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World Journal of Gastroenterology 2024年第26期30卷 3185-3192页

作者： Alessandro Mussetto Elettra Merola Cesare Casadei Daniele salvi Fabiola Fornaroli silvia Cocca Margherita Trebbi Armando Gabbrielli Cristiano spada Andrea Michielan Department of Gastroenterology S Maria della Croci HospRavenna 48121Italy Department of Gastroenterology Unit G.B.Grassi Hospital(ASL Roma 3)Roma 00122Italy section of Digestive Endoscopy and Gastroenterology Fondazione PoliambulanzaBrescia 25124Italy Gastroenterology and Endoscopy Unit Department of Medicine and SurgeryUniversity of ParmaParma 43125Italy Gastroenterology and Endoscopy Unit Azienda Ospedaliero Universitaria Policlinico di ModenaModena 41121Italy Center for Medical sciences(CIsMed) University of TrentoTrento 38122Italy Gastroenterology and Digestive Endoscopy Unit Santa Chiara HospitalAzienda Provinciale per i Servizi SanitariTrento 38122Italy Digestive Endoscopy Unit Fondazione Policlinico Universitario A.Gemelli IRCSSRoma 00168Italy

Motorized spiral enteroscopy(MsE)is the latest advance in device-assisted *** events related to MsE were discussed in a recent large systematic review and meta-analysis and were directly compared with those of balloon enteroscopy in a case-matched study and a randomized controlled *** the real-life application of MsE,an unexpected safety issue emerged regarding esophageal injury and the technique has been withdrawn from the global market,despite encouraging results in terms of diagnostic and therapeutic *** conducted an Italian multicenter real-life prospective study,which was prematurely terminated after the withdrawal of MsE from the *** primary goals were the evaluation of MsE performance(both diagnostic and therapeutic)and its safety in routine endoscopic practice,particularly in the early phase of introduction in the endoscopic unit.A subanalysis,which involved patients who underwent MsE after unsuccessful balloon enteroscopy,demonstrated,for the first time,the promising performance of MsE as a rescue *** its remarkable performance in clinical practice and its potential role as a backup technique following a previously failed enteroscopy,it may be more appropriate to refine and enhance MsE in the future rather than completely abandoning it.

关键词： Motorized spiral enteroscopy Rescue enteroscopy Diagnostic yield Adverse events AGREE classification

2009年意大利中部阿奎拉地震DInsAR同震位移的有限断层反演

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世界地震译丛 2009年第4期40卷 30-36页

作者： s．Atzori I．Hunstad M．Chini s.salvi C．Tolomei C．Bignami s．stramondo E．Trasatti A．Antonioli E．Boschi 李晶（译）不详陕西省地震局

根据环境卫星Envisat和COsMO-skyMed模型(为同震位错研究而首次设计的X波段反演干涉图)的DInsAR干涉图,确定了2009年4月6日阿奎拉MW=6.3级地震时激发的断层几何形状及运动特征。我们的主震最佳拟合解为一个约16km长、12km宽的正断层,存... 详细信息

根据环境卫星Envisat和COsMO-skyMed模型(为同震位错研究而首次设计的X波段反演干涉图)的DInsAR干涉图,确定了2009年4月6日阿奎拉MW=6.3级地震时激发的断层几何形状及运动特征。我们的主震最佳拟合解为一个约16km长、12km宽的正断层,存在小的右旋分量,向西南倾斜47°,最大滑动约90cm。虽然地震位错可能只有1km深,但是断层面的上倾投影与标绘的帕加尼卡—南德米特里奥断层的北段相符合,在现场观察到了该断层地表破裂的迹线。该断层在现有震源目录中的缺失表明,需要对具体的地表和地下进行进一步的地质和地球物理勘测,以便对局部规模的地震危险性做出更准确的评估。

关键词： DInsAR 断层反演地震位错同震位移意大利 Envisat 地表破裂 COsMO

1997年9月26日意大利Colfiorito地震:用sAR干涉和GPs模拟的同震地表位移

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世界地震译丛 2000年第5期31卷 28-31页

作者： s.stramondo M.Tesauro P.Briole E.sansosti s.salvi R.Lanari M.Anzidei P.Baldi G.Fornaro A.Avallone M.F.Buongiorno G.Franceschetti E.Boschi 乔子云宋胜合不详河北省地震局分析预报中心

1997年翁布里亚—马尔凯地震序列的最大事件是9月26日M_W5.7(00:33GMT)和M_W6.0(09:40GMT)两个地震,它们引起震中周围大面积的严重破坏和地裂缝。我们给出了一个ERs-sAR差分干涉图,图中在Colfiorito盆地内部及周围可见9个干涉条纹,这对... 详细信息

1997年翁布里亚—马尔凯地震序列的最大事件是9月26日M_W5.7(00:33GMT)和M_W6.0(09:40GMT)两个地震,它们引起震中周围大面积的严重破坏和地裂缝。我们给出了一个ERs-sAR差分干涉图,图中在Colfiorito盆地内部及周围可见9个干涉条纹,这对应于25cm的同震地表位移。GPs数据表明最大水平位移是14±1.8cm,最大沉降量为24±3cm。我们用这些测地数据和地震参数来估计断层面的几何特征和走滑分布。模拟的断层深度和最大滑动幅度对第一次地震分别是6.5km和47cm,对第二次地震分别是7km和72cm,这与由地震数据得到的很一致。

关键词：地震序列走滑 GPs 地裂缝地震数据断层面震中地表位移沉降量水平位移

钙感受器受体高水平表达的人类乳腺癌小鼠模型3T在体成像

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国际医学放射学杂志 2012年第3期 291-291页

作者： G.Baio M.Fabbi L.Emionite M.Cilli s.salvi P.Ghedin 杨治国 Department of Diagnostic Imaging ISTNational Cancer InstituteLargo Rosanna Benzi 1016132 GenoaItaly

目的临床3TMR评估证实锰能够显示人类乳腺癌鼠类模型的钙感受器受体(CasR)表达细胞。方法人类MDA-MB-231-Luc或MCF7-Luc的乳腺癌细胞可常位生长于NOD/sCID的小鼠体内形成最小为5mm的肿块。对静脉注射MnCl2前后的小鼠均采用T1WI序列进行... 详细信息

目的临床3TMR评估证实锰能够显示人类乳腺癌鼠类模型的钙感受器受体(CasR)表达细胞。方法人类MDA-MB-231-Luc或MCF7-Luc的乳腺癌细胞可常位生长于NOD/sCID的小鼠体内形成最小为5mm的肿块。对静脉注射MnCl2前后的小鼠均采用T1WI序列进行评估。为阻断

关键词： MRI 二氯化锰乳腺癌钙感受器在体小动物MRI

Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a Delphi consensus project

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Asian Journal of Urology 2024年第2期11卷 271-279页

作者： Andrea Cocci Marta Pezzoli Fernando Bianco Franco Blefari Pierluigi Bove Francois Cornud Gaetano De Rienzo Paolo Destefanis Danilo Di Trapani Alessandro Giacobbe Luca Giovanessi Antonino Laganà Giovanni Lughezzani Guglielmo Manenti Gianluca Muto Gianluigi Patelli Novello Pinzi stefano Regusci Giorgio I.Russo Juan I.M.salamanca Matteo salvi Luigi silvestri Fabrizio Verweij Eric Walser Riccardo GBertolo Valerio Iacovelli Alessandro Bertaccini Debora Marchiori Hugo Davila Pasquale Ditonno Paolo Gontero Gennaro Iapicca Theo M De Reijke Vito Ricapito Pierluca Pellegrini Andrea Minervini sergio serni Francesco sessa Department of Urology Careggi HospitalUniversity of FlorenceFlorenceItaly Urology section University of FlorenceFlorenceItaly Urological Research Network MiamiFLUSA Urology section Prato HospitalPratoItaly Torvergata Oncoscience Research Centre of Excellence TORDepartment of Experimental MedicineUniversity of Rome Tor VergataRomeItaly Department of Urology San Carlo di Nancy HospitalRomeItaly Department of Radiology Hôpital CochinParis Descartes UniversityParisFrance Urology and Andrology Unit II Department of Emergency and Organ TransplantationUniversity of BariBariItaly Unit of Urology Cittàdella Salute e della Scienza HospitalUniversity of TurinTurinItaly Urology Unit Buccheri La Ferla Fatebenefratelli HospitalPalermoItaly Department of Urology Humanitas Gradenigo HospitalTurinItaly Urology Unit Surgical DepartmentFondazione Poliambulanza Istituto OspedalieroBresciaItaly Departement of Urology “S.Giovanni Evangelista”HospitalTivoliItaly Humanitas Clinical and Research CentereIRCCs Department of UrologyRozzanoItaly Department of Biomedical sciences Humanitas UniversityPieve EmanueleItaly Department of Biomedicine and Prevention University of Rome“Tor Vergata”RomeItaly Department of Diagnostic Imaging and Interventional Radiology University of Rome“Tor Vergata”RomeItaly Department of Interventional Radiology Pesenti-Fenaroli Hospital-ASST Bergamo EstAlzano LombardoItaly Department of Urology University of SienaSienaItaly swiss International Prostate Center GenevaSwitzerland Clinique Générale Beaulieu GenevaSwitzerland Department of Urology University of CataniaItaly Department of Urology Puerta de Hierro-Majadahonda University HospitalMadridSpain Lyx Institute of Urology Universidad Francisco de VitoriaMadridSpain Department of Medico-surgical sciences and Biotechnologies Sapienza University of RomeFaculty of Pharmacy and MedicineUrology Unit ICOTLatinaItaly Department of Urology European Institute of Oncology(IEO)IRCCSMilanItaly Department of Radiology D

Objective: To evaluate transperineal laser ablation (TPLA) with Echolaser® (Echolaser® TPLA, Elesta s.p.A., Calenzano, Italy) as a treatment for benign prostatic hyperplasia (BPH) and prostate cancer (PCa) using the Delphi consensus ***: Italian and international experts on BPH and PCa participated in a collaborative consensus project. During two rounds, they expressed their opinions on Echolaser® TPLA for the treatment of BPH and PCa answering online questionnaires on indications, methodology, and potential complications of this technology. Level of agreement or disagreement to reach consensus was set at 75%. If the consensus was not achieved, questions were modified after each round. A final round was performed during an online meeting, in which results were discussed and ***: Thirty-two out of forty invited experts participated and consensus was reached on all topics. Agreement was achieved on recommending Echolaser® TPLA as a treatment of BPH in patients with ample range of prostate volume, from 80 mL (80%), comorbidities (100%), antiplatelet or anticoagulant treatment (96%), indwelling catheter (77%), and strong will of preserving ejaculatory function (100%). Majority of respondents agreed that Echolaser® TPLA is a potential option for the treatment of localized PCa (78%) and recommended it for low-risk PCa (90%). During the final round, experts concluded that it can be used for intermediate-risk PCa and it should be proposed as an effective alternative to radical prostatectomy for patients with strong will of avoiding urinary incontinence and sexual dysfunction. Almost all participants agreed that the transperineal approach of this organ-sparing technique is safer than transrectal and transurethral approaches typical of other techniques (97% of agreement among experts). Pre-procedural assessment, technical aspects, post-procedural catheterization, pharmacological therapy, and expected outcomes were discussed, leading t

关键词： Transperineal laser ablation Prostatecancer Benignprostatic hyperplasia Delphi consensus

Gene expression in cisplatin ototoxicity and protection with p53 inhibitor

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Journal of Otology 2009年第2期4卷 61-70页

作者： Donald Coling Richard salvi Center for Hearing & Deafness 137 Cary HallUniversity at Buffalo

Cisplatin damages cochlear hair cells and spiral ganglion neurons through cell death signaling pathways that are not fully understood. We used focused apoptosis gene microarrays to study early changes in gene expres- sion in cochlear cultures from P3 neonatal rats treated with cisplatin (0.2 mM). After 12 hours of cisplatin treat- ment, more than 50% of the 96 genes on the array showed a significant decrease in expression, consistent with widespread cell death. However, after 3 hours of cisplatin treatment, 10 genes showed significant increase in ex- pression in total cochlear tissue. In experiments with subsets of cochlear tissues, at 3h, cisplatin induced increased expression of 12 genes in the cochlear sensory epithelium (basilar membrane) and 11 genes in the spiral ganglion (tissue of Rosenthal’s canal, containing the spiral ganglion). These included pro- and anti-apoptotic genes in- volved in the p53 signaling pathway, TNF receptor family, NF-kappaB pathway, death domain family, death effec- tor domain family, Bcl-2 family, CARD family, TRAF family, and GTP signal transduction. Although the changes in gene expression showed an overlap between basilar membrane and spiral ganglion, other changes, which may reflect the unique response of each tissue, were also observed. Pifithrin-α blocked cisplatin-induced up-regulation of genes in the p53 signaling pathway when assayed by both superarray and real time PCR. The data add to our understanding of the involvement of p53 in cisplatin-induced ototoxicity and otoprotection, conferred by the p53 inhibitor Pifithrin-α.

关键词： cisplatin p53 Pifithrin-α gene expression ototoxicity cochlea hair cells spiral ganglion neurons

Protein kinase CK2: a potential therapeutic target for diverse human diseases

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signal Transduction and Targeted Therapy 2021年第6期6卷 1698-1717页

作者： Christian Borgo Claudio D'Amore stefania sarno Mauro salvi Maria Ruzzene Department of Biomedical sciences University of PaduaPaduaItaly CNR Institute of Neuroscience University of PaduaPaduaItaly

CK2 is a constitutively active ser/Thr protein kinase,which phosphorylates hundreds of substrates,controls several signaling pathways,and is implicated in a plethora of human *** best documented role is in cancer,where it regulates practically all malignant *** well-known functions of CK2 are in human infections;in particular,several viruses exploit host cell CK2 for their life *** recently,also sARs-CoV-2,the virus responsible for the COVID-19 pandemic,has been found to enhance CK2 activity and to induce the phosphorylation of several CK2 substrates(either viral and host proteins).CK2 is also considered an emerging target for neurological diseases,inflammation and autoimmune disorders,diverse ophthalmic pathologies,diabetes,and *** addition,CK2 activity has been associated with cardiovascular diseases,as cardiac ischemia-reperfusion injury,atherosclerosis,and cardiac *** hypothesis of considering CK2 inhibition for cystic fibrosis therapies has been also entertained for many ***,psychiatric disorders and syndromes due to CK2 mutations have been recently *** these bases,CK2 is emerging as an increasingly attractive target in various fields of human medicine,with the advantage that several very specific and effective inhibitors are already ***,we review the literature on CK2 implication in different human pathologies and evaluate its potential as a pharmacological target in the light of the most recent findings.

关键词： diseases inflammation potential

standardized surgical approaches to ear surgery in rats

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Journal of Otology 2015年第2期10卷 72-77页

作者： Peng Li Dalian Ding Kelei Gao Richard salvi Department of Otolaryngology Head and Neck surgery The Third Affiliated Hospital of Sun Yat-Sen University Center for Hearing and Deafness University of New York at Buffalo Department of Otolaryngology Head and Neck surgery Xiangya Hospital Central South University

Objective： To describe several approaches of ear surgeries for experimental studies in rats. Methods： Anesthetized rats were prepared for demonstration of various ear surgery approaches designed to optimize experimental outcomes in studies with specific goals and exposure requirements. The surgical approaches included the posterior tympanum, superior tympanum, inferior tympanum and occipital approaches. Results： The middle ear cavity and inner ear were successfully exposed from different angles via the mentioned surgical approaches. For example, electrode placement for recording of cochlear bioelectric responses was easily achieved through the posterior tympanum or inferior tympanum approach. Alternatively, drug delivery or gene transfection via round window membrane was most easily accomplished using the posterior tympanum approach. Cochlear perfusion of protective or ototoxic drugs was best performed using the inferior tympanum approach. Ossicular chain interruption to induce a prolonged conductive hearing loss was readily achieved using a superior tympanum approach. Lastly, surgical destruction of the endolymphatic sac to induce experimental endolymphatic hydrops was readily performed via an occipital surgical ***： These standardized surgical approaches can be applied in scientific studies of the ear with different purposes covering electro- physiology, conductive hearing loss, intra-cochlear drug perfusion and experimental studies relevant to Meniere＇s disease.

关键词： Rat Middle ear Inner ear surgical approach

Ability of Mn2＋ to Permeate the Eye and Availability of Manganese-enhanced Magnetic Resonance Imaging for Visual Pathway Imaging via Topical Administration

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Chinese Medical Journal 2016年第15期129卷 1822-1829页

作者： Yao Chen Chun-Yan shi Ying Li Yun-Tao Hu Hong-Bin Han Xiao-Dong sun salyajeel s.salvi Zhi-Zhong Ma Department of Ophthalmology Key Laboratory of Vision Loss and Restoration Ministry of Education Peking University Third Hospital Beijing 100191 China Department of Radiology Key Laboratory of Magnetic Resonance Imaging Equipment and Technology Peking University Third Hospital Beijing 100083 China Department of Ophthalmology Beijing Tsinghua Chang Gung Hospital Beijing 102218 China Department of Ophthalmology Affiliated First People's Hospital of Shanghai Jiao Tong University Shanghai 200080 China

Background： Manganese-enhanced magnetic resonance imaging （MEMR1） for visual pathway imaging via topical administration requires further research. This study investigated the permeability of the corneal epithelium and corneal toxicity after topical administration of Mn2＋ to understand the applicability of MEMR1. Methods： Forty New Zealand rabbits were divided into 0.05 mool/L, 0.10 mol/L, and 0.20 mol/L groups as well as a control group （n ： 10 in each group）. Each group was i-hrther subdivided into epithelium-removed and epithelium-intact subgroups （n = 5 in each subgroup）. Rabbits were given 8 drops of MnCl2 in 5 min intervals. The Mn2＋ concentrations in the aqueous and vitreous humors were analyzed using inductively coupled plasma-mass spectrometry at different time points. MEMRI scanning was carried out to image the visual pathway after 24 h. The corneal toxicity of Mn2＋ was evaluated with corneal imaging and pathology slices. Results： Between the aqueous and vitreous humors, there was a 10 h lag for the peak Mn2＋ concentration times. The intraocular Mn2＋ concentration increased with the concentration gradients ofMn2＋ and was higher in the epithelium-removed subgroup than that in the epithelium-intact subgroup. The enhancement of the visual pathway was achieved ill the 0.10 mol/L and 0.20 mol/L epithelium-removed subgroups. The corresponding peak concentrations of Mn2. were 5087 ~ 666 ng/ml, 22920 ± 1188 ng/ml ill the aqueous humor and 884 ± 78 ng/ml, 2556 ± 492 ng/ml in the vitreous body, respectively. Corneal injury was evident in the epithelium-removed and 0.20 mol/L epithelium-intact subgroups. Conclusions： The corneal epithelium is a barrier to Mn2＋, and the iris and lens septum might be another intraocular banier to the permeation of Mn2＋. An elevated Mn2＋ concentration contributes to the increased permeation of Mn2＋, higher MEMRI signal, and corneal toxicity. The enhancement of the visual pathway requires an effective Mn2＋ concentration in the vitreous bo

关键词： Corneal Permeability Manganese Manganese-enhanced Magnetic Resonance Imaging Optic Nerve superior Colliculus Topical Toxicity Visual Pathway