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Genes & Diseases 2024年第3期11卷 128-131页

作者： Tomas Cerdo Teresa Torres Moral Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Reina Sofia University HospitalUniversity of CordobaCordoba 14004Spain Centre for Rheumatology Research Division of MedicineUniversity College LondonLondon W1T 4JFUK Faculty of Computer sciences Multimedia and TelecommunicationUniversitat Oberta de CatalunyaBarcelona 08018Spain Dermatology Department Melanoma UnitAugust Pi i Sunyer Biomedical Research Institute(IDIBAPS)and Hospital ClinicBarcelona 08036Spain Center for Networked Biomedical Research on rare Diseases(CIBERER) Carlos II Health InstituteMadrid 28029Spain

Primary sjogren's syndrome(pss)is one of the most widespread autoimmune diseases with unknown origin,characterized by a lymphocytic infiltrate of the exocrine glands and the production of anti-ssA/Ro and anti-ssB/La antibodies that cause dysfunction and destruction mainly of salivary and lachrymal glands,leading to dry eyes and dry *** the absence of a standardized evidence-based screening tool to decide which patients with dry eye must be referred for study of this pathology.

关键词： sjogren lymphocytic salivary

Features of sampling stream sediments of large river valleys under cryolithogenesis conditions in the Balygychan-sugoy trough,North-East of Russia

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Acta Geochimica 2024年第4期43卷 638-660页

作者： Artem s.Makshakov raisa G.Kravtsova A.P.Vinogradov Institute of Geochemistry Siberian Branch of the Russian Academy of SciencesFavorskiy Str 1AIrkutskRussia 664033

Comprehensive research has been implemented to raise the efficiency of the geochemical survey of stream sediments(sss)that formed under the cryolithogenesis *** authors analysed the composition,structure and specific features of the formation of exogenous anomalous geochemical fields(AGFs)identified through sss of large river valleys of IV *** our case,these were the valleys of Maly Ken,Ken and Tap *** rivers are located in the central and southern parts of the Balygychan-sugoy trough enclosed in the Magadan region,North-East of *** authors proposed a new technique to sample loose alluvium of sss in the large river valleys along the *** profiles were located across the *** AGFs of Au,Ag,Pb,Zn,sn,Bi,Mo and W were *** between elements have been *** elements are the main indicator elements of Au-Ag,Ag-Pb,sn-Ag,Mo-W and sn-W mineralization occurring on the sites under *** results obtained were compared with the results of geochemical surveys of *** is concluded that the AGFs recognized along the profiles reflect the composition and structure of eroded and drained ore zones,uncover completely and precisely the pattern of element distribution in loose sediments of large water *** alluvium fractionseems to be most significant in a practical sense,as it concentrated numerous ore *** of this fraction in the river valleys of IV order does not cause any difficulty,for this kind of material is *** developed technique of alluvium sampling within large river valleys is efficient in searching for diverse mineralization at all stages of prognostic *** is applicable for geochemical survey of sss performed at different scales both in the North-East of Russia,as well as other regions with similar climatic conditions,where the sss are formed under the cryolithogenesis conditions.

关键词： stream sediments Large river valleys Geochemical fields Mineralization Indicator elements Geochemical survey

On the Geometry of the Anti-canonical Bundle of the Bott–samelson–Demazure–Hansen Varieties

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Acta Mathematica sinica,English series 2024年第8期40卷 1920-1940页

作者： Indranil BIsWAs s.senthamarai KANNAN Pinakinath sAHA school of Mathematics Tata Institute of Fundamental Research1 Homi Bhabha RoadMumbai 400005India Chennai Mathematical Institute Plot H1SIPCOT IT ParkSiruseriKelambakkam603103India

Let G be a semi-simple simply connected algebraic group over the field C of complex *** T be a maximal torus of G,and let W be the Weyl group of G with respect to *** Z(w,i)be the Bott–samelson–Demazure–Hansen variety corresponding to a tuple i associated to a reduced expression of an element w∈*** prove that for the tuple i associated to any reduced expression of a minuscule Weyl group element w,the anti-canonical line bundle on Z(w,i)is globally *** consequence,we prove that Z(w,i)is weak *** that G is a simple algebraic group whose type is different from *** s={α1,...,αn}be the set of simple *** w be such that support of w is equal to *** prove that Z(w,i)is Fano for the tuple i associated to any reduced expression of w if and only if w is a Coxeter element and w^(−1)(Σ_(t=1)^(n)α_(t))∈−s.

关键词： Bott-samelson-Demazure-Hansen variety Coxeter element anti-canonical line bundle Fano weak Fano

Targeting gut microbiota in osteoporosis:impact of the microbial based functional food ingredients

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Food science and Human Wellness 2024年第1期13卷 1-15页

作者： Pauline Duffuler Khushwant s.Bhullar Jianping Wu Department of Agricultural Food&Nutritional science University of AlbertaEdmonton T6G 2P5Canada

Osteoporosis is the most common bone disorder,characterized by low bone mineral density and microarchitectural deterioration of the bone tissue,which increases the susceptibility to *** the past decade,emerging research findings reported the implication of gut microbiota on bone health and osteoporosis *** patients or individuals with a lower bone mineral density exhibit an alteration of the gut microbiota at several taxonomic *** reports demonstrate that gut microbiota regulates bone metabolism through the modulation of the gut function(mineral availability and absorption,gut integrity),the immune system,and the endocrine ***,based on the vital role of gut microbiota on bone health,it has emerged as a novel therapeutic target for the prevention of bone loss and the treatment of ***-based functional food ingredients,such as probiotics,prebiotics,synbiotics,and fermented foods,have been developed to alter the gut microbiota composition and function and thus,to provide benefits to the host bone *** promising initial results,microbial-based therapies are still under ***,additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.

关键词： Dysbiosis Bone health Probiotic Prebiotic Fermented food synbiotic

A review of control strategies used for morphing aircraft applications

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Chinese Journal of Aeronautics 2024年第4期37卷 436-463页

作者： Muhammed s.PAraNCHEERIVILAKKATHIL Jafar s.PILAKKADAN rafic M.AJAJ Mohammadreza AMOOZGAR Davood AsADI Yahya ZWEIRI Michael I.FRIsWELL Department of Aerospace Engineering Khalifa University of Science and TechnologyAbu DhabiUnited Arab Emirates Department of Aerospace Engineering Advanced Research and Innovation Center(ARIC)Khalifa University of Science and TechnologyAbu DhabiUnited Arab Emirates Department of Mechanical Materials&Manufacturing EngineeringUniversity of NottinghamNottingham NG72RDUK Department of Aerospace Engineering Adana Alparslan Turkes Science and Technology UniversityTurkey College of Engineering Swansea UniversitySwansea SA18ENUK

This paper reviews the various control algorithms and strategies used for fixed-wing morphing aircraft applications. It is evident from the literature that the development of control algorithms for morphing aircraft technologies focused on three main areas. The first area is related to precise control of the shape of morphing concepts for various flight conditions. The second area is mainly related to the flight dynamics, stability, and control aspects of morphing aircraft. The third area deals mainly with aeroelastic control using morphing concepts either for load alleviation purposes and/or to control the instability boundaries. The design of controllers for morphing aircraft/wings is very challenging due to the large changes that can occur in the structural, aerodynamic, and inertial characteristics. In addition, the type of actuation system and actuation rate/speed can have a significant effect on the design of such controllers. The aerospace community is in strong need of such a critical review especially as morphing aircraft technologies move from fundamental research at a low Technology Readiness Level(TRL) to real-life applications. This critical review aims to identify research gaps and propose future directions. In this paper, research activities/papers are categorized according to the control strategy used. This ranges from simple Proportional Integral Derivative(PID) controllers at one end to complex robust adaptive controllers and deep learning algorithms at the other end. This includes analytical, computational, and experimental studies. In addition, the various dynamic models used and their fidelities are highlighted and discussed.

关键词： Control strategies Morphing aircraft shape morphing Flight dynamics Aeroelasticity

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Genes & Diseases 2024年第3期11卷 66-68页

作者： Aswathi N Jincy M.Jose sreelata B.Nair Prabha s.N Pappachan s Department of Medical Genetics Lifeline Super Specialty HospitalPathanamthittaKerala 691523India Lifeline super specialty Hospital PathanamthittaKerala 691523India

Alagille syndrome(ALGs;OMIM#118450)is a highlyvariable,multi-systemic,autosomal dominant disorder,caused by mutations in the Jagged Canonical Notch Ligand 1(JAG1)gene(20p12.2)or in the Neurogenic locus notch homolog protein 2(NOTCH2)gene(1p13).^(1)It primarily affects the liver,heart,eyes,face,kidney,skin,vertebrae,and skeleton.^(1,2)The JAG1 gene has 26 exons and about 90%of the ALGs cases result from pathogenic variants in the JAG1 and around 7%of cases have deletions in chromosome 20 that include this gene.

关键词： JAG1 cases Notch

Complexed amino acid minerals vs. bis-glycinate chelated minerals:Impact on the performance of old laying hens

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Animal Nutrition 2024年第1期16卷 395-408页

作者： Marcos J.B.santos Maria C.M.M.Ludke Leandro M.silva Carlos B.V.rabello Mércia R.Barros Fabiano s.Costa Clariana s.santos Jamille s.s.Wanderley Department of Animal science Rural Federal University of Pernambuco Department of Veterinary science Rural Federal University of Pernambuco

The present study was to evaluate the effect of trace minerals(Zn, Mn, and Cu) from complexed amino acid minerals(ZMCAA) and bis-glycinate chelated minerals(ZMCGly) in laying hen diets on performance,internal and external egg quality, yolk mineral deposition, intestinal morphometry, and bone characteristics. From 78 to 98 weeks of age, 400 White LsL-Lite strain laying hens were distributed in a randomized design with 4 treatments with 10 replicates per treatment. Treatments were distributed in a 2 ×2 factorial arrangement using either Zn, Mn, and Cu of ZMCAA or ZMCGly source at 2 levels: low(20, 20,and 3.5 mg/kg of Zn, Mn, and Cu, respectively) or high(40, 40, and 7 mg/kg of Zn, Mn, and Cu,respectively). The analysis of variance was performed, and in cases where differences were observed, the means were compared using Tukey?s test(P source and level of trace mineral supplementation had a significant impact on the performance of laying hens. Hens fed ZMCAA had higher egg production(P = 0.01), egg weight(P = 0.02), egg mass(P = 0.01), and lower feed conversion ratio(P =0.05) compared to those fed ZMCGly. The ZMCAA supplementation showed higher albumen height(P =0.01), albumen weight(P = 0.01), and eggshell thickness(P sition of Zn(P s greater for hens received ZMCAA. Tibia weight(P = 0.04)and bone densitometry(P supplementation. In the small intestine, ZMCAA resulted in longer villi(P = 0.02) and shorter crypt depth(P = 0.01) in the *** and ileum measurements were influenced by the level and source of trace minerals(P s fed ZMCAA exhibited superior performance, egg quality, deposition of trace minerals in the egg yolk, and bone density compared to hens fed ZMCGly. In this study, older laying hens supplemented with ZMCAA at lower levels demonstrated adequate levels of supplementation.

关键词： Bis-glycinates Metal-amino acids radiodensity Trace minerals

Data-Driven Learning Control Algorithms for Unachievable Tracking Problems

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IEEE/CAA Journal of Automatica sinica 2024年第1期11卷 205-218页

作者： Zeyi Zhang Hao Jiang Dong shen samer s.saab the school of Mathematics Renmin University of ChinaBeijing 100872China IEEE the school of Engineering Lebanese American UniversityByblos 2038Lebanon

For unachievable tracking problems, where the system output cannot precisely track a given reference, achieving the best possible approximation for the reference trajectory becomes the objective. This study aims to investigate solutions using the Ptype learning control scheme. Initially, we demonstrate the necessity of gradient information for achieving the best ***, we propose an input-output-driven learning gain design to handle the imprecise gradients of a class of uncertain systems. However, it is discovered that the desired performance may not be attainable when faced with incomplete *** address this issue, an extended iterative learning control scheme is introduced. In this scheme, the tracking errors are modified through output data sampling, which incorporates lowmemory footprints and offers flexibility in learning gain *** input sequence is shown to converge towards the desired input, resulting in an output that is closest to the given reference in the least square sense. Numerical simulations are provided to validate the theoretical findings.

关键词： Data-driven algorithms incomplete information iterative learning control gradient information unachievable problems

Evaluation of the seismic behavior of reinforced concrete structures with flat slab-column gravity frame and shear walls through nonlinear analysis methods

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 713-726页

作者： M.A.Najafgholipour s.Heidarian radbakhsh E.Erfani Department of Civil and Environmental Engineering Shiraz University of TechnologyShiraz ***Iran Department of Building Civiland Environmental EngineeringConcordia UniversityMontréal H3G 1M8Canada

This paper presents an investigation of the seismic behavior of reinforced concrete(RC)structures in which shear walls are the main lateral load-resisting elements and the participation of flat slab floor systems is not considered in the seismic design *** this regard,the behavior of six prototype structures(with different heights and plan layouts)is investigated through nonlinear static and time history analyses,implemented in the Opensees *** results of the analyses are presented in terms of the behavior of the slab-column connections and their mode of failure at different loading ***,the global response of the buildings is discussed in terms of some parameters,such as lateral overstrength due to the gravity flat slab-column *** to the nonlinear static analyses,in structures in which the slab-column connections were designed only for gravity loads,the slab-column connections exhibited a punching mode of failure even in the early stages of ***,the punching failure was eliminated in structures in which a minimum transverse reinforcement recommended in ACI 318(2019)was provided in the slabs at joint ***,despite neglecting the contribution of gravity flat slab-column frames in the lateral load resistance of the structures,a relatively significant overstrength was imposed on the structures by the gravity frames.

关键词： RC flat slab-column frames seismic behavior nonlinear analysis time history analysis

Emission colour tuning in KLnF_(4):Yb^(3+),Er^(3+)/Ho^(3+)phosphor

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Journal of rare Earths 2024年第1期42卷 57-65,I0002页

作者： Janani K Gayathri E Vijayatha V ramasubramanian s Thiyagarajan P Department of science and Humanities Nehru Institute of TechnologyKaliapuramThirumalayampalayamCoimbatoreIndia Department of sciences Amrita School of Physical SciencesAmrita Vishwa VidyapeethamCoimbatoreIndia Department of Physics Anna UniversityChennaiIndia

KLnF_(4):Yb^(3+),Er^(3+)/Ho^(3+)(Ln=Y,Yb,Gd)phosphors were prepared by solid-state reaction *** each of the Yb^(3+)/Er^(3+)and Yb^(3+)/Ho^(3+)co-doped phosphors independently,phase confirmation and morphological examination were accomplished using the X-ray diffraction technique and scanning electron microscope analysis.X-ray photoelectron spectroscopy analysis shows the charge state and existence of lanthanides and *** luminescence emissions of green and red colour were detected for the synthesized *** changes in the upconverted emission intensities and colour output pertaining to the change of the lanthanide host matrix along with dopants were investigated for the prepared *** the upconversion luminescence,erbium-doped samples exhibit a predominance of red emission while holmium-doped samples display a prevalence of green *** rare-earth Er/Ho doped KYbF4shows strong red emission compared to other ***_(4):Yb,Er/Ho exhibits relatively significant green upconve rsion emissions,while Yb,Er-doped KGdF_(4)host displays a 10-fold increase in green/red emission ratio with an increase in the input power of 20-780 *** photoluminescence studies and decay curve analysis were carried out using UV light excitation for the developed phosphors.A higher lifetime of 2.2 ms was measured for the downshifting red emission in the Ho doped KYbF_(4)*** study suggests a potential for colour tunability in the upconversion and downshifting emissions through host modifications to the fluoride phosphor.

关键词： rare earths Energy transfer upconversion Downshifting Colour coordinates