea Perrelli Kiran Kumar Bali Raffaella Mastrocola Arpita kar Bushra Khan Luis Gand Arnab Nayak Christian Hartmann Wolfram sKunz Amir samii Helmut Bertalanffy saverio Francesco Retta International Neuroscience Institute Rudolf-PichlmayrStrasse 4Hannover 30625Germany Department of Clinical and Biological sciences University of TorinoOrbassano(TO)10043Italy CCM Italia Research Network National Coordination Center at the Department of Clinical and Biological SciencesUniversity of TorinoOrbassano(TO)10043Italy Department of Experimental Pain Research Mannheim Center for Translational Neuroscience(MCTN)Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Department of Kidney Liver and Metabolic DiseasesChildren’s HospitalHannover Medical SchoolHannover 30625Germany Ricarda-Huch-street-10B Hannover 30880Germany Institute of Molecular and Cell Physiology Hannover Medical SchoolHannover 30625Germany Department of Neuropathology Institute of PathologyHannover Medical SchoolHannover 30625Germany Institute of Experimental Epileptology and Cognition Research and Department of Epileptology University Hospital BonnVenusberg-Campus 1Bonn 53127Germany epartment of Pharmacology and Physiology University of Rochester Medical CenterRochesterNY 14642USA

cerebrovascular disease of genetic origin characterized by abnormally dilated capillaries and a wide spectrum of symptoms,including headaches,seizures,neurological deficits,and intracerebral *** unpredictable clinical course and the current lack of therapies make the identification of prognostic and predictive biomarkers an imperative research challenge.1 Herein,we provide evidence that galectin-3(Gal-3),a major tissue and circulating biomarker of oxidative stress and inflammation,is significantly up-regulated both in CCM patients and ***,wholetranscriptome sequencing,qRT-PCR,and Western blotting studies demonstrated a significant up-regulation of Gal-3 expression levels both in surgical CCM specimens and in blood samples of CCM patients.

关键词： inflammation cerebral dilated

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Transcultural adaptation of Odia version of health-related kidney disease and quality of life-36 instrument

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Journal of Integrative Nursing 2024年第1期6卷 41-48页

作者： Rashmimala PRADHAN Pravati TRIPATHY Debaprasad kar Department of Medical surgical Nursing SUM Nursing CollegeSiksha‘O'Anusandhan(Deemed to be University)BhubaneswarOdishaIndia sUM Nursing College Siksha‘O'Anusandhan(Deemed to be University)BhubaneswarOdishaIndia Department of Nephrology IMS and SUM HospitalBhubaneswarOdishaIndia

Objective:The study objective was to translate,validate,and test the reliability of the original kidney disease and quality of life-36(KDQOL-36^(TM))instruments in *** and Methods:A cross-sectional design with a purposive sampling technique was *** to RAND Corporation guidelines,initially,the items of the KDQOL-36^(TM)questionnaires were translated into Odia by two independent,bilingual,professional translators,and then back-translated to English,followed by tryout and field *** experts validated the KDQOL-36^(TM)instrument review committee for review related to kidney health *** tool was implemented among 180 patients undergoing“maintenance”*** following tests evaluated reliability and validity:test-retest reliability with Cronbach’s alpha correlation(stability),(reliability)internal consistency,and contents validity ***:The Cronbach’s alpha value and intraclass correlation coefficient(ICC)score of all five domains,namely“physical component summary,mental component summary(MCs),the burden of kidney disease,symptoms and problems of kidney disease,and effects of kidney disease”of both KDQOL-36^(TM)English and Odia(KDQOL-36-E^(TM)and KDQOL-36-O^(TM))version,recommended excellent homogeneity.A high positive correlation(r=0.998)was found between the Odia version of KDQOL-36^(TM)and the English version KDQOL-36^(TM)*** ICC score ranges from 0.889 to 0.997 at a 95%confidence interval for test-retest reliability,and Cronbach’s alpha was ***:This study explores the Odia version of KDQOL-36^(TM)psychometric properties,depicted at an acceptable level of internal *** KDQOL-36-O^(TM)instrument is a valid and reliable tool for assessing the kidney disease-related quality of life in Odia-speaking hemodialysis patients.

关键词： Hemodialysis patients kidney disease and quality of life‑36 reliability transcultural validation

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Improved reservoir characterization by means of supervised machine learning and model-based seismic impedance inversion in the Penobscot field,scotian Basin

Energy Geoscience

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Energy Geoscience 2024年第2期5卷 183-201页

作者： satya Narayan soumyashree Debasis sahoo soumitra kar sanjit Kumar Pal subhra Kangsabanik Oil and Natural Gas Corporation(ONGC)Limited DehradunIndia Department of Applied Geophysics IIT(ISM)DhanbadIndia

The present research work attempted to delineate and characterize the reservoir facies from the Dawson Canyon Formation in the Penobscot field,scotian *** integrated study of instantaneous frequency,P-impedance,volume of clay and neutron-porosity attributes,and structural framework was done to unravel the Late Cretaceous depositional system and reservoir facies distribution patterns within the study *** strikes were found in the EW and NEE-sWW directions indicating the dominant course of tectonic activities during the Late Cretaceous period in the region.P-impedance was estimated using model-based seismic *** properties such as the neutron porosity(NPHI)and volume of clay(VCL)were estimated using the multilayer perceptron neural network with high ***,a combination of low instantaneous frequency(15-30 Hz),moderate to high impedance(7000-9500 gm/cc*m/s),low neutron porosity(27%-40%)and low volume of clay(40%-60%),suggests fair-to-good sandstone development in the Dawson Canyon *** calibration with the welllog data,it is found that further lowering in these attribute responses signifies the clean sandstone facies possibly containing *** present study suggests that the shale lithofacies dominates the Late Cretaceous deposition(Dawson Canyon Formation)in the Penobscot field,scotian *** faults and overlying shale facies provide structural and stratigraphic seals and act as a suitable hydrocarbon entrapment mechanism in the Dawson Canyon Formation's *** present research advocates the integrated analysis of multi-attributes estimated using different methods to minimize the risk involved in hydrocarbon exploration.

关键词： Reservoir characterization Model-based inversion Multilayer perceptron(MLP) Impedance Petrophysical properties scotian Basin

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Transcranial direct current stimulation as early augmentation in adolescent obsessive compulsive disorder:A pilot proof-of-concept randomized control trial

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World Journal of Clinical Pediatrics 2024年第2期13卷 161-170页

作者： Aditya Agrawal Vivek Agarwal sujita Kumar kar Amit Arya Department of Psychiatry King George Medical UniversityUttar PradeshLucknow 226003India

BACKGROUND Transcranial direct current stimulation(tDCs)is proven to be safe in treating various neurological conditions in children and *** is also an effective method in the treatment of OCD in *** To assess the safety and efficacy of tDCs as an add-on therapy in drug-naive adolescents with *** We studied drug-naïve adolescents with OCD,using a Children’s Yale-Brown obsessive-compulsive scale(CY-BOCs)scale to assess their *** active and sham groups were given fluoxetine,and we applied cathode and anode over the supplementary motor area and deltoid for 20 min in 10 *** occurred at 2,6,and 12 wk using *** Eighteen adolescents completed the study(10-active,8-sham group).CY-BOCs scores from baseline to 12 wk reduced significantly in both groups but change at baseline to 2 wk was significant in the active group *** mean change at 2 wk was more in the active group(11.8±7.77 vs 5.25±2.22,P=0.056).Adverse effects between the groups were *** tDCs is safe and well tolerated for the treatment of OCD in ***,there is a need for further studies with a larger sample population to confirm the effectiveness of tDCs as early augmentation in OCD in this population.

关键词： Adolescents Early augmentation Obsessive compulsive disorder safety Transcranial direct current stimulation

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Graphene quantum dots:preparations,properties,functionalizations and applications

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Materials Futures 2024年第2期3卷 36-84页

作者： Pin Tian Libin Tang kar-seng Teng shu-Ping Lau Kunming Institute of Physics 650223 KunmingYunnanPeople’s Republic of China Department of Electronic and Electrical Engineering Faculty of Science and EngineeringSwansea UniversityBay CampusFabian WaySwansea SA18ENUnited Kingdom Department of Applied Physics The Hong Kong Polytechnic UniversityHung HomKowloonHong KongPeople’s Republic of China

Zero-dimensional graphene quantum dots(GQDs)exhibit many different properties,such as strong fluorescence,nonzero bandgap and solubility in solvents,compared to two-dimensional *** are biocompatible and have low toxicity;hence,they are widely used in the biomedical *** edge effect of GQDs is of particular interest because edge modification can regulate the performance of *** this review,various preparation methods for GQDs,which can be divided into three main categories,namely top-down,bottom-up and chemical methods,are *** unique optical,electrical,thermal and magnetic properties of GQDs are *** functionalization of GQDs by doping with heteroatoms and forming composites with other materials is studied,and the characteristics of these GQDs are also *** applications of these GQDs in the fields of optics,electricity,optoelectronics,biomedicine,energy,agriculture and other emerging interdisciplinary fields are reviewed to highlight the enormous potential of *** review reports on the recent advancement in GQD research and suggests future directions for the development of GQDs.

关键词： graphene quantum dots:preparations properties functionalizations and applications

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Dietary supplementation of zinc oxide modulates intestinal functionality during the post-weaning period in clinically healthy piglets

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Journal of Animal science and Biotechnology 2024年第1期15卷 313-328页

作者： Dirkjan schokker soumya K.kar Els Willems Alex Bossers Ruud A.Dekker Alfons J.M.Jansman Wageningen Bioveterinary Research LelystadThe Netherlands Wageningen Livestock Research Wageningen University&ResearchWageningenThe Netherlands Royal Agrifirm Group ApeldoornThe Netherlands Institute for Risk Assessment sciences Utrecht UniversityUtrechtThe Netherlands

Background To improve our understanding of host and intestinal microbiome interaction,this research investigated the effects of a high-level zinc oxide in the diet as model intervention on the intestinal microbiome and small intestinal functionality in clinically healthy post-weaning *** study 1,piglets received either a high concentration of zinc(Zn)as zinc oxide(Zn O,Zn,2,690 mg/kg)or a low Zn concentration(100 mg/kg)in the diet during the post weaning period(d 14–23).The effects on the piglet's small intestinal microbiome and functionality of intestinal tissue were *** study 2,the impact of timing of the dietary zinc intervention was investigated,i.e.,between d 0–14 and/or d 14–23 post weaning,and the consecutive effects on the piglet's intestinal functionality,here referring to microbiota composition and diversity and gene expression *** Differences in the small intestinal functionality were observed during the post weaning period between piglets receiving a diet with a low or high concentration Zn O content.A shift in the microbiota composition in the small intestine was observed that could be characterized as a non-pathological change,where mainly the commensals *** the immediate post weaning period,i.e.,d 0–14,the highest number of differentially expressed genes(DEGs)in intestinal tissue were observed between animals receiving a diet with a low or high concentration Zn O content,i.e.,23 DEGs in jejunal tissue and 11 DEGs in ileal *** genes are involved in biological processes related to immunity and inflammatory *** example,genes CD59 and REG3G were downregulated in the animals receiving a diet with a high concentration Zn O content compared to low Zn O content in both jejunum and ileum *** the second study,a similar result was obtained regarding the expression of genes in intestinal tissue related to immune pathways when comparing piglets receiving a diet with a high concentration Zn O con

关键词： Immune system Intestinal functionality Microbiota Piglets Zinc oxide

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Effects of early postnatal gastric and colonic microbiota transplantation on piglet gut health

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Journal of Animal science and Biotechnology 2024年第2期15卷 645-658页

作者： Christina Larsen simone Margaard Offersen Anders Brunse Mattia Pirolo soumya Kanti kar Luca Guadabassi Thomas Thymann Department of Veterinary and Animal science University of CopenhagenDyrlagevej 681870 Frederiksberg CDenmark Animal Nutrition Wageningen Livestock ResearchWageningen University&Research1 De Elst6708 WageningenThe Netherlands

Background Diarrhea is a major cause of reduced growth and mortality in piglets during the suckling and weaning periods and poses a major threat to the global pig *** and gut dysbiosis may in part be prevented via improved early postnatal microbial colonization of the *** secure better postnatal gut colonization,we hypothesized that transplantation of colonic or gastric content from healthy donors to newborn recipients would prevent diarrhea in the recipients in the post-weaning *** objective was to examine the impact of transplanting colonic or gastric content on health and growth parameters and paraclinical parameters in recipient single-housed piglets exposed to a weaning transition and challenged with enterotoxigenic Escherichia coli(ETEC).Methods seventy-two 1-day-old piglets were randomized to four groups:colonic microbiota transplantation(CMT,n=18),colonic content filtrate transplantation(CcFT,n=18),gastric microbiota transplantation(GMT,n=18),or saline(CON,n=18).Inoculations were given on d 2 and 3 of life,and all piglets were milk-fed until weaning(d 20)and shortly after challenged with ETEC(d 24).We assessed growth,diarrhea prevalence,ETEC concentration,organ weight,blood parameters,small intestinal morphology and histology,gut mucosal function,and microbiota composition and *** Episodes of diarrhea were seen in all groups during both the milk-and the solid-feeding phase,possibly due to stress associated with single ***,CcFT showed lower diarrhea prevalence on d 27,28,and 29 compared to CON(all Pso showed a lower ETEC prevalence on d 27(Pshowed a higher alpha diversity and a difference in beta diversity compared to CON(Ps were similar across *** In conclusion,only CcFT reduced ETEC-related post-weaning ***,the protective effect was marginal,suggesting that higher doses,more effective modalities of administration

关键词： Colonic content filtrate transplantation Colonic microbiota transplantation Gastric microbiota transplantation Gut microbiota Mucosa Neonatal Post-weaning diarrhea

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Inhibiting the phase transition of WO_(3)for highly stable aqueous electrochromic battery

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Journal of Energy Chemistry 2024年第8期95卷 86-95,I0003页

作者： Zhisheng Wu Zhendong Lian Ting Ding Jielei Li Jincheng Xu Jinxiao Wang Liangxing Zhang Bo Wang shi Chen Peng Xiao Hua Xu shuang-Peng Wang kar Wei Ng Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoAvenida da UniversidadeMacao 999078China school of Applied Physics and Materials Wuyi UniversityJiangmen 529020GuangdongChina Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology School of Physics and Optoelectronic EngineeringFoshan UniversityFoshan 528225GuangdongChina Guangzhou New Vision Optoelectronic Technology Co. Ltd.Guangzhou 510530GuangdongChina

Aqueous electrochromic battery(ECB)has shown intense potential for achieving energy storage and saving *** tungsten oxide(WO_(3))is the most promising EC material for commercialization,the cycling stability of WO_(3)-based aqueous ECBs is currently unsatisfactory due to the repeated phase transition during the redox process and the corrosion by acidic ***,we present a titanium-tungsten oxide alloy(Ti-WO_(3))with controllable morphology and crystal phase synthesized by a facile hot injection method to overcome the *** contrast to conventional monoclinic WO_(3),the Ti-WO_(3)nanorods can stably maintain their cubic crystal phase during the redox reaction in an acidic electrolyte,thus leading to dramatically enhanced response speed and cycling stability,specifically,when working in a well-matched hybrid Al^(3+)/Zn^(2+)aqueous electrolyte,our phasetransition-free cubic Ti-WO_(3)exhibits an ultra-high cycling stability(>20000 cycles),fast response speed(3,95 s/4,65 s for bleaching/coloring),as well as excellent discharge areal capacity of 214.5 mA h m^(-2),We further fabricate a fully complementa ry aqueous electrochromic device,for the first time,using a Ti-WO_(3)/Prussian blue device ***,the complementary ECB shows>10000 stable operation cycles,attesting to the feasibility of our Ti-WO_(3)for practical *** work validates the significance of inhibiting the phase transitions of WO_(3)during the electrochromic process for realizing highly cyclable aqueous ECB,which can possibly provide a generalized design guidance for other high-quality metallic oxides for electrochemical applications.

关键词： Aqueous electrochromic battery Ti-WO_(3) Phase transition Long-term stability

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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

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signal Transduction and Targeted Therapy 2024年第3期9卷 945-997页

作者： Jian sheng Loh Wen Qi Mak Li kar stella Tan Chu Xin Ng Hong Hao Chan shiau Hueh Yeow Jhi Biau Foo Yong sze Ong Chee Wun How Kooi Yeong Khaw school of Pharmacy Monash University MalaysiaJalan Lagoon Selatan47500 Bandar SunwaySelangorMalaysia school of Pharmacy Faculty of Health&Medical SciencesTaylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia Digital Health&Medical Advancements Taylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia school of Biosciences Faculty of Health&Medical SciencesTaylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia UCL school of Pharmacy University College London29-39 Brunswick SquareLondon WC1N 1AXUK

The human gastrointestinal tract is populated with a diverse microbial *** vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect of human biology,including health maintenance,development,aging,and *** advent of new sequencing technologies and culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations to shed light on microbiome–host *** has unveiled the bidirectional communication between the gut microbiome and the central nervous system,referred to as the“microbiota–gut–brain axis”.The microbiota–gut–brain axis represents an important regulator of glial functions,making it an actionable target to ameliorate the development and progression of neurodegenerative *** this review,we discuss the mechanisms of the microbiota–gut–brain axis in neurodegenerative *** the gut microbiome provides essential cues to microglia,astrocytes,and oligodendrocytes,we examine the communications between gut microbiota and these glial cells during healthy states and neurodegenerative ***,we discuss the mechanisms of the microbiota–gut–brain axis in neurodegenerative diseases using a metabolite-centric approach,while also examining the role of gut microbiota-related neurotransmitters and gut ***,we examine the potential of targeting the intestinal barrier,blood–brain barrier,meninges,and peripheral immune system to counteract glial dysfunction in ***,we conclude by assessing the pre-clinical and clinical evidence of probiotics,prebiotics,and fecal microbiota transplantation in neurodegenerative diseases.A thorough comprehension of the microbiota–gut–brain axis will foster the development of effective therapeutic interventions for the management of neurodegenerative diseases.

关键词： degenerative therapeutic diseases

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国外藏文传记研究现状及思考

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中国藏学 2024年第2期 186-197,220页

作者：德格吉中国社会科学院中国边疆研究所北京100029

藏文传记是藏族传统文学、史学和宗教学的重要文类,是中华民族优秀传统文化和中华古籍文献的重要组成部分。20世纪60年代,随着传记学研究的兴起,藏文传记逐渐成为国外藏学研究的一个专题领域。自20世纪90年代以来,随着研究的进一步深入... 详细信息

藏文传记是藏族传统文学、史学和宗教学的重要文类,是中华民族优秀传统文化和中华古籍文献的重要组成部分。20世纪60年代,随着传记学研究的兴起,藏文传记逐渐成为国外藏学研究的一个专题领域。自20世纪90年代以来,随着研究的进一步深入,藏文传记研究的交叉视野和创新成果为藏学发展注入了新鲜活力,成为国外藏学研究中引人注目的研究领域。文章通过梳理近30年来国外研究藏文传记的主要英文成果,基于传记类型和研究内容,初步将相关成果分为四大研究主题,详细介绍了每个专题领域代表性成果的主要内容、理论方法和研究视角,剖析了主流的学科框架、命题概念和研究进路,并结合新近研究呈现的学术转向和多样化研究实践,从理论视野和学术路径两个宏观层面总结了国外藏文传记研究的发展演变和主要特征,对国外藏文传记研究的现状、趋势和存在问题进行了初步的反思和总结。

关键词：藏文传记国外藏学藏学学术史

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