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中国处方药 2010年第3期9卷 39-39页

作者： ott J Wirth s Nouri K

本研究探讨了促黄体生成素（LH）、促卵泡生成素（FsH）、睾丸酮和雄烯二酮预测腹腔镜卵巢打孔术后排卵的价值。

关键词：独立预测因素促黄体生成素卵巢打孔雄烯二酮腹腔镜排卵术后促卵泡生成素

Genetics of macrovascular complications in type 2 diabetes

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World Journal of Diabetes 2021年第8期12卷 1200-1219页

作者： Ziravard N Tonyan Yulia A Nasykhova Maria M Danilova Andrey s Glotov Department of Genomic Medicine D.O.Ott Research Institute of ObstetricsGynecology and ReproductologySaint-Petersburg 199034Russia Laboratory of Biobanking and Genomic Medicine of Institute of Translation Biomedicine St.Petersburg State UniversitySaint-Petersburg 199034Russia

Type 2 diabetes mellitus(T2DM)is a metabolic disorder that currently affects more than 400 million worldwide and is projected to cause 552 million cases by the year ***-term vascular complications,such as coronary artery disease,myocardial infarction,stroke,are the leading causes of morbidity and mortality among diabetic *** recent advances in genome-wide technologies have given a powerful impetus to the study of risk markers for multifactorial *** date,the role of genetic and epigenetic factors in modulating susceptibility to T2DM and its vascular complications is being successfully studied that provides the accumulation of genomic *** the future,this will provide an opportunity to reveal the pathogenetic pathways in the development of the disease and allow to predict the macrovascular complications in T2DM *** review is focused on the evidence of the role of genetic variants and epigenetic changes in the development of macrovascular pathology in diabetic patients.

关键词： Type 2 diabetes Epigenetics Genetics Macrovascular complications

Impact of the 2010 resuscitation guidelines training on layperson chest compressions

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World Journal of Emergency Medicine 2015年第4期6卷 270-276页

作者： Audrey L.Blewer David G.Buckler Jiaqi Li Marion Leary Lance B.Becker Judy A.shea Peter W.Groeneveld Mary E.Putt Benjamin s.abella Department of Emergency Medicine and Center for resuscitation science University of Pennsylvania school of Nursing University of Pennsylvania Department of Medicine University of Pennsylvania Department of Biostatistics and Epidemiology University of Pennsylvania

BACKGrOUND: survival from cardiac arrest is sensitive to the quality of delivered CPr. In 2010, updated international resuscitation guidelines emphasized deeper chest compressions and faster rates, yet it is unknown whether training laypersons using updated guidelines resulted in changed CPr performance. We hypothesized that laypersons taught CPr using the 2010 guidelines performed deeper and faster compressions than those taught using the 2005 ***: This work represents a secondary analysis of a study conducted at eight hospitals where family members of hospitalized cardiac patients were trained in CPr. An initial cohort was trained using the 2005 guidelines, and a subsequent cohort was trained using the 2010 guideline materials. Post training, CPr skills were quantified using a recording ***: Between May 2009 to August 2013, 338 subjects completed the assessment. Among the subjects, 176 received 2005 training and 162 underwent 2010 training. The mean compression rate in the 2005 cohort was 87(95%CI 83–90) per minute, and in the 2010 cohort was 86(95%CI 83–90) per minute(P=ns), while the mean compression depth was 34(95%CI 32–35) mm in the 2005 cohort and 46(95%CI 44–47) mm in the 2010 cohort(PsIONs: Training with the 2010 CPr guidelines resulted in a statistically significant increase in trainees' compression depth but there was no change in compression rate. Nevertheless, the majority of CPr performed by trainees in both cohorts was below the guideline recommendation, highlighting an important gap between training goals and trainee performance.

关键词： Cardiopulmonary resuscitation Cardiac arrest sudden death Education Guidelines

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缺氧对脑星状细胞内皮素系统基因表达的影响

暨南大学学报（自然科学与医学版） 1998年第6期19卷 130-131页

作者：徐安定 Tusch.,s 暨南大学医学第一附属医院神经内科

内皮素－１（ＥＴ－１）广泛存在于中枢神经系统（ＣＮＳ）并通过其受体Ａ和Ｂ（ＥＴＡＲ，ＥＴＢＲ）产生众多的血管和非血管活性作用，内皮素转换酶（ＥＣＥ）－２是ＣＮＳ中主要的ＥＣＥ形式，它将几乎无活性的ＥＴ－１转换成活性的... 详细信息

内皮素－１（ＥＴ－１）广泛存在于中枢神经系统（ＣＮＳ）并通过其受体Ａ和Ｂ（ＥＴＡＲ，ＥＴＢＲ）产生众多的血管和非血管活性作用，内皮素转换酶（ＥＣＥ）－２是ＣＮＳ中主要的ＥＣＥ形式，它将几乎无活性的ＥＴ－１转换成活性的ＥＴ－１。脑星状细胞（ＡＣ）是ＣＮＳ重要组成部分，可产生ＥＴ－１并合有其受体结合点。缺氧可使ＡＣ分泌ＥＴ－１水平增高，但是否对ＡＣＥＴ－１ｍＲＮＡ水平有调节作用则尚无报道。也未见有缺氧对ＡＣ或脑组织ＥＣＥ－２和ＥＴ受体ｍＲＮＡ水平影响的报道。本研究的目的是观察缺氧对上述内皮素系统成份基因报道的影响，进一步阐明内皮素系统在脑缺氧后的分子生物学作用机制。方法：ＡＣ取自新生ＮＭＲＩ小鼠大脑，培养５天后转至不含血清的培养基中，在缺氧箱（０３％氧）或正常氧供下培养２４小时。提取细胞总ＲＮＡ后，在甲醛／０１％琼脂糖凝胶上电泳使其变性和分离，并转移至尼龙膜上。样本加样ＲＮＡ量用溴化乙锭染色法评估。ＥＴ－１，ＥＴＲＡ，ＥＴＢＲ和ＥＣＥ－２ｃＤＮＡ探针用磷３２－ｄＣＴＰ标记。北部杂交放射自显影后的ｍＲＮＡ水平用计算机进行分析和统计。结果：北部杂交ＲＮＡ分析显示缺氧后小鼠培养星状细胞的ＥＴ－１ｍＲＮＡ水平有显著?

关键词：缺氧脑星状细胞内皮素基因表达

缺氧对脑星状细胞GAPDH和β-Actin基因表达的影响

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暨南大学学报（自然科学与医学版） 1998年第6期19卷 128-130页

作者：徐安定 Tusch.,s 暨南大学医学院第一附属医院神经内科

样本ＲＮＡ加样量的差异是影响Ｎｏｒｔｈｅｒｎ杂交ＲＮＡ分析和反转录ＰＣＲ（ＲＴ－ＰＣＲ）半定量分析的重要因素。因５－磷酸甘油醛脱氢酶（ＧＡＰＤＨ）和β－肌动蛋白（β－ａｃｔｉｎ）ｍＲＮＡ水平一般相对恒定，常用于基因表... 详细信息

样本ＲＮＡ加样量的差异是影响Ｎｏｒｔｈｅｒｎ杂交ＲＮＡ分析和反转录ＰＣＲ（ＲＴ－ＰＣＲ）半定量分析的重要因素。因５－磷酸甘油醛脱氢酶（ＧＡＰＤＨ）和β－肌动蛋白（β－ａｃｔｉｎ）ｍＲＮＡ水平一般相对恒定，常用于基因表达研究时样本加样量的校正。但有报道表明某些因素对ＧＡＰＤＨ和β－ａｃｔｉｎ的ｍＲＮＡ水平有一定影响。脑星状细胞（ＡＣ）是近年来神经科学的研究热点之一，有关其基因表达的研究得到广泛的重视。本研究的目的是观察ＧＡＰＤＨ和β－ａｃｔｉｎ的ｍＲＮＡ水平是否作为培养ＡＣ缺氧状态下基因表达研究的标准参照。方法：ＡＣ取自新生ＮＭＩＲ小鼠大脑。培养５天后转至不含血清的培养基中，在缺氧箱（０３％氧）或正常氧供下培养２４小时。提取细胞总ＲＮＡ后，在甲醛／０１％琼脂糖凝胶上电泳使其变性和分离，并转移至尼龙膜上。样本加样ＲＮＡ量用溴化乙锭染色法评估。ＧＡＰＤＨ和β－ａｃｔｉｎｃＤＮＡ探针用磷３２－ｄＣＴＰ标记。Ｎｏｒｔｈｅｒｎ杂交放射自显影后的ｍＲＮＡ水平用计算机进行分析和统计学处理。结果：２４小时缺氧后，ＡＣ的ＧＡＰＤＨｍＲＮＡ水平（ｎ＝９）显著增高，达正常组（ｎ＝１０）５０３．０％，其Ｐ＜０００１。与此相反?

关键词：缺氧脑星状细胞 β-Actin GAPDH 基因表达

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院内心脏骤停期间心肺复苏的质量

世界核心医学期刊文摘（心脏病学分册） 2005年第6期1卷 21-21页

作者： abella B.s. Alvarado J.P. Myklebust H. L.B. Becker 腾增辉 Dr.University of Chicago Hospitals Section of Emergency MedicineMC 5068 5841 S Maryland Ave ChicagoIL 60637 United States

Context: The survival benefit of well-performed cardiopulmonary resuscitation(CPr) is well-documented, but little objective data exist regarding actual CPr quality during cardiac arrest. recent studies have challenged the notion that CPr is uniformly performed according to established international guidelines. Objectives: To measure multiple parameters of in-hospital CPr quality and to determine compliance with published American Heart Association and international guidelines. Design and setting: A prospective observational study of 67 patients who experienced in-hospital cardiac arrest at the University of Chicago Hospitals, Chicago, Ill, between December 11, 2002, and April 5, 2004. Using a monitor/-defibrillator with novel additional sensing capabilities, the parameters of CPr quality including chest compression rate, compression depth, ventilation rate, and the fraction of arrest time without chest compressions(no-flow fraction) were recorded. Main Outcome Measure: Adherence to American Heart Association and international CPr guidelines. results: Analysis of the first 5 minutes of each resuscitation by 30-second segments revealed that chest compression rates were less than 90/min in 28.1%of segments. Compression depth was too shallow(defined asr 37.4%of compressions. Ventilation rates were high, with 60.9%of segments containing a rate of more than 20/min. Additionally, the mean(sD) no-flow fraction was 0.24(0.18). A 10-second pause each minute of arrest would yield a no-flow fraction of 0.17. A total of 27 patients(40.3%) achieved return of spontaneous circulation and 7(10.4%) were discharged from the hospital. Conclusions: In this study of in-hospital cardiac arrest, the quality of multiple parameters of CPr was inconsistent and often did not meet published guideline recommendations, even when performed by well-trained hospital staff. The importance of high-quality CPr suggests the need for rescuer feedback and monitoring of CPr quality during resusc

关键词：心脏骤停心肺复苏胸部按压美国心脏学会国际指南自主循环美国心脏病学会传感功能芝加哥大学前瞻性观察

超声剪切波弹性成像在评价儿童肝脏硬度及纤维化中的可行性及准确性:一项包含96例病人的初步研究

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国际医学放射学杂志 2016年第2期 196-196页

作者： s.F.abella L.Corno E.Gonzales G.Antoni M.Fabre B.Ducot 王巧丽 Department of Pediatric radiology Hopital Bicêtre Hopitaux Universitaires Paris SudAssistance Publique Hopitaux de ParisUniversité Paris Sud

摘要目的评估超声剪切波弹性成像(ssWE)在儿童病人中应用的可行性;测量对照组不同年龄受试者(从新生儿至青少年)肝脏硬度的正常值;以组织学评分系统为标准,评估ssWE诊断肝脏疾病病人肝纤维化的准确性,尤其关注肝纤维化早期病人的诊断。... 详细信息

摘要目的评估超声剪切波弹性成像(ssWE)在儿童病人中应用的可行性;测量对照组不同年龄受试者(从新生儿至青少年)肝脏硬度的正常值;以组织学评分系统为标准,评估ssWE诊断肝脏疾病病人肝纤维化的准确性,尤其关注肝纤维化早期病人的诊断。材料与方法本项前瞻性研究经伦理委员会审查批准,并由患儿家属或大于7岁的患儿签署知

关键词：超声剪切波弹性成像病人肝脏儿童

多佐胺在6岁以下青光眼患者中的效果:一项随机试验

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世界核心医学期刊文摘(眼科学分册) 2006年第1期 24-24页

作者： ott E.Z. Mills M.D. Arango s. I.A. Adamsons 王大江 Merck research Laboratories Inc. BLX-30 PO Box 4 West Point PA 19486United States Dr

Objective: To evaluate dorzolamide hydrochloride in patients younger than 6 years who have an elevated intraocular pressure or glaucoma. Design: A 3-month, controlled, randomized, double-masked, multicenter, clinical trial. Patients were randomized to 2% dorzolamide 3 times daily or timolol maleate gel-forming solution (0.25% for patients rs and 0.5% for patients≥ 2 butrs) once daily plus placebo twice daily. If the intraocular pressure was not controlled through monotherapy, younger patients received concomitant dorzolamide 3 times daily and 0.25% timolol gel-forming solution once daily and older patients received a fixed combination of 2% dorzolamide and 0.5% timolol twice daily. The primary safety variable was the proportion of patients who discontinued therapy for a drugrelated adverse experience. Intraocular pressure reduction was a secondary measure. results: One younger patient (1.8% )-of 56 randomized to dorzolamide discontinued concomitant therapy because of bradycardia. Two older patients (3.0% ) of 66 discontinued dorzolamide because of ocular adverse experiences. The most frequent ocular adverse experiences were discharge and ocular hyperemia (younger cohort) and ocular hyperemia and burning/stinging (older cohort). At week 12, the mean change in intraocular pressure for dorzolamide was statistically significant from baseline (-7.3 mmHg [20.6% ]-and-7.1 mmHg [23.3% ]) in the younger and older cohorts, respectively; P r both. Conclusion: Dorzolamide was generally well tolerated and demonstrated efficacy for up to 3 months in patients younger than 6 years.

关键词：多佐胺青光眼患者

Opportunistic Infections in Late Kidney Transplantation with Death Outcome: Case report

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Open Journal of Nephrology 2021年第2期11卷 171-182页

作者： Miriam Viviane Baron Carina Marangoni Michele Paula dos santos Célia regina Martins Korzenieski Vitória Pereira Itaquy Tais Michele Werle Gabriela Di Lorenzo Garcia scherer Joice Nedel ott Marcus Vinicius de Mello Pinto Janine Koepp Carolina Gonçalves Pinheiro Nathália Ken Pereira Iketani Cristine Brandenburg Aline ronis sampaio Alexandre sancho Danielle de Mello Florentino Bartira Ercília Pinheiro da Costa Postgraduate Program in Medicine and Health sciences of the Pontifical Catholic University of rio Grande do sul (PUC/rs) Porto Alegre Brazil Coordination for the Improvement of Higher Education Personnel Brazilia Brazil school of Medicine of the Pontifical Catholic University of rio Grande do sul (PUC/rs) Porto Alegre Brazil schoolof Health and Life sciences of the Pontifical Catholic University of rio Grande do sul (PUC/rs) Porto Alegre Brazil CelulareInstitute Rio de Janeiro Brazil University of santa Cruz do sul (UNIsC) Santa Cruz do Sul Brazil Postgraduate Program in Health sciences of the Faculty of Medicine of ABC (FMABC) S&atilde o Paulo Brazil Hospital Beneficiente Portuguesa of Belém Pará Brazil Dom José Institute of Education and Culture/University of Vale do Acaraú (IDJ/UVA) Ceará Brazil Unigranrio University Rio de Janeiro Brazil Uniredentor University Rio de Janeiro Brazil

Cytomegalovirus (CMV) and Pneumocystis jirovecii fungus are the main opportunistic microorganisms that affect transplanted individuals. Immunosuppressive drugs administered to prevent organ rejection leave the immune system vulnerable to these infections. The present report is about a kidney transplanted patient using immunosuppressants who was diagnosed with cytomegalovirus and pneumocystosis requiring admission to the intensive care unit (ICU). Female patient, 57 years old, a kidney transplanted three years ago, with comorbidities, such as systemic arterial hypertension, hypertriglyceridemia and type 2 diabetes mellitus. she was admitted to the hospital in January 2020 with a history of diarrhea, cough, malaise and weight loss of seven kg in a month. she made continuous use of the immunosuppressants tacrolimussup>®sup> and mycophenolate sodium (MFs). After five days of hospitalization, she was transferred to the ICU due to refractory diarrhea, worsening renal function and respiratory pattern, requiring mechanical ventilation. Chest tomography showed changes that led to the diagnostic hypothesis of CMV pneumonia or Pneumocystis jirovecii. Treatment with Ganciclovirsup>®sup> and Bactrimsup>®sup> was started. The bronchial lavage polymerase chain reaction test confirmed the infectious condition for CMV and Pneumocystis jirovecii. Despite the drug therapy instituted, there was no improvement in the infectious condition. The patient started to present a general and progressive worsening of the clinical picture with loss of renal graft function, respiratory failure, metabolic acidosis, hemodynamic instability and severe distributive shock, evolving to death. In the present report, it was observed that after late kidney transplantation the fragility of the immune system caused by the use of immunosuppressants contributed to the development of a severe infection with CMV and Pneumocystis jirovecii. Adjusting the doses of immunos

关键词： renal Transplantation Infections Opportunistic Immunosuppressive Agent Cytomegalovirus Pneumocystis

光子探测器在芬兰HIP和克罗地亚rBI的研发制作（英文）

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湘潭大学学报（自然科学版） 2018年第4期40卷 115-120页

作者： Brücken Erik Gadda Akiko ott Jennifer Naaranoja Tiina Martikainen Laura Karadzhinova-Ferrer Aneliya Kalliokoski Matti Golovlova Maria Kirschenmann stefanie Litichevskyi Vladyslav Petrine Ana Luukka Panja Harkonen Jaakko 赫尔辛基物理研究所(HIP) 芬兰赫尔辛基FI-00014 罗德波士克维奇研究所(rBI) 克罗地亚萨格勒布10000 艾得维堪公司芬兰艾斯堡FI-02150 斯拜得康公司芬兰艾斯堡FI-02150

该文描述了碲化镉(CdTe)探测器,硅漂移探测器和外加一层转换闪烁体硅探测器(sis)的设计与制作方法 .这些硅及CdTe芯片制作工艺及其连接方法是在芬兰的Micronova中心完成的.与硅工艺不同的是,CdTe工艺必须在低于150℃的温度下完成.我们... 详细信息

该文描述了碲化镉(CdTe)探测器,硅漂移探测器和外加一层转换闪烁体硅探测器(sis)的设计与制作方法 .这些硅及CdTe芯片制作工艺及其连接方法是在芬兰的Micronova中心完成的.与硅工艺不同的是,CdTe工艺必须在低于150℃的温度下完成.我们因此专门为CdTe探测器开发了一种低温原子层淀积的氧化铝(Al2O3)薄膜工艺,大小为(10×10×1)mm3的CdTe晶圆由一种无接触的光刻工艺完成.探测器性能是由电流-电压(I-V),电容-电压(C-V)、瞬间电流方法和精确微质子数方法来检测的.实验结果与具有材料和缺陷参数的TCAD模拟结果相符.

关键词：硅探测器碲化镉探测器 I-V、C-V 和TCT方法原子层淀积(ALD)法