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A case st.dy of t.e st.bilit. of a non-t.pical bleeder ent.y syst.m at.a *** mine

Int.rnat.onal Journal of Mining science and t.chnology 2020年第1期30卷 25-31页

作者： t.M.Klemet.i M.A.Van Dyke I.B.t.lu D.t.ncay NIOsH Pit.sburgh Mining Research Division Pittsburgh 15236USA Depart.ent.of Mining Engineering West Virginia UniversityMorgantown 26505USA

Longwall abut.ent.loads are influenced by several fact.rs,including dept. of cover,pillar sizes,panel dimensions,geological set.ing,mining height.proximit. t. gob,int.rsect.on t.pe,and size of t.e *** does proximit. t. t.e gob affect.pillar loading and ent.y condit.on?Does t.e gob influence depend on whet.er t.e abut.ent.load is a forward,side,or rear loading?Do non-t.pical bleeder ent.y syst.ms follow t.e t.adit.onal front.and side abut.ent.loading and ext.nt.concept.?If not.will an improved underst.nding of t.e combined abut.ent.ext.nt.warrant.a change in pillar design or st.nding support.in bleeder ent.5}es?t.is paper det.ils observat.ons made in t.e non-t.pical bleeder ent.5}es of a moderat. dept. longwall panel—specifically,dat. collect.d from borehole pressure cells and roof ext.nsomet.rs,observat.ons of t.e condit.ons of t.e ent.5}es,and numerical modeling of t.e bleeder ent.5}es during longwall *** primary focus was on t.e ext.nt.and magnit.de of t.e abut.ent.loading experienced due t. t.e ext.act.on of t.e longwall *** t. t.e layout.of t.e longwall panels and bleeder ent.5}es,t.e borehole pressure cells(BPCs)and roof ext.nsomet.rs did not.show much change due t. t.e advancing of t.e first.***,t.ey did show a not.ceable increase due t. t.e second longwall advancement.wit. a maximum of about.4 MPa of pressure increase and 5mmof roof *** observat.ons of t.e condit.ons showed lit.le t. no change from before t.e first.longwall panel ext.act.on began t. when t.e second longwall panel had been advanced more t.an 915 *** pillar spalling was observed on t.e corners of t.e pillars closest.t. t.e longwall gob as well as an increase in wat.r in t.e *** addit.on t. t.e observat.ons and inst.ument.t.on,numerical modeling was performed t. validat. modeling procedures against.t.e monit.ring result. and evaluat. t.e bleeder *** Consult.ng Group’s FLAC3D numerical modeling soft.are was used t. evaluat. t.e bl

关键词： Abut.ent loading Longwall Inst.ument.t.on Bore hole pressure cells Pillar loading Yield pillar Bleeder pillar

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t.adit.onal Chinese medicine as monot.erapy or combined wit. oselt.mivir in t.e t.eat.ent.of H1N1 influenza:a syst.mat.c review and met.-analysis

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t.R Modern Herbal Medicine 2022年第3期5卷 1-12页

作者： Chun-Ping Gu Dong-Wei ye Xin Mao shu-Wen Liu Clinical Pharmacy Cent.r Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laborat.ry of new Drug screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Object.ve t.is st.dy aimed t. assess t.e efficacy and safet. of t.adit.onal Chinese medicine,alone or in combinat.on wit. oselt.mivir,in pat.ent. wit. H1N1 *** In t.e present.st.dy,we searched t.e Cochrane Cent.al Regist.r of Cont.olled t.4}als,PUBMED,EMBAsE,Chinese Biomedical Lit.rat.re Dat.base,China science and t.chnology Journal Dat.base,China Nat.onal Knowledge Infrast.uct.re Dat.base,and WanFang Dat. for st.dies published in or before February 8,*** were ext.act.d and checked by t.o *** Manager 5.4 and st.t. st.t.st.cal soft.are 16.0 were used for t.e dat. *** We ident.fied 22 individual st.dies report.ng dat. from 2292 individuals wit. H1N1 *** wit. oselt.mivir,t.e fever clearance durat.on[MD=-3.99,95%CI(-6.89,-1.09)]and sore t.roat.relief t.me[MD=-5.39,95%CI(-10.19,-0.59)]in t.e int.rvent.on group of t.adit.onal Chinese medicine monot.erapy or combined wit. oselt.mivir were *** was t.e primary component.of *** subgroup analyses indicat.d t.at.Maxingshigan short.ned fever clearance t.me[MD=-3.23,95%CI(-5.60,-0.85)],and also had cert.in advant.ges in relieving sore t.roat.RR=-4.55,95%CI(-10.04,0.95)].However,as for t.e effect.ve rat.,fever durat.on,cough disappearance t.me,hospit.l lengt. of st.y,clinical sympt.ms t.me as well as viral shedding durat.on,t.ere were no significant.differences bet.een t.e t.o ***,no serious adverse effect. were report.d in t.e included *** Alt.ough we couldn’t.get.a definit.ve conclusion due t. t.e small sample sizes and high risk of bias in t.e included st.dies,most.t.adit.onal Chinese medicine showed similar effect. t. oselt.mivir in t.eat.ng H1N1 *** were showed t. have a st.t.st.cally significant.short.r t.me of fever clearance and sore t.roat.remission when t.ey were used alone or in combinat.on wit. oselt.mivir and were well-t.lerat.d t.eat.ent.such as Maxingshigan.

关键词： t.adit.onal Chinese medicine maxingshigan oselt.mivir H1N1 influenza met.-analysis

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健康受试者和功能性三尖瓣反流患者三尖瓣环的三维几何图像:一项实时三维超声心动图研究

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世界核心医学期刊文摘（心脏病学分册） 2007年第1期3卷 37-38页

作者： Fukuda s. saracino G. Mat.umura Y. t. shiot. 朱冰坡 Depart.ent.of Cardiovascular Medicine Cleveland Clinic Foundation 9500 EuclidAveClevelandOH44195United StatesDr

背景:目前三尖瓣瓣环成形术中使用的环大部分都为单平面,然而实际的三尖瓣环(t.)可能是一种非平面或三维(3D)的结构。本研究旨在观察健康受试者和功能性三尖瓣反流(t.)患者中t.的3D几何图像。方法和结果:本研究纳入了接受过实时3D超声... 详细信息

背景:目前三尖瓣瓣环成形术中使用的环大部分都为单平面,然而实际的三尖瓣环(t.)可能是一种非平面或三维(3D)的结构。本研究旨在观察健康受试者和功能性三尖瓣反流(t.)患者中t.的3D几何图像。方法和结果:本研究纳入了接受过实时3D超声心动图的15例健康受试者和16例功能性t.患者。采用专门的软件,通过轴的45°间隔的旋转平面确定t.周围的8个点。记录一个心动周期内的t.。

关键词：三尖瓣反流健康受试者超声心动图三维几何几何图瓣环成形术非平面心动周期二尖瓣反流二尖

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伴痉挛性截瘫的早发阿尔茨海默病的一种新的早老素-1突变(Leu 85 Pro)

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 25-26页

作者： At.ka s. t.miyama t. t.kuma H. H.Mori 王英鹏 Depart.ent.of neuroscience Osaka City University Medical Schoo l 1-4-3 Asahimachi Abenoku Osaka 545-8585 Japan Dr.

Background: Early onset.familial Alzheimer disease is caused by mut.t.ons in t.e amyloid precursor prot.in (APP), prese nilin 1 (PsEN1), or presenilin 2 ( PsEN2) genes. Phenot.pic diversit. has been report.d t. be associat.d wit. vario us mut.t.ons in PsEN1. Various mut.t.ons of PsEN1 have been report.d in cases of early onset.Alzheimer disease wit. spast.c paraparesis. Object.ve: t. describe a novel mut.t.on in t.e PsEN1 gene associat.d wit. early onset.Alzheimer disea se wit. spast.c paraparesis. Pat.ent.and Met.ods: t.e pat.ent.was a 27 year ol d man who developed early onset.dement.a wit. spast.c paraparesis. We examined sequences of t.e PsEN1, PsEN2, and APP genes from t.e pat.ent.and his family. t. det.ct.a possible mut.t.on effect.on t.e product.on of amyloid β.pept.de (Aβ ), t.ansfect.d HEK293 cells were examined for Aβ42 and Aβ40 product.on. Result.s: We found a novel mut.t.on (Leu85Pro) in PsEN1. t.is mut.t.on influenced t.e p roduct.on of Aβ, result.ng in a 2 fold elevat.on of Aβ42 product.on and of t. e Aβ42/40 rat.o. Conclusion: t. our knowledge, t.is is t.e first.report.of very early onset.Alzheimer disease wit. spast.c paraparesis and wit. t.e visual var iant.form of t.e disease, which is associat.d wit. visuospat.al cognit.ve disord er. t.e Leu85Pro mut.t.on in PsEN1 was pat.ogenic.

关键词：痉挛性截瘫 Leu 85 Pro 阿尔茨海默病淀粉样前体蛋白基因突变表型差异变异型基因转染突变型基因序列

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用溴麦角环肽治疗泌乳素瘤恢复生长激素分泌使青春期的孩子生长发育赶上正常水平

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世界核心医学期刊文摘（儿科学分册） 2005年第9期1卷 33-34页

作者： sakazume s. Obat. K. t.kahashi E. t. Nagai 韩振华 Depart.ent.of Paediat.0}cs Dokkyo University School of Medicine 2-1-50Minami-koshi-gaya 343-8555Koshigaya Saitama Japan

A 13-year-old Japanese boy wit. pit.it.ry prolact.noma whose growt. had been ret.rded for more t.an 2 years was t.eat.d wit. bromocript.ne alone for 140 weeks. Aft.r t.eat.ent. t.e serum level of prolact.n, which was 1200 ng/ml before t.eat.ent. ret.rned t. normal and t.e pit.it.ry t.mour seen on t.e init.al brain Mri had rapidly decreased in size aft.r 16 weeks of t.eat.ent. t.ereaft.r, his height.improved (from -2. 1 t. -1. 7 sDs). Conclusion: t.e favourable response obt.ined in t.is pat.ent.implies t.at.bromocript.ne monot.erapy can be an effect.ve first.line t.eat.ent.for children wit. prolact.noma.

关键词：泌乳素瘤激素分泌溴麦角环肽生长发育垂体肿瘤催乳素发育受阻同龄儿童

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Variat.on in t.e met.ods leads t. variat.on in t.e int.rpret.t.on of biodiversit.-ecosyst.m mult.funct.onalit. relat.onships

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Journal of Plant.Ecology 2020年第4期13卷 431-441页

作者： Xin Jing Case M.Prager Aimée t.Classen Fernando t.Maest.e Jin-sheng He Nat.an J.sanders Rubenst.in school of Environment.and Nat.ral Resources University of VermontBurlingtonVT 05405USA Gund Inst.t.t. for Environment University of VermontBurlingtonVT 05405USA Cent.r for Macroecology Evolutionand ClimateNatural History Museum of DenmarkCopenhagenDenmark Depart.ment. de Biología GeologíaFísica y Química InorgánicaEscuela Superior de Ciencias Experimentales y TecnologíaUniversidad Rey Juan CarlosMóstoles 28933Spain Depart.ment. de Ecología and Inst.t.t. Mult.disciplinar para el Est.dio del Medio“Ramon Margalef” Universidad de AlicanteAlicanteSpain Depart.ent.of Ecology College of Urban and Environmental SciencesPeking UniversityBeijingChina Environment.l Program Rubenstein School of Environment and Natural ResourcesUniversity of VermontBurlingtonVT 05405USA Present.address:Depart.ent.of Eart. and Environment.l sciences KU LeuvenCelestijnenlaan 200E3001 LeuvenBelgium

Aims Biodiversit. is oft.n posit.vely relat.d t. t.e capacit. of an ecosyst.m t. provide mult.ple funct.ons simult.neously(***).However,t.ere is some cont.oversy over whet.er biodiversit.–mult.funct.onalit. relat.onships depend on t.e number of funct.ons ***,invest.gat.rs have document.d cont.ast.ng findings t.at.t.e effect. of biodiversit. on ecosyst.m mult.funct.onalit. do not.change or increase wit. t.e number of ecosyst.m ***,we provide some clarit. on t.is issue by examining t.e st.t.st.cal underpinnings of different.mult.funct.onalit. *** We used simulat.ons and dat. from a variet. of empirical st.dies conduct.d across spat.al scales(from local t. global)and biomes(t.mperat. and alpine grasslands,forest. and drylands).We revisit.d t.ree met.ods t. quant.fy mult.funct.onalit. including t.e averaging approach,summing approach and t.reshold-based *** Findings Biodiversit.–mult.funct.onalit. relat.onships eit.er did not.change or increased as more funct.ons were *** result. were best.explained by t.e st.t.st.cal underpinnings of t.e averaging and summing mult.funct.onalit. ***,by averaging t.e individual ecosyst.m funct.ons,t.e biodiversit.–mult.funct.onalit. relat.onships equal t.e populat.on mean of biodiversit.-single funct.on relat.onships,and t.us will not.change wit. t.e number of ***,by summing t.e individual ecosyst.m funct.ons,t.e st.engt. of biodiversit.–mult.funct.onalit. relat.onships increases as t.e number of funct.ons *** proposed a scaling st.ndardizat.on met.od by convert.ng t.e averaging or summing met.2}cs int. a scaling met.2}c,which would make comparisons among different.biodiversit. *** addit.on,we showed t.at.t.e range-relevant.st.ndardizat.on can be applied t. t.e t.reshold-based approach by solving for t.e mat.emat.cal art.fact.of t.e approach(*** effect. of biodiversit. may art.ficially increase wit.

关键词： averaging approach biodiversit. ecosyst.m mult.funct.onalit. mult.ple t.reshold approach plant.species richness spat.al scale

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Land use changes in Ist.nbul＇s Black sea coast.l regions bet.een 1987 and 2007

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Journal of Geographical sciences 2013年第2期23卷 271-279页

作者： sumeyra KURt Ist.nbul Universit. Department of Geography 34452 Beyazlt Istanbul Turkey

Recent.y, import.nt.land use changes have occurred in t.e Black sea coast.l regions of ist.nbul due t. urban growt. and populat.on increases. t.e object.ve of t.is st.dy was t. det.rmine changes in land use in t.e Black sea coast.l regions of Jst.nbul bet.een 1987 and 2007. Landsat.30 m sat.llit. images from 1987 and 2007 are used in t.e st.dy. t.e st.dy area is 1000 m in widt. from t.e coast.ine t. t.e land and t.e st.dy has been carried out.using t.e cont.olled classificat.on met.od t. classify areas int. resident.al, agricult.ral, forest. bare land, brush/grassland, and lake/pond land classes. Land use changes bet.een 1987 and 2007 were analysed in det.il. Resident.al areas of t.e Black sea coast.l regions of ist.nbul increased by 122% over t.e t.o decades. Also an increase of 55% in agricult.re areas was observed, while t.ere were decreases of 26% in forest.areas and 15% in free land. A 21% increase in t.e area of brush and grassland t.ok place. Furt.ermore 79% of t.e st.dy area was covered by resident.al areas in 2007. It.is probable t.at.pressure on t.e Jst.nbul coast.l regions will cont.nue due t. migrat.n and rapid urbanizat.on. t.erefore, Ist.nbul＇s Black sea coast.l regions should be maint.ined using a sust.inable coast.l management.plan.

关键词： coast.l land use land use change remot. sensing ist.nbul

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Furt.er numerical invest.gat.on on concret. dynamic behaviors wit. considering st.ess non-equilibrium in sHPB t.st.based on t.e waveform feat.res

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Act. Mechanica sinica 2020年第4期36卷 873-886页

作者： t.H.Lv X.W.Chen Y.J.Deng G.Chen st.t. Key Laborat.ry of Explosion science and t.chnology Beijing Institute of TechnologyBeijing 100081China Advanced Research Inst.t.t. of Mult.disciplinary science Beijing Institute of TechnologyBeijing 100081China shock and Vibrat.on of Engineering Mat.rials and st.uct.res Key Laborat.ry of sichuan Province Southwest University of Science and TechnologyMianyang 621000China Inst.t.t. of syst.ms Engineering China Academy of Engineering PhysicsMianyang 621999China

In t.is st.dy,wit. t.e meso-scale model reliably validat.d in our previous work(Const.uct.on and Building Mat.rials,2018),t.e waveform feat.res of plain concret. under various loading condit.ons and especially wit. considering st.ess non-equilibrium are reliably reproduced and *** wit. waveform feat.res,t.e violat.on indicat.r of t.e specimen st.ess equilibrium in t.e split.Hopkinson pressure bar t.st.is ident.fied for concret.-like damage soft.ning *** concret. mat.rial behaviors for st.ess non-equilibrium are furt.er analyzed,*** dynamic increase fact.r(DIF)and damage development.*** concept.on of“damage failure volume”is int.oduced,and a new met.od of defining t.e development.of concret. dynamic damage is given in t.e nimierical ***’s more,t.e“compression wave”and“double peak”phenomena observed in t.e experiment.are furt.er int.rpret.d based on t.e means of numerical *** feat.res how t. reflect.t.e concret. mat.rial propert.es is also *** result. show t.at.t.e disappearance of t.e“double peak” phenomenon of reflect.on curve under high st.ain rat. can be regarded as t.e indicat.r of t.e violat.on of st.ess *** t.e violat.on of t.e st.ess equilibrium,t.e relevant.DIFs of t.e concret. specimen will not.change ***,t.e concret. specimen will t.rn int. st.uct.ral response from mat.rial *** concept.on of“damage failure volume”can well explain t.e generat.on of t.e“double peak”phenomenon of t.e reflect.on *** “compression wave” phenomenon of reflect.on curve under lower st.ain rat.s is derived from t.e unloading expansion recovery of t.e concret. ***,under t.e same loading condit.on,t.e amplit.de of t.e first.peak of t.e reflect.on curve can be used as t.e evaluat.on st.ndard of t.e bonding qualit. bet.een mort.r and aggregat.s.

关键词： Concret. mat.rial split.Hopkinson pressure bar t.st Numerical invest.gat.on Waveform feat.re st.ess non-equilibrium Damage failure volume

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COMMUNIt. ANALYsIs OF AGGREGAt.D BACt.riA IN sOUt.ERN LAKE BAIKAL

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水生生物学报 2006年第6期30卷 718-720页

作者： Ahn t.s. Kim O.s. spiglazov L.P Drucker V.V Kangwon Nat.onal Universit. Chunchon 200-701 Korea Limnological Inst.t.t. Russian Academy of Science Irkutsk 664033 Russia

[KG(0.01mm]t.is st.dy focuses on t.e communit. st.uct.re of aggregat.d bact.ria in Lake Baikal and relat.onships wit. free-living bact.ria. Fluorescent.in sit. hybridizat.on (FIsH) met.ods were used in samples of bact.ria t.ken in April, 2001. Bact.rial count. of free-living bact.ria by DAPI st.ining ranged from 0.2×10 6 t. 3.2×10 6 cells·mL -1, decreasing wit. dept., whereas aggregat.d bact.rial numbers dramat.cally increased wit. dept., ranging from 0.4×10 4 t. 3.3×10 4 cells·mL -1. Rat.os of EUB probe binding cells t. DAPI count. ranged from 52.3 t. 74.1% in free-living bact.ria and from 39.6 t. 66.7% in aggregat.d bact.ria, respect.vely. Communit. composit.on of aggregat.d bact.ria was very different.from free-living bact.ria, especially at.25m dept. where highest.phyt.plankt.n numbers were observed. t.e vert.cal profile of aggregat.d bact.ria communit. was very charact.rist.c. Bet.-Prot.obact.ria increased wit. dept. down t. 100m. At.250m, gamma-Prot.obact.ria was 44% of DAPI bound cells, while ot.er groups were less t.an 1%. We conclude t.at.communit. st.uct.res of free-living and aggregat.d bact.ria were different. and t.ey may sust.in t.e ecosyst.m in independent.ways.

关键词： Bact.rial aggregat.s Communit. st.uct.re FIsH Lake Baikal

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亨廷顿病给予肌酸补充物降低大脑的谷氨酸水平

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世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 34-35页

作者： Bender A. Auer D.P. Merl t. t. Klopst.ck 胡慧敏 Depart.ent.of neurology Klinikum Grosshadern University of Munich Marchioninistr. 15 81377 Munich Germany Dr.

t.ere is evidence from in vit.o and animal experiment. t.at.oral creat.ne (Cr) supplement.t.on might.prevent.or slow down neurodegenerat.on in Hunt.ngt.n’ s disease (HD). However, t.is neuroprot.ct.ve effect.could not.be replicat.d in clinical t.0}als, possibly owing t. t.eat.ent.periods being t.o short.t. impact.on clinical endpoint.. We used prot.n magnet.c resonance spect.oscopy (1H- MRs) as a surrogat. marker t. evaluat. t.e effect.of Cr supplement.t.on on brain met.bolit. levels in HD. t.ent. pat.ent. (age 46 ± 7.3 years, mean durat.on of sympt.ms 4.0 ± 2.1 years, number of CAG repeat. 44.5 ± 2.7) were included. t.e primary endpoint.was met.bolic alt.rat.on as measured by 1H- MRs in t.e pariet.- occipit.l cort.x before (t.) and aft.r 8- 10 weeks (t.) of Cr administ.at.on. secondary measures comprised t.e mot.r sect.on of t.e Unified Hunt.ngt.n’ s Disease Rat.ng scale and t.e Mini Ment.l st.t. Examinat.on. 1H- MRs showed a 15.6% decrease of unresolved glut.mat. (Glu) + glut.mine (Gln; Glu + Gln = Glx; p se of Glu (p t.r Cr t.eat.ent. N- acet.laspart.t. t.ended t. fall (p = 0.073) whereas t.t.l Cr, choline- cont.ining compounds, glucose, and lact.t. remained unchanged. t.ere was no effect.on clinical rat.ng scales. t.is cort.cal Glx and Glu decrease may be explained by Cr enhancing t.e energy- dependent.conversion of Glu t. Gln via t.e Glu- Gln cycle, a pat.way known t. be impaired in HD. since Glu- mediat.d excit.t.xicit. is presumably pivot.l in HD pat.ogenesis, t.ese result. indicat. a t.erapeut.c pot.nt.al of Cr in HD. t.us, long- t.rm clinical t.0}als are warrant.d.

关键词：亨廷顿病肌酸症状持续时间神经退行性病变兴奋毒性临床试验保护效应临床终点磁共振波谱成像乳酸盐

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