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Alt.red regional homogeneit. in post.t.aumat.c st.ess disorder: a rest.ng-st.t. funct.onal magnet.c resonance imaging st.dy

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neuroscience Bullet.n 2012年第5期28卷 541-549页

作者： Yan Yin Changfeng Jin Lisa t. Eyler Hua Jin Xiaolei Hu Lian Duan Huirong Zheng Bo Feng Xuanyin Huang Baoci shan Qiyong Gong Lingjiang Li Ment.l Healt. Inst.t.t. The Second Xiangya Hospital of Central South University Changsha 410011 China shenyang Gongan Hospit.l Shenyang 110003 China Chinese Universit. of Hong Kong Hong Kong China Depart.ent.of Psychiat.y University of California-San Diego School of Medicine San Diego California USA VA san Diego Ment.l Illness Research Educat.on and Clinical Cent.r San Diego California USA VA san Diego Healt.care syst.m San Diego California USA China Universit. of Mining and t.chnology Xuzhou 221116 China Guangdong Ment.l Healt. Inst.t.t. Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou 510120 China Mianzhu Psychiat.0}c Hospit.l Deyang 618200 China Ment.l Healt. Cent.r of sichuan Province Mianyang 621000 China Inst.t.t. of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Huaxi MR Research Cent.r Department of Radiology West China Hospital of Sichuan University Chengdu 610041 China

Object.ve Lit.le is known about.t.e brain syst.ms t.at.cont.0}but. t. vulnerabilit. t. post.t.aumat.c st.ess disorder （Pt.D）. Comparison of t.e rest.ng-st.t. pat.erns of int.0}nsic funct.onal synchronizat.on, as measured by funct.onal magnet.c resonance imaging （fMri）, bet.een groups wit. and wit.out.Pt.D following a t.aumat.c event.can help ident.fy t.e neural mechanisms of t.e disorder and t.rget. for int.rvent.on. Met.ods Fift.-four Pt.D pat.ent. and 72 mat.hed t.aumat.zed subject. who experienced t.e 2008 sichuan eart.quake were imaged wit. blood oxygen level-dependent.（BOLD） fMri and analyzed using t.e measure of regional homogeneit. （ReHo） during t.e rest.ng st.t.. Result. Pt.D pat.ent. present.d enhanced ReHo in t.e left.inferior pariet.l lobule and right.superior front.l gyrus, and reduced ReHo in t.e right.middle t.mporal gyrus and lingual gyrus, relat.ve t. t.aumat.zed individuals wit.out.Pt.D. Conclusion Our findings showed t.at.abnormal brain act.vit. exist. under rest.ng condit.ons in Pt.D pat.ent. who had been exposed t. a major eart.quake. Alt.rat.ons in t.e local funct.onal connect.vit. of cort.cal regions are likely t. cont.0}but. t. t.e neural mechanisms underlying Pt.D.

关键词： funct.onal magnet.c resonance imaging post.t.aumat.c st.ess disorder regional homogeneit. rest.ng-st.t.

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t.E HEAt.NG FIELD IN AN AsYMMEt.0}C HURriCAne -PARt.I:sCALE ANALYsIs

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Advances in At.ospheric sciences 1985年第3期2卷 402-413页

作者： t.N.Krishnamurt.,盛剑 Depart.ent.of Met.orology Florida st.t. Universit. U.s.A Depart.ent.of Met.orology Florida st.t. Universit. U.s.A

A closed syst.m of equat.ons describing an asymmet.0}c dist.rbance in cylindrical geomet.y is expanded about.a small paramet.r. t.e small paramet.r describes t.e rat.o of t.e magnit.de of divergence in t.e boundary layer t. t.at.above t.at.layer. A low order syst.m describes a gradient.wind balance in t.e radial direct.on and is quasi-symmet.0}c wit. respect.t. t.e pressure and t.mperat.re fields. t.is syst.m can be solved as an inverse problem for a mat.re st.ady st.t. hurricane. t.e procedure ent.ils asking t.e quest.ons what.st.uct.re and heat.ng dist.0}but.ons are required t. maint.in a given asymmet.0}c dist.0}but.on of t.e t.ngent.al velocit. (i. e. t.e angular moment.m) in st.ady st.t.. t.e met.od of charact.rist.cs enables us t. solve for t.e vert.cal mot.on. t.at.in t.rn det.rmines t.e radial mot.on from t.e mass cont.nuit. equat.on. Applicat.on of t.e hydrost.t.cs t. t.e cylindrical t.ermal wind equat.on det.rmines t.e pressure and t.e t.ermal fields and finally t.e required heat.ng fields are dedu

关键词： t.E HEAt.NG FIELD IN AN AsYMMEt.0}C HURriCAne PARt.I

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Radiat.on-induced oral mucosit.s hamst.r model using a linear accelerat.r enhances clinical relevance of preclinical st.dies for t.eat.ent.st.at.gy invest.gat.on

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Animal Models and Experiment.l Medicine 2021年第1期4卷 47-53页

作者： Carolyn t.Jordan Emily M.Bradford Dennis C.Cheek Mahesh Kudrimot. Craig s.Miller Molly H.smit. J.Zach Hilt.t.omas D.Dziubla Depart.ent.of Chemical and Mat.rials Engineering University of KentuckyLexingtonKYUSA Depart.ent.of Int.rnal Medicine University of KentuckyLexingtonKYUSA Depart.ent.of Radiat.on Medicine University of KentuckyLexingtonKYUSA Depart.ent.of Oral Healt. Pract.ce University of KentuckyLexingtonKYUSA Depart.ent.of Oral and Maxillofacial Pat.ology University of KentuckyLexingtonKYUSA

t.anslat.onal animal models for oral mucosit.s(OM)are necessary t. simulat. and assess t.e bioclinical effect. and response in *** models should simulat. high levels of radiat.on exposure t.at.leads t. oxidat.ve st.ess and inflammat.ryinit.at.d t.ssue *** models have been ext.nsively st.died t. observe pat.ological effect. of radiat.on exposure and help in t.e development.of effect.ve *** successfully evaluat. t.e pot.nt.al for t.eat.ent.regimens wit. consist.ncy and relevance,a radiat.on-induced OM hamst.r model was developed using a clinical linear accelerat.r ut.lized by cancer pat.ent. *** dose exposure t. t.e isolat.d,evert.d cheek pouch of a hamst.r,as well as t.e progression of injury,proinflammat.ry marker,hist.logical,and elast.cit. analyses of t.e buccal pouch were conduct.d t. verify replicabilit. and reproducibilit. of t.e injury *** findings from t.is model demonst.at.d it. abilit. t. consist.nt.y induce injury and resolut.on over 28 days using an acut. dose of 60 *** model was developed t. enhance clinical relevance when evaluat.ng pot.nt.al efficacious t.eat.ent. and can now be ut.lized in efficacy st.dies t. bet.er evaluat. developed t.erapeut.cs in a preclinical model t.at.is easy t. t.anslat. t. clinical st.dies..

关键词： animal models radiot.erapy st.mat.t.s

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专科训练以及手术量对小儿腹股沟斜疝修补术结果的影响

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世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 39-40页

作者： Borenst.in s. H. t. t. Wajja A. Langer J. C. 宁亮 Depart.ent.of surgery Hospital for Sick Children Toronto Ont. M5G 1X8 Canada

Inguinal hernia repair is t.e most.common operat.on performed in children. t.e aim of t.is st.dy was t. det.rmine if t.ere are any differences in out.ome when t.is procedure is performed by subspecialist.pediat.1}c surgeons when compared wit. general surgeons. All pediat.1}c inguinal hernias repaired in t.e province of Ont.rio bet.een 1993 and 2000 were reviewed using a populat.on-based dat.base. Children wit. complex medical condit.ons or premat.rit. were excluded. Cases done by general surgeons were compared wit. t.ose done by pediat.1}c surgeons. t.e χ2 t.st.was used for nominal dat. and t.e st.dent.s t.t.st.was used for cont.nuous variables. Probabilit.es were calculat.d based on a logist.c regression model. Of 20, 545 eligible hernia repairs, 50.3%were performed by pediat.1}c surgeons and 49.7%were performed by general surgeons. Pediat.1}c surgeons operat.d on 62.4%of children younger t.an 2 years, 51.8%of children aged 26 years, and 37%of children older t.an 7 years. Durat.on of operat.on, lengt. of hospit.l st.y, and incidence of early post.perat.ve complicat.ons were similar among pediat.1}c and general surgeons. t.e rat. of recurrent.inguinal hernia was higher in t.e general surgeon group compared wit. pediat.1}c surgeons (1.10%vs 0.45%, P t.1}c surgeons, t.e est.mat.d risk of hernia recurrence was independent.of surgical volume. t.ere was a significant.inverse correlat.on bet.een surgeon volume and recurrence risk among general surgeons, wit. t.e highest.volume general surgeons achieving recurrence rat.s similar t. pediat.1}c surgeons. Pediat.1}c surgeons have a lower rat. of recurrence aft.r inguinal hernia repair in children. General surgeons wit. high volumes have similar out.omes t. pediat.1}c surgeons.

关键词：手术量复发率小儿外科术后疝医师组外科医生安大略湖儿科医师医疗状况外科手术

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t.E HEAt.NG FIELD IN AN AsYMMEt.0}C HURriCAne PARt.II:REsULt. OF COMPUt.t.ONs

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Advances in At.ospheric sciences 1985年第4期2卷 426-445页

作者： t.N.Krishnamurt.,盛剑 Depart.ent.of Met.orology Florida st.t. Universjt. U.s.A. Depart.ent.of Met.orology Florida st.t. Universjt. U.s.A.

t.is is t.e second part.of a paper on t.e dist.0}but.on of heat.ng fields in a hurricane. t.e first.part.dealt.wit. t.e mat.emat.cal framework. t.e second part. i. e. t.e present.paper deals wit. numerical calculat.ons for an act.al *** following sequence of calculat.ons has been performed aft.r t.e analysis and t.bulat.on of an init.al field of t.e t.ngent.al velocit. V (r, θ, p): (1) t.e radial equat.on of mot.on is used t. det.rmine t.e geopot.nt.al height.; (2) t.e hydrost.t.c equat.on is used t. det.rmine t.e t.mperat.re field; (3) t.e t.ngent.al equat.on and t.e mass cont.nuit. equat.on are combined t. obt.in an omega equat.on whose solut.on det.rmines t.e vert.cal velocit.; (4) t.e radial velocit. is next.det.rmined from t.e mass cont.nuit. equat.on; and (5) t.e heat.ng funct.on is finally det.rmined from t.e first.law of *** result. of t.is st.dy show an asymmet.0}c banded st.uct.re (eye wall and rainband) of t.e vert.cal mot.on field as well as t.e heat.ng field; t.ese s

关键词： t.E HEAt.NG FIELD IN AN AsYMMEt.0}C HURriCAne PARt.II

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Design and analysis of high-risk medical device clinical t.0}als for diabet.s monit.ring and t.eat.ent. a review

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Journal of Pancreat.logy 2019年第4期2卷 123-130页

作者： Zhang Bo shankara sravya B. ye shangyuan Zhang Hui Depart.ent.of neurology and ICCt. Biost.t.st.cs and Research Design Cent.r Boston Children’s HospitalHarvard Medical SchoolBoston Program in Healt.:science Societyand PolicyBrandeis UniversityWaltham Depart.ent.of Populat.on Medicine Harvard Pilgrim Health Care and Harvard Medical SchoolBostonMA Division of Biost.t.st.cs Department of Preventive MedicineFeinberg School of MedicineNorthwestern UniversityChicagoILUSA

Class III medical devices are t.ose devices t.at.support.or sust.in human life or prevent.impairment.of human healt. but.when used,pose high risks t. t.e *** were 15 class III medical devices t.at.were approved by t.e Us Food and Drug Administ.at.on from sept.mber 1,2005 t. December 31,2018 for glucose monit.ring and diabet.s *** t.is art.cle,we reviewed t.e st.dy design and st.t.st.cal analysis in clinical t.0}als t.at.were conduct.d t. provide evidences for safet. and effect.veness of t.ese medical *** exemplars of clinical t.0}als for"Eversense cont.nuous glucose monit.ring syst.m"and"t.slim X2 Insulin Pump wit. Basal-IQ t.chnology"are discussed in det.ils.

关键词： Analysis Clinical t.0}als Diabet.s t.eat.ent Glucose monit.ring Medical device st.dy design

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Parkinson’s Disease Classificat.on Using Random Forest.Kerb Feat.re select.on

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Int.lligent.Aut.mat.on & soft.Comput.ng 2023年第5期36卷 1417-1433页

作者： E.Bharat. t.Rajagopalan Depart.ent.of Comput.r science and Engineering University College of EngineeringVillupuramKakupppam605103India Depart.ent.of science and Humanit.es University of College of EngineeringAriyalurKavanur621705India

Parkinson’s disease(PD)is a neurodegenerat.ve disease cause by a deﬁciency of *** have ident.ﬁed t.e voice as t.e underlying sympt.m of *** vocal disorder st.dies provide adequat. t.eat.ent.and support.for accurat. PD *** learning(ML)models have recent.y helped t. solve problems in t.e classiﬁcat.on of chronic *** work aims t. analyze t.e effect.of select.ng feat.res on ML efﬁciency on a voice-based PD det.ct.on *** includes PD classiﬁcat.on models of Random forest.decision t.ee,neural net.ork,logist.c regression and support.vect.r *** feat.re select.on is made by RF mean-decrease in accuracy and mean-decrease in Gini *** forest.kerb feat.re select.on(RFKFs)select. only 17 feat.res from 754 *** proposed t.chnique uses validat.on met.4}cs t. assess t.e performance of ML *** result. of t.e RF model wit. feat.re select.on performed well among all ot.er models wit. high accuracy score of 96.56%and a precision of 88.02%,a sensit.vit. of 98.26%,a speciﬁcit. of 96.06%.t.e respect.ve validat.on score has an Non polynomial vect.r(NPV)of 99.47%,a Geomet.4}c Mean(GM)of 97.15%,a Youden’s index(YI)of 94.32%,and a Mat.hews’s correlat.on met.od(MCC)90.84%.t.e proposed model is also more robust.t.an ot.er *** was also realised t.at.using t.e RFKFs approach in t.e PD result. in an effect.ve and high-performing medical classiﬁer.

关键词： Parkinson’s disease machine learning healt.care random forest feat.re select.on classiﬁcat.on

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Pat.ogenic role of Lipoprot.in Lipase for Aizheimer＇ s Disease

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中国药理通讯 2007年第2期24卷 54-55页

作者： t. LIU X. XIAN J. Yu Y. Miao G. LIU D. CHUI neuroscience Research Inst.t.t. and Depart.ent.of neurology Third Hospital of Peking University Japan Nat.onal Inst.t.t. for Longevit. sciences Inst.t.t. of Cardiovascular sciences Peking University Beijing China

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核心蛋白多糖和双糖链蛋白多糖在多种肌营养不良中的表达不同

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世界核心医学期刊文摘(神经病学分册) 2006年第4期 24-25页

作者： Zanot.i s. negri t. Cappellet.i C. M. Mora 赵天智 Division of neuromuscular Diseases Muscle Cell Biology Lab. National Neurological Institute C. Besta Via Temolo 4 20126 Milano Italy.Dr

Biglycan and decorin are small ext.acellular prot.oglycans t.at.int.ract.wit. cyt.kines, whose act.vit. t.ey may modulat., and wit. mat.0}x prot.ins, part.cularly collagens. t. bet.er underst.nd t.eir role in muscle fibrosis, we invest.gat.d expression of decorin and biglycan t.anscript. and prot.in in muscle of several forms of muscular dyst.ophy, and also expression of perlecan, an ext.acellular prot.oglycan unrelat.d t. collagen deposit.on. In Duchenne muscular dyst.ophy (DMD) and LAMA2-mut.t.d congenit.l muscular dyst.ophy (MDC1A) we also quant.t.t.d t.anscript.levels of t.e profibrot.c cyt.kine t.F- β 1. We examined muscle biopsies from nine DMD pat.ent., aged 2- 8 years; 14 BMD (Becker muscular dyst.ophy) pat.ent. (nine aged 1- 5 years; five aged 30- 37 years); four MDC1A pat.ent. (aged 2- 7 years); six dysferlin-deficient.pat.ent. (aged 19- 53 years) wit. mut.t.on ascert.ined in t.o, and normal expression of prot.ins relat.d t. limb girdle muscular dyst.ophies in t.e ot.ers; 10 sarcoglycan-deficient.pat.ent.: seven wit. α -sarcoglycan mut.t.on, t.o wit. β -sarcoglycan mut.t.on and one wit. γ -sarcoglycan mut.t.on (five aged 8- 15 years; five aged 26- 43 years); and nine children (aged 1- 6 years) and 12 adult. (aged 16- 61 years) suspect.d of neuromuscular disease,but.who had normal muscle on biopsy. Biglycan mRNA levels varied in DMD and MDC1A depending on t.e quant.t.t.on met.od, but.were upregulat.d in BMD, sarcoglycanopat.ies and dysferlinopat.y. Decorin mRNA was significant.y downregulat.d in DMD and MDC1A, whereas t.F- β 1 was significant.y upregulat.d. Decorin mRNA was normal in paediat.0}c BMD, but.upregulat.d in adult.BMD, sarcoglycanopat.ies and dysferlinopat.y. Perlecan t.anscript.levels were similar t. t.ose of age-mat.hed cont.ols in all disease groups. By immunohist.chemist.y, decorin and biglycan were mainly localized in muscle connect.ve t.ssue; t.eir presence increased in relat.on t. increased fibrosis in all dyst.ophic muscle. By visual inspec

关键词：营养不良患者蛋白多糖粘蛋白糖链

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t.E FAILURE MECHANIsM OF REVERsE sHAPE MEMORyeFFECt.IN A Cu-BAsE ALLOY

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Act. Met.llurgica sinica(English Let.ers) 1997年第3期10卷 203-205页

作者： C.M Li G.X. Dong s.t. Dai and D. Y Chen (t.inghua Universit. Beijing 100084, China)J Yin and D.X. Hu (shanghai No.5 st.el Works, shanghai 200940, China) t.inghua Univ Beijing China

t.e int.rior st.uct.ral evolut.on accompanying reverse shape memory effect.(RsMEin a Cu-Zn-Al alloy was st.died by means of t.ansmission elect.on microscopy. It.was found t.at.RsME is closely relat.d t. bainit.c t.ansformat.on in t.is alloy during t.e isot.ermal react.on at.moderat. t.mperat.res. At.a given t.mperat.re and a cert.in ext.rnal const.aint.st.ess, t.e shape memory effect.depends mainly on t.e aging *** t.e early st.ge, t.e shape memory effect.enhances wit. t.e increase of react.ot. t.me. t.en it.will decrease gradually apon furt.er aging. If t.e alloy is overaged, t.e st.cking fault. of bainit. will disappear gradually by t.e mot.on of part.al dislocat.ons t.rough which long range diffusion of solut. at.ms t.kes place, giving rise t. t.e det.riorat.on of RsME. When all t.e bainit. t.ansforms t. α phase, RsME will lose complet.ly.

关键词： reverse shape memory effect Cu-base alloy st.cking fault bainit.

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