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High Cholesterol Disorders, Myocardial Infarction and Its Therapeutics

World Journal of Cardiovascular Diseases 2023年第8期13卷 433-469页

作者： Ravi kant Upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

The current review article discusses several conditions linked to high cholesterol, including their causes, diagnoses, and treatments. Cardiovascular disease is one of the leading causes of death worldwide, and hypercholesterolemia is a standalone risk factor for the condition. Numerous cardiovascular illnesses (CVDs) and disorders, including myocardial infarction, hypertension, peripheral vascular diseases, and coronary heart diseases, were highlighted in this article. Low density lipoprotein (LDL) is the key factor in the majority of CVDs. It adheres to fatty deposits and forms plaques inside artery lumen, preventing the heart and other body organs from receiving enough blood and oxygen. Cardiomyopathies and dyslipidemias are the most common causes of morbidity and mortality in men and place a considerable health cost on society. Age, hypertension, obesity-induced blood pressure, and a rise in plasma cholesterol are all factors that raise the risk of coronary heart disease (CHD). Calorie intake must be controlled, meal composition must be changed, a natural cycle must be established, and circadian timeliness must be maintained in order to live a healthy life. To lower the risks of metabolic and cardiovascular diseases, try to go vegetarian and always consume traditional plant-based diets and herbal remedies. Exercise yoga and aerobics every day to stay physically healthy, and have your blood pressure, blood sugar, and cholesterol levels checked on a regular basis. Follow your family doctor’s recommendations for managing high cholesterol risks and diagnosing CVD, obtain a lipid profile, take the recommended medications, maintain composure, and adopt a positive outlook for a long and healthy life.

关键词： Hypercholestemia Coronary Heart Diseases (CHD) Cardiovascular Diseases. Hypercholestemia Cardiomyopathy Cardiac Infarction Risks Diagnosis Lipoproteins Lipid Profile Polyunsaturated Fatty Acids Antioxidants

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Cosmological parameters for spatially flat dust filled Universe in Brans-Dicke theory

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Research in Astronomy and Astrophysics 2017年第3期17卷 55-66页

作者： Gopi kant Goswami Department of Mathematics Kalyan E G.CollegeBhilai-490 006C.G.India

We have investigated late time acceleration for a spatially fiat dust filled Universe in Brans- Dicke theory in the presence of a positive cosmological constant A. Expressions for Hubble＇s constant, luminosity distance and apparent magnitude have been obtained for our model. The theoretical results are compared with observed values of the latest 287 high redshift （0.3 ≤ z ≤1.4） Type Ia supernova data taken from the Union 2.1 compilation to estimate present values of matter and dark energy parame- ters, （Ωm）0 and （ΩA）0. We have also estimated the present value of Hubble＇s constant H0 in light of an updated sample of Hubble parameter measurements including 19 independent data points. The results are found to be in good agreement with recent astrophysical observations. We also calculated various physical parameters such as matter and dark energy densities, present age of the Universe and decelera- tion parameter. The value for Brans-Dicke-coupling constant ω is set to be 40 000 based on accuracy of solar system tests and recent experimental evidence.

关键词： cosmology osmological parameters - cosmology observations- dark energy-Brans-Dicke theory

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Bird assemblages in natural and urbanized habitats along elevational gradient in Nainital district （western Himalaya） of Uttarakhand state, India

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Current Zoology 2011年第3期57卷 318-329页

作者： Dinesh BHATT Kamal kant JOsHI Avian Diversity and Bioacoustics Lab Department of Zoology and Environmental Science Gurukula Kangri University Harid- war 249 404 Uttarakhand India

The Indian subcontinent is amongst the biologically better known parts of the tropics and its bird fauna has been well documented. However, avian community composition and diversity along elevational gradients and amongst habitat types remains unclear in India. We attempted to estimate bird assemblages in terms of diversity, species composition, status and abundance in urban and forest habitats of Nainital district of Uttarakhand (350–2450 m asl; 29°N), Western Himalayas. We sampled different elevational gradients and to understand the effect of urbanization and season on avian community composition. Field studies were conducted during January 2005 to January 2007. Results indicated that the forest had more complex bird community structure in terms of higher species richness (14.35 vs 8.69), higher species diversity (shannon’s index 4.00 vs 3.54), higher evenness (0.838 vs 0.811) and more rare species (17 vs 5) as compared to urban habitat. However, the abundance of 11 species was higher in urban habitats. Bird species Richness (BsR) varied considerably among study areas (91 to 113 species), was highest (113 species) at mid elevation (1450–1700 m asl) and decreased (22 species) at high elevation (1900–2450 m asl). It seems that high BsR at mid altitudes is not caused by the presence of a group of mid altitude specialists but rather that there is an overlap in the distribution of low land and high elevation specialists at this altitude. BsR and Bird species Diversity fluctuated across seasons but not habitat type.

关键词：喜马拉雅山脉印度次大陆海拔梯度鸟类动物栖息地城市化自然灾害物种多样性

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Field evidences showing rapid frontal degeneration of the Kangriz glacier,western Himalayas,Jammu&Kashmir

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Journal of Mountain science 2018年第6期15卷 1199-1208页

作者： garg siddhi shukla aparna mehta manish kumar vinit samuel shruti anna bartarya s.k. shukla uma kant wadia institute of himalayan geology 33GMS RoadDehradun 248001India department of geology banaras hindu universityVaranasi 221005India

Life cycle of glaciers in the Himalayan region has notably changed due to the climatic variability since last few decades. Glaciers across the world and specially the Himalayan glaciers have shown large scale degeneration in the last few decades. Himalayan glaciers serve as an important fresh water resource for the downstream communities, who are dependent on this water for domestic and other purposes. Therefore, glacier shrinkage and the associated hydrological changes pose a significant problem for regional-scale water budgets and resource management. These issues necessitate the regular and rigorous monitoring of the wastage pattern of the Himalayan glaciers in field and using satellite remote sensing data. In this work, we report rapid and enhanced degeneration of the frontal part of the Kangriz glacier, Jammu and Kashmir(J & K), in terms of surface melting, debris cover, snout characteristics and meltwater discharge. Ablation data acquired during 2016-2017 shows the average lowering of the frontal part of the glacier to be ~148 ± 34 cm, one-third of which was found to have occurred within a 13 day time period in september, 2017. Also, the quantum of ice melt was found to be inversely influenced(r =-0.84) by the debris thickness. 15 day meltwater discharge measurement revealed its strong relationship with snout disintegration pattern, evidenced twice during the said time period. Volume of water discharged from the glacier was estimated to be 7.91×10~6 m^3 for the measurement duration. Also, mean daily discharge estimated for the 15 days interval showed good positive correction(r = 0.78) with temperature indicating the direct dependency of the former on land surface temperature conditions of the region. Besides the lowering and discharge observations, the frequent ice-block break-offs at the glacier snout further enhance its overall drastic degeneration. The study suggests that, being the largest glacier in the suru basin, the Kangriz glacier needs to be continuo

关键词：数据显示克什米尔喜马拉雅山脉冰河退化西方证据卫星遥感数据

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synthesis and evaluation of novel analogues of mangiferin as potent antipyretic

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Asian Pacific Journal of Tropical Medicine 2011年第11期4卷 866-869页

作者： shashi kant singh saurabh K s.nha sK Prasad R Kumar Bhawani s Bithu s sadish Kumar P singh Varanasi College of Pharmacy Uttar PradeshVaranasiIndia Department of Pharmaceutics Institute of TechnologyBanaras Hindu UniversityVaranasiUttar PradeshIndia Institute of Technology and sciences Paramedical College(Pharmacy)MuradnagarUttar PradeshIndia Uday Pratap College VaranasiUttar PradeshIndia

Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera *** was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin *** synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/*** and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral ***:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 ***:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines.

关键词： Mangifera indica Mangiferin Antipyretic

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Hexadecanoic acid-enriched extract of Halymenia durvillei induces apoptotic and autophagic death of human triple-negative breast cancer cells by upregulating ER stress

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Asian Pacific Journal of Tropical Biomedicine 2022年第3期12卷 132-140页

作者： kant sangpairoj Rapeewan settacomkul Tanapan siangcham Krai Meemon Nakorn Niamnont Nilubon sornkaew Montakan Tamtin Prasert sobhon Pornpun Vivithanaporn Division of Anatomy Department of Preclinical ScienceFaculty of MedicineThammasat UniversityPathum ThaniThailand Thammasat University Research Unit in Neutraceuticals and Food safety Pathum ThaniThailand Chakri Naruebodindra Medical Institute Faculty of Medicine Ramathibodi HospitalMahidol UniversitySamut PrakanThailand Faculty of Allied Health sciences Burapha UniversityChonburiThailand Department of Anatomy Faculty of ScienceMahidol UniversityBangkokThailand Department of Chemistry Faculty of ScienceKing Mongkut's University of Technology ThonburiBang ModBangkokThailand Department of Fisheries Phetcha Buri Coastal Aquaculture Research and Development CenterPhetcha BuriThailand

Objective:To investigate the effect of the hexane solvent fraction of Halymenia durvillei(HDHE)on triple-negative breast ***:The phytochemical profile of HDHE was investigated by *** cytotoxicity of HDHE against MDA-MB-231 cells was *** apoptotic and autophagic effects of HDHE were *** expression of molecular markers controlling apoptosis,autophagy,DNA damage,and endoplasmic reticulum(ER)stress was ***:HDHE contains a mixture of fatty acids,mainly hexadecanoic *** at a cytotoxic concentration induced apoptotic death of MDA-MB-231 cells through mitochondrial membrane dysfunction,and induction of apoptosis markers,and increased the expression of proteins related to DNA damage *** also induced the expression of LC-3,a marker of autophagic cell death at a cytotoxic ***,HDHE modulated the expression of ER stress ***:The hexadecanoic acid-enriched extract of Halymenia durvillei promotes apoptosis and autophagy of human triple-negative breast cancer *** extract may be further explored as an anticancer agent for triple-negative breast cancer.

关键词： Halymenia durvillei Triple-negative breast cancer Apoptosis Autophagy Endoplasmic reticulum stress Red algae Hexadecanoic acid

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Prevalence and predictors of smartphone addiction and insomnia among nurses working in the outpatient department after the second wave of the coronavirus disease 2019 pandemic

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Journal of Integrative Nursing 2023年第4期5卷 273-279页

作者： Manisha MEHRA Poonam JOsHI surya kant TIWARI Praveen AGGRAWAL Kamlesh CHANDELIA srinithya RAGHAVAN Department of Nursing services All India Institute of Medical SciencesNew DelhiIndia College of Nursing All India Institute of Medical SciencesKalyaniWest BengalIndia College of Nursing All India Institute of Medical SciencesRaebareliUttar PradeshIndia Department of Emergency Medicine All India Institute of Medical SciencesNew DelhiIndia Department of In-service Education All India Institute of Medical SciencesNew DelhiIndia

Objectives:The present study aims to assess the prevalence and predictors of smartphone addiction and insomnia among nurses working in the outpatient department(OPD)after the second wave of the coronavirus disease 2019(COVID-19)*** and Methods:A descriptive,cross-sectional study was carried out among 117 OPD nurses between October and December 2021 using a purposive sampling *** self-reported standardized scales,the smartphone Addiction scale-shortVersion and Insomnia severity Index were ***–smirnov test,Mann–Whitney U,and Kruskal–Wallis Htest were ***’s correlation and scatter plot were used to determine the relationship between the study variables.A stepwise multiple linear regression analysis was also ***:The majority of participants had slight smartphone addiction(78.6%)and suffered from sub-threshold to severe forms of insomnia(73.5%).A significant mild positive correlation was found between smartphone addiction and insomnia(r=0.195,Pstepwise multivariate logistic regression analysis predicted factors such as female gender and exposure to smartphones for more than 5 years influencing smartphone addiction.A strong influence of exposure to the smartphone for more than 5 years was found on insomnia ***:smartphone addiction and insomnia were identified problems among nurses working in the OPD after the second wave of the COVID-19 pandemic,requiring an urgent need to identify and manage various factors responsible for smartphone addiction and insomnia such as female gender and years of exposure to smartphones.

关键词： Coronavirus disease 2019 insomnia nurses sleeping disturbances smartphone addiction

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Toxicity of Tagetes erecta Essential Oil Based Combinatorial Formulations on Various Metabolic Enzymes in Indian White Termite Odontotermes obesus

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Advances in Enzyme Research 2023年第2期11卷 58-81页

作者： susheel Kumar Ravi kant Upadhyay Department of Zoology (Environmental science) Deen Dayal Upadhyaya Gorakhpur University Uttar Pradesh India

Plant essential oils and their constituents have proven to be very effective against insects, especially termites. They are the best alternative to synthetic pesticides that are harmless to the environment and human health. In the present study, different enzymes, namely alkaline phosphatase, acid phosphatase, glutamate-oxaloacetate transaminase, glutamate-pyruvate transaminase and acetylcholinesterase, were evaluated in Indian termite Odontotermes obesus in a combination preparation based on Tagetes erecta essential oil. For the study of anti-termite effects against worker termites were treated topically with 40% and 80% of the 24-hour LD50 values of various combination formulations. subsequent bioassays at 40% and 80% of LD50 of combinatorial preparations s-AsT-A, s-AsT-B, and s-AsT-C resulted in a significant (p > 0.05) decrease in glutamate-oxaloacetate transaminase. After 16 hours of treatment, they were 87.92%, 80.17%, 89.30%, 79.17%, 81.92% and 73.17% respectively. In vivo exposures of 40% and 80% of the LD50 of the combination formulation caused a highly significant (p > 0.05) reduction (p > 0.05) of all test enzymes tested compared to controls. The effects of different oil formulations exhibited time- and dose-dependent responses, resulting in physiological changes in the concentrations of various enzymes. The combined mixture of Tagetes erecta essential oils has significantly better anti-termite ability compared to inorganic insecticides. Findings from this study will help support termite control in fields, gardens and homes in a sustainable way, without the downsides of insecticide resistance and pollution. These could potentially be used to produce commercial formulations for use against pests.

关键词： Tagetes erecta Essential Oils Odontotermes obesus Enzymes Inhibition Termiticidal Action

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Toxic Effects of Citrus maxima Based Combinatorial Formulations on Important Metabolic Enzymes in Indian White Termite Odontotermes obesus

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Advances in Enzyme Research 2023年第2期11卷 11-33页

作者： Lokpriy Pandey Ravi kant Upadhyay Department of Zoology (Environmental science) Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In the present study, Citrus maxima essential crude oil extract was used to prepare combinatorial formulations and workers of Indian white termite Odontotermes obesus were treated topically with 40% and 80% of 24 hr LD50 values of these formulations. In subsequent bioassays levels of various enzymes i.e. alkaline phosphatase, acid phosphatase, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and acetylcholinesterase were evaluated to determine the anti-termite efficacy of Citrus maxima essential oil based combinatorial formulations. s-RET-A, s-RET-B and s-RET-C caused significant (p > 0.05) decrease in glutamate oxaloacetate transaminase i.e. 87.47%, 86.81% and 81.77% & 82.04%, 79.39% and 74.75% respectively at 16 h treatment. In vivo exposure of 40% and 80% of LDsub>50sub> of combinatorial formulations caused very significant (p > 0.05) reduction in all the test enzymes i.e. alkaline phosphatase, acid phosphatase, glutamate oxaloacetate transaminase and glutamate pyruvate transaminase expect acetylcholinesterase levels after 16 h all tested treatments in comparison to control. Both dose-response and time period were found important in physiological alteration in levels of various enzymes. Combinatorial mixtures of Citrus essential oils have shown synergistic activity against termites. The research findings of the present study would help termite control in crop fields, gardens and houses in a sustainable way.

关键词： Citrus maxima Essential Oils Odontotermes obesus Enzymes Inhibition Termiticidal Action

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Effect of Ficus benghalensis Latex Based Combinatorial Formulations on Various Bio-Molecules in Indian White Termite Odontotermes obesus

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Journal of Biosciences and Medicines 2023年第4期11卷 82-102页

作者： Abhishek Kumar Tripathi Ravi kant Upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In present investigation, various bioassays were conducted to evaluate the alteration in levels of certain biomolecules, such as glycogen, protein, amino acid, DNA, RNA and lipids. For this purpose, worker termites were treated with sub-lethal dose 40% and 80% of 24 hrs LDsub>50sub> values and observations were taken at 4 hrs interval up to 24 hrs. Crude latex and its combinatorial mixtures, like s-MLT-A, B-MLT-A, C-MLT-A, CU-MLT-A, AQ-MLT significantly altered level of bio-molecules in Odontotermes obesus. This effect was found time and dose dependent. Reduction or increase in biomolecules was calculated by using corresponding control. Maximum decrease in glycogen level was observed at 16 h when termites were treated with 80% of LDsub>50sub> of Ficus benghalensis aqueous extract i.e. 56.88% at 16 h of treatment. A similar dose caused very slight decrease in lipid contents at 4 h of treatment but it was found further significantly (p > 0.05) decreased in other successive treatments. 40% and 80% of LDsub>50sub> of C-MLT-B mixture caused significant (p > 0.05) decrease in DNA and RNA level at 16 h treatment. The level of DNA and RNA level was recorded 83.90%, 90.18% and 85.42% and 74.05% respectively. similarly, total proteins were also found to be decreased with 40% and 80% of LDsub>50sub> of C-MLT-B mixture i.e. 71.47% and 66.45% respectively. All these alterations found in levels of various bio-molecules confirm the action of latex ingredients on worker termites that was antifeedant or deterrent types. These ingredients can be used to control not only termites but also other phytophagous insects in a sustainable and eco-friendly way.

关键词： Ficus benghalensis Odontotermes obesus Latexes Antifeedant or Deterrent Termiticides

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