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Computer simulation of Effect of Intergrain Exchange Interaction on Magnetic Properties of Nanocomposite Magnets

Journal of Rare Earths 2004年第1期22卷 146-151页

作者： fukunaga H Mukaino H Department of Electrical Engineering & Electronics Graduate School of Science & Technology Nagasaki University Nagasaki 852-8521 Japan Nagasaki University Nagasaki 852-8521 Japan

Effects of the intergrain exchange interaction on magnetic properties of nanocomposite magnets were investigated by using the computer simulation based on the micromagnetic theory. The simulation was carried out under the assumptions that the strength of the intergrain exchange interaction is weaker than that of the intragrain exchange interaction, that inhomogeneous nanostructures result in the distribution of the strength of the intergrain exchange interaction, and that there exists nonmagnetic intergranular phase (NMIP) between grain boundaries. The distribution of the strength of the intergrain exchange interaction was simulated by the lognormal distribution with the standard deviation of σ.The calculations for Nd 2Fe 14B/α-Fe nanocomposite magnets reveal that a suitably weak intergrain exchange interaction and small grain size enable us to improve magnetic properties. It is also found that a Nd 2Fe 14B/α-Fe nanocomposite magnet has a potential of a (BH) max value exceeding 300 kJ·m -3. On the other hand, the calculations for Nd 2Fe 14B/Fe 3B nanocomposite magnets reveal that the distribution of the strength of the intergrain exchange interaction deteriorates magnetic properties significantly. Particularly, this tendency is remarkable, when the grain size L is larger than its optimum value, 11 nm. The existence of nonmagnetic boundary layers accelerats this tendency. At σ=0.2, the calculated demagnetization curve for the model magnet composed of Nd 2Fe 14B(36%)/Fe 3B(54%)/NMIP(10%) (Valume fraction) grains (L=15 nm) agrees with that obtained experimentally for a Nd 2Fe 14B/Fe 3B nanocomposite magnet. These results suggest importance of refinement of grain size, suppression of a nonmagnetic intergranular phase, and preparation of homogeneous nanostructure for superior magnetic properties.

关键词： metal materials nanocomposite magnet exchange interaction nanostructure remanence intergranular phase

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Current surgical treatment of esophagogastric junction adenocarcinoma

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World Journal of Gastrointestinal Oncology 2019年第8期11卷 567-578页

作者： shun Zhang Hajime Orita Tetsu fukunaga Department of Gastroenterology surgery Shanghai East Hospital(East Hospital Affiliated to Tongji University)Shanghai 200120China Department of Gastroenterology and Minimally Invasive surgery Juntendo University HospitalTokyo 113-8431Japan

The incidence of esophagogastric junction(EGJ)adenocarcinoma has shown an upward trend over the past several decades *** this article,we review previous studies and aimed to provide an update on the factors related to the surgical treatment of EGJ *** siewert classification has implications for lymph node spread and is the most commonly used *** types of EGJ cancer have different incidences of mediastinal and abdominal lymph node metastases,and different surgical approaches have unique advantages and *** invasive surgeries have been increasingly applied in clinical practice and show comparable oncologic *** resection may be a good therapy for early EGJ ***,there is still a great need for well-designed,large RCTs to forward our knowledge on the surgical treatment of EGJ cancer.

关键词： Esophagogastric junction cancer surgery Lymph nodes siewert classification

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A nucleotide substitution at the 5′ splice site of intron 1 of rice HEADING DATE 1(HD1) gene homolog in foxtail millet, broadly found in landraces from Europe and Asia

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The Crop Journal 2015年第6期3卷 481-488页

作者： Kenji fukunaga Naoko Izuka Takehiro Hachiken satoshi Mizuguchi Hidemi Ito Katsuyuki Ichitani Faculty of Life and Environmental sciences Prefectural University of Hiroshima Faculty of Agriculture Kagoshima University

We investigated genetic variation of a rice HEADING DATE 1(HD1) homolog in foxtail ***, we searched for a rice HD1 homolog in a foxtail millet genome sequence and designed primers to amplify the entire coding sequence of the gene. We compared full HD1 gene sequences of 11 accessions(including Yugu 1, a Chinese cultivar used for genome sequencing) from various regions in Europe and Asia, found a nucleotide substitution at a putative splice site of intron 1, and designated the accessions with the nucleotide substitution as carrying a splicing variant. We verified by RT-PCR that this single nucleotide substitution causes aberrant splicing of intron 1. We investigated the geographical distribution of the splicing variant in 480 accessions of foxtail millet from various regions of Europe and Asia and part of Africa by d CAPs and found that the splicing variant is broadly distributed in Europe and Asia. Differences of heading times between accessions with wild type allele of the HD1 gene and those with the splicing variant allele were unclear. We also investigated variation in 13 accessions of ssp. viridis, the wild ancestor, and the results suggested that the wild type is predominant in the wild ancestor.

关键词： Foxtail millet Geographical distribution HD1(HEADING DATE 1) homolog setaria italica splice site

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Progress in the mechanism and targeted drug therapy for COPD

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signal Transduction and Targeted Therapy 2020年第1期5卷 359-378页

作者： Cuixue Wang Jiedong Zhou Jinquan Wang shujing Li Atsushi fukunaga Junji Yodoi Hai Tian Department of Basic Medicine Medical CollegeShaoxing UniversityShaoxing 312000China Division of Dermatology Department of Internal RelatedKobe University Graduate School of MedicineKobe 650-0017Japan Laboratory of Infection and Prevention Department of Biological ResponseInstitute for Virus ResearchKyoto UniversityKyoto 606-8501Japan Jiaozhimei Biotechnology(shaoxing)Co LtdShaoxing 312000China

Chronic obstructive pulmonary disease(COPD)is emphysema and/or chronic bronchitis characterised by long-term breathing problems and poor *** prevalence of COPD has increased over the last decade and the drugs most commonly used to treat it,such as glucocorticoids and bronchodilators,have significant therapeutic effects;however,they also cause side effects,including infection and *** we reviewed the pathogenesis and progression of COPD and elaborated on the effects and mechanisms of newly developed molecular targeted COPD therapeutic *** these new drugs,we focussed on thioredoxin(Trx).Trx effectively prevents the progression of COPD by regulating redox status and protease/anti-protease balance,blocking the NF-κB and MAPK signalling pathways,suppressing the activation and migration of inflammatory cells and the production of cytokines,inhibiting the synthesis and the activation of adhesion factors and growth factors,and controlling the cAMP-PKA and PI3K/Akt signalling *** mechanism by which Trx affects COPD is different from glucocorticoid-based mechanisms which regulate the inflammatory reaction in association with suppressing immune *** addition,Trx also improves the insensitivity of COPD to steroids by inhibiting the production and internalisation of macrophage migration inhibitory factor(MIF).Taken together,these findings suggest that Trx may be the ideal drug for treating COPD.

关键词： drugs targeted inhibiting

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Laparoscopic hemicolectomy in a patient with situs inversustotalis

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World Journal of Gastroenterology 2007年第37期13卷 5035-5037页

作者： Yushi Fujiwara Yosuke fukunaga Masayuki Higashino shinya Tanimura Masashi Takemura Yoshinori Tanaka Harushi Osugi Department of Gastroenterological surgery Osaka City General Hospital 2-13-22 Miyakojima-Hondoori Miyakojima-ku Osaka 534-0021 Japan Department of Gastroenterological surgery Osaka City University Graduate School of Medicine 1-4-3 Asahi-machi Abeno-ku Osaka 545-8585 Japan

As among persons with normal anatomy, occasional patients with situs inversus develop malignant tumors. Recently, several laparoscopic operations have been reported in patients with situs inversus. We describe laparoscopic hemicolectomy with radical lymphadenectomy in such a patient. Careful consideration of the mirror-image anatomy permitted safe operation using techniques not otherwise differing from those in ordinary cases. Thus, curative laparoscopic surgery for colon cancer in the presence of situs inversus is feasible and safe.

关键词： situs inversus Colon cancer Laparoscopicsurgery Hemicolectomy Radical lymphadenectomy

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Isolated pancreatic metastasis from a malignant pleural mesothelioma diagnosed using endoscopic ultrasonography-guided fne needle aspiration biopsy

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 196-198页

作者： Yuki Ishikawa-Kakiya Hirotsugu Maruyama Kojiro Tanoue shusei fukunaga Yasuaki Nagami Yasuhiro Fujiwara Department of Gastroenterology Osaka City University Graduate School of Medicine1-4-3AsahimachiAbeno-kuOsaka 545-8585Japan

To the Editor:Malignant pleural mesothelioma is a rare and aggressive form of cancer with a poor prognosis [1].Its progression is mainly a direct invasion from the primary lesion,and metastasis to distant regions rarely *** was found that metastasis of malignant pleural mesothelioma may occur in the liver,adrenal glands,and kidneys in autopsy cases [2].

关键词： metastasis pleural needle

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Three-dimensional imaging identified the accessory bile duct in a patient with cholangiocarcinoma

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World Journal of Gastroenterology 2014年第32期20卷 11451-11455页

作者： Ryoichi Miyamoto Yukio Oshiro shinji Hashimoto Keisuke Kohno Kiyoshi fukunaga Tatsuya Oda Nobuhiro Ohkohchi Division of Gastroenterological and Hepatobiliary surgery and Organ Transplantation Department of Surgery University of Tsukuba Ibaraki 305-8575 Japan

The development of diagnostic imaging technology, such as multidetector computed tomography(MDCT) and magnetic resonance cholangiopancreatography(MRCP), has made it possible to obtain detailed images of the bile duct. Recent reports have indicated that a 3-dimensional(3D) reconstructed imaging system would be useful for understanding the liver anatomy before surgery. We have investigated a novel method that fuses MDCT and MRCP images. This novel system easily made it possible to detect the anatomical relationship between the vessels and bile duct in the portal hepatis. In this report, we describe a very rare case of extrahepatic cholangiocarcinoma associated with an accessory bile duct from the caudate lobe connecting with the intrapancreatic bile duct. We were unable to preoperatively detect this accessory bile duct using MDCT and MRCP. However, prior to the second operation, we were able to clearly visualise the injured accessory bile duct using our novel 3D imaging modality. In thisreport, we suggest that this imaging technique can be considered a novel and useful modality for understanding the anatomy of the portal hepatis, including the hilar bile duct.

关键词： 3-dimensional imaging Hepatobiliary and pancreatic surgery Accessory bile duct Caudate lobe bile duct Cholangiocarcinoma

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signalling pathways in autism spectrum disorder:mechanisms and therapeutic implications

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signal Transduction and Targeted Therapy 2022年第8期7卷 2863-2898页

作者： Chen-Chen Jiang Li-shan Lin sen Long Xiao-Yan Ke Kohji fukunaga Ying-Mei Lu Feng Han International Joint Laboratory for Drug Target of Critical Illnesses Key Laboratory of Cardiovascular&Cerebrovascular MedicineSchool of PharmacyNanjing Medical UniversityNanjing 211166China Department of Physiology School of Basic Medical SciencesNanjing Medical UniversityNanjing 211166China Department of Pharmacy Hangzhou Seventh People’s HospitalMental Health Center Zhejiang University School of MedicineHangzhou 310013China Child Mental Health Research Center Nanjing Brain HospitalNanjing Medical UniversityNanjing 210029China Department of CNs Drug Innovation Graduate School of Pharmaceutical SciencesTohoku UniversitySendai 980-8578Japan Institute of Brain science The Affiliated Brain Hospital of Nanjing Medical UniversityNanjing 210029China Gusu school Nanjing Medical UniversitySuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215002China

Autism spectrum disorder(AsD)is a prevalent and complex neurodevelopmental disorder which has strong genetic *** the rapidly rising incidence of autism,little is known about its aetiology,risk factors,and disease *** are currently neither validated biomarkers for diagnostic screening nor specific medication for *** the last two decades,there have been remarkable advances in genetics,with hundreds of genes identified and validated as being associated with a high risk for *** convergence of neuroscience methods is becoming more widely recognized for its significance in elucidating the pathological mechanisms of *** have been devoted to exploring the behavioural functions,key pathological mechanisms and potential treatments of ***,as we highlight in this review,emerging evidence shows that signal transduction molecular events are involved in pathological processes such as transcription,translation,synaptic transmission,epigenetics and immunoinflammatory *** involvement has important implications for the discovery of precise molecular targets for ***,we review recent insights into the mechanisms and clinical implications of signal transduction in autism from molecular,cellular,neural circuit,and neurobehavioural ***,the challenges and future perspectives are discussed with regard to novel strategies predicated on the biological features of autism.

关键词： mechanisms spectrum behaviour

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Donepezil rescues the medial septum cholinergic neurons via nicotinic ACh receptor stimulation in olfactory bulbectomized mice

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Advances in Alzheimer's Disease 2013年第4期2卷 161-170页

作者： Yui Yamamoto Kohji fukunaga Department of Pharmacology Graduate School of Pharmaceutical Science Tohoku University Sendai Japan

Olfactory bulbectomy (OBX) causes cognitive dysfunction by degeneration of cholinergic neurons in the medial septum. Here, we define an involvement of nicotinic acetylcholine receptor (nAChR) in neuroprotective effect of donepezil in the septum neurons of OBX mice. Neuroprotective effects on the medial septal cholinergic neurons were assessed after chronic donepezil administration in OBX mice. We also measured Akt and ERK phosphorylation to define the neuroprotective mechanism of donepezil. We found that treatment with donepezil (1 - 3 mg/kg) for 15 consecutive days completely rescued cholinergic neurons in the OBX mice with concomitant improved memory. Reduction of both protein kinase B (Akt) and extracellular signal-regulated kinase (ERK) phosphorylation were restored by chronic donepezil administration (1 - 3 mg/kg) in OBX mouse medial septum. Both phosphorylated Akt and ERK immunoreactivities were localized in cell bodies of choline acetyltransferase (ChAT)-positive cholinergic cells in the medial septum. Enhancement of Akt and ERK phosphorylation seen following donepezil administration was totally blocked by pre-administration of mecamylamine (10 μM), a nicotinic acetylcholine receptor antagonist. Donepezil increases phosphorylation of Akt and ERK via nAChR stimulation in the medial septum cholinergic neurons. The Akt and ERK stimulation by donepezil is associated with its ability of neuroprotection in the medial septum and memory improvement.

关键词： Donepezil Neuroprotection Medial septum Nicotinic Acetylcholine Receptors

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Two Forensic Autopsy Cases of Liposarcoma

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Journal of Forensic science and Medicine 2016年第3期2卷 175-178页

作者： Kino Hayashi Kumiko Asakura Nao Miyashita Akihiko Hamamatsu Akio shigeta Tatsushige fukunaga Tokyo Medical Examiner’s Office 1Specific Disease Control SectionBureau of Social Welfare and Public HealthTokyo Metropolitan GovernmentTokyoJapan

Primary liposarcoma outside thighs is *** present two forensic autopsy cases of clinically undiagnosed primary liposarcoma(Case 1:Mediastinum,Case 2:Mesentery).Case 1 was a thin male in his 60s who had a well‑differentiated liposarcoma(850 g,23 cm×20 cm×10 cm)in the superior *** 2 was a thin female in her 50s who had a pleomorphic liposarcoma(10 kg,40 cm×25 cm×11 cm)in the abdominal cavity with liver *** cause of death in Case 1 was airway obstruction due to liposarcoma of the neck;that in Case 2 was complications of liposarcoma with *** liposarcoma often appears in deeper tissue without pain,it will grow quite large before it is noticed.

关键词： Forensic autopsy case mediastinal liposarcoma mesenteric liposarcoma

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