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Inflammation-induced PINCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons

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Translational Neurodegeneration 2020年第3期9卷 393-408页

作者： Kalimuthusamy Natarajaseenivasan santhanam shanmughapriya Prema Velusamy Matthew sayre Alvaro Garcia Nestor Mas gomez Dianne Langford Department of Neurosciences and Center for Neurovirology Lewis Katz School of Medicine at Temple UniversityPhiladelphiaPA 19140USA Department of Microbiology Bharathidasan UniversityTiruchirappalli 620024India Heart and Vascular Institute Department of MedicineDepartment of Cellular and Molecular PhysiologyPenn State College of MedicineHersheyPA 17033USA

Background:Diseases and disorders with a chronic neuroinflammatory component are often linked with changes in brain *** neurodegenerative disorders,people living with human immunodeficiency virus(HIM)and Alzheimer's disease(AD)are particularly vulnerable to metabolic disturbances,but the mechanistic connections of inflammation,neurodegeneration and bioenergetic deficits in the central nervous system(CNs)are poorly *** particularly interesting new cysteine histidine-rich-protein(PINCH)is nearly undetectable in healthy mature neurons,but is robustly expressed in tauopathy-associated neurodegenerative diseases including HIV infection and *** robust PINCH expression has been reported in neurons in the brains of patients with HIV and AD,the molecular mechanisms and cellular consequences of increased PINCH expression in CNs disease remain largely ***:We investigated the regulatory mechanisms responsible for PINCH protein-mediated changes in bioenergetics,mitochondrial subcellular localization and bioenergetic deficits in neurons exposed to physialogical levels of TNFa or the HIV protein *** in the PINCH-ILK-Parvin(PIP)complex association with cofilin and TEsK1 were assessed to identify factors responsible for actin depolymerization and mitochondrial *** and pharmacological inhibition experiments were conducted to confirm PINCH specificity and to reinstate proper protein-protein complex ***:We identified MEF2A as the PINCH transcription factor in neuroinflammation and determined the biological consequences of increased PINCH in ***-mediated activation of MEF2A via increased cellular calcium induced PINCH,leading to disruption of the PIP ternary complex,cofilin activation by TEsK1 inactivation,and actin *** disruption of actin led to perinuclear mislocalization of mitochondria by destabilizing the kinesin-dependent mitochondrial transport machinery,resulting i

关键词： Neuron Mitochondria Actin PINCH Neuroinflammation

synthesis and Device Applications of High-Density Aligned Carbon Nanotubes Using Low-Pressure Chemical Vapor Deposition and stacked Multiple Transfer

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Nano Research 2010年第12期3卷 831-842页

作者： Chuan Wang Koungmin Ryu Lewis gomez De Arco Alexander Badmaev Jialu Zhang Xue Lin Yuchi Che Chongwu Zhou Ming Hsieh Department of Electrical Engineering University of Southern CaliforniaLos AngelesCalifornia 90089USA

For nanotube-based electronics to become a viable alternative to silicon technology,high-density aligned carbon nanotubes are *** this paper,we report the combined use of low-pressure chemical vapor deposition and stacked multiple transfer to achieve high-density aligned *** using an optimized nanotube synthesis recipe,we have achieved high-density aligned carbon nanotubes with density as high as 30 tubes/μ*** addition,a facile stacked multiple transfer technique has been developed to further increase the nanotube density to 55 tubes/μ***,high-performance submicron carbon nanotube field-effect transistors have been fabricated on the high-density aligned *** removing the metallic nanotubes by electrical breakdown,the devices exhibit on-current density of 92.4μA/μm and normalized transconductance of 13.3μs/μ***,benchmarking with the aligned carbon nanotube transistors in the literature indicates that our devices exhibit the best performance so far,which is attributed to both the increased nanotube density and scaling down of channel *** study shows the great potential of using such high-density aligned nanotubes for high performance nanoelectronics and analog/RF applications.

关键词： Aligned carbon nanotubes chemical vapor deposition high-density high performance transistors

Identification of Potential Areas for Establishment of Plantations of <i>Agave lechuguilla</i>Torr. in Coahuila, Mexico

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Open Journal of Forestry 2014年第5期4卷 520-526页

作者： David Castillo-quiroz Oscar Ulises Martínez-Burciaga Diana Yemilet ávila-Flores Francisco Castillo-Reyes Juan David sánchez-Chaparro National Institute of Forestry Agriculture and Livestock Research (INIFAP) Experimental Station Saltillo Saltillo Mexico

Adverse weather conditions and intensive use for fiber production have caused decline of natural populations of Agave lechuguilla. By these reasons, it is important to develop a sustainable management of this specie to avoid this situation. One of the first steps is to establish forest plantations as an alternative to restore A. lechuguilla habitat and increase its range while at the same time indirectly reducing erosion rates. The aim of this study was to identify the potential areas for establishment of plantations of A. lechuguilla in the state of Coahuila, Mexico. Areas for planting establishment were selected according to multi-criteria analysis using Geographic Information system (GIs) Idrisi32 Ver 2.0 and 3.2 ***. The analysis was based on comparison of climate and soil requirements in contrast to environmental conditions of the tested area. The evaluated variables were: soil type, texture, depth, average annual temperature, annual precipitation, elevation and slope. Results derive in potential area maps, geo-referenced and their distribution by Agricultural Development District. An area of 5 million 159,273 hectares was determined with potential for establishment of A. lechuguilla forest plantations in the state of Coahuila. It was concluded that, use of GIs is a reliable tool to determine potential areas for A. lechuguilla forest plantations, where this specie has higher probability of success in survival and biomass production. This study will support programs aimed to strengthen the economy of rural producers and also recover and preserve the arid state.

关键词： Agave lechuguilla Forest Plantations Natural-Fiber Geographical Information systems

solvent-free fabrication of broadband Ws2 photodetectors on paper

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Opto-Electronic Advances 2023年第3期6卷 1-11页

作者： Wenliang Zhang Onur Çakıroğlu Abdullah Al-Enizi Ayman Nafady Xuetao Gan Xiaohua Ma sruthi Kuriakose Yong Xie Andres Castellanos-gomez Materials science Factory Instituto de Ciencia de Materiales de Madrid(ICMM-CSIC)Madrid E-28049Spain Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi’an 710129China school of Advanced Materials and Nanotechnology Xidian UniversityXi’an 710071China

Paper-based devices have attracted extensive attention due to the growing demand for disposable flexible ***,we integrate semiconducting devices on cellulose paper substrate through a simple abrasion technique that yields high-performance photodetectors.A solvent-free Ws_(2) film deposited on paper favors an effective electron-hole separation and hampers *** as-prepared paper-based Ws2 photodetectors exhibit a sensitive photoresponse over a wide spectral range spanning from ultraviolet(365 nm)to near-infrared(940 nm).Their responsivity value reaches up to~270 mA W^(−1) at 35 V under a power density of 35 mW cm^(−2).A high performance photodetector was achieved by controlling the environmental exposure as the ambient oxygen molecules were found to decrease the photoresponse and stability of the Ws_(2) ***,we have built a spectrometer using such a paperbased Ws_(2) device as the photodetecting component to illustrate its potential *** present work could promote the development of cost-effective disposable photodetection devices.

关键词： paper electronics photodetector van der Waals materials solvent-free deposition tungsten disulfide

ZnO Planar-Tetrapod synthesized by Cethyltrimethylamonium Hydroxide-Assisted Hydrothermal Method at Low Temperature

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World Journal of Condensed Matter Physics 2015年第4期5卷 339-345页

作者： sebastián López-Romero Manuel García-Hipólito Mayte saraí Valverde Labastida María de Jesús quiroz Jiménez Instituto de Investigaciones en Materiales Universidad Nacional Autónoma de México México DF México

Planar tetrapods ZnO (PTP-ZnO) or cross shaped tetrapod nanostructures were synthesized by a cethyltrimethylamonium hydroxide (CTAOH)-assisted hydrothermal method at low temperature (120°C). The XRD diffractogram showed that the PTP-ZnO nanostructures showed a hexagonal wurtzite phase. The studies with high resolution transmission electron microscopy (HRTEM) and select area specific diffraction (sAED) revealed that the ZnO pods were single crystals and preferentially grew up along [002] direction. The growth mechanism of the CTAOH assisted-hydrothermal synthesized PTP-ZnO nanostructures is explained using the final shape guiding of materials nanostructured and surfactant-action theories.

关键词： ZnO CTAOH surfactant Assisted-Hydrothermal Technique Cross shaped Tetrapod

Effects of the Cu Ion on the structural and Optical Properties of Yttrium Doped ZnO by solution Combustion

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World Journal of Condensed Matter Physics 2017年第4期7卷 89-98页

作者： s. López-Romero M. J. quiroz-Jiménez M. García-Hipólito A. Aguilar-Castillo Departamento de Materia Condensada y Criogenia Universidad Nacional Autónoma de México Instituto de Investigaciones en Materiales circuito exterior S/N Ciudad de México Coyoacán Ciudad de México México

In this experiment, pure, Y3+ doped ZnO and Cu2+ + Y3+ co-doped ZnO were synthesized by a solution combustion method. The Y3+ dopant concentration was fixed in 3%wt. and the Cu2+ dopant concentrations were 0, 1, 2, 3, 10, and 20%wt. The XRD spectra showed that the original hexagonal wurtzite structure of ZnO is conserved after doping process, an increasing red shift until 10%wt. Cu2+ doping and decrease at higher Cu2+ doping and also, the chemical creation of the news Y2O3 and Y2Cu2O5 phases. The behavior of the photoluminescence of the samples as a function of Cu2+ doping reveal that the green emission band of the ZnO is quenching and the ZnO UV emission intensity decrease notably for all Cu2+ doping. The scanning electron microscope analysis of the Cu2+ + Y3+ co-doped ZnO samples reveal the existence of grains agglutinated forming like-spheres particles. However, the nano-sized characteristic of the crystals is confirmed.

关键词： Zinc Oxide solution Combustion X-Ray Photoluminescence Morphology

Early vs. Delayed Cord Clamping at Full-Term Planned Cesarean section: A Randomized study

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Open Journal of Obstetrics and Gynecology 2021年第6期11卷 647-653页

作者： K. Morales-Allard C. Montufar-Rueda s. gomez-Manrique Department of Obstetrics and Gynecology Complejo Hospitalario Dr. Arnulfo Arias M. CSS Panama City Panama Critical Care Obstetrics Unit Department of Obstetrics and Gynecology Complejo Hospitalario Dr. Arnulfo Arias M. CSS Panama City Panama Neonatal Intensive Care Unit Complejo Hospitalario Dr. Arnulfo Arias M. CSS Panama City Panama

Objective: In cesarean section (Cs), which, early vs. delayed cord clamping is better for neonatal and maternal hematocrit/hemoglobin level is not yet completely determined. This randomized controlled study attempted ... 详细信息

strong>Objective:strong> In cesarean section (CS), which, early vs. delayed cord clamping is better for neonatal and maternal hematocrit/hemoglobin level is not yet completely determined. This randomized controlled study attempted to determine this issue.span>span> span>span>Methods:span>span> Study population consisted of 64 full-term pregnant women/neonates undergoing planned CS: 32 received early cord clamping (ECC: 15 seconds after birth) and 32 delayed cord clamping (DCC: 90 seconds). We measured and analyzed span>span>1span>span>) neonatal hematocrit at the first 24span>span> span>span>-span>span> span>span>48 hours, and span>span>2span>span>) maternal-hemoglobin-change before and after CS.span>span> span>s

关键词： Umbilical Cord Clamping Elective Cesarean section Neonatal Hematocrit Neonatal Jaundice Obstetric Hemorrhage

Potential Areas for Commercial Timber Plantations of Tabebuia rosea(Bertol.)*** Michoacan,Mexico

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Open Journal of Forestry 2017年第1期7卷 48-57页

作者： Hipolito Jesus Munoz-Flores David Castillo-quiroz Francisco Castillo-Reyes J.Trinidad sáenz-Reyes Diana Avila-Flores Agustín Rueda-sánchez National Institute of Forestry Agriculture and Livestock Research(INIFAP)-Experimental Station UruapanUruapanMéxico National Institute of Forestry Agriculture and Livestock Research(INIFAP)-Experimental Station SaltilloSaltilloMéxico

The targeted area for plant reforestation in the state of Michoacan is made up of eroded areas and pasture induced areas, both adding to 525,260 ha and representing 10.9% of the total surface of the state. The regions with the largest areas in need of reforestation are the Costa with 185,396 ha (29%), Oriente with 106,836 (17%) and Tierra Caliente with 96,284 (15%). Commercial forest plantations are an alternative for reducing the pressure on natural forests and creating options for sustainable and diversified development, changing the land use from fragmented agricultur and livestock purposes to forestry. The object of this study was to determine potential areas for the establishment of commercial forest plantations of Tabebuia rosea (Bertol.) DC. in the state of Michoacan, Mexico, by using geographic information systems. The outlining of potential areas was performed with the IDRIsI 32 and ArcView programs, according to the environmental requirements of T. rosea. These environmental requirements include precipitation, temperature, soil, altitude, land use and slope. The analysis resulted in two maps where the potential areas for the establishment of commercial forest plantations with this species were shown, which turned out a total potential area of 54,320 ha, distributed in 47,566 ha considering a slope of 0% - 15% for non-manual forest plantations, and 6754 ha considering a slope of 15% - 30% for manual forest plantations. The ecologic conditions in Michoacan are favorable for successful establishment and development of commercial forest plantations of T. rosea.

关键词： Potential Areas Michoacan Commercial Forest Plantations Tabebuia rosea Geographic Information system

3-Phase hierarchical graphene-based epoxy nanocomposite laminates for automotive applications

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Journal of Materials science & Technology 2019年第10期35卷 2169-2177页

作者： Ahmed Elmarakbi Panagiotis Karagiannidis Alessandra Ciappa Franco Innocente Francesco Galise Brunetto Martorana Francesco Bertocchi Francesco Cristiano Elvira Villaro Abalos Julio gomez Department of Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastleNE18STUnited Kingdom school of Engineering Faculty of TechnologyUniversity of SunderlandSunderlandSR6 ODDUnited Kingdom Delta-Tech s.pA. localita Rifoglieto 60/a-int.155011AltopascioLUItaly Fiat Research Center via ex Aeroporto80038 Pomigliano d'ArcoNaplesItaly Nanesa srl.Via Del Gavardello 59/c 52100 ArezzoARItaly Instituto de Tecnologfas Quimicas Emergences de La Rioja Antonio de Nebrija826006 LogronoSpain Avanzare Innovacion Tecnologica s.L Avda.Lentiscares 4-626370 NavarreteSpain

Two different types of graphene flakes were produced following solution processing methods and dispersed using shear mixing in a bifunctional(A) and a multifunctional(B) epoxy resin at a concentration of 0.8 and 0.6 wt%, respectively. The graphene/epoxy resin mixtures were used to impregnate unidirectional carbon fibre tapes. These prepregs were stacked(seven plies) and cured to produce *** interlaminar fracture toughness(mode-I) of the carbon fiber/graphene epoxy laminates with resin B showed over 56% improvement compared with the laminate without graphene. single lap joints were prepared using the laminates as adherents and polyurethane adhesives(sika 7666 and sika 7888). The addition of graphene improved considerably the adhesion strength from 3.3 to 21 MPa(sample prepared with resin A and sika 7888) highlighting the potential of graphene as a secondary filler in carbon fibre reinforced polymer composites.

关键词： Graphene Carbon fibre reinforced polymer(CFRP) Fracture toughness shear lap joints