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Iodine Malnutrition and Associated Factors in schoolchildren Aged 6 to 14 Years in a Municipality situated in the semi-Arid Region of the state of Minas Gerais, Brazil, 2008

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Food and Nutrition sciences 2014年第20期5卷 2008-2019页

作者： Mariana de souza Macedo Romero Alves Teixeira élido Bonomo Camilo Adalton Mariano da silva Mariangela Carneiro Marcelo Eustáquio silva Emília sakurai Joel Alves Lamounier Graduate Center School of Medicine Federal University of Minas Gerais Belo Horizonte Brazil Department of Nutrition School of Biological and Health Sciences Federal University of the Jequitinhonha and Mucuri Diamantina Brazil school of Nutrition Federal University of Ouro Preto Ouro Preto Brazil Institute of Biological sciences Federal University of Minas Gerais Belo Horizonte Brazil Institute of Mathematical sciences Federal University of Minas Gerais Belo Horizonte Brazil Department of Pediatrics School of Medicine Federal University of S&#227 o Joã o Del Rei Divinópolis Brazil

The objective of this study was to assess the prevalence of iodine deficiency and possible correlated factors among schoolchildren in the municipality of Novo Cruzeiro-MG by means of an evaluation of urinary iodine excretion. Five hundred and forty schoolchildren aged 6 to 14 years selected by stratified sampling, were evaluated. Urine samples were analyzed using the sandell-Kolthoff method preconized by the WHO and iodine concentrations in the salt were assessed by means of volumetric analysis, in accordance with recommendations from the Ministry of Health. Iodine deficiency was observed in 38.9% of the schoolchildren. Of these, 28.7% of them presented slight deficiency, 6.2% of them were moderately deficient and 4% of them were seriously deficient. Median urinary iodine levels in the urban and rural population were 150.8 and 119.2 μg/L, respectively, with a clear distribution of iodine deficiency among the populations (p stered. It was also observed that there was a high prevalence of deficient urinary iodine excretion among schoolchildren that consumed salt with an insufficient iodine content. In relation to the quality of the salt consumed by families, in 12.2% of the residences studied the iodine content in salt was below the recommended level (20 mg/kg), while the iodine content was below 15 mg/kg in only 5.3% of them. The results indicated that, although not characterized as a public health issue, according to WHO criteria, iodine deficiency showed very high prevalence among schoolchildren in this region. Regarding the iodine content of salt found in household consumption, our findings indicated the National Program of salt Iodination was not efficient in the city, since it did not hit the target proposed by the Ministry of Health. Furthermore, low urinary iodine excretion associated with the consumption of salt with low iodine content suggests the need for periodical evaluations in order to provide effective control of the endemic disease.

关键词： Iodine status Iodine Deficiency Urinary Iodine Iodized salt schoolchildren

New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury

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World Journal of Gastroenterology 2015年第45期21卷 12778-12786页

作者： Naoki sano Takafumi Tamura Naoyuki Toriyabe Takeshi Nowatari Ken Nakayama Tomohito Tanoi soichiro Murata Yu sakurai Mamoru Hyodo Kiyoshi Fukunaga Hideyoshi Harashima Nobuhiro Ohkohchi Department of surgery Doctoral Program in Clinical Science Graduate School of Comprehensive Human Sciences University of Tsukuba Faculty of Pharmaceutical sciences Hokkaido University

AIM: To investigate the cytoprotective effects in hepatic ischemia-reperfusion injury, we developed a new formulation of hyaluronic acid(HA) and sphingosine ***: We divided sprague-Dawley rats into 4 groups: control, HA, sphingosine 1-phosphate(s1P), and HA-s1 P. After the administration of each agent, we subjected the rat livers to total ischemia followed by reperfusion. After reperfusion, we performed the following investigations: alanine aminotransferase(ALT), histological findings, Td T-mediated d UTP-biotin nick end labeling(TUNEL) staining, and transmission electron microscopy(TEM). We also investigated the expressionof proteins associated with apoptosis, hepatoprotection, and s1 P accumulation. REsULTs: s1 P accumulated in the HA-s1 P group livers more than s1 P group livers. serum ALT levels, TUNEL-positive hepatocytes, and expression of cleaved caspase-3 expression, were significantly decreased in the HA-s1 P group. TEM revealed that the liver sinusoidal endothelial cell(LsEC) lining was preserved in the HA-s1 P group. Moreover, the HA-s1 P group showed a greater increase in the HO-1 protein levels compared to the s1 P ***: Our results suggest that HA-s1 P exhibits cytoprotective effects in the liver through the inhibition of LsEC apoptosis. HA-s1 P is an effective agent for hepatic ischemia/reperfusion injury.

关键词： Hyaluronic acid sphingosine 1-phosphate Liver sinu

EVALUATION OF AXILLARY LYMPH NODE sTATUs IN BREAsT CANCER WITH MRI

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中国现代普通外科进展 1999年第3期 38-44页

作者： Goro Yoshimura, Takeo sakurai, syoji Oura, Takaomi suzuma, Takeshi Tamaki, Qifeng YangDepartment of surgery, Kihoku Hospital, Wakayama Medical College (219, Katsuragi, Ito-gun, Wakayama 649 -7113, Japan)

Objective:We performed a retrospective study to establish the optimalradiological criteria for axillary lymph node metastases from breast cancer by measuringall dissected nodes,and to determine whether magnetic resonance imaging(MRI)couldreliably reveal axillary ***:Pathological findings and MRI scans of 202patients with invasive breast cancer were *** long-and short-axis dimensions ofall level Ⅰ and Ⅱ lymph nodes were measured microscopically,and then the long-to-shortaxis(L/s)ratio of each node was *** parameters were compared withpathological nodal status to define radiological criteria for axillary *** wascarried iut using T1-weighted spin-eho sequences in the coronal and sagittal ***,every detected lymph node was measured and the shape of the nodal cortex was *** the diagnostic ability of MRI was assessed using these morphologic ***:On histopathological examinations of 4043 dissected lymph nodes,a long-axisdime

关键词： Breast cancer Axiliary lymph node metastases Radiological criteria MRl

Castor oil as booster for colon capsule endoscopy preparation reduction: A prospective pilot study and patient questionnaire

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2021年第4期12卷 79-89页

作者： Kota Takashima Yoriaki Komeda Toshiharu sakurai sho Masaki Tomoyuki Nagai shigenaga Matsui satoru Hagiwara Mamoru Takenaka Naoshi Nishida Hiroshi Kashida Konosuke Nakaji Tomohiro Watanabe Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka 589-8511Japan Division of Gastroenterology Department of Internal MedicineEndoscopy CenterAishinkai Nakae HospitalWakayama-Shi 640-8461Japan

BACKGROUND Preparation for colon capsule endoscopy(CCE)requires a large liquid laxative volume for capsule excretion,which compromises the procedure's *** To assess the safety and utility of castor oil-boosted bowel *** This prospective cohort study including 20 patients(age range,16-80 years;six men and 14 women)suspected of having colorectal disease was conducted at Kindai University Hospital from september 2017 to August *** patients underwent CCE because of the following inclusion criteria:previous incomplete colonoscopy in other facility(n=20),history of abdominal surgery(n=7),or organ abnormalities such as multiple diverticulum(n=4)and adhesion after surgery(n=6).The exclusion criteria were as follows:Dysphagia,history of allergic reactions to the drugs used in this study(magnesium citrate,polyethylene glycol,metoclopramide,and castor oil),possibility of pregnancy,possibility of bowel obstruction or stenosis based on symptoms,or scheduled magnetic resonance imaging within 2 wk after *** primary outcome was the capsule excretion rate within the battery life,as evaluated by the total large bowel observation rate,large bowel transit time,and bowel creasing level using a fivegrade scale in different colorectal *** secondary outcomes were complications,colorectal lesion detection rates,and patients’*** The castor oil-based regimen was implemented in 17 *** patients cancelled CCE because they could tolerate castor oil,but not liquid *** capsule excretion rate within the battery life was 88%(15/17).The mean large bowel transit time was 236 *** 70%of patients had satisfactory colon cleansing *** detected colon polyps(14/17,82%)and colonic diverticulum(4/12,33%).The sensitivity,specificity,and diagnostic accuracy rates for detecting colorectal polyps(size≥6 mm)were 76.9%,75.0%,and 76.4%,*** sensitivity,specificity,and diagnostic accuracy rates for dete

关键词： Bowel preparation regimen Castor oil Colon capsule endoscopy Colonoscopy Colorectal diseases Prospective study

Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer

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World Journal of Gastroenterology 2008年第31期14卷 4880-4888页

作者： Nozomi Togo susumu Ohwada shinji sakurai Hiroyuki Toya Ichiro sakamoto Tatsuya Yamada Tetsuhiro Nakano Ken Muroya Izumi Takeyoshi Takashi Nakajima Takashi sekiya Yusuke Yamazumi Tsutomu Nakamura Tetsu Akiyama Departments of surgery Graduate School of Medicine Gunma University Gunma 371-8511 Japan Departments of Tumor Pathology Graduate School of Medicine Gunma University Gunma 371-8511 Japan Laboratory of Molecular and Genetic Information Institute for Molecular and Cellular Biosciences University of Tokyo Tokyo 113-0032 Japan

AIM: To investigate the clinical significance of BMP and activin membrane-bound inhibitor (BAMBI) which is a pseudoreceptor of transforming growth factor-beta (TGF-β) type Ⅰreceptors and acts as a negative regulator of TGF-β signaling and expression aberrantly elevated in colorectal cancers (CRCs). We studied BAMBI expression in CRCs. METHODs: We studied BAMBI expression in 183 surgically resected CRCs by immunochemical and immunoblotting analyses using a generated monoclonal anti-BAMBI antibody. Commercially available anti-β-catenin and anti-p53 antibodies were also applied for immunochemical analyses as a comparison ***: Immunohistochemical analysis revealed that BAMBI expression was observed in 148 (80.8%), and strong BAMBI expression was observed in 46% of the CRCs. strong BAMBI expression was positively correlated with histological type, depth of invasion, lymph node metastases, and tumor node metastasis (TNM) stage (P ssociations were found between BAMBI and β-catenin (P = 0.035) and p53 (P = 0.049) expression. In curatively resected CRC, 5-year recurrence-free survival was 51.9% (P = 0.037) for strong BAMBI expression compared to 79.8% for weak BAMBI expression. In the Cox’s multivariate analysis, lymph node metastases (RR 6.685; P sion (RR 14.0; P = 0.013) were signifi cant indicators for recurrence, and strong BAMBI expression (RR 2.26; P = 0.057) tended to be signifi cant. CONCLUsION: BAMBI was linked to a potentially aggressive tumor phenotype and predicted tumor recurrence and cancer-related death in CRC. BAMBI expression might be applicable in the routine clinical setting of CRC.

关键词：转换生长因子结肠癌直肠癌治疗方法

Usefulness of Hexamethylenetetramine as an Adjuvant to Radiotherapy and Cisplatin Treatment for solid Tumors:its independency of p53 status

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Usefulness of Hexamethylenetetramine as an Adjuvant to Radio...

电针“足三里”穴对孕期及哺乳期尼古丁暴露新生鼠肺发育不良的影响

作者： s.Masunaga K.Tano J.Nakamura M.Watanabe G.Kashino A.Takahashi H.Tanaka Y.sakurai M.suzuki K.Ohnishi Y.Kinashi Y.Liu T.Ohnishi K.Ono University of North Carolina at Chapel Hill USA Nara Medical University

BACKGROUNDs AND PURPOsEs:Formaldehyde preserves or fixes tissue or cells by irreversibly cross-linking primary amine groups in proteins with other nearby nitrogen atoms in protein or DNA through a -CH2- *** acid-dependent formaldehyde donor, hexamethylenetetramine(HMTA),has been used as an antiseptic for urinary tract infections and it has been supposed to be characterized as a non-carcinogen in animals. In the hypoxic condition in a solid tumor,pyruvate

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中国医药导报 2018年第7期15卷 4-8页

作者：刘翼天嵇波苏杭葛云鹏王丹赵国桢 Reiko sakurai Virender Kumar Rehan 北京中医药大学针灸推拿学院北京100029 首都医科大学附属北京中医医院北京100010 加州大学洛杉矶分校Harbor医学中心生物医学研究所儿科洛杉矶90502

目的观察电针"足三里"穴对孕期及哺乳期尼古丁暴露新生鼠肺功能、肺指数和肺组织形态学的影响。方法将20只成年sD雌鼠采用随机数字表法分为生理盐水组(s组)、生理盐水加电针"足三里"组(s+sT36组)、尼古丁组(N组)、尼古丁加电针"足三里"... 详细信息

目的观察电针"足三里"穴对孕期及哺乳期尼古丁暴露新生鼠肺功能、肺指数和肺组织形态学的影响。方法将20只成年sD雌鼠采用随机数字表法分为生理盐水组(s组)、生理盐水加电针"足三里"组(s+sT36组)、尼古丁组(N组)、尼古丁加电针"足三里"组(N+sT36组),采用皮下注射尼古丁注射液[1 mg/(kg·d),100μL]造模,从妊娠第6天至新生鼠出生后21 d,用动物肺功能分析系统检测各组新生鼠肺功能,根据肺组织重量和体重计算各组新生鼠肺指数,采用HE染色法观察各组新生鼠肺组织形态学变化。结果与s组比较,N组呼气峰值(PEF)、肺动脉顺应性(Cdyn)显著降低(PsT36组PEF、Cydn显著升高(P<0.05),RL显著降低(P<0.05),肺指数显著升高(P<0.05);新生鼠肺组织中肺泡数量增多、肺泡面积减小和肺泡壁破裂融合情况减少。结论电针孕期和哺乳期尼古丁暴露大鼠"足三里"穴可能通过改善新生鼠肺功能、肺指数及肺组织形态学变化发挥对新生鼠肺发育的保护效应。

关键词：孕期及哺乳期尼古丁暴露足三里肺指数肺功能肺组织形态学

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Modified boron neutron capture therapy for malignant gliomas performed using epithermal neutron and two boron compounds with different accumulation mechanisms： an efficacy study based on findings on neuroimages

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中国神经肿瘤杂志 2005年第4期3卷 266-266页

作者： Miyatake s Kawabata s Kafimoto Y Aoki A Yokoyama K Yamada M Kuroiwa T Tsuji M Imahori Y Kirihata M sakurai Y Masunaga s Nagata K Maruhashi A Ono K Department of Neurosurgery Osaka Medical College Takatsuki City Japan

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初产妇和经产妇妊娠期间的诊室和家庭血压

中华高血压杂志 2013年第6期21卷 598-598页

作者： Ishikuro M Obara T Metoki H Ohkubo T Yamamoto M Akutsu K sakurai K Iwama N Katagiri M Yagihashi K Yaegashi N Mori s suzuki M Kuriyama s Imai Y 罗冬梅叶鹏

妊娠高血压可导致分娩时产生严重的并发症，如脑卒中、早产或低出生体质量。初产妇被认为是妊娠高血压的一个危险因素。产次与妊娠期间家庭血压相关性仍不明确。方法：入选初产妇和经产妇共575名，评估妊娠高血压和先兆子痫的发病率。... 详细信息

妊娠高血压可导致分娩时产生严重的并发症，如脑卒中、早产或低出生体质量。初产妇被认为是妊娠高血压的一个危险因素。产次与妊娠期间家庭血压相关性仍不明确。方法：入选初产妇和经产妇共575名，评估妊娠高血压和先兆子痫的发病率。收集在一家日本产科医院接受产前检查的530名正常血压孕妇的家庭和诊室血压值。诊室血压为产前检查2次测量的血压平均值，参与者妊娠期间每日清晨在家自测血压。

关键词：妊娠高血压妊娠期间初产妇家庭诊室低出生体质量产前检查危险因素

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