Signalling pathways in autism spectrum disorder:mechanisms and therapeutic implications
作者机构：International Joint Laboratory for Drug Target of Critical IllnessesKey Laboratory of Cardiovascular&Cerebrovascular MedicineSchool of PharmacyNanjing Medical UniversityNanjing 211166China Department of PhysiologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 211166China Department of PharmacyHangzhou Seventh People’s HospitalMental Health Center Zhejiang University School of MedicineHangzhou 310013China Child Mental Health Research CenterNanjing Brain HospitalNanjing Medical UniversityNanjing 210029China Department of CNS Drug InnovationGraduate School of Pharmaceutical SciencesTohoku UniversitySendai 980-8578Japan Institute of Brain ScienceThe Affiliated Brain Hospital of Nanjing Medical UniversityNanjing 210029China Gusu SchoolNanjing Medical UniversitySuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215002China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2022年第7卷第8期
页 面：2863-2898页
核心收录：
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
基 金：supported by the National Innovation of Science and Technology-2030(Program of Brain Science and Brain-Inspired Intelligence Technology Grant 2021ZD0204002)
主 题：mechanisms spectrum behaviour
摘 要：Autism spectrum disorder(ASD)is a prevalent and complex neurodevelopmental disorder which has strong genetic *** the rapidly rising incidence of autism,little is known about its aetiology,risk factors,and disease *** are currently neither validated biomarkers for diagnostic screening nor specific medication for *** the last two decades,there have been remarkable advances in genetics,with hundreds of genes identified and validated as being associated with a high risk for *** convergence of neuroscience methods is becoming more widely recognized for its significance in elucidating the pathological mechanisms of *** have been devoted to exploring the behavioural functions,key pathological mechanisms and potential treatments of ***,as we highlight in this review,emerging evidence shows that signal transduction molecular events are involved in pathological processes such as transcription,translation,synaptic transmission,epigenetics and immunoinflammatory *** involvement has important implications for the discovery of precise molecular targets for ***,we review recent insights into the mechanisms and clinical implications of signal transduction in autism from molecular,cellular,neural circuit,and neurobehavioural ***,the challenges and future perspectives are discussed with regard to novel strategies predicated on the biological features of autism.
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